Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Post‐Ejaculatory Prolactin Elevation Resolves Within 2 Hours: Implications for Blood Sampling in Male Infertility Evaluation. |
| Συγγραφείς: |
Li, Shuai1 (AUTHOR), Tian, Junjie2 (AUTHOR), Zhao, Li3 (AUTHOR), Xu, Yaoting1 (AUTHOR), Zhu, Bo1 (AUTHOR), Li, Lejun2 (AUTHOR) lilejun@zju.edu.cn |
| Πηγή: |
Andrology. Oct2026, p1. 9p. 3 Illustrations. |
| Θεματικοί όροι: |
*Blood sampling, *Prolactin, *Hyperprolactinemia, *Male infertility |
| Περίληψη: |
ABSTRACT Background Objectives Materials and Methods Results Conclusions The acute post‐ejaculatory prolactin (PRL) elevation is well recognized, but its magnitude and recovery kinetics remain poorly defined.To delineate the post‐ejaculatory PRL kinetics, define its recovery window, and assess the clinical impact of improper sampling timing on hyperprolactinemia misclassification.This single‐center retrospective cohort study included 22,590 infertile men (aged 20–45 years). Participants were classified into pre‐ejaculatory (n = 8804) and post‐ejaculatory (n = 13,786) groups, with the latter subdivided into 17 subgroups by sequential post‐ejaculatory time intervals. Serum PRL, testosterone, luteinizing hormone (LH), follicle‐stimulating hormone (FSH), and estradiol were measured. The proportion of participants with PRL exceeding the local upper reference limit (17 ng/mL) was calculated. Interaction effects of ejaculation, sampling time of day, and age were evaluated using three‐way ANOVA.Ejaculation induced a rapid and pronounced elevation in serum PRL, peaking within the ≤ 0.1 h interval (median 17.9 ng/mL, 58.4% increase from baseline, p < 0.01) and returning to baseline by the ≤ 2 h interval. Other sex hormones showed only minimal changes. PRL exhibited significant diurnal variation and age‐related decline, but no significant interactions were observed between ejaculation and sampling time of day (p = 0.111) or age (p = 0.330). Notably, the percentage of participants with PRL >17 ng/mL increased from 15.8% at baseline to > 50% within the first 0.2 h, and remained significantly elevated through the ≤ 1.5 h interval. At the ≤ 2 h interval, the proportion (17.4%) was no longer significantly different from baseline.Post‐ejaculatory prolactin elevation resolves within 2 h. This effect is independent of diurnal variation and age. Blood for PRL measurement should be collected either before ejaculation or at least 2 h after ejaculation to avoid misdiagnosis. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: |
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