Academic Journal
The immune niche of the liver.
| Τίτλος: | The immune niche of the liver. |
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| Συγγραφείς: | Cheng ML; Ajmera Family Transplant Centre, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Nakib D; Ajmera Family Transplant Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Perciani CT; Ajmera Family Transplant Centre, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., MacParland SA; Ajmera Family Transplant Centre, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada. |
| Πηγή: | Clinical science (London, England : 1979) [Clin Sci (Lond)] 2021 Oct 29; Vol. 135 (20), pp. 2445-2466. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Portland Press on behalf of the Medical Research Society and the Biochemical Society Original Publication: London, Medical Research Society. |
| Ιατρικοί όροι (MeSH): | Cellular Microenvironment*, Immune System/*immunology , Liver/*immunology , Liver Diseases/*immunology, Immune System/metabolism ; Immune System/pathology ; Liver/metabolism ; Liver/pathology ; Liver Diseases/genetics ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Animals ; Gene Expression Regulation ; Genomics ; Humans ; Single-Cell Analysis ; Transcriptome |
| Περίληψη: | The liver is an essential organ that is critical for the removal of toxins, the production of proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit, termed lobules, hides a heterogeneous, complex, and well-orchestrated system. Despite parenchymal cells being most commonly associated with the liver's primary functionality, it has become clear that it is the immune niche of the liver that plays a central role in maintaining both local and systemic homeostasis by propagating hepatic inflammation and orchestrating its resolution. As such, the immunological processes that are at play in healthy and diseased livers are being investigated thoroughly in order to understand the underpinnings of inflammation and the potential avenues for restoring homeostasis. This review highlights recent advances in our understanding of the immune niche of the liver and provides perspectives for how the implementation of new transcriptomic, multimodal, and spatial technologies can uncover the heterogeneity, plasticity, and location of hepatic immune populations. Findings from these technologies will further our understanding of liver biology and create a new framework for the identification of therapeutic targets. (© 2021 The Author(s).) |
| Grant Information: | 162098 Canada CIHR; 142832 Canada CIHR |
| Contributed Indexing: | Keywords: hepatic physiology; immunology; multi-modal technologies; single cell RNA sequencing; spatial transcriptomics |
| Entry Date(s): | Date Created: 20211028 Date Completed: 20211206 Latest Revision: 20211214 |
| Update Code: | 20260130 |
| DOI: | 10.1042/CS20190654 |
| PMID: | 34709406 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1470-8736 |
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| DOI: | 10.1042/CS20190654 |