Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Recent advances in design of new urease inhibitors: A review. |
| Συγγραφείς: |
Kafarski, Paweł1, Talma, Michał1 |
| Πηγή: |
Journal of Advanced Research. Sep2018, Vol. 13, p101-112. 12p. |
| Θεματικοί όροι: |
*Urease genetics, *Enzyme inhibitors, *Bacterial enzymes, *Microbial virulence, *Pharmaceutical chemistry, *Molecular models |
| Περίληψη: |
Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi. Bacterial enzyme is of special importance since it has been demonstrated as a potent virulence factor for some species. Especially it is central to Helicobacter pylori metabolism and virulence being necessary for its colonization of the gastric mucosa, and is a potent immunogen that elicits a vigorous immune response. Therefore, it is not surprising that efforts to design, synthesize and evaluate of new inhibitors of urease are and active field of medicinal chemistry. In this paper recent advances on this field are reviewed. [ABSTRACT FROM AUTHOR] |
| Βάση Δεδομένων: |
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