The polyfunctionality of punctuation marks in poetic text

Authors: A.V. Kanafieva

Source: Language and Text. 13:66-76

Polyfunctionality and distribution of reflexive verbs in Latvian

Authors: Andra Kalnača, Ilze Lokmane

Source: Baltistica, Vol 51, Iss 1, Pp 97-116 (2017)

Subject Terms: evaluation, object verbs, impersonal verbs, subject verbs, aspect, reflexive verbs, P1-1091, Latvian, syntax, Philology. Linguistics

Access URL: https://doaj.org/article/5ab55dcb8d3c4034b18faab6de30c9c1

New Insights Into Factors Shaping CMV ‐Specific T‐Cell Polyfunctionality After Hematopoietic Cell Transplantation

Authors: Alicja Sadowska‐Klasa, Fang Yun Lim, Hu Xie, Danniel Zamora, Terry Stevens‐Ayers, Wendy M. Leisenring, Bradley C. Edmison, Stephen C. De Rosa, Marco Mielcarek, Michael Boeckh

Source: Am J Hematol

Subject Terms: Male, Adult, CD4-Positive T-Lymphocytes, CMV-specific T cells, Hematopoietic Stem Cell Transplantation, Cytomegalovirus, immunosuppressive treatment, Middle Aged, CD8-Positive T-Lymphocytes, Mycophenolic Acid, HCT, Adrenal Cortex Hormones, drug effects, Cytomegalovirus Infections, Cyclosporine, Humans, Female, Cyclophosphamide, Immunosuppressive Agents, Research Article, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/41324241
https://pmc.ncbi.nlm.nih.gov/articles/PMC12766359/
https://pubmed.ncbi.nlm.nih.gov/41324241/
https://doi.org/10.1002/ajh.70152

CD19 expression associates with polyfunctionality and altered secretion dynamics in individual activated human B cells

Authors: Luca Johannes Schlotheuber, Morten Øgelund Overgaard, Klaus Eyer

Source: Schlotheuber, L J, Overgaard, M Ø & Eyer, K 2026, 'CD19 expression associates with polyfunctionality and altered secretion dynamics in individual activated human B cells', Journal of Immunology, vol. 215, no. 4. https://doi.org/10.1093/jimmun/vkag063

Subject Terms: temporal dynamics, Interleukin-6/metabolism, Cytokines/metabolism, B-Lymphocytes/immunology, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism, Lymphocyte Activation/immunology, Antigens, CD19/immunology, regulatory B cells, Interleukin-10/metabolism, B-cell functionalities, Toll-Like Receptor 4/metabolism, Memory B Cells/immunology, Immunoglobulin G/metabolism, Humans, single-cell analysis, Cells, Cultured, inflammatory B cells

POLIFUNKCIONALNOST KAO PRINCIP / POLYFUNCTIONALITY AS A PRINCIPLE: UPOTREBA LEKSEMA ḤATTĀ U ARAPSKOM JEZIKU / THE USE OF LEXEME ḤATTĀ IN ARABIC

Authors: Elma Dizdar

Source: Journal of the Faculty of Philosophy in Sarajevo / Radovi Filozofskog fakulteta u Sarajevu, ISSN 2303-6990 on-line. :13-44

Modal polyfunctionality and German modals revisited

Authors: Masár Machová, Dagmar

Source: Studies About Languages

Subject Terms: polyfunctionality, definition of modality, modal, German, grammaticalization

Access URL: http://publikace.k.utb.cz/handle/10563/1012222

SYNTACTIC POLYFUNCTIONALITY OF STABLE PREPOSITIONAL COMBINATIONS IN THE RUSSIAN LANGUAGE OF THE XVI–XVII CENTURIES

Authors: A. I. Reiner

Source: Proceedings of Petrozavodsk State University. 47:28-35

The Concept of Function Words and Their Polyfunctionality in Russian Studies

Authors: Maria Krylova

Source: Stephanos Peer reviewed multilanguage scientific journal. 70:7-18

SYNTACTIC PARALLELISM AND ITS POLYFUNCTIONALITY IN THE TEXT

Authors: A. E. Abdykerimova, Zh. S. Sulaymanova

Source: Вестник Иссык-Кульского университета. :241-247

Quantitative peripheral live single T-cell dynamic polyfunctionality profiling predicts lung cancer checkpoint immunotherapy treatment response and clinical outcomes

Authors: Lim, Zuan-Fu, Wu, Xiaoliang, Zhu, Lin, Albandar, Heidar, Hafez, Maria, Zhao, Chenchen, Almubarak, Mohammed, Smolkin, Matthew, Zheng, Hong, Wen, Sijin, Ma, Patrick C.

Source: Transl Lung Cancer Res

Subject Terms: Original Article

Access URL: https://pubmed.ncbi.nlm.nih.gov/39830778

Polyfunctionality as a Condition for Urban Development: A Case Study of Small Towns in the Western Region of Ukraine

Authors: Olga Meshcheryakova, Roman Trach

Source: Current problems of architecture and urban planning. :292-300

Decitabine Conditioning Improves Natural Killer Cell Maturation and Limits CD8(+) T Cell Terminal Differentiation Post-Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Patients.

Additional Titles: Allogeneic stem cell transplantation (alloSCT) can be curative for acute myeloid leukemia (AML) patients due to graft-versus-tumor immune responses. However, relapse post-alloSCT remains a major clinical challenge, underscoring the necessity for adjuvant treatments that both reduce tumor load before alloSCT and strengthen natural killer (NK) cell and T cell immunity post-transplantation. The hypomethylating agent decitabine (DAC) holds promise as it is well-tolerated and has direct antiproliferative and proapoptotic effects on leukemic cells. In addition, DAC modulates tumor immunogenicity and exhibits immunomodulatory properties. Yet integral insight into the impact of adding DAC to the pre-alloSCT conditioning on the immunophenotype and function of NK and T cells post-alloSCT is lacking. Here we investigated the immunomodulatory effects of adding DAC to the pre-alloSCT conditioning on the NK and T cell landscape and function in AML patients post-transplantation. This retrospective cohort study included AML patients who underwent alloSCT with DAC (n = 30) or without DAC (n = 22) as part of their conditioning regimen. Peripheral blood samples were collected at 3 months and 6 months post-alloSCT. High-dimensional flow cytometry was used to assess the phenotypic profiles, whereas proliferation, cytokine production, and cytotoxicity assays were performed to study their function. Irrespective of the conditioning regimen, checkpoint molecules on NK cells, including PD-1, TIM-3, LIGHT, and OX40, were low post-alloSCT. Notably, DAC conditioning significantly increased the abundance of mature NK cell clusters coexpressing KIRah, KIRb, CD69, CD57, and DNAM-1. Interestingly, NK cells from DAC-conditioned patients retained their cytotoxic and cytokine production capacity, with mature NK cells demonstrating significantly enhanced responsiveness to K562 stimulation compared to immature NK cells. Within the CD4(+) T cells, DAC conditioning reduced the frequencies of T(H1)/T(H17) cells and a proportion of T(H17) cells. Interestingly, DAC treatment led to a diminished abundance of CD8(+) T cell clusters coexpressing immune checkpoint molecules, including PD-1, TIGIT, KLRG1, TIM-3, and CD57, implying a less terminally differentiated phenotype. Functionally, CD4(+) and CD8(+) T cells from DAC-conditioned patients demonstrated robust proliferation in response to anti-CD3 stimulation and exhibited polyfunctionality, producing IFN-γ, TNF-α, and IL-2. Notably, the higher abundance of CD8⁺ T cells co-expressing inhibitory checkpoint molecules in non-DAC-conditioned patients was inversely associated with IL-2 production on polyclonal stimulation. Overall, the addition of DAC to the conditioning regimen was associated with favorable immunomodulatory effects on NK cells and T cells post-alloSCT in AML patients. These findings suggest that DAC may enhance donor NK and T cell-mediated graft-versus-tumor responses, supporting its further clinical evaluation as an adjuvant prior to alloSCT. © 2025 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Authors: Eck van der Sluijs, J. van

Subjects: Haematology - Radboud University Medical Center., Laboratory Medicine - Radboud University Medical Center.

Index Terms: Article / Letter to editor.

URL: https://repository.ubn.ru.nl//bitstream/handle/2066/331499/331499.pdf
https://hdl.handle.net/2066/331499
https://doi.org/10.1016/j.jtct.2025.11.039

Baseline Single‐Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls

Authors: Linder, Aline, Diab, Farah, de Pontual, Loïc, Giurgea, Irina, Eyer, Klaus

Contributors: Couvet, Sandrine

Source: Eur J Immunol
Linder, A, Diab, F, de Pontual, L, Giurgea, I & Eyer, K 2025, 'Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls', European Journal of Immunology, vol. 55, no. 9, e70047. https://doi.org/10.1002/eji.70047

Subject Terms: Male, Adult, Inflammation, Single-Cell Analysis/methods, Cytokines/metabolism, Notes and Insights, Inflammation/immunology, Middle Aged, Autoinflammatory Diseases/immunology, Autoimmune Diseases, [SDV] Life Sciences [q-bio], Case-Control Studies, Humans, Cytokines, Female, Single-Cell Analysis, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40899100
https://pubmed.ncbi.nlm.nih.gov/40899100/
https://doi.org/10.1002/eji.70047
https://pmc.ncbi.nlm.nih.gov/articles/PMC12405973/
https://inserm.hal.science/inserm-05292862v1/document
https://inserm.hal.science/inserm-05292862v1
https://doi.org/10.1002/eji.70047
https://www.scopus.com/pages/publications/105015125135
https://pure.au.dk/portal/en/publications/380d49a5-1a37-4d93-8af2-43928c761950
https://doi.org/10.1002/eji.70047

The impact of cryopreservation on cytokine secretion and polyfunctionality in human PBMCs: a comparative study

Authors: Aline Linder, Kevin Portmann, Klaus Eyer

Source: Front Immunol
Frontiers in Immunology, Vol 15 (2024)
Frontiers in Immunology, 15
Linder, A, Portmann, K & Eyer, K 2024, ' The impact of cryopreservation on cytokine secretion and polyfunctionality in human PBMCs : a comparative study ', Frontiers in Immunology, vol. 15, 1478311 . https://doi.org/10.3389/fimmu.2024.1478311
Linder, A, Portmann, K & Eyer, K 2024, 'The impact of cryopreservation on cytokine secretion and polyfunctionality in human PBMCs : a comparative study', Frontiers in Immunology, vol. 15, 1478311, pp. 1478311. https://doi.org/10.3389/fimmu.2024.1478311

Subject Terms: Cryopreservation, human peripheral blood mononuclear cells, cytokine secretion, Immunology, RC581-607, cryopreservation, polyfunctionality, single-cell analysis, Leukocytes, Mononuclear, Humans, Cytokines, Immunologic diseases. Allergy, Cells, Cultured

File Description: application/application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39434875
https://doaj.org/article/d952adcff0a74943aa1d9ffd17680477
http://hdl.handle.net/20.500.11850/702400

The Polyfunctionality and Origins of makee in Chinese Pidgin English

Authors: Michelle Li

Source: Journal of Language Contact. 17:727-755

Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies

Authors: Dong, Zhengyuan ¹, Budde, L. Elizabeth ², Oh, Elizabeth ¹, Szymura, Szymon ¹, Anderson, Aaron ¹, Del Real, Marissa ², Cha, Soung-chul ¹, Forman, Stephen J. ², Kwak, Larry W. ^{1, ∗}, Wang, Xiuli ²

Source: In Blood Advances 13 August 2024 8(15):4066-4076

Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality

Authors: Shoffner-Beck, Suzanne K., Theisen, Robert M., Wong, Kade E., Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Kent, Stephen, Chung, Amy W., Arnold, Kelly B.

Source: Front Immunol

Subject Terms: Phagocytosis, Immunoglobulin G, Immunology, Receptors, IgG, Antibody-Dependent Cell Cytotoxicity, Models, Immunological, Humans, Computer Simulation, Antigen-Antibody Complex, Immunoglobulin Fc Fragments

Access URL: https://pubmed.ncbi.nlm.nih.gov/41035650
https://pubmed.ncbi.nlm.nih.gov/41035650/
https://doi.org/10.3389/fimmu.2025.1578500
https://pmc.ncbi.nlm.nih.gov/articles/PMC12479434/

Polyfunctionality of CD4+ T lymphocytes in buffaloes and cattle: comparative antigen-specific cytokine responses in bovine tuberculosis infection

Authors: Flores-Villalva, Susana, De Matteis, Giovanna, Grandoni, Francesco, Scatà, Maria Carmela, Donniacuo, Anna, Schiavo, Lorena, Franzoni, Giulia, Mazzone, Piera, Elnaggar, Mahmoud, De Carlo, Esterina, Galiero, Giorgio, Davis, William C., Martucciello, Alessandra

Contributors: Flores-Villalva, Susana, De Matteis, Giovanna, GRANDONI, FRANCESCO, Scatà, Maria Carmela, Donniacuo, Anna, Schiavo, Lorena, Franzoni, Giulia, Mazzone, Piera, Elnaggar, mahmoud, De Carlo, Esterina, Galiero, Giorgio, Davis, William, MARTUCCIELLO, ALESSANDRA

Source: Front Immunol

Subject Terms: CD4-Positive T-Lymphocytes, Antigens, Bacterial, tuberculosis, Buffaloes, Immunology, T cells, Animals, Cytokines, Cattle, Tuberculosis, Bovine, Mycobacterium bovis, cytokines

Access URL: https://pubmed.ncbi.nlm.nih.gov/40990013
https://pubmed.ncbi.nlm.nih.gov/40990013/
https://doi.org/10.3389/fimmu.2025.1608065
https://pmc.ncbi.nlm.nih.gov/articles/PMC12450747/

Study of the Phenomenon of Polyfunctionality in the Course of Russian as a Foreign Language (Based on Comparatives bigger/more, better, shorter/anyway)

Authors: I. R. Matiishina

Source: Prepodavatel XXI vek. :197-207

Subject Terms: 4. Education

Affix polyfunctionality in French deverbal nominalizations

Authors: Salvadori, Justine^{Aff1, IDs11525022094014_cor1}, Huyghe, Richard^Aff1

Source: Morphology. 33(1):1-39