Academic Journal
Interfacial amplifier: High-throughput visual protein detection via droplet dynamics.
| Τίτλος: | Interfacial amplifier: High-throughput visual protein detection via droplet dynamics. |
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| Συγγραφείς: | Ge, Tianxin1, He, Xuexue1, Zhang, Shouzi1, Chen, Haofeng1, Hu, Wenxu1, Luo, Zhaofan2, Wang, Liqiu3 liqiu.wang@polyu.edu.hk, Dai, Zong1 daizong@mail.sysu.edu.cn, Han, Xing1 hanx83@mail.sysu.edu.cn |
| Πηγή: | Science Advances. 8/14/2026, Vol. 12 Issue 33, p1-9. 9p. |
| Θεματικοί όροι: | *Proteinuria, *Surfaces (Technology), *Diagnostic services, *Protein analysis, *Point-of-care testing, *Biosensors, *Fluid dynamics, *Analytical chemistry techniques |
| Περίληψη: | Rapid, visual protein detection at ultralow cost remains a critical unmet need for scalable point-of-care testing. We introduce a high-throughput platform leveraging interfacial droplet dynamics on a slippery liquid-infused porous surface (SLIPS) to directly translate protein-specific adsorption into macroscopic behavior. Protein concentration and identity modulate the critical sliding angle of droplets via interfacial film formation, enabling pretreatment-free, instrument-free identification of clinically relevant targets like proteinuria within minutes. This approach achieves parallel analysis of 170 samples on a single A4-sized substrate (5 minutes, ~$0.008 per sample), requiring only visual readout. By amplifying nanoscale interfacial interactions into intuitive visual outputs, our SLIPS-based technology establishes a scalable, user-friendly paradigm for decentralized diagnostics and continuous health monitoring across diverse settings. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: | Academic Search Index |
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