Academic Journal
Review: Advances in implant material design and surface engineering for optimised soft- and hard-tissue integration.
| Τίτλος: | Review: Advances in implant material design and surface engineering for optimised soft- and hard-tissue integration. |
|---|---|
| Συγγραφείς: | Singh, Rohit1 (AUTHOR), Mitsimponas, Konstantinos2 (AUTHOR), Raveendran, Sreejith3 (AUTHOR), Arackal Narayanan, Jinoop4 (AUTHOR) J.ArackalNarayanan@tees.ac.uk |
| Πηγή: | Journal of Materials Science. Aug2026, Vol. 61 Issue 29, p20774-20818. 45p. |
| Θεματικοί όροι: | *Osseointegration, *Surfaces (Technology), *Biocompatibility, *Metals in surgery, *Solid freeform fabrication, *Surface preparation |
| Περίληψη: | The success of biomedical implants largely depends on the selection of appropriate materials and their interaction with surrounding soft and hard tissues. Metallic, ceramic, and polymeric materials such as Ti alloys, hydroxyapatite, and Polyether–Ether–Ketone are commonly employed due to their biocompatibility, corrosion resistance, and mechanical reliability. However, poor soft tissue integration, inflammation, and foreign body response remain persistent challenges that compromise long-term functionality. This review provides a comprehensive overview of implant materials, their soft tissue interactions, surface modification strategies, and future directions for optimising osseointegration in next generation biomedical implants. Recent studies highlight the significance of surface morphology, chemistry, and energy in modulating protein adsorption, macrophage polarisation, and cellular adhesion, key determinants for achieving stable osseointegration and minimising adverse immune reactions. Various surface modification techniques, including mechanical, physical, chemical, and biochemical, have been developed to enhance both osseointegration and soft tissue sealing. Additive manufacturing enables hierarchical surface design and patient-specific implant fabrication, broadening the scope of clinical applications. Despite these advancements, achieving a biologically functional interface that mimics natural tissue remains a key limitation. Future research should focus on multifunctional and biomimetic surfaces that integrate mechanical, biochemical, and immunomodulatory cues to achieve superior implant performance and longevity. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: | Academic Search Index |
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