Academic Journal
Losartan treatment significantly attenuates the fibrotic changes in the corpus cavernosum of castrated rats.
| Τίτλος: | Losartan treatment significantly attenuates the fibrotic changes in the corpus cavernosum of castrated rats. |
|---|---|
| Συγγραφείς: | Kucukdurmaz F; Sutcu Imam University, Department of Urology, Kahramanmaras, Turkey. Electronic address: farukfkd@yahoo.com., Efe E; Sutcu Imam University, Department of Urology, Kahramanmaras, Turkey., Kurutas EB; Sutcu Imam University, Department of Biochemistry, Kahramanmaras, Turkey., Olmez C; Sutcu Imam University, Department of Urology, Kahramanmaras, Turkey., Temizer M; Gaziantep Community Health Center, Gaziantep, Turkey., Resim S; Sutcu Imam University, Department of Urology, Kahramanmaras, Turkey. |
| Πηγή: | Revista internacional de andrologia [Rev Int Androl] 2020 Jan - Mar; Vol. 18 (1), pp. 14-20. Date of Electronic Publication: 2018 Sep 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MRE Press Country of Publication: Singapore NLM ID: 101500934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1698-0409 (Electronic) Linking ISSN: 1698031X NLM ISO Abbreviation: Rev Int Androl Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : Singapore : MRE Press Original Publication: Barcelona : Elsevier Doyma |
| Ιατρικοί όροι (MeSH): | Orchiectomy*, Angiotensin II Type 1 Receptor Blockers/*pharmacology , Losartan/*pharmacology , Penis/*drug effects, Actins/analysis ; Biomarkers/analysis ; Collagen/analysis ; Fibronectins/analysis ; Muscle, Smooth/anatomy & histology ; Penis/chemistry ; Penis/pathology ; Testosterone/blood ; Thrombospondin 1/analysis ; Transforming Growth Factor beta/analysis ; Animals ; Body Weight ; Fibrosis ; Male ; Rats ; Rats, Wistar |
| Περίληψη: | Introduction and Objectives: The aim of this study is to evaluate the effects of castration and subsequent losartan administration on the fibrosis-related parameters in the corpora cavernosa of castrated rats. Material and Methods: Twenty-four male rats were divided into four equal groups. Group 1:sham surgery plus vehicle (0.9% NaCl) (control:con), group 2:sham surgery plus losartan (con+los), group 3: castration plus vehicle (castration:cast) and group 4:castration plus losartan (cast+los). After four weeks of oral losartan treatment, corporal levels of transforming growth factor-beta (TGF-β), thrombospondin-1 (TSP-1), alpha-actin, beta-actin and fibronectin were investigated by ELISA kits. Changes in the collagen and smooth muscle content were evaluated by histological analysis with Masson trichrome staining. Results: Initial and post-treatment body weights of rats were similar among groups. Castration significantly increased the expression of TGF-β, TSP-1 and fibronectin and resulted in a significant decrease in alpha-actin levels in the corpora cavernosa. Administration of losartan reduced the levels of TGF-β, TSP-1 and fibronectin in castrated rats. Alpha actin levels also increased after losartan treatment. Beta-actin levels were not significantly different among 4 groups. The levels of all markers were similar in group 1 and 2. Rate of fibrosis was significantly higher in castrated rats and treatment with losartan reduced this rate. Conclusion: Castration increased the expression of fibrosis-related markers in the corpora cavernosa of rats. Administration of losartan significantly attenuated those changes and exerted an antifibrotic effect. (Copyright © 2018. Publicado por Elsevier España, S.L.U.) |
| Contributed Indexing: | Keywords: Castración; Castration; Corporal fibrosis; Disfunción eréctil; Erectile dysfunction; Fibrosis corporal; Losartan; Losartán |
| Substance Nomenclature: | 0 (Actins) 0 (Angiotensin II Type 1 Receptor Blockers) 0 (Biomarkers) 0 (Fibronectins) 0 (Thrombospondin 1) 0 (Transforming Growth Factor beta) 0 (Thbs1 protein, rat) 3XMK78S47O (Testosterone) 9007-34-5 (Collagen) JMS50MPO89 (Losartan) |
| Entry Date(s): | Date Created: 20180925 Date Completed: 20210930 Latest Revision: 20250103 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.androl.2018.07.001 |
| PMID: | 30245178 |
| Βάση Δεδομένων: | MEDLINE |
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