Academic Journal
Cervical surgery for cervical intraepithelial neoplasia and prolonged time to conception of a live birth: a case-control study.
| Τίτλος: | Cervical surgery for cervical intraepithelial neoplasia and prolonged time to conception of a live birth: a case-control study. |
|---|---|
| Συγγραφείς: | Spracklen CN; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA., Harland KK, Stegmann BJ, Saftlas AF |
| Πηγή: | BJOG : an international journal of obstetrics and gynaecology [BJOG] 2013 Jul; Vol. 120 (8), pp. 960-5. Date of Electronic Publication: 2013 Mar 14. |
| Τύπος έκδοσης: | Journal Article; Research Support, N.I.H., Extramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100935741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0528 (Electronic) Linking ISSN: 14700328 NLM ISO Abbreviation: BJOG Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: Oxford [England] : Blackwell Science, [2000]- |
| Ιατρικοί όροι (MeSH): | Infertility, Female/*etiology , Pregnancy Complications, Neoplastic/*surgery , Uterine Cervical Neoplasms/*surgery , Uterine Cervical Dysplasia/*surgery, Infertility, Female/epidemiology ; Infertility, Female/surgery ; Adolescent ; Adult ; Case-Control Studies ; Female ; Fertilization ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Small for Gestational Age ; Iowa ; Live Birth ; Middle Aged ; Pregnancy ; Prevalence ; Risk Factors ; Young Adult |
| Περίληψη: | Objective: To determine whether women with a history of surgery for cervical intraepithelial neoplasia (CIN) are at an increased risk of subfertility, measured as a time to pregnancy of more than 12 months. Design: Case-control study. Setting: Iowa Health in Pregnancy Study (IHIPS), a population-based case-control study of preterm and small-for-gestational-age (SGA) live birth outcomes (from May 2002 through June 2005) in the USA. Sample: Women with an intended pregnancy and a history of either one prior cervical surgery (n = 152), colposcopy only (n = 151), or no prior cervical surgery or colposcopy (n = 1021). Methods: Cervical treatment history, pregnancy intention, time to pregnancy, and other variables were self-reported by computer-assisted telephone interviews. Odds ratios were calculated using logistic regression to estimate the risk of prolonged time to pregnancy among women with a history of cervical surgery or colposcopy alone, compared with untreated women (control group). Main Outcome Measure: Prolonged time to pregnancy (i.e. >1 year). Results: Prolonged time to pregnancy was most prevalent among treated women (16.4%), compared with untreated women (8.4%) and women with colposcopy only (8.6%) (P = 0.039). After adjusting for covariates, women with prior cervical surgery had a more than two-fold higher risk of prolonged time to pregnancy compared with untreated women (aOR 2.09, 95% CI 1.26-3.46). In contrast, women with a history of colposcopy only had a risk equivalent to that found among untreated women (aOR 1.02, 95% CI 0.56-1.89). Conclusions: Women with a history of cervical treatment for CIN are at increased risk of subfertility, measured as a time to pregnancy of more than 12 months. (© 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.) |
| Σχόλια: | Comment in: BJOG. 2013 Dec;120(13):1697-8. doi: 10.1111/1471-0528.12457.. (PMID: 24588998) Comment in: BJOG. 2013 Dec;120(13):1697. doi: 10.1111/1471-0528.12456.. (PMID: 24588999) |
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| Grant Information: | R01 HD039753 United States HD NICHD NIH HHS; R21 AI068111 United States AI NIAID NIH HHS; R01 HD39753 United States HD NICHD NIH HHS; R21 AI1068111 United States AI NIAID NIH HHS |
| Entry Date(s): | Date Created: 20130316 Date Completed: 20130827 Latest Revision: 20221207 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3691952 |
| DOI: | 10.1111/1471-0528.12209 |
| PMID: | 23489374 |
| Βάση Δεδομένων: | MEDLINE |
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