Closed-Loop Control of Arterial CO2 in Mechanical Ventilation of Neonates.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Closed-Loop Control of Arterial CO2 in Mechanical Ventilation of Neonates.
Συγγραφείς:	Buglowski M, Pfannschmidt V, Becker S, Braun O, Hutten M, Ophelders D, Oprea C, Pattai S, Schoberer M, Stollenwerk A
Πηγή:	Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2022 Jul; Vol. 2022, pp. 4991-4995.
Τύπος έκδοσης:	Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: [IEEE] Country of Publication: United States NLM ID: 101763872 Publication Model: Print Cited Medium: Internet ISSN: 2694-0604 (Electronic) Linking ISSN: 23757477 NLM ISO Abbreviation: Annu Int Conf IEEE Eng Med Biol Soc Subsets: MEDLINE
Imprint Name(s):	Original Publication: [Piscataway, NJ] : [IEEE], [2007]-
Ιατρικοί όροι (MeSH):	Respiration, Artificial/methods , Carbon Dioxide, Tidal Volume/physiology ; Animals ; Partial Pressure ; Respiration ; Sheep
Περίληψη:	During mechanical ventilation of the neonate the main goal is to stabilize respiratory function of the often premature lungs. Ventilating the patient without inflicting harm is then the subordinated next goal. Ideally the arterial partial pressure of CO2 lays within a normocapnic range and fluctuations are kept minimal. By closely monitoring CO2 and controlling ventilation parameters accordingly, CO2 levels in the blood can be managed. We present an approach consisting of a cascaded controller for arterial CO2 by approximating arterial partial pressure PaCO2 from end-tidal PetCO2. As a proof of concept, feasibility of the controller was first evaluated on a mathematical patient model and subsequently in-vivo in lamb experiments. The controller is able to regulate CO2 into a normocapnic range in both setups with satisfactory stationarity within the target range. Estimation of the arterial partial pressure of CO2 remains a critical aspect that needs to be further investigated. Clinical relevance-Closed-loop control of CO2 in mechanical ventilation aims to avoid PaC O2 extremes and to reduce fluctuations. Both are a relevant risk factors especially for neurological complications among preterm newborns.
Substance Nomenclature:	142M471B3J (Carbon Dioxide)
Entry Date(s):	Date Created: 20220909 Date Completed: 20220913 Latest Revision: 20250728
Update Code:	20260130
DOI:	10.1109/EMBC48229.2022.9871185
PMID:	36083943
Βάση Δεδομένων:	MEDLINE

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