Academic Journal
Correction: Post-mortem human Alzheimer's brain metallome depends on Braak stages and brain regions.
| Τίτλος: | Correction: Post-mortem human Alzheimer's brain metallome depends on Braak stages and brain regions. |
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| Συγγραφείς: | Parra-Martínez, Cecilio1 (AUTHOR), Callejón-Leblic, Belén1 (AUTHOR) belen.callejon@dqcm.uhu.es, Rodrigo-Lara, Héctor2 (AUTHOR), Fernández-Vega, Iván3 (AUTHOR), Guerrero-Márquez, María Carmen4 (AUTHOR), Rábano, Alberto5 (AUTHOR), García-Barrera, Tamara1 (AUTHOR) tamara@dqcm.uhu.es |
| Πηγή: | Scientific Reports. 4/30/2026, Vol. 16 Issue 1, p1-11. 11p. |
| Θεματικοί όροι: | *Alzheimer's disease, *Metal analysis, *Heavy metal toxicology, *Amyloid beta-protein, *Neurofibrillary tangles, *Brain anatomy, *Oxidative stress, *Tauopathies |
| Περίληψη: | The article focuses on the dysregulation of 15 toxic and essential metals in the frontal cortex (CTX) and basal ganglia (BG) of human brains affected by Alzheimer's disease (AD) across different Braak stages, which classify the severity of AD pathology. Using inductively coupled plasma mass spectrometry (ICP-QQQ-MS), the study found significant alterations in metal concentrations—such as increased manganese (Mn), copper (Cu), molybdenum (Mo), selenium (Se), vanadium (V), and chromium (Cr), and decreased cobalt (Co) and zinc (Zn)—that varied by brain region and disease stage. Correlation analyses indicated associations between specific metals and Braak stages, suggesting metal dyshomeostasis may be linked to AD progression. The findings highlight the complex role of neuro-metals and toxic metals in AD neuropathology, supporting the hypothesis that metal imbalances contribute to oxidative stress, amyloid beta aggregation, tau pathology, and neuronal damage in AD. [Extracted from the article] |
| Βάση Δεδομένων: | Academic Search Index |
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