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Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model.
Συγγραφείς: Wang X; Department of Immunology, University of Toronto, Toronto, ON, Canada., MacParland SA; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Ajmera Family Transplant Centre, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Perciani CT; Ajmera Family Transplant Centre, Toronto General Hospital Research Institute, Toronto, ON, Canada.
Πηγή: Transplantation [Transplantation] 2021 Sep 01; Vol. 105 (9), pp. 1944-1956.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE
Imprint Name(s): Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Williams & Wilkins.
Ιατρικοί όροι (MeSH): Liver Transplantation*/adverse effects , Biomedical Research* , Graft Survival* , Transplantation Tolerance*, Graft Rejection/*prevention & control , Immunosuppressive Agents/*pharmacology, Cytokines/metabolism ; Graft Rejection/immunology ; Graft Rejection/metabolism ; Immune Checkpoint Proteins/metabolism ; Immunosuppressive Agents/toxicity ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Animals ; Humans ; Immunocompromised Host ; Models, Animal ; Rats ; Signal Transduction
Περίληψη: For many individuals with end-stage liver disease, the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24%-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of donor livers available for transplantation is far less than the demand. Well-characterized and physiologically relevant models of liver transplantation are crucial to a deeper understanding of the cellular processes governing the outcomes of liver transplantation and serve as a platform for testing new therapeutic strategies to enhance graft acceptance. Such a model has been found in the rat transplant model, which has an advantageous size for surgical procedures, similar postoperative immunological progression, and high genome match to the human liver. From rat liver transplant studies published in the last 5 years, it is clear that the rat model serves as a strong platform to elucidate transplant immunological mechanisms. Using the model, we have begun to uncover potential players and possible therapeutic targets to restore liver tolerance and preserve host immunocompetence. Here, we present an overview of recent literature for rat liver transplant models, with an aim to highlight the value of the models and to provide future perspectives on how these models could be further characterized to enhance the overall value of rat models to the field of liver transplantation.
(Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
Competing Interests: The authors declare no conflicts of interest.
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Grant Information: PJT 162098 Canada CIHR; NHC-142832 Canada CIHR
Substance Nomenclature: 0 (Cytokines)
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Entry Date(s): Date Created: 20210108 Date Completed: 20211101 Latest Revision: 20231002
Update Code: 20260130
PubMed Central ID: PMC8376267
DOI: 10.1097/TP.0000000000003598
PMID: 33417410
Βάση Δεδομένων: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Immunology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22MacParland+SA%22">MacParland SA</searchLink>; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Ajmera Family Transplant Centre, Toronto General Hospital Research Institute, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Perciani+CT%22">Perciani CT</searchLink>; Ajmera Family Transplant Centre, Toronto General Hospital Research Institute, Toronto, ON, Canada.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220132144%22">Transplantation</searchLink> [Transplantation] 2021 Sep 01; Vol. 105 (9), pp. 1944-1956.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't; Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0132144 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1534-6080 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200411337%22">00411337 </searchLink><i>NLM ISO Abbreviation: </i>Transplantation <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: Hagerstown, MD : Lippincott Williams & Wilkins<br /><i>Original Publication</i>: Baltimore, Williams & Wilkins.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Liver+Transplantation%22">Liver Transplantation*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+Transplantation+adverse+effects%22">adverse effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Biomedical+Research%22">Biomedical Research*</searchLink> <br /><searchLink fieldCode="MM" term="%22Graft+Survival%22">Graft Survival*</searchLink> <br /><searchLink fieldCode="MM" term="%22Transplantation+Tolerance%22">Transplantation Tolerance*</searchLink><br /><searchLink fieldCode="MM" term="%22Graft+Rejection%22">Graft Rejection</searchLink>/<searchLink fieldCode="MM" term="%22Graft+Rejection+prevention+%26+control%22">*prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Immunosuppressive+Agents%22">Immunosuppressive Agents</searchLink>/<searchLink fieldCode="MM" term="%22Immunosuppressive+Agents+pharmacology%22">*pharmacology</searchLink><br /><searchLink fieldCode="MH" term="%22Cytokines%22">Cytokines</searchLink>/<searchLink fieldCode="MH" term="%22Cytokines+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Graft+Rejection%22">Graft Rejection</searchLink>/<searchLink fieldCode="MH" term="%22Graft+Rejection+immunology%22">immunology</searchLink> ; <searchLink fieldCode="MH" term="%22Graft+Rejection%22">Graft Rejection</searchLink>/<searchLink fieldCode="MH" term="%22Graft+Rejection+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Immune+Checkpoint+Proteins%22">Immune Checkpoint Proteins</searchLink>/<searchLink fieldCode="MH" term="%22Immune+Checkpoint+Proteins+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Immunosuppressive+Agents%22">Immunosuppressive Agents</searchLink>/<searchLink fieldCode="MH" term="%22Immunosuppressive+Agents+toxicity%22">toxicity</searchLink> ; <searchLink fieldCode="MH" term="%22T-Lymphocyte+Subsets%22">T-Lymphocyte Subsets</searchLink>/<searchLink fieldCode="MH" term="%22T-Lymphocyte+Subsets+immunology%22">immunology</searchLink> ; <searchLink fieldCode="MH" term="%22T-Lymphocyte+Subsets%22">T-Lymphocyte Subsets</searchLink>/<searchLink fieldCode="MH" term="%22T-Lymphocyte+Subsets+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Immunocompromised+Host%22">Immunocompromised Host</searchLink> ; <searchLink fieldCode="MH" term="%22Models%2C+Animal%22">Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Rats%22">Rats</searchLink> ; <searchLink fieldCode="MH" term="%22Signal+Transduction%22">Signal Transduction</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: For many individuals with end-stage liver disease, the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24%-80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of donor livers available for transplantation is far less than the demand. Well-characterized and physiologically relevant models of liver transplantation are crucial to a deeper understanding of the cellular processes governing the outcomes of liver transplantation and serve as a platform for testing new therapeutic strategies to enhance graft acceptance. Such a model has been found in the rat transplant model, which has an advantageous size for surgical procedures, similar postoperative immunological progression, and high genome match to the human liver. From rat liver transplant studies published in the last 5 years, it is clear that the rat model serves as a strong platform to elucidate transplant immunological mechanisms. Using the model, we have begun to uncover potential players and possible therapeutic targets to restore liver tolerance and preserve host immunocompetence. Here, we present an overview of recent literature for rat liver transplant models, with an aim to highlight the value of the models and to provide future perspectives on how these models could be further characterized to enhance the overall value of rat models to the field of liver transplantation.<br /> (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: The authors declare no conflicts of interest.
– Name: Ref
  Label: References
  Group: RefInfo
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        Text: English
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        StartPage: 1944
    Subjects:
      – SubjectFull: Cytokines metabolism
        Type: general
      – SubjectFull: Graft Rejection immunology
        Type: general
      – SubjectFull: Graft Rejection metabolism
        Type: general
      – SubjectFull: Immune Checkpoint Proteins metabolism
        Type: general
      – SubjectFull: Immunosuppressive Agents toxicity
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        Type: general
      – SubjectFull: T-Lymphocyte Subsets metabolism
        Type: general
      – SubjectFull: Animals
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      – SubjectFull: Humans
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      – SubjectFull: Immunocompromised Host
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      – SubjectFull: Rats
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      – SubjectFull: Signal Transduction
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      – SubjectFull: Liver Transplantation adverse effects
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      – SubjectFull: Biomedical Research
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      – SubjectFull: Graft Survival
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      – SubjectFull: Transplantation Tolerance
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      – SubjectFull: Graft Rejection prevention & control
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      – SubjectFull: Immunosuppressive Agents pharmacology
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      – TitleFull: Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model.
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              Text: 2021 Sep 01
              Type: published
              Y: 2021
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              Value: 1534-6080
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            – TitleFull: Transplantation
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