Academic Journal
Enhancing Immunity with Nanomedicine: Employing Nanoparticles to Harness the Immune System.
| Τίτλος: | Enhancing Immunity with Nanomedicine: Employing Nanoparticles to Harness the Immune System. |
|---|---|
| Συγγραφείς: | Perciani CT; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada., Liu LY; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Wood L; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., MacParland SA; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. |
| Πηγή: | ACS nano [ACS Nano] 2021 Jan 26; Vol. 15 (1), pp. 7-20. Date of Electronic Publication: 2020 Dec 21. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington D.C. : American Chemical Society |
| Ιατρικοί όροι (MeSH): | Nanoparticles* , Vaccines*, Immune System ; Nanomedicine ; Vaccination |
| Περίληψη: | The failure of immune responses to vaccines and dysfunctional immune responses to viral infection, tumor development, or neoantigens lead to chronic viral infection, tumor progression, or incomplete immune protection after vaccination. Thus, strategies to boost host immunity are a topic of intense research and development. Engineered nanoparticles (NPs) possess immunological properties and can be modified to promote improved local immune responses. Nanoparticle-based approaches have been employed to enhance vaccine efficacy and host immune responses to viral and tumor antigens, with impressive results. In this Perspective, we present an overview of studies, such as the one reported by Alam et al. in this issue of ACS Nano, in which virus-like particles have been employed to enhance immunity. We review the cellular cornerstones of effective immunity and discuss how NPs can harness these interactions to overcome the current obstacles in vaccinology and oncology. We also discuss the barriers to effective NP-mediated immune priming including (1) NP delivery to the site of interest, (2) the quality of response elicited, and (3) the potential of the response to overcome immune escape. Through this Perspective, we aim to highlight the value of nanomedicine not only in delivering therapies but also in coordinating the enhancement of host immune responses. We provide a forward-looking outlook for future NP-based approaches and how they could be tailored to promote this outcome. |
| Grant Information: | NHC-142832 Canada CIHR |
| Substance Nomenclature: | 0 (Vaccines) |
| Entry Date(s): | Date Created: 20201221 Date Completed: 20210514 Latest Revision: 20210514 |
| Update Code: | 20260130 |
| DOI: | 10.1021/acsnano.0c08913 |
| PMID: | 33346646 |
| Βάση Δεδομένων: | MEDLINE |
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