Academic Journal
Four-dimensional computed tomography prediction of inter- and intrafractional upper gastrointestinal tumor motion during fractionated stereotactic body radiation therapy.
| Τίτλος: | Four-dimensional computed tomography prediction of inter- and intrafractional upper gastrointestinal tumor motion during fractionated stereotactic body radiation therapy. |
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| Συγγραφείς: | Lischalk JW; Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC. Electronic address: jonathan.lischalk@gunet.georgetown.edu., Kole TP; Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC., Anjum HM; Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC., Obayomi-Davies O; Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC., Rashid A; Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC., Unger K; Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC. |
| Πηγή: | Practical radiation oncology [Pract Radiat Oncol] 2016 May-Jun; Vol. 6 (3), pp. 176-182. Date of Electronic Publication: 2015 Oct 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 101558279 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-8519 (Electronic) Linking ISSN: 18798500 NLM ISO Abbreviation: Pract Radiat Oncol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York : Elsevier |
| Ιατρικοί όροι (MeSH): | Four-Dimensional Computed Tomography/*methods , Stomach Neoplasms/*diagnostic imaging, Radiosurgery/methods ; Female ; Humans ; Male |
| Περίληψη: | Purpose: Respiratory-induced tumor motion of upper gastrointestinal (GI) tumors during radiation therapy is often assessed using a single 4-dimensional computed tomography (4D-CT) and presumed to be representative during fractionated treatment regimens. The purpose of this study was to examine the intra- and interfraction correlations of tumor motion between pretreatment 4D-CT and real-time fiducial-based motion tracking in patients treated with fractionated stereotactic body radiation therapy (SBRT) for upper GI malignancies. Methods and Materials: Fourteen patients with upper GI tumors underwent fractionated SBRT using the CyberKnife radiosurgical system with Synchrony respiratory motion management. Before treatment, each patient underwent a free-breathing 4D-CT scan and fiducial motion was tracked for each phase of the respiratory cycle. Real-time fiducial positions recorded during delivery of each SBRT fraction were extracted from the CyberKnife planning system. Displacements were compared between those predicted by 4D-CT and those recorded by Synchrony during treatment in the left-right (LR), anteroposterior (AP), and superoinferior (SI) directions. Results: The 4D-CT scans demonstrated little correlation with real-time mean fiducial displacement as determined by Pearson correlation with coefficients of 0.45, 0.52, and 0.63 in the SI, AP, and LR directions, respectively. Cohort-averaged maximum fiducial displacements based on 4D-CT and real-time tracking were measured to be 3.86 ± 1.40 mm versus 10.73 ± 7.03 mm, 2.29 ± 1.02 mm versus 4.44 ± 3.33 mm, and 1.45 ± 0.49 mm versus 2.67 ± 2.49 mm in the SI, AP, and LR directions, respectively. Mean fiducial displacements were greater than that predicted by the maximum displacements on the corresponding 4D-CT scan in 39%, 22%, and 25% of SBRT fractions in the SI, AP, and LR directions, respectively. Conclusions: Comparison of 4D-CT with real-time fiducial tracking demonstrated significant inter- and intrafractional discrepancies, particularly in the SI direction, which could result in compromise of target coverage when planning with a single free-breathing 4D-CT. (Copyright © 2015 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.) |
| Entry Date(s): | Date Created: 20160110 Date Completed: 20170327 Latest Revision: 20180604 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.prro.2015.10.006 |
| PMID: | 26746816 |
| Βάση Δεδομένων: | MEDLINE |
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