Developing a urea biosensor and safe blood cleaning method utilizing a novel high throughput La-doped CeO2 nanosized artificial urease with high biocompatibility and enzyme-like activity.

Authors: Ahmad N; Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: anaushad@ksu.edu.sa., Bishoyi AK; Marwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot, Gujarat, India. Electronic address: ashokkumar.bishoyi@marwadieducation.edu.in., Ballal S; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bengaluru, Karnataka, India. Electronic address: b.suhas@jainuniversity.ac.in., Shankhyan A; Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab 140401, India., Al-Hasnaawei S; College of pharmacy, the Islamic University, Najaf, Iraq; Department of medical analysis, Medical laboratory technique college, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq. Electronic address: shakeralhasnawi@iunajaf.edu.iq., Jayabalan K; Department of Chemistry, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India. Electronic address: karthikeyan.chemistry@sathyabama.ac.in., Maharana L; Department of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha 751030, India. Electronic address: laxmidharmaharana@soa.ac.in., Lal M; Department of Medicine, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India. Electronic address: Madan.lal1@nimsuniversity.org.

Source: Enzyme and microbial technology [Enzyme Microb Technol] 2025 Dec; Vol. 191, pp. 110736. Date of Electronic Publication: 2025 Aug 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 8003761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0909 (Electronic) Linking ISSN: 01410229 NLM ISO Abbreviation: Enzyme Microb Technol Subsets: MEDLINE

MeSH Terms: Urease*/metabolism , Urease*/chemistry , Urea*/blood , Urea*/analysis , Biosensing Techniques*/methods , Cerium*/chemistry, Enzymes, Immobilized/metabolism ; Enzymes, Immobilized/chemistry ; Biocompatible Materials/chemistry ; Humans ; Limit of Detection ; Reproducibility of Results

Immobilized pigeon pea urease on chitosan-PEG biocomposite for concurrent urea sensing in milk and blood samples.

Authors: Kumar P; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India., Ghosal A; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India., Kayastha AM; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: kayasthabhu@gmail.com.

Source: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146509. Date of Electronic Publication: 2025 Sep 25.

Publication Type: Journal Article; Evaluation Study

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH Terms: Urease*/chemistry , Milk*/chemistry , Urea*/blood , Urea*/analysis , Cajanus*/enzymology , Cajanus*/chemistry , Plant Proteins*/chemistry , Biosensing Techniques*/methods , Biosensing Techniques*/instrumentation, Chitosan/chemistry ; Enzymes, Immobilized/chemistry ; Polyethylene Glycols/chemistry ; Animals ; Cattle ; Kinetics

Enzyme-coupled polymersome microreactor for point-of-care blood urea sensing.

Authors: Belin C; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada; CPE Lyon, Villeurbanne 69100, Auvergne-Rhône-Alpes, France., Lenglet E; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada; CPE Lyon, Villeurbanne 69100, Auvergne-Rhône-Alpes, France., Al-Hawat ML; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada., Caron J; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada., Bartumeu EG; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada; Faculté Sciences et Ingénierie, Université de Toulouse, Toulouse 31062, Occitanie, France., Djebbar S; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada., Matoori S; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada. Electronic address: simon.matoori@umontreal.ca.

Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Feb 10; Vol. 390, pp. 114557. Date of Electronic Publication: 2025 Dec 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH Terms: Urea*/blood , Urease*/chemistry , Urease*/metabolism , Polyethylene Glycols*/chemistry , Polystyrenes*/chemistry , Point-of-Care Systems*, Ammonia/analysis ; Ammonia/blood ; Animals ; Humans ; Hydrogen-Ion Concentration ; Mice

Watermelon (Citrullus lanatus) urease immobilized on chitosan-unzipped multi-walled carbon nanotubes (UZMWCNTs) nanobiocomposite for enhanced blood urea sensing

Authors: Kumar, Prince ^a, Ali, Ahsan ^b, Srivastava, Anchal ^{b, ⁎}, Kayastha, Arvind M. ^{a, ⁎}

Source: In Journal of Molecular Liquids 1 June 2025 427

Aptamer-based colorimetric detection of ATP and PDGF-BB by silver nanoparticles-mediated signal amplification and urease activity inhibition.

Authors: Wang F; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China., Tang Z; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China., Shan X; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China., Li Y; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China., Zhou F; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Ji X; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. xhu@whu.edu.cn., He Z; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. zhkhe@whu.edu.cn.; Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. zhkhe@whu.edu.cn.

Source: Mikrochimica acta [Mikrochim Acta] 2025 Nov 18; Vol. 192 (12), pp. 825. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

MeSH Terms: Colorimetry*/methods , Aptamers, Nucleotide*/chemistry , Silver*/chemistry , Adenosine Triphosphate*/blood , Adenosine Triphosphate*/analysis , Metal Nanoparticles*/chemistry , Urease*/antagonists & inhibitors , Urease*/metabolism , Becaplermin*/blood , Becaplermin*/analysis , Biosensing Techniques*/methods, Humans ; Limit of Detection

Effectiveness of rapid urease, serum antibody, and histopathological detection of helicobacter pylori infection in children.

Authors: Yang D; Department of Clinical Laboratory, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110034, China., Mo T; Department of Faculty of Biology, Shenzhen MSU-BIT University, Shenzhen, Guangdong 518172, China., Chen Q; Department of Clinical Laboratory, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110034, China., Liang L; Department of Clinical Laboratory, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110034, China.

Source: African journal of reproductive health [Afr J Reprod Health] 2025 Oct 30; Vol. 29 (10), pp. 100-108.

Publication Type: Journal Article

Journal Info: Publisher: Women's Health and Action Research Centre Country of Publication: Nigeria NLM ID: 9712263 Publication Model: Print Cited Medium: Internet ISSN: 1118-4841 (Print) Linking ISSN: 11184841 NLM ISO Abbreviation: Afr J Reprod Health Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Helicobacter Infections*/pathology , Helicobacter Infections*/microbiology , Helicobacter Infections*/blood , Urease*/blood , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/immunology , Antibodies, Bacterial*/blood, Humans ; Child ; Male ; Female ; Sensitivity and Specificity ; Child, Preschool ; Gastroscopy ; Adolescent

The Potential of Urease Enzyme from Staphylococcus Aureus to Stabilize Blood Concentration Levels

Authors: null Rawaa Thamir Alasadi, null Rasha Mohammed Hayder, null Hassanain Jwad Abidalhussein

Source: Academic International Journal of Medical Update. 2:1-6

Subject Terms: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

Urease immobilized GO core@shell heparin-mimicking polymer beads with safe and effective urea removal for blood purification

Authors: Zhang, Jue, Shi, Zhenqiang, He, Chao ^⁎, Song, Xin, Yang, Ye, Sun, Shudong, Zhao, Weifeng, Zhao, Changsheng ^⁎

Source: In International Journal of Biological Macromolecules 1 August 2020 156:1503-1511

Combined effects of feed-grade urea and a urease inhibitor on growth performance, digestibility, blood biochemical indicators, and rumen environment in beef cattle

Authors: Yuan Zhou, Xuerong Song, Dabo Fu, Lizbeth E. Robles-Jimenez, Manuel Gonzalez-Ronquillo, Navid Ghavipanje

Source: Front Vet Sci
Frontiers in Veterinary Science, Vol 12 (2025)

Subject Terms: rumen fermentation, Veterinary medicine, SF600-1100, Veterinary Science, urea, sustainability, ammonia nitrogen, non-protein nitrogen

Access URL: https://pubmed.ncbi.nlm.nih.gov/40395803
https://doaj.org/article/76ee5ffa53174429bb12b71efbd7a6f1

High throughput urease immobilization onto a new metal-organic framework called nanosized electroactive quasi-coral-340 (NEQC-340) for water treatment and safe blood cleaning

Authors: Hormozi Jangi, Saeed Reza, Akhond, Morteza ^*

Source: In Process Biochemistry June 2021 105:79-90

Urease immobilized electrospun PVA/chitosan nanofibers with improved stability and reusability characteristics: an application for removal of urea from artificial blood serum

Authors: Kutlu, Nur, Doğaç, Yasemin İspirli, Deveci, Ilyas, Teke, Mustafa

Contributors: MÜ, Fen Fakültesi, Kimya Bölümü, MÜ, Muğla Meslek Yüksekokulu, Kimya Ve Kimyasal İşleme Teknolojileri Bölümü, Kutlu, Nur, Doğaç, Yasemin İspirli, Teke, Mustafa

Source: Preparative Biochemistry & Biotechnology. 50:425-437

Subject Terms: Chitosan, Electrospinning, Hydrolysis, Nanofibers, Nanofiber, 02 engineering and technology, Enzymes, Immobilized, Urease, Nanocomposites, Immobilization, Kinetics, Blood Substitutes, Polyvinyl Alcohol, Urea, 0210 nano-technology

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/32233958

Urease-Immobilized Magnetic Graphene Oxide as a Safe and Effective Urea Removal Recyclable Nanocatalyst for Blood Purification

Authors: Zhang, Jue, Yan, Bingqing, He, Chao, Hao, Yuanyuan, Sun, Shudong, Zhao, Weifeng, Zhao, Changsheng

Source: Industrial & Engineering Chemistry Research. 59(19):8955-8964

Availability: https://pubs.acs.org/doi/10.1021/acs.iecr.0c00302

Target-Induced Shielding Layer at the Dual-Affinity Probe Interface for Rapid Colorimetric Detection of Cardiac Biomarkers.

Authors: Bharti; Council of Scientific and Industrial Research (CSIR), Institute of Microbial Technology (IMTECH), Sector 39-A, Chandigarh 160036, India.; Department of Biotechnology, Panjab University, Chandigarh 160014, India., Bhardwaj P; Council of Scientific and Industrial Research (CSIR), Institute of Microbial Technology (IMTECH), Sector 39-A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Bisht B; Council of Scientific and Industrial Research (CSIR), Institute of Microbial Technology (IMTECH), Sector 39-A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Bala R; Council of Scientific and Industrial Research (CSIR), Institute of Microbial Technology (IMTECH), Sector 39-A, Chandigarh 160036, India., Sagrika; Council of Scientific and Industrial Research (CSIR), Institute of Microbial Technology (IMTECH), Sector 39-A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Rohit M; Department of Cardiology, PGIMER, Chandigarh 160012, India., Singh J; Department of Biotechnology, Panjab University, Chandigarh 160014, India., Bhalla V; Council of Scientific and Industrial Research (CSIR), Institute of Microbial Technology (IMTECH), Sector 39-A, Chandigarh 160036, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2026 Mar 04; Vol. 18 (8), pp. 12423-12431. Date of Electronic Publication: 2026 Feb 18.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH Terms: Colorimetry*/methods , Troponin I*/blood , Troponin I*/analysis , Metal Nanoparticles*/chemistry , Myocardial Infarction*/diagnosis, Biomarkers/blood ; Biomarkers/analysis ; Silver/chemistry ; Aptamers, Nucleotide/chemistry ; Biosensing Techniques/methods ; Urease/chemistry ; Urease/metabolism ; Humans ; Limit of Detection

Double-Layered Electrospun Nanofiber Filter for the Simultaneous Removal of Urea and Ammonium from Blood

Authors: Sasaki, Makoto^{aff1, aff2}, Szabó, László^aff1, Uto, Koichiro^aff1, Ebara, Mitsuhiro^{aff1, aff2}

Source: ACS Applied Materials & Interfaces. 16(49):67399-67410

Availability: https://pubs.acs.org/doi/10.1021/acsami.4c16068

Urease immobilized core–shell magnetic Fe[NiFe]O4/alginate and Fe3O4/alginate composite beads with improved enzymatic stability properties: removal of artificial blood serum urea

Authors: İspirli Doğaç, Yasemin^{Aff1, IDs13738021022197_cor1}, Teke, Mustafa^Aff2

Source: Journal of the Iranian Chemical Society. 18(10):2637-2648

Diagnostic Value of the Pylori DuoTect Test for Helicobacter pylori Detection in the Vietnamese Population.

Authors: Viet HD; Internal Medicine Faculty, Hanoi Medical University, Hanoi, Vietnam.; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam.; Endoscopy Centre, Hanoi Medical University Hospital, Hanoi, Vietnam., Phuc BN; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam., Thi TD; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam., Huyen TNT; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam., Thu TN; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam., Thu UVT; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam., Bao LH; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam.; College of Health Sciences, VinUniversity, Hanoi, Vietnam., Van LD; Internal Medicine Faculty, Hanoi Medical University, Hanoi, Vietnam.; Institute of Gastroenterology and Hepatology, Hanoi, Vietnam.; Endoscopy Centre, Hanoi Medical University Hospital, Hanoi, Vietnam.

Source: Helicobacter [Helicobacter] 2026 Jul-Aug; Vol. 31 (4), pp. e70155.

Publication Type: Journal Article; Evaluation Study

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9605411 Publication Model: Print Cited Medium: Internet ISSN: 1523-5378 (Electronic) Linking ISSN: 10834389 NLM ISO Abbreviation: Helicobacter Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Helicobacter Infections*/microbiology , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/immunology , Antibodies, Bacterial*/blood, Vietnam/epidemiology ; Antigens, Bacterial/immunology ; Bacterial Proteins/immunology ; Urease/analysis ; Humans ; Female ; Cross-Sectional Studies ; Middle Aged ; Male ; Adult ; Sensitivity and Specificity ; Breath Tests ; Aged

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Authors: Biswas S; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal, 721302, India; Department of Biomedical Engineering, National Institute of Technology Raipur, Chhattisgarh, 492010, India., Pal A; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal, 721302, India; Department of Engineering, University of Exeter, Exeter, EX4 4QJ, UK., Chaudhury K; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal, 721302, India., Das S; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal, 721302, India. Electronic address: sou@smst.iitkgp.ac.in.

Source: Biosensors & bioelectronics [Biosens Bioelectron] 2026 Nov 01; Vol. 311, pp. 118980. Date of Electronic Publication: 2026 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

MeSH Terms: Urea*/blood , Urea*/isolation & purification , Biosensing Techniques*, Aniline Compounds/chemistry ; Urease/chemistry ; Enzymes, Immobilized/chemistry ; Neural Networks, Computer ; Humans ; Paper ; Limit of Detection ; Electric Conductivity ; Equipment Design

Application of potentiometric biosensor based on recombinant urease for urea determination in blood serum and hemodialyzate

Authors: Marchenko, S.V. ^a, Kucherenko, I.S. ^{a, ⁎}, Hereshko, A.N. ^b, Panasiuk, I.V. ^b, Soldatkin, O.O. ^{a, c}, El'skaya, A.V. ^a, Soldatkin, A.P. ^{a, c}

Source: In Sensors & Actuators: B. Chemical February 2015 207 Part B:981-986

The urease E subunit vaccine stimulate the immune response versus Helicobacter pylori in animal model.

Authors: Nikzad-Chaleshtori M; Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Asgari M; Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Rezaeizadeh G; Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran., Aali F; Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran., Doosti A; Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. doostiabbas2021@gmail.com.

Source: Immunologic research [Immunol Res] 2025 Apr 22; Vol. 73 (1), pp. 74. Date of Electronic Publication: 2025 Apr 22.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/immunology , Helicobacter pylori*/physiology , Helicobacter Infections*/immunology , Helicobacter Infections*/prevention & control , Urease*/genetics , Urease*/immunology , Vaccines, DNA*/immunology , Vaccines, DNA*/genetics , Bacterial Vaccines*/immunology , Bacterial Vaccines*/genetics , Bacterial Proteins*/genetics , Bacterial Proteins*/immunology, Antibodies, Bacterial/blood ; Vaccines, Subunit/immunology ; Cytokines/metabolism ; Cytokines/blood ; Immunoglobulin G/blood ; Animals ; Mice ; Mice, Inbred BALB C ; Disease Models, Animal ; Female ; Humans

Producing hybrid nanofiber‐based on /PAN/Fe3O4/zeolite/nettle plant extract/urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients

Authors: Faranak Bahramimehr, Akbar Esmaeili

Source: Journal of Biomedical Materials Research Part A. 107:1736-1743

Subject Terms: 0301 basic medicine, Lamiaceae, Plant Extracts, Polymers, Acrylic Resins, Nanofibers, 02 engineering and technology, Ferric Compounds, Urease, 01 natural sciences, 0104 chemical sciences, 3. Good health, 03 medical and health sciences, X-Ray Diffraction, Renal Dialysis, Creatinine, Tensile Strength, Spectroscopy, Fourier Transform Infrared, Thermogravimetry, Zeolites, Nanoparticles, Spectrophotometry, Ultraviolet, Particle Size, 0210 nano-technology

Access URL: https://pubmed.ncbi.nlm.nih.gov/30942935