Academic Journal
Προβολή σε EDS

Model-based analysis and quantification of age trends in auditory evoked potentials

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Model-based analysis and quantification of age trends in auditory evoked potentials
Συγγραφείς: Kerr, C.C.1,2 ckerr@physics.usyd.edu.au, Rennie, C.J.1,2,3, Robinson, P.A.1,2,4
Πηγή: Clinical Neurophysiology. Jan2011, Vol. 122 Issue 1, p134-147. 14p.
Θεματικοί όροι: *Auditory evoked response, *Brain -- Mathematical models, *Aging, *Human research subjects, *Neurons, *Thalamus, *Cerebral cortex, *Excitation (Physiology)
Περίληψη: Abstract: Objective: The physiological basis for the changes in auditory evoked potentials (AEPs) during development and aging is currently unknown. This study investigates age- and task-related changes via a mathematical model of neuronal activity, which allows a number of physiological changes to be inferred. Methods: A quantitative, physiology-based model of activity in cortical and thalamic neurons was used to analyze oddball AEPs recorded from 1498 healthy subjects aged 6–86 years. Results: Differences between standard and target responses can be largely explained by differences in connection strengths between thalamic and cortical neurons. The time it takes signals to travel between the thalamus and cortex decreases during development and increases during aging. Strong age trends are also seen in intracortical and thalamocortical neuronal connection strengths. Conclusions: Changes in AEP latency can be attributed to changes in the thalamocortical signal propagation time. Large changes in the connection strengths between neuronal populations occur during development, resulting in increased thalamocortical inhibition and decreased thalamocortical excitation. Standard and target parameters are similar in children but diverge during adolescence, due to changes in thalamocortical loop activity. Significance: Model-based AEP analysis links age-related changes in brain electrophysiology to underlying changes in brain anatomy and physiology, and yields quantitative predictions of several currently unknown physiological and anatomical properties of the brain. [Copyright &y& Elsevier]
Βάση Δεδομένων: Academic Search Index
FullText Links:
  – Type: other
Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.clinph.2010.05.030?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
Header DbId: asx
DbLabel: Academic Search Index
An: 56500468
RelevancyScore: 1204
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1204.03820800781
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Model-based analysis and quantification of age trends in auditory evoked potentials
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kerr%2C+C%2EC%2E%22">Kerr, C.C.</searchLink><relatesTo>1,2</relatesTo><i> ckerr@physics.usyd.edu.au</i><br /><searchLink fieldCode="AR" term="%22Rennie%2C+C%2EJ%2E%22">Rennie, C.J.</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Robinson%2C+P%2EA%2E%22">Robinson, P.A.</searchLink><relatesTo>1,2,4</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Clinical+Neurophysiology%22">Clinical Neurophysiology</searchLink>. Jan2011, Vol. 122 Issue 1, p134-147. 14p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Auditory+evoked+response%22">Auditory evoked response</searchLink><br />*<searchLink fieldCode="DE" term="%22Brain+--+Mathematical+models%22">Brain -- Mathematical models</searchLink><br />*<searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br />*<searchLink fieldCode="DE" term="%22Human+research+subjects%22">Human research subjects</searchLink><br />*<searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br />*<searchLink fieldCode="DE" term="%22Thalamus%22">Thalamus</searchLink><br />*<searchLink fieldCode="DE" term="%22Cerebral+cortex%22">Cerebral cortex</searchLink><br />*<searchLink fieldCode="DE" term="%22Excitation+%28Physiology%29%22">Excitation (Physiology)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Objective: The physiological basis for the changes in auditory evoked potentials (AEPs) during development and aging is currently unknown. This study investigates age- and task-related changes via a mathematical model of neuronal activity, which allows a number of physiological changes to be inferred. Methods: A quantitative, physiology-based model of activity in cortical and thalamic neurons was used to analyze oddball AEPs recorded from 1498 healthy subjects aged 6–86 years. Results: Differences between standard and target responses can be largely explained by differences in connection strengths between thalamic and cortical neurons. The time it takes signals to travel between the thalamus and cortex decreases during development and increases during aging. Strong age trends are also seen in intracortical and thalamocortical neuronal connection strengths. Conclusions: Changes in AEP latency can be attributed to changes in the thalamocortical signal propagation time. Large changes in the connection strengths between neuronal populations occur during development, resulting in increased thalamocortical inhibition and decreased thalamocortical excitation. Standard and target parameters are similar in children but diverge during adolescence, due to changes in thalamocortical loop activity. Significance: Model-based AEP analysis links age-related changes in brain electrophysiology to underlying changes in brain anatomy and physiology, and yields quantitative predictions of several currently unknown physiological and anatomical properties of the brain. [Copyright &y& Elsevier]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asx&AN=56500468
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.clinph.2010.05.030
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 134
    Subjects:
      – SubjectFull: Auditory evoked response
        Type: general
      – SubjectFull: Brain -- Mathematical models
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Human research subjects
        Type: general
      – SubjectFull: Neurons
        Type: general
      – SubjectFull: Thalamus
        Type: general
      – SubjectFull: Cerebral cortex
        Type: general
      – SubjectFull: Excitation (Physiology)
        Type: general
    Titles:
      – TitleFull: Model-based analysis and quantification of age trends in auditory evoked potentials
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kerr, C.C.
      – PersonEntity:
          Name:
            NameFull: Rennie, C.J.
      – PersonEntity:
          Name:
            NameFull: Robinson, P.A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2011
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-print
              Value: 13882457
          Numbering:
            – Type: volume
              Value: 122
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Clinical Neurophysiology
              Type: main
ResultId 1