Academic Journal
Pathogen-inspired drug delivery to the central nervous system.
| Τίτλος: | Pathogen-inspired drug delivery to the central nervous system. |
|---|---|
| Συγγραφείς: | McCall RL; Barrow Brain Tumor Research Center; Barrow Neurological Institute ; Phoenix, AZ USA., Cacaccio J; Blue Ocean Biomanufacturing , Worcester, MA USA., Wrabel E; Nemucore Medical Innovations, Inc. ; Worcester, MA USA., Schwartz ME; Nemucore Medical Innovations, Inc. ; Worcester, MA USA., Coleman TP; Blue Ocean Biomanufacturing , Worcester, MA USA ; Nemucore Medical Innovations, Inc. ; Worcester, MA USA ; Center for Translational Cancer Nanomedicine; Northeastern University ; Boston, MA USA ; Foundation for the Advancement of Personalized Medicine Manufacturing ; Phoenix, AZ USA., Sirianni RW; Barrow Brain Tumor Research Center; Barrow Neurological Institute ; Phoenix, AZ USA. |
| Πηγή: | Tissue barriers [Tissue Barriers] 2014 Aug 08; Vol. 2 (4), pp. e944449. Date of Electronic Publication: 2014 Aug 08 (Print Publication: 2014). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101601065 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8362 (Print) Linking ISSN: 21688362 NLM ISO Abbreviation: Tissue Barriers Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: Oct. 2014- : Abingdon, Oxfordshire, OX : Taylor & Francis Original Publication: [Austin, TX ] : Landes Bioscience |
| Περίληψη: | For as long as the human blood-brain barrier (BBB) has been evolving to exclude bloodborne agents from the central nervous system (CNS), pathogens have adopted a multitude of strategies to bypass it. Some pathogens, notably viruses and certain bacteria, enter the CNS in whole form, achieving direct physical passage through endothelial or neuronal cells to infect the brain. Other pathogens, including bacteria and multicellular eukaryotic organisms, secrete toxins that preferentially interact with specific cell types to exert a broad range of biological effects on peripheral and central neurons. In this review, we will discuss the directed mechanisms that viruses, bacteria, and the toxins secreted by higher order organisms use to enter the CNS. Our goal is to identify ligand-mediated strategies that could be used to improve the brain-specific delivery of engineered nanocarriers, including polymers, lipids, biologically sourced materials, and imaging agents. |
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| Grant Information: | U54 CA151881 United States CA NCI NIH HHS |
| Contributed Indexing: | Keywords: DGL, dendrigraft poly-l-lysine; Drug delivery; GABA, gamma-aminobutyric acid receptor; MMP-2, matrix metalloprotease-2; NCAM, neural cell adhesion molecule; NMDA, N-methyl-D-aspartate; PEG, polyethylene glycol; PEI, polyethylenimine; brain; central nervous system; nAchR, nicotinic acetylcholine receptor; pathogen; peptide; toxin |
| Entry Date(s): | Date Created: 20150123 Date Completed: 20150122 Latest Revision: 20181113 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4292043 |
| DOI: | 10.4161/21688362.2014.944449 |
| PMID: | 25610755 |
| Βάση Δεδομένων: | MEDLINE |
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