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1Book
Additional Titles: The prevalence of depression in women increases during the postpartum period. We previously reported that subchronic exposure to social stress decreased passive coping in postpartum female mice. This study aimed to investigate whether noradrenaline regulation might regulate coping styles in mice. We first determined whether a different type of stress, subchronic physical stress, decreases passive coping in postpartum females. Postpartum female, virgin female, and male mice were exposed to subchronic restraint stress (restraint stress for 4h for 5 consecutive days). Subchronic restraint stress decreased passive coping in postpartum females but not in virgin females and males in the forced swim and tail suspension tests. We next examined the neuronal mechanism by which subchronic stress decreases passive coping in postpartum female mice. Neuronal activity and expression of noradrenergic receptors in the medial prefrontal cortex (mPFC) were analyzed using immunohistochemistry and reverse transcription-quantitative polymerase chain reaction, respectively. The mPFC was manipulated using chemogenetics, knockdown, or an α2A adrenergic receptor (AR) antagonist. Immunohistochemistry revealed that subchronic restraint stress increased glutamatergic neuron activation in the mPFC via forced swim stress and decreased α2A AR expression in postpartum females. Chemogenetic activation of glutamatergic neurons in the mPFC, knockdown of α2AAR in the mPFC, and the α2A AR receptor antagonist atipamezole treatment decreased passive coping in postpartum females. Subchronic restraint stress decreased passive coping in postpartum females by increasing glutamatergic neuron activity in the mPFC through α2A AR attenuation. The noradrenergic regulation of the mPFC may be a new target for treating postpartum depression. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Συγγραφείς: Muroi, Yoshikage, Ishii, Toshiaki, Horie, Ikuko
Όροι ευρετηρίου: Medial Prefrontal Cortex, Postpartum Female, Stress Coping, Subchronic Restraint Stress, Journal Article., AM.
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2Mixed Materials
Additional Titles: Immune Checkpoint Inhibitors (ICIs) have revolutionized cancer treatment, offering hope for patients with various malignancies. However, along with their remarkable anticancer effects, ICIs can also trigger immune-related adverse events (irAEs). One such noteworthy complication is the development of Diabetes Mellitus (DM), which particularly resembles Type 1 Diabetes Mellitus (T1DM). The aim of this review is to provide insights into the epidemiology, pathophysiology, diagnostic issues, and treatment considerations of ICI-induced DM (ICI-DM), emphasizing the importance of early recognition and management to mitigate adverse outcomes. Although still rare, the incidence has increased with the widespread use of ICIs, especially PD-1/PD-L1 blockers (from 0.2% to 1.9%). Factors affecting the development of ICI-DM, such as specific ICIs, patient demographics, and genetic predispositions, are discussed. The complex interplay between immune dysregulation and pancreatic β-cell destruction contributes to diagnostic challenges, with presentations varying from asymptomatic hyperglycemia to diabetic ketoacidosis (DKA). Management strategies prioritize meticulous glycemic and electrolyte regulation along with tailored intravenous insulin therapy in cases of DKA. DM remission is rare, therefore treatment with both long-acting insulin at bedtime and short-acting insulin before meals is needed in longterm. Total daily insulin requirements can be estimated at 0.3–0.4 units/kg/day for most patients as a starting dose. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Συγγραφείς: Kani, Eleni-Rafaela, Karaviti, Eleftheria, Karaviti, Dimitra, Gerontiti, Eleni, Paschou, Ioanna A., Saltiki, Katerina, Stefanaki, Katerina, Psaltopoulou, Theodora, Paschou, Stavroula A.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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3Mixed Materials
Additional Titles: This paper presents a mid-infrared absorber based on anisotropic black phosphorus (BP) stacked with magnesium fluoride (MgF2). BP has a sufficiently large electronic bandgap, and its high carrier mobility allows for efficient free-carrier absorption in the mid-infrared regimes. Magnesium fluoride is an ideal candidate for the mid-infrared absorber, providing optical transparency, efficient absorption, and antireflection properties due to its low refractive index. Different unit cell shapes were used to examine the absorbance for both the transverse electric mode (TE) and transverse magnetic mode (TM) polarization components. The results show that the absorbance for TM polarization is approximately 48% and 50% at around 7 μm and 12 μm, respectively. For TE polarization, the absorbance occurs at 9 μm with a value of around 8.5%. Rotating the unit cell to be out of phase by 90 degrees from the neighboring unit cell improved the low absorbance to 45%, and the absorbance peak shifted to 17 μm. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Συγγραφείς: Abdulkawi, Wazie M., Aladadi, Yosef T., Al-Moliki, Yahya Mohammed, Alresheedi, Mohammed Thamer, Mahdi, Mohd Adzir, Abas, Ahmad Fauzi, Ng, Eng Khoon
Όροι ευρετηρίου: Article, PeerReviewed
Σύνδεσμος:
http://psasir.upm.edu.my/id/eprint/115019/ https://link.springer.com/article/10.1007/s11082-024-06874-x?error=cookies_not_supported&code=ce45936e-e24c-444b-8694-7aa81558f81e http://psasir.upm.edu.my/id/eprint/115019 https://link.springer.com/article/10.1007/s11082-024-06874-x?error=cookies_not_supported&code=ce45936e-e24c-444b-8694-7aa81558f81e
10.1007/s11082-024-06874-x -
4Mixed Materials
Additional Titles: Background: Fingolimod hydrochloride (FH) has emerged as a vital medication for managing Multiple Sclerosis (MS). Despite its high oral bioavailability of 93%, it is plagued by slow oral absorption (Tmax = 8–12 h) and extensive hepatic metabolism. Intranasal administration has emerged as an alternative to address these limitations, ensuring efficient central nervous system delivery and minimizing peripheral exposure and first-pass metabolism. Objective: This study aims to develop and evaluate FH nasal films for enhanced drug delivery. Methods: A Design of Experiments approach was employed to formulate FH nasal films, utilizing HPMC E50 as a film-forming polymer, PEG 400 as a plasticizer, and Me-β-CD as a permeation enhancer. Two formulations with superior in vitro and ex vivo performance were selected for in vivo evaluation. A comparative pharmacokinetic study was conducted in C57BL/6 J mice in the brain and serum after administration of nasal films and oral FH solution, respectively. Sparse sampling and non-compartmental analysis were used. Results: FH nasal films efficiently delivered the drug to both serum (Cmax(F3) = 0.35 ± 0.021, Cmax(F4) = 0.38 ± 0.029 μg/mL) and brain (Cmax(F3) = 0.39 ± 0.05, Cmax(F4) = 0.44 ± 0.048 μg/mL), achieving higher levels than oral delivery. Brain relative bioavailability (% Frel (0-6 h)) was 519% and 534%, while serum % Frel (0-6 h) was 295% and 343%. Conclusions: The rapid nose-to-brain delivery within 30 min, in contrast to 10-h Tmax of the oral solution, indicates the potential of a combined IN and oral treatment regimen. This approach could expedite the attainment of steady-state concentrations, offering a promising method for managing multiple sclerosis (MS). Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Συγγραφείς: Papakyriakopoulou, Paraskevi, Balafas, Evangelos, Kostomitsopoulos, Nikolaos, Rekkas, Dimitrios M., Dev, Kumlesh K., Valsami, Georgia
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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5Mixed Materials
Additional Titles: Purpose: Το formulate a methodology for the assessment of bioequivalence using metrics, which are based on the physiologically sound F.A.T. concept. Methods: The equations of the physiologically based finite time pharmacokinetic models for the one-and two-compartment model with one and two input stages of absorption were solved to derive metrics for the extent and rate of absorption. Simulated data were used to study the proper way for the estimation of metrics. A bioequivalence study was analyzed using these metrics. Results: The rate of drug absorption was found to be equal to the slope of the amount absorbed versus time curve. The amount of drug absorbed at the end of the absorption process, corresponding to the blood concentration at F.A.T. is an indicator of the extent of absorption. The plot of the ratio test/reference of the simulated data for the amount absorbed as a function of time becomes constant beyond the end of drug absorption from the formulation exhibiting the longer absorption. The assessment of the bioequivalence study was based on the slope of the amount absorbed versus time curve for the rate of absorption, while the estimate for the constant ratio test/reference for the amount absorbed was used for the assessment of extent of absorption. Conclusions: The assessment of rate in bioequivalence studies can be based on the estimation of slope of the percent absorbed versus time curve while the constant ratio test/reference for the amount of drug absorbed is an indicator of the extent of absorption. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Συγγραφείς: Tsekouras, Athanasios A., Macheras, Panos
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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6Mixed Materials
Additional Titles: Purpose: Antiangiogenic agents have been used for many years as a first-line systemic treatment for advanced HCC. Embolization with cytostatic drugs on the other hand is the first-line treatment for intermediate HCC. The two types of drugs have not been combined for intraarterial delivery yet. The loading and release dynamics and the in vitro effect of their combination are tested in this experimental study. Materials and Methods: Drug-eluting beads were loaded with doxorubicin, sunitinib and sunitinib analogue piperazine (SAP) alone and with their combinations. Diameter change, loading, release, and effect in cellular proliferation were assessed. Results: The average microsphere diameter after loading was 473.7 µm (μm) for Doxorubicin, 388.4 μm for Sunitinib, 515.5 μm for SAP, 414.8 μm for the combination Doxorubicin/Sunitinib and 468.8 μm for the combination Doxorubicin /SAP. Drug release in 0.9% NaCl was 10% for Doxorubicin, 49% for Sunitinib, 25% for SAP, 20%/18% for the combination Doxorubicin/Sunitinib, and 18%/23% for the combination Doxorubicin/SAP whereas in human plasma it was 56%, 27%, 13%, 76%/63% and 62%/15%, respectively. The mean concentration of Doxorubicin that led to inhibition of 50% of cellular proliferation in an HCC Huh7 cell line was 163.1 nM (nM), for Sunitinib 10.3 micromolar (μΜ), for SAP 16.7 μΜ, for Doxorubicin/Sunitinib 222.4 nM and for Doxorubicin/SAP 275 nM. Conclusions: Doxorubicin may be combined with antiangiogenic drugs with satisfactory in vitro loading and release outcomes and effect on cellular lines. Graphical Abstract: (Figure presented.) © Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2024.
Συγγραφείς: Krokidis, Miltiadis, Fakitsa, Danae, Malagari, Katerina, Karampelas, Theodoros, Fokas, Demosthenes, Tamvakopoulos, Constantin, Chatziioannou, Achilles
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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7Mixed Materials
Additional Titles: Purpose: To revise the IVIVC considering the physiologically sound Finite Absorption Time (F.A.T.) and Finite Dissolution Time (F.D.T.) concepts. Methods: The estimates τ and τd for F.A.T. and F.D.T., respectively are constrained by the inequality τd ≤ τ; their relative magnitude is dependent on drug’s BCS classification. A modified Levy plot, which includes the time estimates for τ and τd was developed. IVIVC were also considered in the light of τ and τd estimates. The modified Levy plot of theophylline, a class I drug, coupled with the rapid (30 min) and very rapid (15 min) dissolution time limits showed that drug dissolution/absorption of Class I drugs takes place in less than an hour. We reanalyzed a carbamazepine (Tegretol) bioequivalence study using PBFTPK models to reveal its complex absorption kinetics with two or three stages. Results: The modified Levy plot unveiled the short time span (~ 2 h) of the in vitro dissolution data in comparison with the duration of in vivo dissolution/absorption processes (~ 17 h). Similar results were observed with the modified IVIVC plots. Analysis of another set of carbamazepine data, using PBFTPK models, confirmed a three stages absorption process. Analysis of steady-state (Tegretol) data from a paediatric study using PBFTPK models, revealed a single input stage of duration 3.3 h. The corresponding modified Levy and IVIVC plots were found to be nonlinear. Conclusions: The consideration of Levy plots and IVIVC in the light of the F.A.T. and F.D.T. concepts allows a better physiological insight of the in vitro and in vivo drug dissolution/absorption processes. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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8Mixed Materials
Additional Titles: MDS constacyclic codes over finite fields are important in both theory and practice. In this paper, all [q + 1,2,q] and [q + 1,3,q − 1] MDS λ-constacyclic codes over GF(q) are characterized, three classes of [q + 1,4,q − 2] MDS λ-constacyclic codes over GF(q) are constructed, and four classes of [q + 1,k,q − k + 2] MDS λ-constacyclic codes over GF(q) for variable k are presented. Rationales for distinguishing the class of cyclic codes, the class of λ-constacyclic codes with λ≠ 1, and the class of non-constacyclic linear codes are given. Some applications of MDS codes in cryptography are also summarised. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Wang, Xiaoqiang, Ding, Cunsheng, Liu, Hongwei, Zheng, Dabin
Όροι ευρετηρίου: Constacyclic code, Cryptography, Cyclic code, Linear code, MDS code, Article
Σύνδεσμος:
http://repository.hkust.edu.hk/ir/Record/1783.1-124450 https://doi.org/10.1007/s12095-022-00624-0 http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=1936-2447&rft.volume=&rft.issue=&rft.date=2023&rft.spage=&rft.aulast=Wang&rft.aufirst=&rft.atitle=MDS+constacyclic+codes+of+length+q+%2B+1+over+GF%28q%29&rft.title=Cryptography+and+Communications http://www.scopus.com/record/display.url?eid=2-s2.0-85146245370&origin=inward http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000917851800001 -
9Book
Additional Titles: We designed a study with the objective to determine the long-term radiation effects of gamma rays, originating from a single shot of Co60 at a dose of 2 Gy on the 7-month-old male mice of the ICR line in 30 days after the irradiation. The aim of this study was to characterize the behavior of animals using the Open Field test, immuno-hematological status, and morpho-functional changes in the central nervous system of mice. Irradiated animals displayed significantly different behavior in the OF in comparison with the control group. The radiation damage was confirmed by assessing the ratio of leukocytes in the peripheral blood of mice at a later date after exposure to Co60. After irradiation, a decrease in the glioneuronal complex was observed in the irritated group as well as histological changes of brain cells. To sum up, not only was the hematological status of mice altered upon the total gamma irradiation, but also their behavior, which was most probably due to significant alterations in the CNS. Graphical Abstract: Study of influence of ionizing radiation on female mice, comparison between different age groups. Open Field test on the 30 days after 2 Gy of γ-rays and histological analysis indicated changes in behavioral patterns, leucocytes, and brain tissue. [Figure not available: see fulltext.] © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Kolesnikova, I. A., Lalkovičova, M., Severyukhin, Yu. S., Golikova, K. N., Utina, D. M., Pronskikh, E. V., Despotović, Sanja Z., Gaevsky, V. N., Pirić, David, Masnikosa, Romana, Budennaya, N. N.
Πηγή: Cellular and Molecular Neurobiology
Όροι ευρετηρίου: Behavior, Gamma irradiation, Long-term effects, Neurodegeneration, Patho-morphology, article
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10Mixed Materials
Additional Titles: Microeukaryotic diversity, community structure, and their regulating mechanisms remain largely unclear in chemosynthetic ecosystems. Here, using high-throughput sequencing data of 18S rRNA genes, we explored microeukaryotic communities from the Haima cold seep in the northern South China Sea. We compared three distinct habitats: active, less active, and non-seep regions, with vertical layers (0–25 cm) from sediment cores. The results showed that seep regions harbored more abundant and diverse parasitic microeukaryotes (e.g., Apicomplexa and Syndiniales) as indicator species, compared to nearby non-seep region. Microeukaryotic community heterogeneity was larger between habitats than within habitat, and greatly increased when considering molecular phylogeny, suggesting the local diversification in cold-seep sediments. Microeukaryotic α-diversity at cold seeps was positively increased by metazoan richness and dispersal rate of microeukaryotes, while its β-diversity was promoted by heterogeneous selection mainly from metazoan communities (as potential hosts). Their combined effects led to the significant higher γ-diversity (i.e., total diversity in a region) at cold seeps than non-seep regions, suggesting cold-seep sediment as a hotspot for microeukaryotic diversity. Our study highlights the importance of microeukaryotic parasitism in cold-seep sediment and has implications for the roles of cold seep in maintaining and promoting marine biodiversity. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Xu, Zhimeng, Chen, Jiawei, Li, Yingdong, Shekarriz, Erfan, Wu, Wenxue, Chen, Bingzhang, Liu, Hongbin
Όροι ευρετηρίου: Article
Σύνδεσμος:
http://repository.hkust.edu.hk/ir/Record/1783.1-126054 https://doi.org/10.1007/s00248-023-02212-y http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=&rft.volume=&rft.issue=&rft.date=2023&rft.spage=&rft.aulast=Xu&rft.aufirst=Zhimeng&rft.atitle=High+Microeukaryotic+Diversity+in+the+Cold-Seep+Sediment&rft.title=Microbial+Ecology http://www.scopus.com/record/display.url?eid=2-s2.0-85150956877&origin=inward http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000959311900002 -
11Mixed Materials
Additional Titles: BCL2 antagonist/killer (BAK) is a multidomain pro-apoptotic effector protein, encoded by the human BAK1 gene, which has emerged as a key checkpoint in the apoptotic machinery. Disassembly of BAK’s tertiary structure, such as the truncation of the α1 helix, leads to deregulation of the pro-apoptotic functions and reduction of the protein’s stability, thus being implicated in human malignancies. Although many studies have already clarified the vital role of BAK in cellular mechanisms, its pre-mRNA maturation process under cancerous and physiological human cells is neglected. In the present work, we developed and employed a custom multiplexed nanopore sequencing approach that enabled the identification and structural characterization of previously undescribed BAK1 mRNA transcripts (BAK1 v.2–v.11). The described novel mRNAs are derived from multiple types of alternative splicing events, including exon skipping and intron retentions. The implemented multiplexed long-read sequencing approach provided the detailed expression profile of the novel mRNAs in a wide panel of human malignancies and at the same time allowed their relative quantification as compared to the annotated BAK1 v.1. The validation of each novel transcript was carried out with qPCR-based assays. Our results strongly support that most of the novel BAK1 mRNAs harbor open reading frames with conserved BH domains that provide new insights into the correlated mechanisms of apoptosis suppression and cancer. The current study highlights for the first time the hidden aspects of BAK1’s transcriptional landscape in both physiological and cancerous human cells and distinguishes the amino acid sequence of the putative BAK isoforms that may possess key apoptosis-related functions not only in diseases, but also under normal cellular conditions. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Athanasopoulou, K., Adamopoulos, P.G., Daneva, G.N., Scorilas, A.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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12Mixed Materials
Additional Titles: Although the HIV epidemic in Athens, Greece has reemerged and spread in men who have sex with men (MSM), state-supported PrEP programs have not been instituted. A PrEP intervention was implemented building upon an existing network cohort of MSM (308 participants; 1212 network members). A PrEP intervention cohort of 106 participants was selected based upon sex behaviors. Individual, partner, and network characteristics were compared between the cohorts. The PrEP cohort members were more highly connected and in more influential positions in the network than their peers. Further, their sexual network connections’ behaviors increased their vulnerability to HIV infection relative to the rest of the network’s sex partners. This included greater stimulant use (24.2% vs 7.0%; χ2 = 28.2; p < 0.001), greater rates of at least weekly condomless sex (OR = 2.7; 95% CI 2.1–3.5; χ2 = 59.2; p < 0.001) and at least weekly use of drugs or alcohol during sex (OR = 3.4; 95% CI 2.6–4.3; χ2 = 89.7; p < 0.001). Finally the PrEP cohort’s social networks showed similarly increased vulnerability to seroconversion, including greater rates of injection drug use (4.1% vs 0.5%; χ2 = 3.9; p = 0.04), greater stimulant use (33.6% vs 14.6%; χ2 = 16.9, p < 0.001), and higher rates of recent STIs (21.6% vs 13.1%; χ2 = 4.4; p = 0.04). Thus, this PrEP intervention engaged individuals in vulnerable positions with vulnerable connections within an MSM community. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Fouché, T., Del Vecchio, N., Papadopoulou, M., Sypsa, V., Roussos, S., Paraskevis, D., Chanos, S., Dedes, N., Khanna, A., Hotton, A., Hatzakis, A., Psichogiou, M., Schneider, J.A.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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13Mixed Materials
Additional Titles: Partners play a crucial role in patients’ adaptation to a chronic illness, yet very little is known about the impact of partners’ representations on rheumatic patients’ coping behaviors. The aim of the present cross-sectional study was to examine the relation of partners’ representations of control/cure, consequences and emotional representations to patients’ coping behaviors through patients’ representations, and to assess the impact of the potential interactions between patients’ and partners’ representations. The study was conducted at the Rheumatology Clinic, University of Crete Hospital in Heraklion, Greece. One hundred three heterosexual patients with Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE) and their spouses (patients’ mean age = 53.87 years; SD = 9.6; partners’ mean age = 51.23; SD = 7.2; 91.3% women) participated in the study. All of them completed the Revised Illness Perception Questionnaire. Patients’ behaviors were assessed with the Coping with Health Injuries and Problems Scale. Structural Equation Modeling and mediation analysis were conducted. Partners’ illness representations were only indirectly related to patients’ coping behaviors through patients’ representations (χ2 = 20.39, df = 16, p < 0.05). Furthermore, the negative relation of patients’ representations of personal control to palliative coping was stronger when partners perceived the rheumatic disease as less controllable (b = −0.07, t(82) = −2.36, p < 0.05). The findings emphasize the importance of partners’ representations for patients’ coping process and provide support to the need for partners to participate in relevant interventions. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Dimitraki, G., Papastefanakis, E., Ktistaki, G., Fanouriakis, A., Adamichou, C., Kougkas, N., Repa, A., Avgoustidis, N., Bertsias, G., Sidiropoulos, P., Vgontzas, A.N., Simos, P.G., Karademas, E.C.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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14Mixed Materials
Additional Titles: The first-row transition metal catalysis often serves as a complementary strategy to traditional precious metal catalysis. Other than their advantages in abundance and sustainability, their unique electronic properties often give rise to more complicated reactivities. Co-catalyzed hydrogenation is an example of these relatively underexplored first-row transition metal catalysis. In this work, we will focus on an example of Co-catalyzed hydrogenation, which was reported to be able to selectively hydrogenate C=C but not C=O. We have performed DFT calculations on the model reactions, accompanied by a series of structure and bonding analysis, to investigate the underlying reason for the observed selectivity. We have identified the predominant σ-donating nature of phosphine and the π-accepting nature of C=C/C=O fragments upon interaction with Co(I) center, and we have also analyzed why these differences would lead to different coordination geometry, stability, and reactivity. We anticipate that all these analyses would advance our understanding in Co(I) catalysis and are beneficial for future Co-based catalyst design. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Yang, Tilong, Sheong, Fu Kit, Lin, Zhenyang
Όροι ευρετηρίου: Cobalt catalyst, DFT calculations, Hydrogenation, PIO, Structure and bonding analysis, Article
Σύνδεσμος:
http://repository.hkust.edu.hk/ir/Record/1783.1-112269 https://doi.org/10.1007/s11244-021-01481-6 http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=1022-5528&rft.volume=&rft.issue=&rft.date=2021&rft.spage=&rft.aulast=Yang&rft.aufirst=&rft.atitle=Understanding+of+Co%28I%29-Catalyzed+Hydrogenation+of+C%3DC+and+C%3DO+Substrates&rft.title=Topics+in+Catalysis http://www.scopus.com/record/display.url?eid=2-s2.0-85110994701&origin=inward http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000675293100002 -
15Mixed Materials
Additional Titles: The changing climatic conditions are imposing a vital re-consideration on the hydro-chemical pathways for contaminants. The circumference Mediterranean countries will be possibly under imminent water stress. The present study attempts to identify the sources and the leaching capacity of Cr(VI) in a coastal alluvial fan and aeolian soil and in a serpentine soil in an area offering an aridity analogue, like Oman. Magnetic separation and different leaching media were applied along with Cr(VI) sorption experiments in daylight (open air) and in laboratory conditions (without direct sunlight). In most of the samples the released Cr(VI) concentration was higher that the drinking water standard (50 μg L−1). Magnetic soil fraction has the highest bulk Cr concentration, however, the leaching of Cr with phosphate extraction solution was high in the no-magnetic fraction. Immobilization of Cr(VI) was higher in the sunlight conditions for the serpentine soil and not for the alluvial/aeolian soils. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Moraetis, D., Al-Suhai, A.S., Pracejus, B., Pyrgaki, K., Argyraki, A., Dermatas, D.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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16Mixed Materials
Additional Titles: To evaluate the association between baseline global longitudinal strain (GLS) and ΔGLS (difference of baseline GLS and follow-up) and cardiac resynchronization therapy (CRT) response defined either with clinical or with echocardiographic characteristics. This meta-analysis was performed in accordance to both the Meta-Analysis of Observational Studies in Epidemiology and Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Two independent investigators performed a comprehensive systematic search in MedLine, EMBASE and Cochrane databases through September 2019 without limitations. Data analysis was performed by using the Review Manager software (RevMan), version 5.3, and Stata 13 software. A p value of less than 0.05 (two-tailed) was considered statistically significant. Twelve studies (1004 patients, mean age 63.8 years old, males 69.4%) provided data on the association of baseline GLS with the response to CRT therapy. We found that CRT responders had significantly better resting GLS values compared with non-responders [GLS mean difference −2.13 (−3.03, −1.23), p < 0.001, I2 78%]. Furthermore, CRT responders had significantly greater improvement of GLS at follow-up compared with non-responders [ΔGLS mean difference −3.20 (−4.95, −1.45), p < 0.001, I2 66%]. These associations remained significant in a subgroup analysis including only studies with similar CRT response definition. In this meta-analysis, we found that CRT responders had a baseline and ΔGLS significantly higher than the non-responders strengthening the central role of GLS as a tool for selecting candidates for CRT. Furthermore, improved GLS values after CRT may be used to better define CRT responders. Graphical abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Bazoukis, G., Thomopoulos, C., Tse, G., Tsioufis, K., Nihoyannopoulos, P.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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17Mixed Materials
Additional Titles: Many bioactive substances face the problem of limited bioavailability, mainly due to low aqueous solubility and poor metabolic stability. Their complexation with drug delivery systems offers a more optimum pharmacological profile. Some of these drug delivery systems that have promising potential form complexes with bioactive compounds such as cyclodextrins and calixarenes. The monitoring of the success and the type of the complexation are of great importance and two-dimensional diffusion-ordered NMR spectroscopy (2D DOSY) is a valuable tool for the studying of these complexes and described as “NMR chromatography.” Herein we report the procedure for the complexation of the natural product quercetin in 2-hydroxypropyl-β-cyclodextrin and the anticancer drug temozolomide in p-sulfonatocalix[4]arene and the determination of the complexation with 2D DOSY spectroscopy. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Chatzigiannis, C.M., Kiriakidi, S., Tzakos, A.G., Mavromoustakos, T.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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18Mixed Materials
Additional Titles: Due to their low toxicity and high aqueous solubility, cyclodextrins have emerged as a distinctive class of supramolecules with wide application in the pharmaceutical and food industry. Their ability to improve the water solubility, stability and pharmacokinetic profile of small molecules has established them as a rich toolkit for drug formulation. In order to improve the physicochemical characteristics and the pharmacokinetic profile of a drug through cyclodextrin inclusion, the proper cyclodextrin type has to be selected among the existing great variety consisting of both natural and synthetic variants. The selection of the most proper cyclodextrin variant comes after drug-cyclodextrin screening studies targeting the characterization of the complex formation and evaluation of the affinity and interaction forces participating in the complexation. Numerous analytical, spectroscopic, separation and electrochemical techniques have been applied to elucidate the interaction profile in a cyclodextrin-drug complex. Herein, we describe the application of Isothermal Titration Calorimetry (ITC) on cyclodextrin-drug complexes that enables the charting of the binding affinity and the thermodynamic profile of the inclusion complexes. We focus on the experimental design and present technical tips of the ITC application. To better illustrate the technique’s rationale, the interaction between 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and the antihypertensive drug losartan is investigated. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Chatziathanasiadou, M.V., Mavromoustakos, T., Tzakos, A.G.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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19Mixed Materials
Additional Titles: Differential scanning calorimetry (DSC) is a widely utilized method for the interactions of drug molecules with drug delivery systems (DDSs). Herein is described a protocol for studying the interactions and entrapment efficiency of the prototype sartan losartan and the polydynamic, structurally similar irbesartan inside the nontoxic 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The thermal scan properties of both sartan molecules have been studied when physically mixed or complexed with the cyclodextrin. The thermograms indeed showed significant differences between the mixtures and complexes, establishing DSC as a valuable method to characterize the state of the drugs in these pharmaceutical formulations. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Naziris, N., Chountoulesi, M., Ntountaniotis, D., Mavromoustakos, T., Demetzos, C.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article
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20Mixed Materials
Additional Titles: Purpose: Neuroendocrine neoplasms (NENs) differ in their biological behavior and growth potential in a way that can be predicted using histological classification and grading systems. A subset of pancreatic NENs (pNENs) may develop a more aggressive phenotype during the course of the disease, associated with an increase in the Ki-67 proliferation index (PI). The purpose of the study was to present the clinical characteristics of these patients. Methods: Using re-biopsy of growing lesions, we investigated the increase in Ki-67 PI sufficient to change initial grading (G). Results: Of 264 patients with well differentiated (WD) pNENs who showed progressive disease during follow-up, 15 (6%) exhibited an increase in Ki-67 PI at a median time 36.8 (9.3–255.8) months. All neoplasms had WD-morphology: five had G1 (Ki-67 median value 1%), nine G2 (median value 5%), one G3 (25%) grades. Upon change of Ki-67 PI, 3 patients had G2 (8%) and 12 G3 (57.5%) NENs, while all retained their WD-morphology. At last follow-up, eight patients were alive with a median overall survival (OS) of 52.5 (9.5–264.3) months. Μedian OS was shorter in patients who had a change in Ki-67 PI before 36 months compared to those who had a change of Ki-67 PI at a later stage (27.5 95%CI: 11.88–43.06 vs. 120.87 95%CI: 96.05–145.69; log-rank p = 0.018). Conclusions: During the course of their disease, 6% patients with progressive pNENs develop an increase in Ki-67 PI resulting in an increase in grading status while maintaining their morphology. This process is associated with worse OS when it occurs at an early stage. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς: Alexandraki, K.I., Kaltsatou, M., Kyriakopoulos, G., Mavroeidi, V., Kostopoulou, A., Atlan, K., Theocharis, S., Rindi, G., Grossman, A.B., Grozinsky-Glasberg, S., Kaltsas, G.A.
Όροι ευρετηρίου: scientific_publication_article, Scientific publication - Journal Article