Academic Journal
Προβολή σε EDS

Enhancing Immunity with Nanomedicine: Employing Nanoparticles to Harness the Immune System.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Enhancing Immunity with Nanomedicine: Employing Nanoparticles to Harness the Immune System.
Συγγραφείς: Perciani CT; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada., Liu LY; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Wood L; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., MacParland SA; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Πηγή: ACS nano [ACS Nano] 2021 Jan 26; Vol. 15 (1), pp. 7-20. Date of Electronic Publication: 2020 Dec 21.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
Imprint Name(s): Original Publication: Washington D.C. : American Chemical Society
Ιατρικοί όροι (MeSH): Nanoparticles* , Vaccines*, Immune System ; Nanomedicine ; Vaccination
Περίληψη: The failure of immune responses to vaccines and dysfunctional immune responses to viral infection, tumor development, or neoantigens lead to chronic viral infection, tumor progression, or incomplete immune protection after vaccination. Thus, strategies to boost host immunity are a topic of intense research and development. Engineered nanoparticles (NPs) possess immunological properties and can be modified to promote improved local immune responses. Nanoparticle-based approaches have been employed to enhance vaccine efficacy and host immune responses to viral and tumor antigens, with impressive results. In this Perspective, we present an overview of studies, such as the one reported by Alam et al. in this issue of ACS Nano, in which virus-like particles have been employed to enhance immunity. We review the cellular cornerstones of effective immunity and discuss how NPs can harness these interactions to overcome the current obstacles in vaccinology and oncology. We also discuss the barriers to effective NP-mediated immune priming including (1) NP delivery to the site of interest, (2) the quality of response elicited, and (3) the potential of the response to overcome immune escape. Through this Perspective, we aim to highlight the value of nanomedicine not only in delivering therapies but also in coordinating the enhancement of host immune responses. We provide a forward-looking outlook for future NP-based approaches and how they could be tailored to promote this outcome.
Grant Information: NHC-142832 Canada CIHR
Substance Nomenclature: 0 (Vaccines)
Entry Date(s): Date Created: 20201221 Date Completed: 20210514 Latest Revision: 20210514
Update Code: 20260130
DOI: 10.1021/acsnano.0c08913
PMID: 33346646
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 33346646
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Enhancing Immunity with Nanomedicine: Employing Nanoparticles to Harness the Immune System.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Perciani+CT%22">Perciani CT</searchLink>; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+LY%22">Liu LY</searchLink>; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Wood+L%22">Wood L</searchLink>; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22MacParland+SA%22">MacParland SA</searchLink>; Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.; Department of Immunology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6271, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101313589%22">ACS nano</searchLink> [ACS Nano] 2021 Jan 26; Vol. 15 (1), pp. 7-20. <i>Date of Electronic Publication: </i>2020 Dec 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't; Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101313589 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1936-086X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219360851%22">19360851 </searchLink><i>NLM ISO Abbreviation: </i>ACS Nano <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Washington D.C. : American Chemical Society
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Nanoparticles%22">Nanoparticles*</searchLink> <br /><searchLink fieldCode="MM" term="%22Vaccines%22">Vaccines*</searchLink><br /><searchLink fieldCode="MH" term="%22Immune+System%22">Immune System</searchLink> ; <searchLink fieldCode="MH" term="%22Nanomedicine%22">Nanomedicine</searchLink> ; <searchLink fieldCode="MH" term="%22Vaccination%22">Vaccination</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The failure of immune responses to vaccines and dysfunctional immune responses to viral infection, tumor development, or neoantigens lead to chronic viral infection, tumor progression, or incomplete immune protection after vaccination. Thus, strategies to boost host immunity are a topic of intense research and development. Engineered nanoparticles (NPs) possess immunological properties and can be modified to promote improved local immune responses. Nanoparticle-based approaches have been employed to enhance vaccine efficacy and host immune responses to viral and tumor antigens, with impressive results. In this Perspective, we present an overview of studies, such as the one reported by Alam et al. in this issue of ACS Nano, in which virus-like particles have been employed to enhance immunity. We review the cellular cornerstones of effective immunity and discuss how NPs can harness these interactions to overcome the current obstacles in vaccinology and oncology. We also discuss the barriers to effective NP-mediated immune priming including (1) NP delivery to the site of interest, (2) the quality of response elicited, and (3) the potential of the response to overcome immune escape. Through this Perspective, we aim to highlight the value of nanomedicine not only in delivering therapies but also in coordinating the enhancement of host immune responses. We provide a forward-looking outlook for future NP-based approaches and how they could be tailored to promote this outcome.
– Name: GrantInfo
  Label: Grant Information
  Group: Grant
  Data: NHC-142832 Canada CIHR
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Vaccines)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20201221 <i>Date Completed: </i>20210514 <i>Latest Revision: </i>20210514
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260130
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1021/acsnano.0c08913
– Name: AN
  Label: PMID
  Group: ID
  Data: 33346646
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=33346646
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acsnano.0c08913
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 7
    Subjects:
      – SubjectFull: Immune System
        Type: general
      – SubjectFull: Nanomedicine
        Type: general
      – SubjectFull: Vaccination
        Type: general
      – SubjectFull: Nanoparticles
        Type: general
      – SubjectFull: Vaccines
        Type: general
    Titles:
      – TitleFull: Enhancing Immunity with Nanomedicine: Employing Nanoparticles to Harness the Immune System.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Perciani CT
      – PersonEntity:
          Name:
            NameFull: Liu LY
      – PersonEntity:
          Name:
            NameFull: Wood L
      – PersonEntity:
          Name:
            NameFull: MacParland SA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 01
              Text: 2021 Jan 26
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 1936-086X
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: ACS nano
              Type: main
ResultId 1