Academic Journal
Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed Ester/Amide-Based Derivatives as Jack Bean Urease Inhibitors.
| Τίτλος: | Enzyme Inhibitory Kinetics and Molecular Docking Studies of Halo-Substituted Mixed Ester/Amide-Based Derivatives as Jack Bean Urease Inhibitors. |
|---|---|
| Συγγραφείς: | Rashid M; Department of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan., Rafique H; Department of Chemistry, University of Gujrat, Gujrat 50700, Pakistan., Roshan S; Department of Zoology, University of Gujrat, Gujrat 50700, Pakistan., Shamas S; Department of Zoology, University of Gujrat, Gujrat 50700, Pakistan., Iqbal Z; Department of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan., Ashraf Z; Department of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan., Abbas Q; Department of Physiology, University of Sindh, Jamshoro, Pakistan., Hassan M; Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan., Qureshi ZUR; Department of Pharmacy, SBK Women University, Quetta, Balochistan, Pakistan., Asad MHHB; Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan.; Institute of Fundamental Medicine, Department of Genetics, Kazan Federal University, Russia. |
| Πηγή: | BioMed research international [Biomed Res Int] 2020 Dec 24; Vol. 2020, pp. 8867407. Date of Electronic Publication: 2020 Dec 24 (Print Publication: 2020). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Hoboken, NJ] : Wiley Original Publication: New York, NY : Hindawi Pub. Co. |
| Ιατρικοί όροι (MeSH): | Benzoates*/chemistry , Benzoates*/metabolism , Benzoates*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/metabolism , Enzyme Inhibitors*/pharmacology, Canavalia/*enzymology , Plant Proteins/*antagonists & inhibitors , Urease/*antagonists & inhibitors, Amides/chemistry ; Amides/metabolism ; Esters/chemistry ; Esters/metabolism ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Urea/metabolism ; Urease/chemistry ; Urease/metabolism ; Binding Sites ; Hydrolysis ; Kinetics ; Molecular Docking Simulation |
| Περίληψη: | A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl-substituted anilines 1a-b reacted with chloroacetyl chloride to afford intermediates 2a-b, which were then reacted with different halo-substituted benzoic acids 3a-f to prepare the title compounds 4a-l. The chemical structures of final products 4a-l were ascertained by FTIR, 1H NMR, 13C NMR, and mass spectra. The compound 4b showed remarkable activity with IC (Copyright © 2020 Muhammad Rashid et al.) |
| Competing Interests: | The authors declare no conflicts of interest. |
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| Substance Nomenclature: | 0 (Amides) 0 (Benzoates) 0 (Enzyme Inhibitors) 0 (Esters) 0 (Plant Proteins) 8W8T17847W (Urea) EC 3.5.1.5 (Urease) |
| Entry Date(s): | Date Created: 20210111 Date Completed: 20210524 Latest Revision: 20240330 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC7775144 |
| DOI: | 10.1155/2020/8867407 |
| PMID: | 33426080 |
| Βάση Δεδομένων: | MEDLINE |
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