Protocol for identifying cellular reprogramming minimal networks using combinatorial transcription factor screening

Συγγραφείς: Altman, Abigail R., Author, Pértiga-Cabral, Diogo, Author, Pereira, Carlos Filipe, Author, Kurochkin, Ilia, Author, Lund University, Faculty of Medicine, Centre for Research Infrastructure in Health and Life Sciences (CRI), WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, Centre for Research Infrastructure in Health and Life Sciences (CRI), WCMM- Wallenberg center för molekylär medicinsk forskning, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Molecular Medicine and Gene Therapy, Cell Reprogramming in Hematopoiesis and Immunity, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för molekylärmedicin och genterapi, Cellulär omprogrammering i hematopoes och immunitet, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), StemTherapy: National Initiative on Stem Cells for Regenerative Therapy, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), StemTherapy: National Initiative on Stem Cells for Regenerative Therapy, Originator, Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator

Συνεισφορές: Altman, Abigail R., Author, Pértiga-Cabral, Diogo, Author, Pereira, Carlos Filipe, Author, Kurochkin, Ilia, Author, Lund University, Faculty of Medicine, Centre for Research Infrastructure in Health and Life Sciences (CRI), WCMM-Wallenberg Centre for Molecular Medicine, Lunds universitet, Medicinska fakulteten, Centre for Research Infrastructure in Health and Life Sciences (CRI), WCMM- Wallenberg center för molekylär medicinsk forskning, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Molecular Medicine and Gene Therapy, Cell Reprogramming in Hematopoiesis and Immunity, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för molekylärmedicin och genterapi, Cellulär omprogrammering i hematopoes och immunitet, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), StemTherapy: National Initiative on Stem Cells for Regenerative Therapy, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), StemTherapy: National Initiative on Stem Cells for Regenerative Therapy, Originator, Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator

Πηγή: STAR Protocols. 7(2)

Θεματικοί όροι: Medical and Health Sciences, Basic Medicine, Cell and Molecular Biology, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Cell- och molekylärbiologi

Σύνδεσμος πρόσβασης: https://doi.org/10.1016/j.xpro.2026.104527

[Molecular mechanism of intervertebral disc cell senescence: telomeres, mitochondria, and cellular metabolic reprogramming].

Συγγραφείς: Deng W; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; Department of Minimally Invasive Spine Surgery, The First Clinical Medical College of Guangzhou University of Chinese Medicine/The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Zhu RC; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; Department of Minimally Invasive Spine Surgery, The First Clinical Medical College of Guangzhou University of Chinese Medicine/The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Kong FG; The Second Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Zhengzhou 450000, China., Luan JY; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; The Second Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Zhengzhou 450000, China.

Πηγή: Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2026 Jun 25; Vol. 78 (3), pp. 566-578.

Τύπος έκδοσης: Journal Article; Review; English Abstract

Στοιχεία περιοδικού: Publisher: Science Press Country of Publication: China NLM ID: 20730130R Publication Model: Print Cited Medium: Internet ISSN: 0371-0874 (Print) Linking ISSN: 03710874 NLM ISO Abbreviation: Sheng Li Xue Bao Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/physiology , Cellular Senescence*/genetics , Mitochondria*/physiology , Mitochondria*/metabolism , Telomere*/physiology , Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc*/cytology , Intervertebral Disc*/metabolism , Cellular Reprogramming*, Humans ; Metabolic Reprogramming ; Animals

A cross-talk between p16High senescence and cellular reprogramming.

Συγγραφείς: Emelyanov A; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, INSERM, CNRS, Nice, France., Bulavin DV; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, INSERM, CNRS, Nice, France.

Πηγή: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2026 Jun 10; Vol. 140 (6), pp. 1137-1147.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/genetics , Cellular Senescence*/physiology , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Cyclin-Dependent Kinase Inhibitor p16*/genetics , Cellular Reprogramming*, Fibroblasts/metabolism ; Humans ; Kruppel-Like Factor 4 ; Animals ; Epigenesis, Genetic ; Signal Transduction

Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis.

Συγγραφείς: Coleman D; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Iwase A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; JST, PRESTO, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076Japan., Kawamura A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takebayashi A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Chen Y; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Minne M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Jager KE; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Peng M; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Kodama Y; Center for Bioscience Research and Education, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi 331-8505, Japan., Favero DS; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takahashi T; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Ikeuchi M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Division of Biological Sciences, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan., Suzuki T; Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan., Ohama N; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Yamaguchi-Shinozaki K; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Wigge PA; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany.; Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25 Haus 25, Raum B1.11-12, Potsdam 14476, Germany., De Veylder L; Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.; Center for Plant Systems Biology, VIB, Gent, Belgium., Sugimoto K; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis*/physiology , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Gene Expression Regulation, Plant/genetics

Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming.

Συγγραφείς: Murano T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Hagihara H; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Tajinda K; Astellas Research Institute of America, San Diego, CA, USA., Takao K; Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Takamiya Y; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Katoh K; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Ph.D. Program in Humanics, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Japan.; The Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases (NIID), Tokyo, Japan., Robison AJ; Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI, USA., Matsumoto M; Astellas Research Institute of America, San Diego, CA, USA.; Arialys Therapeutics Inc., La Jolla, CA, USA., Namihira M; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Laboratory of Neural Regeneration and Brain Repair, Division of Biological Science, Graduate School of Science andTechnology, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, Japan., Miyakawa T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan. miyakawa@fujita-hu.ac.jp.

Πηγή: Nature communications [Nat Commun] 2026 Jul 17; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neurons*/physiology , Neurons*/metabolism , Neurons*/cytology , Dentate Gyrus*/cytology , Dentate Gyrus*/physiology , Dentate Gyrus*/metabolism , Cellular Reprogramming*/physiology, Animals ; Mice ; Optogenetics ; Male ; Mice, Inbred C57BL ; Mice, Knockout

Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism.

Συγγραφείς: Wang L; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Song S; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Yao S; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Wang Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li Q; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Ma Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li J; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li Y; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Yang M; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Zhang K; Chongqing Animal Husbandry Technology Extension Station, Chongqing 401121, China., Han Y; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: hyg2015@swu.edu.cn., Xu D; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: xdj2020@swu.edu.cn., Zhao Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: zhaozhongquan@swu.edu.cn.

Πηγή: Cellular signalling [Cell Signal] 2026 Jul; Vol. 143, pp. 112483. Date of Electronic Publication: 2026 Mar 13.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Histones*/metabolism , Epigenesis, Genetic* , Cellular Reprogramming*, Humans ; Animals ; Acetylation ; Protein Processing, Post-Translational ; Transcription, Genetic

Phospholipid remodeling interplays with auxin signaling to modulate cellular reprogramming in Arabidopsis regeneration.

Συγγραφείς: Chang P; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China., Yang X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo S; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhou J; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., He M; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Li Z; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Xu E; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Xin W; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Hu Y; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; National Center for Plant Gene Research, Beijing 100093, China., Xu C; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Indoleacetic Acids*/metabolism , Indoleacetic Acids*/pharmacology , Arabidopsis*/physiology , Arabidopsis*/metabolism , Arabidopsis*/genetics , Regeneration*/physiology , Phospholipids*/metabolism , Cellular Reprogramming*, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Phosphatidic Acids/metabolism ; Plant Growth Regulators/metabolism ; Signal Transduction ; Gene Expression Regulation, Plant ; Plants, Genetically Modified

Remodeling of Mitochondrial Networks: Cellular Adaptation and Microenvironmental Reprogramming in Hematologic Malignancies.

Συγγραφείς: Li Y; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Hu X; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China., Zhou X; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China.

Πηγή: Blood cancer discovery [Blood Cancer Discov] 2026 Mar 04; Vol. 7 (2), pp. 212-224.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hematologic Neoplasms*/metabolism , Hematologic Neoplasms*/pathology , Hematologic Neoplasms*/genetics , Mitochondria*/metabolism , Mitochondria*/pathology , Mitochondria*/genetics , Tumor Microenvironment* , Cellular Reprogramming*, Humans ; Animals ; Metabolic Reprogramming ; Mitophagy

Integrative methylation and transcriptomic analysis reveals key genes linking cellular senescence and metabolic reprogramming in colorectal liver metastasis

Συγγραφείς: Xiaochen, Ma, Lu, Chen, Chenhe, Yi, Yitong, Li, Yan, Geng, Baorui, Tao, Jinhong, Chen

Πηγή: BioScience Trends. 19:672-683

Θεματικοί όροι: Metabolic Reprogramming, Gene Expression Profiling, Chemokine CXCL1, Liver Neoplasms, Intracellular Signaling Peptides and Proteins, Cell Cycle Proteins, DNA Methylation, Cellular Reprogramming, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Oxaliplatin, Plasminogen Activator Inhibitor 1, Biomarkers, Tumor, Humans, Fluorouracil, Colorectal Neoplasms, Transcriptome, Cellular Senescence, N-myc Downstream-Regulated Gene 1 Protein

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41183917

Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming.

Συγγραφείς: Diak N; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Sieroń L; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Janelt K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Chajec L; Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Bankowa 9, 40-007, Katowice, Poland., Fus-Kujawa A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Dziedzic-Kowalska A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Trybus A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Raszczok K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland.; Students Scientific Society, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland., Bajdak-Rusinek K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland. kbajdak-rusinek@sum.edu.pl.

Πηγή: Histochemistry and cell biology [Histochem Cell Biol] 2026 Apr 20; Vol. 164 (1). Date of Electronic Publication: 2026 Apr 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Mitochondria*/metabolism , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Cellular Reprogramming*, Fibroblasts/metabolism ; Fibroblasts/cytology ; Reactive Oxygen Species/metabolism ; Humans ; Cells, Cultured ; Membrane Potential, Mitochondrial

Developmental stage-dependent cellular plasticity governs β-cell reprogramming efficiency in human fibroblasts.

Συγγραφείς: Raj N; Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: naveenraj@iitg.ac.in., Panneerselvam DS; Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: p.dhaya@iitg.ac.in., Thummer RP; Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: rthu@iitg.ac.in.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Sep 03; Vol. 829, pp. 154188. Date of Electronic Publication: 2026 Jun 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Fibroblasts*/cytology , Fibroblasts*/metabolism , Insulin-Secreting Cells*/cytology , Insulin-Secreting Cells*/metabolism , Cellular Reprogramming* , Cell Plasticity*, Lentivirus/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Basic Helix-Loop-Helix Proteins/genetics ; Basic Helix-Loop-Helix Proteins/metabolism ; Humans ; Cells, Cultured ; Cell Differentiation

Proteomic Signatures of Cellular Reprogramming in Bladder Cancer: Insights into the Acquisition of Cancer Stem-like States and Phenotypic Plasticity.

Συγγραφείς: Barlak BSR; Protein Research and Proteomics Laboratory, Department of Medical Biology, Faculty of Medicine, Kocaeli University, Izmit, Türkiye., Iskender B; Protein Research and Proteomics Laboratory, Department of Medical Biology, Faculty of Medicine, Kocaeli University, Izmit, Türkiye banu.iskender@kocaeli.edu.tr.

Πηγή: Cancer genomics & proteomics [Cancer Genomics Proteomics] 2026 Mar-Apr; Vol. 23 (2), pp. 300-321.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 101188791 Publication Model: Print Cited Medium: Internet ISSN: 1790-6245 (Electronic) Linking ISSN: 11096535 NLM ISO Abbreviation: Cancer Genomics Proteomics Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Proteomics*/methods , Cellular Reprogramming*, Humans ; Cell Line, Tumor ; Phenotype ; Epithelial-Mesenchymal Transition ; Cell Plasticity

Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis.

Συγγραφείς: Liu YW; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Zou JT; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Gong JS; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Jin L; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Cao J; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China., He ZH; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Qian YX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Wang X; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Wan MD; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Hu XY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China., Hong CG; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Du W; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Chen CY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Liu HJ; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. liuhongji@hnu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. liuhongji@hnu.edu.cn., Xie H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. huixie@csu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. huixie@csu.edu.cn.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China. huixie@csu.edu.cn., Wang ZX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. wangzx@csu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. wangzx@csu.edu.cn.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China. wangzx@csu.edu.cn.

Πηγή: Experimental & molecular medicine [Exp Mol Med] 2026 Mar; Vol. 58 (3), pp. 782-797. Date of Electronic Publication: 2026 Mar 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Osteoarthritis*/therapy , Osteoarthritis*/pathology , Osteoarthritis*/metabolism , Osteoarthritis*/genetics , Osteoarthritis*/etiology , Cellular Reprogramming*/genetics , Kruppel-Like Transcription Factors*/genetics , Kruppel-Like Transcription Factors*/metabolism , SOXB1 Transcription Factors*/genetics , SOXB1 Transcription Factors*/metabolism , Cartilage*/pathology , Cartilage*/metabolism, Chondrocytes/metabolism ; Dependovirus/genetics ; Genetic Vectors/genetics ; Genetic Vectors/administration & dosage ; Animals ; Mice ; Kruppel-Like Factor 4 ; Fibrosis ; Humans ; Male ; Disease Models, Animal ; Cell Differentiation

Redefining cellular reprogramming with advanced genomic technologies.

Συγγραφείς: Morris SA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.

Πηγή: Nature reviews. Genetics [Nat Rev Genet] 2026 Mar; Vol. 27 (3), pp. 193-211. Date of Electronic Publication: 2025 Oct 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962779 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0064 (Electronic) Linking ISSN: 14710056 NLM ISO Abbreviation: Nat Rev Genet Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Genomics*/methods , Cellular Reprogramming Techniques*/methods, Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Cell Differentiation/genetics ; Regenerative Medicine/methods ; Humans ; Animals ; Single-Cell Analysis

Navigating the landscape of direct cellular reprogramming with DiReG.

Συγγραφείς: Lauber M; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., List M; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. markus.list@tum.de.; Munich Data Science Institute (MDSI), Technical University of Munich, Garching, Germany. markus.list@tum.de.

Πηγή: NPJ systems biology and applications [NPJ Syst Biol Appl] 2026 Feb 06; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Computational Biology*/methods, Transcription Factors/metabolism ; Transcription Factors/genetics ; Regenerative Medicine/methods ; Humans ; Animals ; Software

Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction

Συγγραφείς: Glynnis Garry Bann, Matthieu Dos Santos, Kenian Chen, Wei Tan, Svetlana Bezprozvannaya, Peiheng Gan, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson

Πηγή: Circulation

Θεματικοί όροι: Male, MEF2 Transcription Factors, Myocardial Infarction, Fibroblasts, Cellular Reprogramming, Mice, Inbred C57BL, Mice, Disease Models, Animal, Original Research Articles, Animals, Humans, Myocytes, Cardiac, T-Box Domain Proteins, Cells, Cultured, Transcription Factors

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40631661
https://pmc.ncbi.nlm.nih.gov/articles/PMC12327843/
https://pubmed.ncbi.nlm.nih.gov/40631661/
https://doi.org/10.1161/CIRCULATIONAHA.124.072733

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples.

Συγγραφείς: Art J; Center for Molecular Medicine, University of Georgia; Interdisciplinary Neuroscience, University of Georgia; js.esquibel@yahoo.com., James C; Center for Molecular Medicine, University of Georgia; Department of Biochemistry and Molecular Biology, University of Georgia., Dalal B; Center for Molecular Medicine, University of Georgia; Department of Biochemistry and Molecular Biology, University of Georgia., Fantone K; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia., Rada B; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia., Felner EI; Division of Pediatric Endocrinology, Emory University School of Medicine., Gonzalez-Duarte A; Dysautonomia Center, New York University Langone Health., Michopoulos V; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine., Corneo B; Stem Cell Core, Columbia Stem Cell Initiative, Columbia University., Zeltner N; Center for Molecular Medicine, University of Georgia; Department of Biochemistry and Molecular Biology, University of Georgia; Department of Cellular Biology, University of Georgia.

Πηγή: Journal of visualized experiments : JoVE [J Vis Exp] 2026 Apr 10 (230). Date of Electronic Publication: 2026 Apr 10.

Τύπος έκδοσης: Journal Article; Video-Audio Media; Research Support, N.I.H., Extramural

Στοιχεία περιοδικού: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Induced Pluripotent Stem Cells*/cytology , Blood Buffy Coat*/cytology , Cellular Reprogramming Techniques*/methods, Leukocytes, Mononuclear/cytology ; Humans ; Cryopreservation ; Cellular Reprogramming

Hepatocyte-specific partial cellular reprogramming via selective OSK mRNA lipid nanoparticle attenuates liver fibrosis.

Συγγραφείς: Zhang C; Human Phenome Institute, Fudan University, Shanghai 201203, China., Bai Y; Human Phenome Institute, Fudan University, Shanghai 201203, China., Yin Q; Human Phenome Institute, Fudan University, Shanghai 201203, China., Li J; Human Phenome Institute, Fudan University, Shanghai 201203, China., Huang K; Human Phenome Institute, Fudan University, Shanghai 201203, China., Qiu M; Human Phenome Institute, Fudan University, Shanghai 201203, China; Center for mRNA Translational Research, Fudan University, Shanghai 200438, China; Zhangjiang mRNA Innovation and Translation Center, Shanghai 201203, China. Electronic address: mqiu@fudan.edu.cn.

Πηγή: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Feb 10; Vol. 390, pp. 114569. Date of Electronic Publication: 2025 Dec 22.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nanoparticles*/administration & dosage , Nanoparticles*/chemistry , RNA, Messenger*/administration & dosage , Hepatocytes*/metabolism , Liver Cirrhosis*/therapy , Liver Cirrhosis*/genetics , Liver Cirrhosis*/pathology , Octamer Transcription Factor-3*/genetics , Lipids*/chemistry , Lipids*/administration & dosage , SOXB1 Transcription Factors*/genetics , Kruppel-Like Transcription Factors*/genetics , Cellular Reprogramming*, Animals ; Kruppel-Like Factor 4 ; Mice, Inbred C57BL ; Male ; Mice ; Humans ; Liposomes

THE DAWN OF HUMAN REJUVENATION: FROM SCIENCE FICTION TO CLINICAL REALITY : A COMPREHENSIVE REVIEW OF CELLULAR REPROGRAMMING, SENOLYTICS, AND EPIGENETIC INTERVENTIONS

Συγγραφείς: Dr. Saloni Jain, Muzzamil Tariq Chowdhary, Ritshi Amchi, Numanbhai Mansuri

Θεματικοί όροι: Rejuvenation, cellular reprogramming, Yamanaka factors, senolytics, DNA methylation clocks, biological age, epigenetic reprogramming, longevity biotechnology, healthspan extension, partial reprogramming

Enhancing cardiomyocyte reprogramming efficiency by targeting cellular senescence is mediated via Rb1 gene.

Συγγραφείς: Fang J; Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.; Circulatory Health Laboratory, UMC Utrecht, Regenerative Medicine Center Utrecht, University Utrecht, Utrecht, 3508 GA, The Netherlands., Yang Q; Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands., Maas RGC; Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.; Circulatory Health Laboratory, UMC Utrecht, Regenerative Medicine Center Utrecht, University Utrecht, Utrecht, 3508 GA, The Netherlands., Vader P; Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands.; Circulatory Health Laboratory, UMC Utrecht, Regenerative Medicine Center Utrecht, University Utrecht, Utrecht, 3508 GA, The Netherlands.; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands., Mokry M; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, 3508 GA, The Netherlands., van den Dungen NAM; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, 3508 GA, The Netherlands., Qian L; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA., Xiao J; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China., Schiffelers R; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands., Lei Z; Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands. Z.Lei-3@umcutrecht.nl.; Circulatory Health Laboratory, UMC Utrecht, Regenerative Medicine Center Utrecht, University Utrecht, Utrecht, 3508 GA, The Netherlands. Z.Lei-3@umcutrecht.nl.; CDL Research, University Medical Center Utrecht, Utrecht, The Netherlands. Z.Lei-3@umcutrecht.nl., Sluijter JPG; Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands. J.Sluijter@umcutrecht.nl.; Circulatory Health Laboratory, UMC Utrecht, Regenerative Medicine Center Utrecht, University Utrecht, Utrecht, 3508 GA, The Netherlands. J.Sluijter@umcutrecht.nl.

Πηγή: Stem cell research & therapy [Stem Cell Res Ther] 2025 Dec 29; Vol. 16 (1), pp. 685. Date of Electronic Publication: 2025 Dec 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/genetics , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/cytology , Cellular Reprogramming*/genetics , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/metabolism , Retinoblastoma Binding Proteins*/genetics , Retinoblastoma Binding Proteins*/metabolism, Fibroblasts/metabolism ; Fibroblasts/cytology ; GATA4 Transcription Factor/metabolism ; GATA4 Transcription Factor/genetics ; MEF2 Transcription Factors/metabolism ; MEF2 Transcription Factors/genetics ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Animals ; Mice ; Humans ; Apoptosis ; Cells, Cultured