Academic Journal
Acute Pancreatitis Is Associated with Increased Risk of In-Hospital Mortality and Health Care Utilization Among Pediatric Patients with Hematopoietic Stem Cell Transplantation.
| Τίτλος: | Acute Pancreatitis Is Associated with Increased Risk of In-Hospital Mortality and Health Care Utilization Among Pediatric Patients with Hematopoietic Stem Cell Transplantation. |
|---|---|
| Συγγραφείς: | Thavamani A; Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH., Umapathi KK; Division of Pediatric Cardiology, Rush University Medical Center, Chicago, IL., Dalal J; Division of Pediatric Hematology/Oncology, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH., Sferra TJ; Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH., Sankararaman S; Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, OH. Electronic address: senthilkumar.sankararaman@uhhospitals.org. |
| Πηγή: | The Journal of pediatrics [J Pediatr] 2022 Jul; Vol. 246, pp. 110-115.e4. Date of Electronic Publication: 2022 Mar 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mosby Country of Publication: United States NLM ID: 0375410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6833 (Electronic) Linking ISSN: 00223476 NLM ISO Abbreviation: J Pediatr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: St. Louis, MO : Mosby |
| Ιατρικοί όροι (MeSH): | Hematopoietic Stem Cell Transplantation*/adverse effects , Pancreatitis*/epidemiology, Acute Disease ; Adolescent ; Child ; Hospital Mortality ; Hospitalization ; Humans ; Patient Acceptance of Health Care ; Retrospective Studies |
| Περίληψη: | Objective: To analyze the impact of acute pancreatitis on mortality and hospital outcomes among the pediatric population following hematopoietic stem cell transplantation (HSCT). Study Design: We analyzed nationally representative, nonoverlapping years of the National Inpatient Sample and Kids Inpatient Database between 2003 and 2016, including all pediatric patients who had HSCT. Patients were divided into those with and without a diagnosis of acute pancreatitis and compared for demographics, clinical characteristics, comorbid conditions related to both HSCT and acute pancreatitis, and outcome measures such as in-hospital mortality and health care resource use (length of hospital stay and total hospitalization charges). Results: We analyzed a total of 128 772 hospitalizations of children and adolescents with HSCT. The overall incidence rate of acute pancreatitis was approximately 1%, with an overall increasing trend between 2003 and 2016, P < .001. The overall mortality rate was significantly greater among patients with acute pancreatitis (14.9% vs 3.6%, P < .001). Multivariate regression analysis showed that acute pancreatitis was independently associated with 3.4 times (95% CI 2.86-4.02, P < .001) increased risk of in-hospital mortality. Patients with acute pancreatitis who underwent HSCT had a greater incidence of end-organ damage and thrombotic events. Pediatric acute pancreatitis was associated with 24.3 additional days of hospitalization (95% CI 22.9-25.7, P < .001) and incurred additional $213 496 in hospitalization charges (95% CI 193 768-233 063, P < .001). Conclusions: Pediatric recipients of HSCT who develop acute pancreatitis have adverse outcomes with increased in-hospital mortality, end-organ damage, prolonged hospital stay, and greater hospitalization charges. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: acute pancreatitis; children; health care use; hematopoietic stem cell transplantation; mortality; population-based study |
| Entry Date(s): | Date Created: 20220331 Date Completed: 20220628 Latest Revision: 20220726 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jpeds.2022.03.037 |
| PMID: | 35358587 |
| Βάση Δεδομένων: | MEDLINE |
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