[Molecular mechanism of intervertebral disc cell senescence: telomeres, mitochondria, and cellular metabolic reprogramming].

Συγγραφείς: Deng W; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; Department of Minimally Invasive Spine Surgery, The First Clinical Medical College of Guangzhou University of Chinese Medicine/The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Zhu RC; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; Department of Minimally Invasive Spine Surgery, The First Clinical Medical College of Guangzhou University of Chinese Medicine/The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Kong FG; The Second Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Zhengzhou 450000, China., Luan JY; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; The Second Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Zhengzhou 450000, China.

Πηγή: Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2026 Jun 25; Vol. 78 (3), pp. 566-578.

Τύπος έκδοσης: Journal Article; Review; English Abstract

Στοιχεία περιοδικού: Publisher: Science Press Country of Publication: China NLM ID: 20730130R Publication Model: Print Cited Medium: Internet ISSN: 0371-0874 (Print) Linking ISSN: 03710874 NLM ISO Abbreviation: Sheng Li Xue Bao Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/physiology , Cellular Senescence*/genetics , Mitochondria*/physiology , Mitochondria*/metabolism , Telomere*/physiology , Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc*/cytology , Intervertebral Disc*/metabolism , Cellular Reprogramming*, Humans ; Metabolic Reprogramming ; Animals

A cross-talk between p16High senescence and cellular reprogramming.

Συγγραφείς: Emelyanov A; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, INSERM, CNRS, Nice, France., Bulavin DV; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, INSERM, CNRS, Nice, France.

Πηγή: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2026 Jun 10; Vol. 140 (6), pp. 1137-1147.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Senescence*/genetics , Cellular Senescence*/physiology , Cyclin-Dependent Kinase Inhibitor p16*/metabolism , Cyclin-Dependent Kinase Inhibitor p16*/genetics , Cellular Reprogramming*, Fibroblasts/metabolism ; Humans ; Kruppel-Like Factor 4 ; Animals ; Epigenesis, Genetic ; Signal Transduction

Wounding activates the HSFA1 transcription factors to promote cellular reprogramming in Arabidopsis.

Συγγραφείς: Coleman D; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Iwase A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; JST, PRESTO, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076Japan., Kawamura A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takebayashi A; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Chen Y; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Minne M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Jager KE; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Peng M; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany., Kodama Y; Center for Bioscience Research and Education, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi 331-8505, Japan., Favero DS; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Takahashi T; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan., Ikeuchi M; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Division of Biological Sciences, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0192, Japan., Suzuki T; Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan., Ohama N; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Yamaguchi-Shinozaki K; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan., Wigge PA; Leibniz-Institut für Gemüse- und Zierpflanzenbau, Theodor-Echtermeyer-Weg 1, Großbeeren 14979, Germany.; Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25 Haus 25, Raum B1.11-12, Potsdam 14476, Germany., De Veylder L; Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.; Center for Plant Systems Biology, VIB, Gent, Belgium., Sugimoto K; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi Ward, Yokohama, Kanagawa 230-0045, Japan.; Department of Biological Sciences, Faculty of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis*/physiology , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Heat Shock Transcription Factors*/metabolism , Heat Shock Transcription Factors*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Gene Expression Regulation, Plant/genetics

Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming.

Συγγραφείς: Murano T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Hagihara H; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Tajinda K; Astellas Research Institute of America, San Diego, CA, USA., Takao K; Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Takamiya Y; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Katoh K; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Ph.D. Program in Humanics, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Japan.; The Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases (NIID), Tokyo, Japan., Robison AJ; Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI, USA., Matsumoto M; Astellas Research Institute of America, San Diego, CA, USA.; Arialys Therapeutics Inc., La Jolla, CA, USA., Namihira M; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Laboratory of Neural Regeneration and Brain Repair, Division of Biological Science, Graduate School of Science andTechnology, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, Japan., Miyakawa T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan. miyakawa@fujita-hu.ac.jp.

Πηγή: Nature communications [Nat Commun] 2026 Jul 17; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neurons*/physiology , Neurons*/metabolism , Neurons*/cytology , Dentate Gyrus*/cytology , Dentate Gyrus*/physiology , Dentate Gyrus*/metabolism , Cellular Reprogramming*/physiology, Animals ; Mice ; Optogenetics ; Male ; Mice, Inbred C57BL ; Mice, Knockout

Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism.

Συγγραφείς: Wang L; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Song S; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Yao S; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Wang Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li Q; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Ma Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li J; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Li Y; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Yang M; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Zhang K; Chongqing Animal Husbandry Technology Extension Station, Chongqing 401121, China., Han Y; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: hyg2015@swu.edu.cn., Xu D; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: xdj2020@swu.edu.cn., Zhao Z; Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: zhaozhongquan@swu.edu.cn.

Πηγή: Cellular signalling [Cell Signal] 2026 Jul; Vol. 143, pp. 112483. Date of Electronic Publication: 2026 Mar 13.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Histones*/metabolism , Epigenesis, Genetic* , Cellular Reprogramming*, Humans ; Animals ; Acetylation ; Protein Processing, Post-Translational ; Transcription, Genetic

Phospholipid remodeling interplays with auxin signaling to modulate cellular reprogramming in Arabidopsis regeneration.

Συγγραφείς: Chang P; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China., Yang X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo S; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhou J; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., He M; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Li Z; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Xu E; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Xin W; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Hu Y; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; National Center for Plant Gene Research, Beijing 100093, China., Xu C; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.

Πηγή: The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Indoleacetic Acids*/metabolism , Indoleacetic Acids*/pharmacology , Arabidopsis*/physiology , Arabidopsis*/metabolism , Arabidopsis*/genetics , Regeneration*/physiology , Phospholipids*/metabolism , Cellular Reprogramming*, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Phosphatidic Acids/metabolism ; Plant Growth Regulators/metabolism ; Signal Transduction ; Gene Expression Regulation, Plant ; Plants, Genetically Modified

Protocol for identifying cellular reprogramming minimal networks using combinatorial transcription factor screening.

Συγγραφείς: Altman AR; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden., Pértiga-Cabral D; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden; CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês Do Pombal, 3004-517 Coimbra, Portugal; CiBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Doctoral Programme in Experimental Biology and Biomedicine, University of Coimbra, Coimbra, Portugal., Pereira CF; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden; CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês Do Pombal, 3004-517 Coimbra, Portugal; CiBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Asgard Therapeutics AB, Medicon Village, 223 81 Lund, Sweden., Kurochkin I; Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Center, Lund University, BMC A12, 221 84 Lund, Sweden; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden. Electronic address: ilia.kurochkin@med.lu.se.

Πηγή: STAR protocols [STAR Protoc] 2026 Jun 19; Vol. 7 (2), pp. 104527. Date of Electronic Publication: 2026 Apr 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Transcription Factors*/metabolism , Transcription Factors*/genetics , Cellular Reprogramming*/genetics, Fibroblasts/cytology ; Fibroblasts/metabolism ; Lentivirus/genetics ; Humans

Remodeling of Mitochondrial Networks: Cellular Adaptation and Microenvironmental Reprogramming in Hematologic Malignancies.

Συγγραφείς: Li Y; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Hu X; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China., Zhou X; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China.

Πηγή: Blood cancer discovery [Blood Cancer Discov] 2026 Mar 04; Vol. 7 (2), pp. 212-224.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hematologic Neoplasms*/metabolism , Hematologic Neoplasms*/pathology , Hematologic Neoplasms*/genetics , Mitochondria*/metabolism , Mitochondria*/pathology , Mitochondria*/genetics , Tumor Microenvironment* , Cellular Reprogramming*, Humans ; Animals ; Metabolic Reprogramming ; Mitophagy

Developmental stage-dependent cellular plasticity governs β-cell reprogramming efficiency in human fibroblasts.

Συγγραφείς: Raj N; Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: naveenraj@iitg.ac.in., Panneerselvam DS; Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: p.dhaya@iitg.ac.in., Thummer RP; Laboratory for Stem Cell Engineering and Regenerative Medicine, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: rthu@iitg.ac.in.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Sep 03; Vol. 829, pp. 154188. Date of Electronic Publication: 2026 Jun 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Fibroblasts*/cytology , Fibroblasts*/metabolism , Insulin-Secreting Cells*/cytology , Insulin-Secreting Cells*/metabolism , Cellular Reprogramming* , Cell Plasticity*, Lentivirus/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Basic Helix-Loop-Helix Proteins/genetics ; Basic Helix-Loop-Helix Proteins/metabolism ; Humans ; Cells, Cultured ; Cell Differentiation

Functional suppression accompanies internal mitochondrial reorganization during cellular reprogramming.

Συγγραφείς: Diak N; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Sieroń L; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Janelt K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Chajec L; Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Bankowa 9, 40-007, Katowice, Poland., Fus-Kujawa A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Dziedzic-Kowalska A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Trybus A; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland., Raszczok K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland.; Students Scientific Society, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland., Bajdak-Rusinek K; Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18 Street, 40-752, Katowice, Poland. kbajdak-rusinek@sum.edu.pl.

Πηγή: Histochemistry and cell biology [Histochem Cell Biol] 2026 Apr 20; Vol. 164 (1). Date of Electronic Publication: 2026 Apr 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 9506663 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-119X (Electronic) Linking ISSN: 09486143 NLM ISO Abbreviation: Histochem Cell Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Mitochondria*/metabolism , Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , Cellular Reprogramming*, Fibroblasts/metabolism ; Fibroblasts/cytology ; Reactive Oxygen Species/metabolism ; Humans ; Cells, Cultured ; Membrane Potential, Mitochondrial

Proteomic Signatures of Cellular Reprogramming in Bladder Cancer: Insights into the Acquisition of Cancer Stem-like States and Phenotypic Plasticity.

Συγγραφείς: Barlak BSR; Protein Research and Proteomics Laboratory, Department of Medical Biology, Faculty of Medicine, Kocaeli University, Izmit, Türkiye., Iskender B; Protein Research and Proteomics Laboratory, Department of Medical Biology, Faculty of Medicine, Kocaeli University, Izmit, Türkiye banu.iskender@kocaeli.edu.tr.

Πηγή: Cancer genomics & proteomics [Cancer Genomics Proteomics] 2026 Mar-Apr; Vol. 23 (2), pp. 300-321.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 101188791 Publication Model: Print Cited Medium: Internet ISSN: 1790-6245 (Electronic) Linking ISSN: 11096535 NLM ISO Abbreviation: Cancer Genomics Proteomics Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/genetics , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Proteomics*/methods , Cellular Reprogramming*, Humans ; Cell Line, Tumor ; Phenotype ; Epithelial-Mesenchymal Transition ; Cell Plasticity

Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis.

Συγγραφείς: Liu YW; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Zou JT; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Gong JS; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Jin L; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Cao J; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China., He ZH; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Qian YX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Wang X; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Wan MD; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Hu XY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China., Hong CG; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China., Du W; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Chen CY; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Angmedicine, Changsha, China.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China., Liu HJ; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. liuhongji@hnu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. liuhongji@hnu.edu.cn., Xie H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. huixie@csu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. huixie@csu.edu.cn.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China. huixie@csu.edu.cn., Wang ZX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China. wangzx@csu.edu.cn.; Hunan Key Laboratory of Angmedicine, Changsha, China. wangzx@csu.edu.cn.; National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Changsha, China. wangzx@csu.edu.cn.

Πηγή: Experimental & molecular medicine [Exp Mol Med] 2026 Mar; Vol. 58 (3), pp. 782-797. Date of Electronic Publication: 2026 Mar 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Osteoarthritis*/therapy , Osteoarthritis*/pathology , Osteoarthritis*/metabolism , Osteoarthritis*/genetics , Osteoarthritis*/etiology , Cellular Reprogramming*/genetics , Kruppel-Like Transcription Factors*/genetics , Kruppel-Like Transcription Factors*/metabolism , SOXB1 Transcription Factors*/genetics , SOXB1 Transcription Factors*/metabolism , Cartilage*/pathology , Cartilage*/metabolism, Chondrocytes/metabolism ; Dependovirus/genetics ; Genetic Vectors/genetics ; Genetic Vectors/administration & dosage ; Animals ; Mice ; Kruppel-Like Factor 4 ; Fibrosis ; Humans ; Male ; Disease Models, Animal ; Cell Differentiation

Redefining cellular reprogramming with advanced genomic technologies.

Συγγραφείς: Morris SA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. samorris2@bwh.harvard.edu.

Πηγή: Nature reviews. Genetics [Nat Rev Genet] 2026 Mar; Vol. 27 (3), pp. 193-211. Date of Electronic Publication: 2025 Oct 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962779 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0064 (Electronic) Linking ISSN: 14710056 NLM ISO Abbreviation: Nat Rev Genet Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Genomics*/methods , Cellular Reprogramming Techniques*/methods, Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Cell Differentiation/genetics ; Regenerative Medicine/methods ; Humans ; Animals ; Single-Cell Analysis

Integrative methylation and transcriptomic analysis reveals key genes linking cellular senescence and metabolic reprogramming in colorectal liver metastasis.

Συγγραφείς: Ma X; Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China., Chen L; Department of Hepatobiliary Cancer, Liver cancer research center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China., Yi C; Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China., Li Y; Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China., Geng Y; Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China., Tao B; Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China., Chen J; Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China.

Πηγή: Bioscience trends [Biosci Trends] 2026 Jan 07; Vol. 19 (6), pp. 672-683. Date of Electronic Publication: 2025 Oct 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: International Research and Cooperation Association for Bio & Socio-Sciences Advancement Country of Publication: Japan NLM ID: 101502754 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-7823 (Electronic) Linking ISSN: 18817815 NLM ISO Abbreviation: Biosci Trends Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Liver Neoplasms*/secondary , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , DNA Methylation*/genetics , Cellular Senescence*/genetics , Cellular Reprogramming*/genetics, Chemokine CXCL1/genetics ; Plasminogen Activator Inhibitor 1/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Biomarkers, Tumor/genetics ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Humans ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Transcriptome ; Epigenesis, Genetic ; Metabolic Reprogramming ; Cell Cycle Proteins ; N-myc Downstream-Regulated Gene 1 Protein

SIRT3 in post-myocardial infarction macrophage reprogramming: linking mitochondrial fitness to inflammation resolution and repair.

Συγγραφείς: Li X; Qihuang College, Guizhou University of Traditional Chinese Medicine, Guiyang, China., Luo X; School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China., Zhang Z; School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China., Tang L; School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China., Meng X; Qihuang College, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jul 08; Vol. 17, pp. 1848626. Date of Electronic Publication: 2026 Jul 08 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review; Systematic Review

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Macrophages*/metabolism , Macrophages*/immunology , Myocardial Infarction*/metabolism , Myocardial Infarction*/pathology , Myocardial Infarction*/immunology , Sirtuin 3*/metabolism , Mitochondria*/metabolism , Cellular Reprogramming*, Inflammation/metabolism ; Inflammation/immunology ; Reactive Oxygen Species/metabolism ; Humans ; Animals ; Efferocytosis ; Metabolic Reprogramming

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Συγγραφείς: Gomez-Escudero J; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK. jesuschgoes@usal.es.; Biochemistry and Molecular Biology Department, Salamanca University, Salamanca, Spain. jesuschgoes@usal.es., Maniati E; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK., Holdsworth J; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK., Beattie G; UCL Cancer Institute, CRUK City of London Centre Single Cell Genomics Facility, University College London, London, UK.; Bioinformatics Hub, UCL Cancer Institute, University College London, London, UK., Hijazi M; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.; Biochemistry and Molecular Biology Department, Salamanca University, Salamanca, Spain., Guelbert M; Division of Cancer Biology, The Institute of Cancer Research, London, UK., Elorbany S; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK., Cutillas P; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK., Wang J; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK., Hodivala-Dilke K; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK. k.hodivala-dilke@qmul.ac.uk., D'Amico G; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK. g.damico@qmul.ac.uk.

Πηγή: Angiogenesis [Angiogenesis] 2026 Jun 22; Vol. 29 (3). Date of Electronic Publication: 2026 Jun 22.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 9814575 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7209 (Electronic) Linking ISSN: 09696970 NLM ISO Abbreviation: Angiogenesis Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Drug Resistance, Neoplasm*/drug effects , Signal Transduction*/drug effects , Neovascularization, Pathologic*/pathology , Neovascularization, Pathologic*/metabolism , Endothelial Cells*/pathology , Endothelial Cells*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/blood supply , Cellular Reprogramming*/drug effects, Doxorubicin/pharmacology ; NF-kappa B/metabolism ; Animals ; Female ; Mice ; Humans ; Metabolic Reprogramming

Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer's disease.

Συγγραφείς: Galán-Ganga M; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Rodríguez-Navarro I; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Zaballa S; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Ramón-Lainez A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Gómez-Rivada N; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Peters C; Department of Molecules-Signaling-Development, Max-Planck Institute for Biological Intelligence, Martinsried, 82152, Germany., Fernández-Irigoyen J; Proteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra UPNA, IdiSNA, Pamplona, 31008, Spain., Santamaría E; Proteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra UPNA, IdiSNA, Pamplona, 31008, Spain., Rabadán MÁ; ZeClinics SL. and ZeNeuroid SL., Barcelona, Spain., Alberch J; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain.; Production and Validation Centre of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain., Rodríguez MJ; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain., Del Toro D; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain. danieldeltoro@ub.edu.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain. danieldeltoro@ub.edu.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain. danieldeltoro@ub.edu.; Production and Validation Centre of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain. danieldeltoro@ub.edu., Giralt A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Barcelona, 08036, Spain. albertgiralt@ub.edu.; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain. albertgiralt@ub.edu.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, 28031, Spain. albertgiralt@ub.edu.; Production and Validation Centre of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain. albertgiralt@ub.edu.

Πηγή: Molecular biomedicine [Mol Biomed] 2026 Jun 10; Vol. 7 (1). Date of Electronic Publication: 2026 Jun 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Alzheimer Disease*/physiopathology , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/genetics , Neurons*/metabolism , Neurons*/pathology , Memory* , Cellular Reprogramming*, Receptors, N-Methyl-D-Aspartate/metabolism ; Hippocampus/metabolism ; Hippocampus/pathology ; Focal Adhesion Kinase 2/metabolism ; tau Proteins/metabolism ; Animals ; Male ; Mice ; Female ; Disease Models, Animal ; Mice, Transgenic ; Humans

Navigating the landscape of direct cellular reprogramming with DiReG.

Συγγραφείς: Lauber M; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., List M; Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. markus.list@tum.de.; Munich Data Science Institute (MDSI), Technical University of Munich, Garching, Germany. markus.list@tum.de.

Πηγή: NPJ systems biology and applications [NPJ Syst Biol Appl] 2026 Feb 06; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellular Reprogramming*/genetics , Cellular Reprogramming*/physiology , Computational Biology*/methods, Transcription Factors/metabolism ; Transcription Factors/genetics ; Regenerative Medicine/methods ; Humans ; Animals ; Software

Spatial-Niche Perspective on the Heterogeneity and Functional Reprogramming of Tumor-Associated Macrophages in Digestive System Tumors.

Συγγραφείς: Zhang J; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Huang Y; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhang M; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Lou J; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhang S; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhao S; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Song Z; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhang K; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Jiang T; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Traditional Chinese Medicine 'Preventing Disease' Wisdom Health Project Research Center of Zhejiang, Hangzhou 310053, China., Zhang G; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Traditional Chinese Medicine 'Preventing Disease' Wisdom Health Project Research Center of Zhejiang, Hangzhou 310053, China.

Πηγή: Cells [Cells] 2026 Jul 01; Vol. 15 (13). Date of Electronic Publication: 2026 Jul 01.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Tumor-Associated Macrophages*/pathology , Tumor-Associated Macrophages*/metabolism , Digestive System Neoplasms*/pathology , Digestive System Neoplasms*/immunology , Digestive System Neoplasms*/metabolism , Tumor Microenvironment* , Cellular Reprogramming*, Humans ; Animals ; Metabolic Reprogramming

Advances in nanodelivery systems based on tumor-associated cell reprogramming strategies for enhanced tumor therapy.

Συγγραφείς: Liu L; Department of Oncology and Hematology, Renshou County People's Hospital, The Second People's Hospital of Meishan City, Meishan, Sichuan, 620500, China., Liu Y; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Tan X; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Ding K; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Li Q; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Zhao T; Analysis and Testing Center, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., He X; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Liu Z; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China., Yang H; Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China; Sichuan Clinical Research Center for Birth Defects, Luzhou, Sichuan 646000, China., Wu M; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China; Chinese Pharmacy Laboratory, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: 379103530@qq.com., Li C; Department of Pharmacy Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China. Electronic address: lispringhong@126.com.

Πηγή: Acta biomaterialia [Acta Biomater] 2026 Jun; Vol. 216, pp. 51-66. Date of Electronic Publication: 2026 Apr 28.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/therapy , Neoplasms*/pathology , Neoplasms*/immunology , Tumor Microenvironment* , Cellular Reprogramming* , Nanomedicine*, Stromal Cells/pathology ; Humans ; Animals