Academic Journal
Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel.
| Τίτλος: | Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel. |
|---|---|
| Συγγραφείς: | Dickson PE; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1700 3rd Ave., Huntington, WV, 25703, USA. price.dickson@marshall.edu.; Department of Psychology, University of Memphis, 400 Innovation Drive, Memphis, TN, 38111, USA. price.dickson@marshall.edu., Mittleman G; Department of Psychological Science, Ball State University, North Quad (NQ), Room 104, Muncie, IN, 47306, USA.; Department of Psychology, University of Memphis, 400 Innovation Drive, Memphis, TN, 38111, USA. |
| Πηγή: | Scientific reports [Sci Rep] 2022 Jan 07; Vol. 12 (1), pp. 69. Date of Electronic Publication: 2022 Jan 07. |
| Τύπος έκδοσης: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Behavior, Animal* , Cognition* , Memory, Short-Term* , Pattern Recognition, Physiological*, Animals ; Conditioning, Operant ; Genotype ; Male ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Phenotype ; Species Specificity ; Mice |
| Περίληψη: | Working memory and pattern separation are fundamental cognitive abilities which, when impaired, significantly diminish quality of life. Discovering genetic mechanisms underlying innate and disease-induced variation in these cognitive abilities is a critical step towards treatments for common and devastating neurodegenerative conditions such as Alzheimer's disease. In this regard, the trial-unique nonmatching-to-location assay (TUNL) is a touchscreen operant conditioning procedure allowing simultaneous quantification of working memory and pattern separation in mice and rats. In the present study, we used the TUNL assay to quantify these cognitive abilities in C57BL/6J and DBA/2J mice. These strains are the founders of the BXD recombinant inbred mouse panel which enables discovery of genetic mechanisms underlying phenotypic variation. TUNL testing revealed that pattern separation was significantly influenced by mouse strain, whereas working memory was not. Moreover, horizontal distance and vertical distance between choice-phase stimuli had dissociable effects on TUNL performance. These findings provide novel data on mouse strain differences in pattern separation and support previous findings of equivalent working memory performance in C57BL/6J and DBA/2J mice. Although working memory of the BXD founder strains was equivalent in this study, working memory of BXD strains may be divergent because of transgressive segregation. Collectively, data presented here indicate that pattern separation is heritable in the mouse and that the BXD panel can be used to identify mechanisms underlying variation in pattern separation. (© 2022. The Author(s).) |
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| Grant Information: | R00 DA043573 United States DA NIDA NIH HHS |
| Entry Date(s): | Date Created: 20220108 Date Completed: 20220223 Latest Revision: 20240226 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC8741792 |
| DOI: | 10.1038/s41598-021-03850-3 |
| PMID: | 34996965 |
| Βάση Δεδομένων: | MEDLINE |
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| Items | – Name: Title Label: Title Group: Ti Data: Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Dickson+PE%22">Dickson PE</searchLink>; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1700 3rd Ave., Huntington, WV, 25703, USA. price.dickson@marshall.edu.; Department of Psychology, University of Memphis, 400 Innovation Drive, Memphis, TN, 38111, USA. price.dickson@marshall.edu.<br /><searchLink fieldCode="AU" term="%22Mittleman+G%22">Mittleman G</searchLink>; Department of Psychological Science, Ball State University, North Quad (NQ), Room 104, Muncie, IN, 47306, USA.; Department of Psychology, University of Memphis, 400 Innovation Drive, Memphis, TN, 38111, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2022 Jan 07; Vol. 12 (1), pp. 69. <i>Date of Electronic Publication: </i>2022 Jan 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: London : Nature Publishing Group, copyright 2011- – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Behavior%2C+Animal%22">Behavior, Animal*</searchLink> <br /><searchLink fieldCode="MM" term="%22Cognition%22">Cognition*</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory%2C+Short-Term%22">Memory, Short-Term*</searchLink> <br /><searchLink fieldCode="MM" term="%22Pattern+Recognition%2C+Physiological%22">Pattern Recognition, Physiological*</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Conditioning%2C+Operant%22">Conditioning, Operant</searchLink> ; <searchLink fieldCode="MH" term="%22Genotype%22">Genotype</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%2C+Inbred+C57BL%22">Mice, Inbred C57BL</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%2C+Inbred+DBA%22">Mice, Inbred DBA</searchLink> ; <searchLink fieldCode="MH" term="%22Phenotype%22">Phenotype</searchLink> ; <searchLink fieldCode="MH" term="%22Species+Specificity%22">Species Specificity</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Working memory and pattern separation are fundamental cognitive abilities which, when impaired, significantly diminish quality of life. Discovering genetic mechanisms underlying innate and disease-induced variation in these cognitive abilities is a critical step towards treatments for common and devastating neurodegenerative conditions such as Alzheimer's disease. In this regard, the trial-unique nonmatching-to-location assay (TUNL) is a touchscreen operant conditioning procedure allowing simultaneous quantification of working memory and pattern separation in mice and rats. In the present study, we used the TUNL assay to quantify these cognitive abilities in C57BL/6J and DBA/2J mice. These strains are the founders of the BXD recombinant inbred mouse panel which enables discovery of genetic mechanisms underlying phenotypic variation. TUNL testing revealed that pattern separation was significantly influenced by mouse strain, whereas working memory was not. Moreover, horizontal distance and vertical distance between choice-phase stimuli had dissociable effects on TUNL performance. These findings provide novel data on mouse strain differences in pattern separation and support previous findings of equivalent working memory performance in C57BL/6J and DBA/2J mice. Although working memory of the BXD founder strains was equivalent in this study, working memory of BXD strains may be divergent because of transgressive segregation. Collectively, data presented here indicate that pattern separation is heritable in the mouse and that the BXD panel can be used to identify mechanisms underlying variation in pattern separation.<br /> (© 2022. The Author(s).) – Name: Ref Label: References Group: RefInfo Data: Baddeley, A. Working memory. Science 255(5044), 556–559 (1992). (PMID: <searchLink fieldCode="PM" term="%22173635910%2E1126%2Fscience%2E1736359%22">173635910.1126/science.1736359)</searchLink><br />Vogel, E. K., McCollough, A. W. & Machizawa, M. G. Neural measures reveal individual differences in controlling access to working memory. Nature 438(7067), 500–503 (2005). (PMID: <searchLink fieldCode="PM" term="%221630699210%2E1038%2Fnature04171%22">1630699210.1038/nature04171)</searchLink><br />Mongillo, G., Barak, O. & Tsodyks, M. Synaptic theory of working memory. Science 319(5869), 1543–1546 (2008). (PMID: <searchLink fieldCode="PM" term="%221833994310%2E1126%2Fscience%2E1150769%22">1833994310.1126/science.1150769)</searchLink><br />Stark, S. M., Yassa, M. A. & Stark, C. E. Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learn. Mem. 17(6), 284–288 (2010). (PMID: <searchLink fieldCode="PM" term="%2220495062288428710%2E1101%2Flm%2E1768110%22">20495062288428710.1101/lm.1768110)</searchLink><br />Wang, M. et al. Neuronal basis of age-related working memory decline. Nature 476(7359), 210–213 (2011). (PMID: <searchLink fieldCode="PM" term="%2221796118319379410%2E1038%2Fnature10243%22">21796118319379410.1038/nature10243)</searchLink><br />Yassa, M. A. et al. Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21(9), 968–979 (2011). (PMID: <searchLink fieldCode="PM" term="%2220865732%22">20865732)</searchLink><br />Holden, H. M., Hoebel, C., Loftis, K. & Gilbert, P. E. Spatial pattern separation in cognitively normal young and older adults. Hippocampus 22(9), 1826–1832 (2012). (PMID: <searchLink fieldCode="PM" term="%2222467270339045910%2E1002%2Fhipo%2E22017%22">22467270339045910.1002/hipo.22017)</searchLink><br />Holden, H. M. & Gilbert, P. E. Less efficient pattern separation may contribute to age-related spatial memory deficits. Front Aging Neurosci. 4, 9 (2012). (PMID: <searchLink fieldCode="PM" term="%2222661945336213510%2E3389%2Ffnagi%2E2012%2E00009%22">22661945336213510.3389/fnagi.2012.00009)</searchLink><br />Luck, S. J. & Vogel, E. K. Visual working memory capacity: From psychophysics and neurobiology to individual differences. Trends Cogn. Sci. 17(8), 391–400 (2013). (PMID: <searchLink fieldCode="PM" term="%2223850263372973810%2E1016%2Fj%2Etics%2E2013%2E06%2E006%22">23850263372973810.1016/j.tics.2013.06.006)</searchLink><br />Ally, B. A., Hussey, E. P., Ko, P. C. & Molitor, R. J. Pattern separation and pattern completion in Alzheimer’s disease: Evidence of rapid forgetting in amnestic mild cognitive impairment. Hippocampus 23(12), 1246–1258 (2013). (PMID: <searchLink fieldCode="PM" term="%2223804525431047410%2E1002%2Fhipo%2E22162%22">23804525431047410.1002/hipo.22162)</searchLink><br />Wesnes, K. A., Annas, P., Basun, H., Edgar, C. & Blennow, K. Performance on a pattern separation task by Alzheimer’s patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E in4 status and cerebrospinal fluid amyloid-beta42 levels. Alzheimers Res. Ther. 6(2), 20 (2014). 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-021-03850-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 69 Subjects: – SubjectFull: Animals Type: general – SubjectFull: Conditioning, Operant Type: general – SubjectFull: Genotype Type: general – SubjectFull: Male Type: general – SubjectFull: Mice, Inbred C57BL Type: general – SubjectFull: Mice, Inbred DBA Type: general – SubjectFull: Phenotype Type: general – SubjectFull: Species Specificity Type: general – SubjectFull: Mice Type: general – SubjectFull: Behavior, Animal Type: general – SubjectFull: Cognition Type: general – SubjectFull: Memory, Short-Term Type: general – SubjectFull: Pattern Recognition, Physiological Type: general Titles: – TitleFull: Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dickson PE – PersonEntity: Name: NameFull: Mittleman G IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 01 Text: 2022 Jan 07 Type: published Y: 2022 Identifiers: – Type: issn-electronic Value: 2045-2322 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: Scientific reports Type: main |
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