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Translating the Power of Precision Medicine Into the World of Communication Disorders.

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Title: Translating the Power of Precision Medicine Into the World of Communication Disorders.
Authors: Peter, Beate1 Beate.Peter@asu.edu, Davis, Jennifer1, Bruce, Laurel1, Finestack, Lizbeth2, Kornelis, Miriam2, Eng, Linda1, Kim, Yookyung1, Scherer, Nancy1, Potter, Nancy3, VanDam, Mark3, Thompson, Lauren3, Loveall, Susan4, Stoel-Gammon, Carol5, Raaz, Caitlin6, Armstrong-Heimsoth, Amy7, Buckley, Sue8,9
Source: Journal of Speech, Language & Hearing Research. Nov2025, Vol. 68 Issue 11, p5174-5189. 16p.
Subject Terms: *Treatment of communicative disorders, *Psychological resilience, *Therapeutics, *Down syndrome, *Translations, *Dyslexia, *Speech-language pathology, *Galactosemia, *Communication, *Language disorders, *Communicative disorders in children, *Early diagnosis, *Genetics, *Phenotypes, *Genotypes
Abstract: Purpose: Precision medicine is an emerging approach to medical diagnostics, prognostics, and intervention that takes an individual's genetic, environmental, and lifestyle-related profile into account to improve outcomes in medical conditions such as diabetes and cancer. Here, we explore how principles of precision medicine can be leveraged in the field of speech-language pathology. Method: We reviewed the literature and report the following: (a) brief introduction to precision medicine, (b) review of a prophylactic intervention for infants at a genetic risk for speech/language disorders, (c) potential approaches to leveraging endophenotypes for individualized interventions in dyslexia, and (d) identified barriers and opportunities for incorporating precision medicine more broadly into the field of communication sciences and disorders. Results: An established example of a prophylactic intervention based on known genotype-phenotype associations is Babble Boot Camp (BBC), a novel personalized and proactive intervention designed to foster precursor and early communication skills of infants at a predictable genetic risk. We describe a successful clinical trial of BBC for infants at a genetic risk due to classic galactosemia and pilot trials for infants with Down syndrome. An experimental example of personalization is addressing the information processing mode shared by some individuals with dyslexia, namely, diminished sensory gating. Conclusions: To implement principles of precision medicine in disorders of spoken and written communication more broadly, novel ways of identifying young children at risk are needed. As more genotype-phenotype discoveries and gene therapies come online, training in genetics can equip clinicians to recognize signs of a genetic disorder, make appropriate referrals, and personalize therapeutic approaches. [ABSTRACT FROM AUTHOR]
Database: Academic Search Index
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  Data: Translating the Power of Precision Medicine Into the World of Communication Disorders.
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  Data: <searchLink fieldCode="AR" term="%22Peter%2C+Beate%22">Peter, Beate</searchLink><relatesTo>1</relatesTo><i> Beate.Peter@asu.edu</i><br /><searchLink fieldCode="AR" term="%22Davis%2C+Jennifer%22">Davis, Jennifer</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bruce%2C+Laurel%22">Bruce, Laurel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Finestack%2C+Lizbeth%22">Finestack, Lizbeth</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kornelis%2C+Miriam%22">Kornelis, Miriam</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Eng%2C+Linda%22">Eng, Linda</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Yookyung%22">Kim, Yookyung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Scherer%2C+Nancy%22">Scherer, Nancy</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Potter%2C+Nancy%22">Potter, Nancy</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22VanDam%2C+Mark%22">VanDam, Mark</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Lauren%22">Thompson, Lauren</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Loveall%2C+Susan%22">Loveall, Susan</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Stoel-Gammon%2C+Carol%22">Stoel-Gammon, Carol</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Raaz%2C+Caitlin%22">Raaz, Caitlin</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Armstrong-Heimsoth%2C+Amy%22">Armstrong-Heimsoth, Amy</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Buckley%2C+Sue%22">Buckley, Sue</searchLink><relatesTo>8,9</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Speech%2C+Language+%26+Hearing+Research%22">Journal of Speech, Language & Hearing Research</searchLink>. Nov2025, Vol. 68 Issue 11, p5174-5189. 16p.
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  Data: *<searchLink fieldCode="DE" term="%22Treatment+of+communicative+disorders%22">Treatment of communicative disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Psychological+resilience%22">Psychological resilience</searchLink><br />*<searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br />*<searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br />*<searchLink fieldCode="DE" term="%22Translations%22">Translations</searchLink><br />*<searchLink fieldCode="DE" term="%22Dyslexia%22">Dyslexia</searchLink><br />*<searchLink fieldCode="DE" term="%22Speech-language+pathology%22">Speech-language pathology</searchLink><br />*<searchLink fieldCode="DE" term="%22Galactosemia%22">Galactosemia</searchLink><br />*<searchLink fieldCode="DE" term="%22Communication%22">Communication</searchLink><br />*<searchLink fieldCode="DE" term="%22Language+disorders%22">Language disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Communicative+disorders+in+children%22">Communicative disorders in children</searchLink><br />*<searchLink fieldCode="DE" term="%22Early+diagnosis%22">Early diagnosis</searchLink><br />*<searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br />*<searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br />*<searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Precision medicine is an emerging approach to medical diagnostics, prognostics, and intervention that takes an individual's genetic, environmental, and lifestyle-related profile into account to improve outcomes in medical conditions such as diabetes and cancer. Here, we explore how principles of precision medicine can be leveraged in the field of speech-language pathology. Method: We reviewed the literature and report the following: (a) brief introduction to precision medicine, (b) review of a prophylactic intervention for infants at a genetic risk for speech/language disorders, (c) potential approaches to leveraging endophenotypes for individualized interventions in dyslexia, and (d) identified barriers and opportunities for incorporating precision medicine more broadly into the field of communication sciences and disorders. Results: An established example of a prophylactic intervention based on known genotype-phenotype associations is Babble Boot Camp (BBC), a novel personalized and proactive intervention designed to foster precursor and early communication skills of infants at a predictable genetic risk. We describe a successful clinical trial of BBC for infants at a genetic risk due to classic galactosemia and pilot trials for infants with Down syndrome. An experimental example of personalization is addressing the information processing mode shared by some individuals with dyslexia, namely, diminished sensory gating. Conclusions: To implement principles of precision medicine in disorders of spoken and written communication more broadly, novel ways of identifying young children at risk are needed. As more genotype-phenotype discoveries and gene therapies come online, training in genetics can equip clinicians to recognize signs of a genetic disorder, make appropriate referrals, and personalize therapeutic approaches. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asx&AN=189241800
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      – Type: doi
        Value: 10.1044/2025_JSLHR-25-00077
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 5174
    Subjects:
      – SubjectFull: Treatment of communicative disorders
        Type: general
      – SubjectFull: Psychological resilience
        Type: general
      – SubjectFull: Therapeutics
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      – SubjectFull: Down syndrome
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      – SubjectFull: Translations
        Type: general
      – SubjectFull: Dyslexia
        Type: general
      – SubjectFull: Speech-language pathology
        Type: general
      – SubjectFull: Galactosemia
        Type: general
      – SubjectFull: Communication
        Type: general
      – SubjectFull: Language disorders
        Type: general
      – SubjectFull: Communicative disorders in children
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      – SubjectFull: Early diagnosis
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      – SubjectFull: Genetics
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      – SubjectFull: Phenotypes
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      – SubjectFull: Genotypes
        Type: general
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      – TitleFull: Translating the Power of Precision Medicine Into the World of Communication Disorders.
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              M: 11
              Text: Nov2025
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