Academic Journal
A Halogen-Substituted Dicyanoisophorone Near-Infrared Fluorescent Probe for the Determination and Imaging of Copper(II)
| Τίτλος: | A Halogen-Substituted Dicyanoisophorone Near-Infrared Fluorescent Probe for the Determination and Imaging of Copper(II) |
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| Συγγραφείς: | Li, Xueqiang1 (AUTHOR) lixueqiang0323@163.com, Guo, Ximei1 (AUTHOR), Chen, Cuiting1 (AUTHOR), Liu, Yan1 (AUTHOR), Zhu, Ying1 (AUTHOR), Wang, Cheng1 (AUTHOR), Hao, Yuanqiang2 (AUTHOR) hao0736@163.com |
| Πηγή: | Analytical Letters. Jul2026, p1-16. 16p. 5 Illustrations. |
| Θεματικοί όροι: | *Fluorescent probes, *Copper analysis, *Analytical biochemistry, *Intramolecular charge transfer, *Analytical chemistry, *Fluorescence, *Luminescent probes, *Environmental monitoring |
| Περίληψη: | AbstractCopper ion (Cu2+) is an essential trace metal in living systems, yet its abnormal accumulation may lead to environmental and biological risks. In this work, a new near-infrared fluorescent probe, DCPCl2-Cu, was designed and synthesized for the selective determination of Cu2+. The probe was constructed by combining a halogen-substituted dicyanoisophorone fluorophore with a 2-picolinate responsive unit. In the presence of Cu2+, the probe underwent a Cu2+-triggered deprotection reaction, which restored the intramolecular charge transfer (ICT) process and produced a significant fluorescence enhancement in the near-infrared region. Under optimized conditions, DCPCl2-Cu showed high sensitivity and good selectivity toward Cu2+, with a detection limit of 26 nM and a linear response range of 0.1–18 μM. The probe was successfully applied to the determination of Cu2+ in tap water and lake water with satisfactory recoveries. In addition, it exhibited low cytotoxicity and enabled fluorescence imaging of exogenous Cu2+ in HepG2 cells. These results indicate that DCPCl2-Cu is a promising tool for Cu2+ detection in environmental and biological systems. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: | Academic Search Index |
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