MiSiPi.Rna: an integrated tool for characterizing small regulatory RNA processing.

Συγγραφείς: Jarva T; Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA., Baugh C; The ATM Solution, Hattiesburg, Mississippi 30403, USA., Zhang J; Department of Mathematics and Statistics, Mississippi State University, Starkville, Mississippi 39762, USA., Lai EC; Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA., Flynt A; Department of Biomedical Engineering, University of Mississippi, Oxford, Mississippi 38655, USA asflynt@olemiss.edu.

Πηγή: RNA (New York, N.Y.) [RNA] 2026 Apr 16; Vol. 32 (5), pp. 584-595. Date of Electronic Publication: 2026 Apr 16.

Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Στοιχεία περιοδικού: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

Ιατρικοί όροι (MeSH): MicroRNAs*/genetics , MicroRNAs*/metabolism , Piwi-Interacting RNA*/genetics , Piwi-Interacting RNA*/metabolism , RNA, Small Interfering*/genetics , RNA, Small Interfering*/metabolism , Software* , RNA Processing, Post-Transcriptional*, Argonaute Proteins/metabolism ; Argonaute Proteins/genetics ; Animals

Lariat RNA debranching prevents harmful siRNA burst in plants.

Συγγραφείς: Tang, Qi, Ding, Chenxi, Zhang, Xiaotuo, Wang, Taiyun, Zhu, Mengjie, Cui, Ruixue, Yang, Wenya, Ma, Jinbiao, Ren, Guodong, Zhang, Xiaoming, Zheng, Binglian

Πηγή: Science; 6/25/2026, Vol. 392 Issue 6805, p1401-1407, 7p

Θεματικοί όροι: Small interfering RNA, Disease resistance of plants, RNA splicing, RNA synthesis, Non-coding RNA, Enzymes, Arabidopsis

甲壳动物中白斑综合征病毒来源小RNA的 特征及其保守富集的结构基础. (Chinese)

Alternate Title: CHARACTERISTICS OF WHITE SPOT SYNDROME VIRUS-DERIVED SMALL RNAS IN CRUSTACEANS AND THE STRUCTURAL BASIS OF THEIR CONSERVED ENRICHMENT. (English)

Συγγραφείς: 亓玉华, 何嘉乐, 刘萍萍, 高杰, 孙磊, 王显伟

Πηγή: Journal of Hydrobiology / Shuisheng Shengwu Xuebao; Jun2026, Vol. 50 Issue 6, p1-10, 10p

Θεματικοί όροι: White spot syndrome virus, Small interfering RNA, Antiviral agents, RNA interference, Viral genomes, Crustacea, Double-stranded RNA

Genome Characterization of a Novel Bisegmented Positive-Sense RNA Virus Infecting the Bean Flower Thrips (Megalurothrips usitatus) Reveals an Active Antiviral RNAi Response.

Συγγραφείς: Zhu, Xitong, Li, Heng, Lin, Lin, Chen, Jian-Ping, Li, Yiyuan, Hu, Xiaodi

Πηγή: Viruses (1999-4915); Sep2026, Vol. 18 Issue 9, p948, 9p

Θεματικοί όροι: Nucleotide sequencing, Small interfering RNA, Virus diseases, Virus diversity, Thrips, Antiviral agents, Phylogeny

Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing.

Συγγραφείς: Seungjae Lee, Sangmi Lee, Desnick, Robert, Makiko Yasuda, Lai, Eric C.

Πηγή: Science (pre-March 2025); 12/20/2024, Vol. 386 Issue 6728, p1427-1434, 8p, 5 Diagrams

Θεματικοί όροι: Small interfering RNA, Heme, Biosynthesis, Liver cells

Εταιρία/Οντότητα: United States. Food & Drug Administration

Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis.

Συγγραφείς: Gao, Yifan, Bai, Yanmin, Mu, Xu, Pang, Xingxue

Πηγή: Frontiers in Pharmacology; 2026, p1-15, 15p

Θεματικοί όροι: Small interfering RNA, Hypertriglyceridemia, Antilipemic agents, Triglycerides, Dyslipidemia, Apolipoprotein C, Randomized controlled trials

Characterization of RNA interference in the cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification.

Συγγραφείς: Admoni, Yael, Lewandowska, Magda, Aharoni, Reuven, Shi, Junchao, Zhang, Xudong, Chen, Qi, Moran, Yehu

Πηγή: PLoS Biology; 1/5/2026, Vol. 24 Issue 1, p1-24, 24p

Θεματικοί όροι: RNA interference, Small interfering RNA, Marine invertebrate populations, Cnidaria, Antiviral agents, Gene expression, Immune response, Double-stranded RNA

Dual regulation of the receptor-like kinase BIR1 involves site-directed transcript cleavage and 5'-leader-mediated translational control.

Συγγραφείς: Guzmán-Benito, Irene, Robinson, Carmen, Donaire, Livia, Fernández-Calvino, Lourdes, Franco-Zorrilla, José Manuel, Niu, Ruixia, Xu, Guoyong, Merchante, Catharina, Llave, César

Πηγή: PLoS Pathogens; 9/15/2026, Vol. 22 Issue 9, p1-24, 24p

Θεματικοί όροι: Receptor-like kinases, RNA regulation, LincRNA, Arabidopsis, Small interfering RNA, Plant viruses, Disease resistance of plants, Messenger RNA

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Additional Titles: Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspects of Aβ production. It is not clear whether there is a causative relationship linking GSL synthesis inhibition, ERK phosphorylation and Aβ production. In the present study, we treated CHO cells (Chinese-hamster ovary cells) and SH-SY5Y neuroblastoma cells, that both constitutively express human wild-type APP (amyloid precursor protein) and process this to produce Aβ, with GSL-modulating agents to explore this relationship. We found that three related ceramide analogue GSL inhibitors, based on the PDMP (D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) structure, reduced cellular Aβ production and in all cases this was correlated with inhibition of pERK (phosphorylated ERK) formation. Importantly, the L-threo enantiomers of these compounds (that are inferior GSL synthesis inhibitors compared with the D-threo-enantiomers) also reduced ERK phosphorylation to a similar extent without altering Aβ production. Inhibition of ERK activation using either PD98059 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] or U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) had no impact on Aβ production, and knockdown of endogenous GCS using small interfering RNA reduced cellular GSL levels without suppressing Aβ production or pERK formation. Our data suggest that the alteration in pERK levels following treatment with these ceramide analogues is not the principal mechanism involved in the inhibition of Aβ generation and that the ERK signalling pathway does not play a crucial role in processing APP through the amyloidogenic pathway.

Συγγραφείς: Li, H, Evin, G, Hill, AF, Hung, YH, Bush, AI, Garner, B

Όροι ευρετηρίου: Journal Article

Σύνδεσμος: https://hdl.handle.net/11343/112602

Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues

Additional Titles: Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspects of Aβ production. It is not clear whether there is a causative relationship linking GSL synthesis inhibition, ERK phosphorylation and Aβ production. In the present study, we treated CHO cells (Chinese-hamster ovary cells) and SH-SY5Y neuroblastoma cells, that both constitutively express human wild-type APP (amyloid precursor protein) and process this to produce Aβ, with GSL-modulating agents to explore this relationship. We found that three related ceramide analogue GSL inhibitors, based on the PDMP (D-threo-1-phenyl-2-decanoylamino- 3-morpholino-1-propanol) structure, reduced cellular Aβ production and in all cases this was correlated with inhibition of pERK (phosphorylated ERK) formation. Importantly, the L-threo enantiomers of these compounds (that are inferior GSL synthesis inhibitors compared with the D-threo-enantiomers) also reduced ERK phosphorylation to a similar extent without altering Aβ production. Inhibition of ERK activation using either PD98059 [2-(2-amino-3-methoxyphenyl)-4H- 1-benzopyran-4-one] or U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) had no impact on Aβ production, and knockdown of endogenous GCS using small interfering RNA reduced cellular GSL levels without suppressing Aβ production or pERK formation. Our data suggest that the alteration in pERK levels following treatment with these ceramide analogues is not the principal mechanism involved in the inhibition of Aβ generation and that the ERK signalling pathway does not play a crucial role in processing APP through the amyloidogenic pathway.

Συγγραφείς: Li, Hongyun, Evin, Genevieve, Hill, Andrew F, HUNG, Ya Hui, BUSH, Ashley I, Garner, Brett

Πηγή: Faculty of Science - Papers (Archive)

Όροι ευρετηρίου: dissociation, erk, analogues, signalling, ceramide, inhibition, synthetic, action, amyloidogenic, anti, CMMB, Life Sciences, Physical Sciences and Mathematics, Social and Behavioral Sciences, article

Σύνδεσμος: https://ro.uow.edu.au/scipapers/4737
https://ro.uow.edu.au/context/scipapers/article/8080/viewcontent/downloadAttachmentForRo.pdf

Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells.

Συγγραφείς: Schlösser, Verena¹ (AUTHOR), Lightfoot, Helen Louise¹ (AUTHOR), Leemann, Christine^2,3 (AUTHOR), Bejoy, Aathma Merin⁴ (AUTHOR), Tiwari, Shashank⁴ (AUTHOR), Schloßhauer, Jeffrey L.⁴ (AUTHOR), Vongrad, Valentina^2,3 (AUTHOR), Brunschweiger, Andreas^1,5 (AUTHOR), Hall, Jonathan¹ (AUTHOR), Metzner, Karin J.^2,3 (AUTHOR) karin.metzner@usz.ch, Imig, Jochen^1,4 (AUTHOR) jochen.imig@mpi-dortmund.mpg.de

Πηγή: Non-Coding RNA. Feb2025, Vol. 11 Issue 1, p8. 21p.

Θεματικοί όροι: *Small interfering RNA, *RNA interference, *MicroRNA, *Antiretroviral agents, *Gene transfection

High levels of EPSTI1 enhance IFN-β-mediated HLA-A expression and chemokine secretion in myoblasts in dermatomyositis.

Συγγραφείς: Li, Xiaojing, Ding, Ting, Xiao, Yizhi, Zhou, Junyu, Huang, Ting, Xie, Shasha, Meng, Qiming, He, Weijia, Zhu, Hongling, Luo, Hui

Πηγή: Rheumatology; Oct2025, Vol. 64 Issue 10, p5529-5538, 10p

Θεματικοί όροι: RNA analysis, Muscle analysis, Chemokines, Dermatomyositis, NF-kappa B, In vitro studies, Small interfering RNA, Carrier proteins, Mononuclear leukocytes, Skeletal muscle, T-test (Statistics), Data analysis, Research funding, Polymerase chain reaction, Enzyme-linked immunosorbent assay, Kruskal-Wallis Test, Cellular signal transduction, Electroporation, Retrospective studies, Mann Whitney U Test, Gene expression, Immunohistochemistry, Genes, Interferons, Messenger RNA, Cell culture, Antigens, Gene expression profiling, Western immunoblotting, Medical records, Acquisition of data, One-way analysis of variance, Statistics, Stem cells, Stains & staining (Microscopy), Data analysis software, HLA-B27 antigen, Immunity, Interleukins, Muscles, Sequence analysis

RNA Therapeutics Targeting Skeletal Muscle: Emerging Antisense and Gene-Modifying Strategies.

Συγγραφείς: Kuroda, Takayuki, Yokota, Toshifumi

Πηγή: Biomolecules (2218-273X); Jun2026, Vol. 16 Issue 6, p794, 17p

Θεματικοί όροι: Duchenne muscular dystrophy, Antisense RNA, Drug delivery systems, Small interfering RNA, Genome editing, Muscle diseases, Spliceosomes, CRISPRs

Precision RNAi in Tomato Using Synthetic Trans‐Acting Small Interfering RNAs Derived From Minimal Precursors.

Συγγραφείς: Tomassi, Ariel H., Juárez‐Molina, María, Cisneros, Adriana E., Alarcia, Ana, Orlando, Francesca, Toledano‐Franco, Sara, Presa, Silvia, Granell, Antonio, Carbonell, Alberto

Πηγή: Plant Biotechnology Journal; Mar2026, Vol. 24 Issue 3, p1269-1284, 16p

Θεματικοί όροι: Small interfering RNA, Tomatoes, Gene silencing, Crop improvement, RNA synthesis, RNA interference, Antiviral agents

SFTSV NSs protein is a tick antiviral RNAi response suppressor.

Συγγραφείς: Fares, Mazigh, McFarlane, Melanie, Parry, Rhys H., Arif, Rozeena, Clarke, Andrew T., Kamel, Wael, Davies, Kelsey, Datta-Savage, Riona, Schwarz-Linek, Ulrich, Bell-Sakyi, Lesley, Petit, Marine J., Schnettler, Esther, Castello, Alfredo, Kohl, Alain, Brennan, Benjamin

Πηγή: Proceedings of the National Academy of Sciences of the United States of America; 5/19/2026, Vol. 123 Issue 20, p1-12, 40p

Θεματικοί όροι: RNA interference, Viral proteins, Small interfering RNA, Virus diseases, Viral replication, Arthropod vectors

Integrative Transcriptomic and Metabolomic Analysis Provides New Insights into the Multifunctional ARGONAUTE 1 Through an Arabidopsis ago1-38 Mutant with Pleiotropic Growth Defects.

Συγγραφείς: Chen, Xiangze, Qing, Xinwen, Peng, Xiaoli, Xu, Xintong, Mo, Beixin, Ren, Yongbing

Πηγή: Plants (2223-7747); Jan2026, Vol. 15 Issue 1, p44, 20p

Θεματικοί όροι: Arabidopsis, Small interfering RNA, Transcriptomes, Metabolomics, Plant hormones, Glutathione, Genetic regulation

Target, silence, replace: a review on RNA-based drugs in modern medicine.

Συγγραφείς: Mundlia, Poonam, Singh, Suraj Pratap, Pothal, Pritiman, Thakur, Tanya, Kathuria, Reema, Maurya, Sudhanshu, Sharma, Akanksha, Goel, Honey, Pandey, Ankur, Ranawat, Pavitra, Singh, Gurpal, Barnwal, Ravi Pratap

Πηγή: Frontiers in Cell & Developmental Biology; 2026, p1-35, 35p

Θεματικοί όροι: Small interfering RNA, mRNA vaccines, RNA-binding proteins, Oligonucleotides, CRISPRs, RNA interference, Cancer treatment, Antisense RNA

A TCER-1-siRNA regulatory axis suppresses antibacterial innate immunity in C. elegans.

Συγγραφείς: Naim, Nikki, Amrit, Francis R.G., Devare, Mayur N., Osman, Guled A., Bahr, Laura L., Henry, Hannah, Montgomery, Brooke E., Kuhn, Spencer M., Montgomery, Taiowa A., Ghazi, Arjumand

Πηγή: PLoS Pathogens; 7/28/2026, Vol. 22 Issue 7, p1-14, 14p

Θεματικοί όροι: Small interfering RNA, Caenorhabditis elegans, Natural immunity

Small Nucleic Acid Therapeutics for Ocular Diseases: Progress, Challenges, and Future Perspectives.

Συγγραφείς: Guo, Qi, Chen, Lushu, Wu, Ziyan, Zhang, Qiuyang, Xue, Jinsong, Zhang, Huiying

Πηγή: Pharmaceutics; Sep2026, Vol. 18 Issue 9, p1189, 23p

Θεματικοί όροι: Small interfering RNA, Oligonucleotides, RNA interference, MicroRNA, Antisense RNA, Intraocular drug administration, Eye diseases

Efficacy of Bioengineered PD-L1 siRNA for Immunotherapy Against Non-Small Cell Lung Cancer Cells.

Συγγραφείς: Batra, Neelu, Tu, Mei-Juan, Guan, Su, Riess, Jonathan W., Yu, Ai-Ming

Πηγή: Non-Coding RNA; Aug2026, Vol. 12 Issue 4, p26, 21p

Θεματικοί όροι: Non-small-cell lung carcinoma, Small interfering RNA, Cancer treatment, Killer cells, Immunotherapy, T cells