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Demand and cross-price elasticity of cocaine and social contact in a free-operant procedure of nonexclusive choice.

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Τίτλος: Demand and cross-price elasticity of cocaine and social contact in a free-operant procedure of nonexclusive choice.
Συγγραφείς: Smith MA; Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA. Electronic address: masmith@davidson.edu., Cha HSH; Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA., Sharp JL; Department of Psychology and Program in Neuroscience, Davidson College, Davidson, NC, USA., Strickland JC; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Πηγή: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2023 Jan; Vol. 222, pp. 173511. Date of Electronic Publication: 2022 Dec 23.
Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE
Imprint Name(s): Publication: Tarrytown, NY : Elsevier
Original Publication: Phoenix, N. Y. Ankho International, ltd.
Ιατρικοί όροι (MeSH): Cocaine*/pharmacology , Cocaine-Related Disorders*, Rats ; Male ; Animals ; Reinforcement, Psychology ; Conditioning, Operant ; Reinforcement Schedule ; Self Administration ; Dose-Response Relationship, Drug
Περίληψη: Research examining the social determinants of addiction has advanced significantly with the recent development of preclinical models of drug use and the social environment. These models reveal that drug use and social contact compete with one another for behavioral expression in discrete-trial choice procedures using concurrent schedules of reinforcement. The purpose of this study was to determine how concurrent access to cocaine and a social partner influences the demand for each alternative under free-operant conditions in which responding maintained by each reinforcer is independent and nonexclusive of the other. To this end, male rats were trained under a free-operant, concurrent schedule of reinforcement in which responding maintained by cocaine and access to a social partner operated independently of one another. Measures of economic demand (e.g., intensity, Omax, cross-price elasticity) were determined by manipulating the response requirement (i.e., fixed ratio value) across sessions. Tests were conducted in which the social partner was either treated or not treated with cocaine to determine whether the intoxication state of the partner influenced demand. The principal findings of this study are (1) demand for a cocaine-treated partner is greater than demand for a cocaine-free partner, (2) demand for cocaine is greater in the presence of a cocaine-treated partner than a cocaine-free partner, and (3) concurrent access to cocaine decreases demand for social contact. Notably, measures of cross-price elasticity indicated that social contact is a robust economic substitute for cocaine.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to report.
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Grant Information: R01 DA031725 United States DA NIDA NIH HHS; R01 DA045364 United States DA NIDA NIH HHS
Contributed Indexing: Keywords: Addiction; Cross-price elasticity; Demand intensity; O(max); Social behavior
Substance Nomenclature: I5Y540LHVR (Cocaine)
Entry Date(s): Date Created: 20221226 Date Completed: 20230117 Latest Revision: 20240102
Update Code: 20260130
PubMed Central ID: PMC9845135
DOI: 10.1016/j.pbb.2022.173511
PMID: 36572113
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-5177
DOI:10.1016/j.pbb.2022.173511