Academic Journal
Suppression of RPL34 Inhibits Tumor Cell Proliferation and Promotes Apoptosis in Glioblastoma.
| Τίτλος: | Suppression of RPL34 Inhibits Tumor Cell Proliferation and Promotes Apoptosis in Glioblastoma. |
|---|---|
| Συγγραφείς: | Du C; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China., Wang T; Department of Neurosurgery, Ningxian Second People's Hospital, Qing'Yang, 745201, Gansu Province, China., Jia J; Department of Neurosurgery, Ningxian Second People's Hospital, Qing'Yang, 745201, Gansu Province, China., Li J; Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China., Xiao Y; Department of Ultrasonography, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China., Wang J; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.; Center of Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an , 710061, Shaanxi Province, China., Mao P; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China., Wang N; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China., Shi L; Department of Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China. lnshi1114@sina.com., Wang M; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China. mdwangxjtu@sina.com.; Center of Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an , 710061, Shaanxi Province, China. mdwangxjtu@sina.com. |
| Πηγή: | Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2022 Aug; Vol. 194 (8), pp. 3494-3506. Date of Electronic Publication: 2022 Apr 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Clifton, N.J. : Humana Press, c1981- |
| Ιατρικοί όροι (MeSH): | Brain Neoplasms*/genetics , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology , Glioblastoma*/genetics , Glioblastoma*/metabolism , Glioblastoma*/pathology , Glioma*/metabolism , Ribosomal Protein L3*/biosynthesis , Ribosomal Protein L3*/genetics , Ribosomal Protein L3*/metabolism, Cell Proliferation/physiology ; Ribosomal Proteins/genetics ; Apoptosis ; Cell Line, Tumor ; Humans |
| Περίληψη: | Accumulating evidence indicates Ribosomal protein 34 (RPL34) promotes tumor malignance and its expression is associated with poor prognosis in multiple cancer cells. However, the physiological role and biological mechanism of RPL34 in glioblastoma (GBM) remain unclear. Hence, this study aimed to investigate the expression and the role of RPL34 in GBM. A total of 59 glioma samples and 12 normal brains for epilepsy surgery were used to determine the underlying mechanisms and the biological behaviors of RPL34 in GBM. In this study, we identified that RPL34 expression was significantly (p < 0.05) enriched in GBM tumors compared with low-grade glioma and normal brain, and its expression was associated with poor survival. Additionally, RPL34 was functionally required for tumor proliferation in vitro. Mechanically, inhibition of RPL34 induced glioma cell apoptosis by activation of Bad/Caspase7/PARP signaling pathway. The RPL34 promotes cell survival in GBM and could be a potential therapeutic target for GBM. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| Contributed Indexing: | Keywords: Apoptosis; BAD; Cleaved PARP; Glioma; Proliferation; RPL34 |
| Substance Nomenclature: | 0 (RPL3 protein, human) 0 (Ribosomal Protein L3) 0 (Ribosomal Proteins) |
| Entry Date(s): | Date Created: 20220404 Date Completed: 20220712 Latest Revision: 20220713 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s12010-022-03857-0 |
| PMID: | 35377127 |
| Βάση Δεδομένων: | MEDLINE |
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