Academic Journal
Clinical and morphopathological assay in vulvovaginal candidiasis.
| Τίτλος: | Clinical and morphopathological assay in vulvovaginal candidiasis. |
|---|---|
| Συγγραφείς: | Manolea MM; Department of Histology, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; ancaofiteru92@yahoo.com; ssidoniam@yahoo.com., Istrate-Ofiţeru AM, Săndulescu MS, Camen IV, Piciu IA, Dijmărescu AL, Vrabie SC, Neamţu SD, Obleagă CV, Siminel MA |
| Πηγή: | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2022 Jul-Sep; Vol. 63 (3), pp. 511-520. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Editura Academiei Române Country of Publication: Romania NLM ID: 9112454 Publication Model: Print Cited Medium: Internet ISSN: 2066-8279 (Electronic) Linking ISSN: 12200522 NLM ISO Abbreviation: Rom J Morphol Embryol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bucuresti, România : Editura Academiei Române, [1990- |
| Ιατρικοί όροι (MeSH): | Candidiasis, Vulvovaginal*/drug therapy , Candidiasis, Vulvovaginal*/diagnosis , Candidiasis, Vulvovaginal*/microbiology, Nystatin/pharmacology ; Nystatin/therapeutic use ; Female ; Humans ; Retrospective Studies ; Neoplasm Recurrence, Local ; Vagina |
| Περίληψη: | Candida vulvovaginitis is characterized by the appearance of inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species. The purpose of this study was to analyze and compare the clinical, microbiological, and histopathological aspects of pregnant and non-pregnant patients, symptomatic or asymptomatic in the case of candida vaginitis and to correlate the microscopic aspects with the symptoms before applying the local treatment with Nystatin. The study presents a retrospective analysis of the management of vaginitis in 166 pregnant or non-pregnant patients during 2021-2022. We observed the structure of the Malpighian squamous epithelium without keratinization present on the vaginal mucosa and the structure of the subepithelial connective tissue, which shows increased numerical values of inflammatory and vascular cellularity in the case of candida vaginitis symptomatic compared to asymptomatic ones. We noticed also in the microscopic study that in cases of asymptomatic patients before treatment, the number of inflammatory cells and blood vessels situated immediately under the epithelium was significantly lower compared to their number in symptomatic patients before treatment. Analyzing the results obtained after the administration of the treatment proposed by us, we can say that local Nystatin treatment is beneficial and safe for pregnant and non-pregnant patients and is a good alternative for patients with recurrent vulvovaginal candidiasis. |
| References: | Oncol Lett. 2017 Sep;14(3):3869-3877. (PMID: 28927159) Am Surg. 2015 Jan;81(1):41-7. (PMID: 25569064) Expert Rev Mol Med. 2011 Jul 11;13:e23. (PMID: 21740602) Nat Rev Cancer. 2017 Oct;17(10):577-593. (PMID: 28912578) J Clin Med. 2022 Aug 30;11(17):. (PMID: 36079025) Rom J Morphol Embryol. 2020;61(1):81-93. (PMID: 32747898) Open Access Maced J Med Sci. 2019 Apr 10;7(7):1067-1070. (PMID: 31049082) Clin Cancer Res. 2015 Feb 15;21(4):882-8. (PMID: 25473000) Prz Gastroenterol. 2019;14(2):89-103. (PMID: 31616522) Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542) Ann Surg Oncol. 2010 Jun;17(6):1471-4. (PMID: 20180029) J Thromb Haemost. 2013 Feb;11(2):223-33. (PMID: 23279708) J Adolesc Young Adult Oncol. 2022 Mar 18;:. (PMID: 35319280) Medicine (Baltimore). 2021 Jan 8;100(1):e24062. (PMID: 33429770) Adv Cancer Res. 2015;128:173-96. (PMID: 26216633) Surgery. 2010 Mar;147(3):339-51. (PMID: 20004450) Rom J Morphol Embryol. 2020 Jul-Sep;61(3):673-680. (PMID: 33817708) Cancer Metastasis Rev. 2019 Jun;38(1-2):205-222. (PMID: 30911978) Thromb Res. 2016 Mar;139:56-64. (PMID: 26916297) Eur J Cancer. 2009 Aug;45(12):2138-45. (PMID: 19409772) Minerva Chir. 2017 Dec;72(6):491-498. (PMID: 28621509) Semin Colon Rectal Surg. 2022 Jun;33(2):. (PMID: 35937614) Eur J Cancer. 2005 Nov;41(17):2645-54. (PMID: 16239109) Rom J Morphol Embryol. 2021 Jan-Mar;62(1):117-124. (PMID: 34609414) Br J Cancer. 2012 Aug 21;107(5):864-73. (PMID: 22878371) World J Surg Oncol. 2019 Jun 29;17(1):112. (PMID: 31255181) Rom J Morphol Embryol. 2021 Oct-Dec;62(4):971-979. (PMID: 35673816) J Immunol Res. 2018 Feb 18;2018:6827237. (PMID: 29670921) Genes (Basel). 2022 Jul 22;13(8):. (PMID: 35893034) Ann Afr Med. 2019 Jul-Sep;18(3):121-126. (PMID: 31417011) |
| Substance Nomenclature: | 1400-61-9 (Nystatin) |
| Entry Date(s): | Date Created: 20230102 Date Completed: 20230103 Latest Revision: 20230217 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC9926141 |
| DOI: | 10.47162/RJME.63.3.05 |
| PMID: | 36588489 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2066-8279 |
|---|---|
| DOI: | 10.47162/RJME.63.3.05 |