Exclusion of intracranial lesions in mild traumatic brain injury using glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1: a European multicenter study

Authors: Lara, Milevoj Kopcinovic, Nora, Nikolac Gabaj, Ivana, Lapić, Dunja, Rogić, Oana Roxana, Oprea, Minodora, Dobreanu, Jakub, Nożewski, Mariusz, Sieminski, Ewelina, Stępniewska, Małgorzata, Dąbrowska, Barbara, Mroczko, Marzena, Wojewódzka-Żelezniakowicz, Rakesh, Jalali, Marcin, Baluch, Joanna, Malinowska, Jerzy, Romaszko, Evgenija, Homšak, Gregor, Prosen, Matej, Strnad, Helena, Ferreira da Silva, Martina, Pavletić, Vesna, Šupak-Smolčić, Lidija, Bilić-Zulle, Ana, Tancabel Mačinković, Mate, Lerga, Dušan, Dobrota, Daniel, Čierny, Štefan, Sivák, Egon, Kurča, Martina, Martiníková

Source: European Journal of Emergency Medicine. 32:351-358

Subject Terms: ubiquitin C-terminal hydrolase L1, glial fibrillary acidic protein, mild traumatic brain injury, biomarkers, computed tomography

Access URL: https://pubmed.ncbi.nlm.nih.gov/40214300

Updated Review of Neurologic Concussion Biomarkers for Time-sensitive Point-of-care Testing

Authors: Milin J Kurup, Amit Agrawal, Sarah R Temple, Sagar Galwankar

Source: J Emerg Trauma Shock
Journal of Emergencies, Trauma and Shock, Vol 18, Iss 2, Pp 74-89 (2025)

Subject Terms: concussions, traumatic brain injuries, RC86-88.9, biomarkers, Medical emergencies. Critical care. Intensive care. First aid, Review Article, point of care, visinin-like protein-1, point-of-care testing, s100 calcium-binding protein b, ubiquitin c-terminal hydrolase l1, neurofilament light chain, glial fibrillary acidic protein, multimodal models, tau

Access URL: https://doaj.org/article/480b73fd148748db81b3037d68ebbf0c

Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis

Authors: Lin, Lu, Yu, Weijun, Yang, Ruhan, Liu, Mingzhi, Shi, Yuanjie, Hu, Shucheng, Li, Guanglong, Tang, Jiaqi, Shen, Yue, Cui, Zhurong, Jin, Min^{Aff1, IDs1328702504399y_cor1}, Gu, Yuting^{Aff1, IDs1328702504399y_cor2}, Lu, Eryi^{Aff1, IDs1328702504399y_cor3}

Source: Stem Cell Research & Therapy. 16(1)

The role of ubiquitin C–terminal hydrolase (UCH‐L1) and protein S100B in differentiating patients with epileptic and psychogenic non‐epileptic seizures – Pilot study

Authors: Biljana Dapic Ivancic, Zeljka Petelin Gadze, Lana Ganoci, Petra Nimac Kozina, Dunja Rogic, Maja Zivkovic

Source: Epilepsia Open
Epilepsia Open, Vol 10, Iss 2, Pp 441-449 (2025)

Subject Terms: Adult, Male, Adolescent, Ubiquitin Thiolesterase / blood, Electroencephalography, Pilot Projects, Epilepsy / blood, Middle Aged, Diagnosis, Differential, Young Adult, protein S100B, ubiquitin C‐terminal hydrolase L1, Seizures / blood, Biomarkers / blood, Humans, epilepsy, Female, psychogenic non‐epileptic seizures, Original Article, Prospective Studies, S100 Calcium Binding Protein beta Subunit / blood, Neurology. Diseases of the nervous system, Seizures / diagnosis, RC346-429, Epilepsy / diagnosis

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40025842
https://doaj.org/article/f09f6a5c3d314a629bf5dc15445bf16f
https://urn.nsk.hr/urn:nbn:hr:105:047060
https://doi.org/10.1002/epi4.13130

Blood-Based Biomarkers for Improved Characterization of Traumatic Brain Injury: Recommendations from the 2024 National Institute for Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Blood-Based Biomarkers Working Group

Authors: Bazarian, Jeffrey J., Zetterberg, Henrik, Büki, Andras, Professor, 1966, Dengler, Bradley A., Diaz-Arrastia, Ramon, Korley, Frederick K., Lazarus, Rachel, Meier, Timothy B., Mondello, Stefania, Moritz, Kasey, Okonkwo, David O., Papa, Linda, Phillips, James B., Posti, Jussi P., Puccio, Ava M., Sloley, Stephanie, Steyerberg, Ewout, Wang, Kevin K., Awwad, Hibah O., Dams-O'Connor, Kristen, Doperalski, Adele, Maas, Andrew I. R., McCrea, Michael A., Umoh, Nsini, Manley, Geoffrey T.

Source: Journal of Neurotrauma. 42(13-14):1065-1085

Subject Terms: S100B calcium-binding protein, brain biomarkers, concussion, glial fibrillary acidic protein, neurofilament light chain, traumatic brain injury, ubiquitin C-terminal hydrolase L1

File Description: print

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-121170

Cerebrospinal fluid levels of GFAP and pNF-H are elevated in patients with chronic spinal cord injury and neurological deterioration

Authors: Holmström, Ulrika, Tsitsopoulos, Parmenion P., Holtz, Anders, Salci, Konstantin, Shaw, Gerry, Mondello, Stefania, Marklund, Niklas

Source: Acta Neurochirurgica. 162(9):2075-2086

Subject Terms: Spinal cord injury, Biomarkers, Syringomyelia, Cerebrospinal fluid, Tethering of the spinal cord (TSC), Glial fibrillary acidic protein (GFAP), Ubiquitin C-terminal hydrolase L1 (UCH-L1), Neurofilament, Post-traumatic myelopathy

File Description: electronic

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423644
https://doi.org/10.1007/s00701-020-04422-6

Serum biomarkers identify critically ill traumatic brain injury patients for MRI

Authors: Richter, Sophie, Winzeck, Stefan, Czeiter, Endre, Amrein, Krisztina, Kornaropoulos, Evgenios N., Verheyden, Jan, Sugar, Gabriela, Yang, Zhihui, Wang, Kevin, Maas, Andrew I. R., Steyerberg, Ewout, Büki, Andras, 1966, Newcombe, Virginia F J, Menon, David K.

Contributors: Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Magnetic Resonance Imaging (CENTER-TBI MRI) Sub-study Participants and Investigators, Contributor

Source: Critical Care. 26(1)

Subject Terms: Diffuse axonal injury, Glasgow Coma Scale, Glial fibrillary acidic protein (GFAP), Magnetic resonance imaging, Neuron-specific enolase (NSE), Serum protein biomarkers, Tau, Traumatic axonal injury, Traumatic brain injury, Ubiquitin C terminal hydrolase L1 (UCH-L1)

File Description: print

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102533
https://doi.org/10.1186/s13054-022-04250-3

Pathogenicity of UCH-L1 autoantibodies in membranous nephropathy

Authors: Frömbling, Sarah

Subject Terms: Ubiquitin C-terminal Hydrolase L1, Membranous nephropathy, Autoantibodies, Glomerular filtration barrier, Autoimmunedisease, 570: Biowissenschaften, Biologie, Autoantikörper, Niere, Podocyte, Membranöse Glomerulonephritis, Autoaggressionskrankheit, ddc:570:

Access URL: http://nbn-resolving.de/urn:nbn:de:gbv:18-ediss-129260
https://ediss.sub.uni-hamburg.de/handle/ediss/11755

Fetal Ovarian Reserve: the Dynamic Changes in Ubiquitin C-Terminal Hydrolase L1

Authors: Ozcan, Meghan C. H.^{Aff1, IDs4303202301275z_cor1}, Cruz, Lisa, Woodman, Morgan F., Gundogan, Fusun, Grive, Kathryn J.

Source: Reproductive Sciences. 30(11):3353-3358

Decipher potential biomarkers of diagnosis and disease activity for NMOSD with AQP4 using LC-MS/MS and Simoa

Authors: Wang, Jinyang ^{a, b, 1}, Wang, Jianan ^{a, c, 1}, Xie, Wei ^d, Liu, Jiayu ^a, Feng, Jie ^a, Wei, Wenbin ^a, Li, Mianyang ^a, Wu, Lei ^{d, ⁎}, Wang, Chengbin ^{a, b, c, ⁎}, Li, Ruibing ^{a, ⁎}

Source: In International Immunopharmacology March 2023 116

Analysis of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase L1 in Postmortem Serum and Cerebrospinal Fluid in Traumatic Cerebral Deaths

Authors: Ayşe KURTULUŞ DERELİ, Mücahit SEÇME, Kemalettin ACAR

Source: Volume: 12, Issue: 1 242-248
Clinical and Experimental Health Sciences

Subject Terms: ubiquitin C-terminal hydrolase L1, Gfap, Sağlık Kurumları Yönetimi, Traumatic brain injury, glial fibrillary acidic protein, autopsy, 3. Good health, Brain-Injury, 03 medical and health sciences, Blood, 0302 clinical medicine, Utility, Ischemia, Health Care Administration, Biomarkers

File Description: application/pdf

Access URL: https://dergipark.org.tr/tr/pub/clinexphealthsci/issue/69145/943779

Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant Traumatic Brain Injury Biomarkers

Authors: Korley, Frederick K, Yue, John K, Wilson, David H, Hrusovsky, Kevin, Diaz-Arrastia, Ramon, Ferguson, Adam R, Yuh, Esther L, Mukherjee, Pratik, Wang, Kevin KW, Valadka, Alex B, Puccio, Ava M, Okonkwo, David O, Manley, Geoffrey T

Source: Journal of Neurotrauma. 36(1)

Subject Terms: Dementia, Brain Disorders, Traumatic Brain Injury (TBI), Traumatic Head and Spine Injury, Physical Injury - Accidents and Adverse Effects, Neurosciences, Acquired Cognitive Impairment, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Neurological, biomarkers, glial fibrillary acidic protein, multiplex immunoassay, neurofilament light chain, total tau, traumatic brain injury, ubiquitin c-terminal hydrolase L1, Clinical Sciences, Neurology & Neurosurgery

File Description: application/pdf

Access URL: https://escholarship.org/uc/item/4dz8q7tn
https://escholarship.org/content/qt4dz8q7tn/qt4dz8q7tn.pdf

Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer’s disease continuum

Authors: Paciotti, Silvia, Wojdała, Anna Lidia, Bellomo, Giovanni, Toja, Andrea, Chipi, Elena, Piersma, Sander R., Pham, Thang V., Gaetani, Lorenzo, Jimenez, Connie R., Parnetti, Lucilla^{Aff3, IDs13195023012698_cor10}, Chiasserini, Davide^{Aff1, IDs13195023012698_cor11}

Source: Alzheimer's Research & Therapy. 15(1)

Evaluation of Acute Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Plasma Levels in Traumatic Brain Injury Patients with and without Intracranial Lesions

Authors: Peter Biberthaler, Ksenia Musaelyan, Sandro Krieg, Bernhard Meyer, Herbert Stimmer, Julian Zapf, Francesca von Matthey, Raj Chandran, Jaime A. Marino, Gangamani Beligere, Markus Hoffmann, Hongwei Zhang, Saul A. Datwyler, Beth McQuiston

Source: Neurotrauma Rep
Neurotrauma Reports, Vol 2, Iss 1, Pp 617-625 (2021)

Subject Terms: 03 medical and health sciences, S100 calcium-binding protein B, traumatic brain injury, 0302 clinical medicine, ubiquitin C-terminal hydrolase L1, RC86-88.9, glial fibrillary acidic protein, point-of-care platform, Medical emergencies. Critical care. Intensive care. First aid, Original Article, blood biomarkers, 3. Good health

Access URL: https://pubmed.ncbi.nlm.nih.gov/35018363
https://doaj.org/article/47d89edc38d243e2baf3ad6711edc2f5

Development of an electrochemical impedance spectroscopy based biosensor for detection of ubiquitin C-Terminal hydrolase L1

Authors: Lee, Jinhee ¹, Kane, Bryant J. ¹, Khanwalker, Mukund ¹, Sode, Koji ^∗

Source: In Biosensors and Bioelectronics 15 July 2022 208

Ubiquitin C-terminal hydrolase L1 after out-of-hospital cardiac arrest

Authors: The FINNRESUSCI Study Group, Wihersaari, Lauri, Reinikainen, Matti, Tiainen, Marjaana, Bendel, Stepani, Kaukonen, Kirsi-Maija, Vaahersalo, Jukka, Romppanen, Jarkko, Pettilä, Ville, Skrifvars, Markus B.

Contributors: HUS Neurocenter, Neurologian yksikkö, Department of Neurosciences, Clinicum, HUS Perioperative, Intensive Care and Pain Medicine, Department of Diagnostics and Therapeutics, HUS Emergency Medicine and Services

Subject Terms: Neurological outcome, ubiquitin C-terminal hydrolase L1, Resuscitation, Ohca, Surgery, anesthesiology, intensive care, radiology, Prognostication, Cardiac arrest, Biomarkers

File Description: application/pdf

Access URL: http://hdl.handle.net/10138/563404

Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes

Authors: Abuhamdah S, Saleem TH, Elsadek BE, Ashraf O, Hamdan AR, El-Khateeb EES, Abd Elwahab SM, Hassan MH

Source: International Journal of General Medicine, Vol 15, Pp 5795-5805 (2022)

Subject Terms: traumatic spinal cord injury, ubiquitin c-terminal hydrolase l1, neuroglobin, diagnostic and prognostic markers., Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/circulating-ubiquitin-carboxyl-terminal-hydrolase-l1-and-neuroglobin-l-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074

Access URL: https://doaj.org/article/cdc92b5cfe97488b8cc9b45b04296794

A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment

Authors: Sebastian Burkart, Christopher Weusthof, Karam Khorani, Sonja Steen, Fabian Stögbauer, Kristian Unger, Julia Hess, Horst Zitzelsberger, Claus Belka, Ina Kurth, Jochen Hess

Source: Cancers, Vol 15, Iss 6, p 1655 (2023)

Subject Terms: ubiquitin C-terminal hydrolase L1, radiotherapy, head and neck squamous cell carcinoma (HNSC, HNSCC), pan-cancer, integrative multi-omics analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Relation: https://www.mdpi.com/2072-6694/15/6/1655; https://doaj.org/toc/2072-6694; https://doaj.org/article/be93a4318f674595bc7271e7f515a107

Availability: https://doi.org/10.3390/cancers15061655
https://doaj.org/article/be93a4318f674595bc7271e7f515a107

Biomolecular Correlates of Chronic Affective Dysregulation in PTSD: A Combined Assessment Using the Cornell Dysthymia Rating Scale (CDRS) and the Serum Markers SUMO1, MDA, CX3CL1, and UCHL1.

Authors: Woźny-Rasała, Izabela, Ogłodek, Ewa Alicja

Source: Int J Mol Sci ; ISSN:1422-0067 ; Volume:26 ; Issue:20

Subject Terms: dysthymia, fractalkine, malondialdehyde, post-traumatic stress disorder, small ubiquitin-like modifier 1, ubiquitin C-terminal hydrolase L1

Relation: https://doi.org/10.3390/ijms262010214; https://pubmed.ncbi.nlm.nih.gov/41155506; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12564795/

Availability: https://doi.org/10.3390/ijms262010214
https://pubmed.ncbi.nlm.nih.gov/41155506
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12564795/

UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle

Authors: Ryan Antony, Katherine Aby, Hongbo Gao, Mary Eichholz, Rekha Srinivasan, Yifan Li

Source: Frontiers in Physiology, Vol 13 (2022)

Subject Terms: skeletal muscle, lipid, ubiquitin C-terminal hydrolase L1, perilipin 2, mice, C2C12 cell, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.855193/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/552d32f24af342c59d432d4602d9f26b