Ruthenium Drug BOLD-100 Regulates BRAF MT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

Authors: Daryl Griffin, Robbie Carson, Debbie Moss, Tamas Sessler, Deborah Lavin, Vijay K. Tiwari, Shivaali Karelia, Richard Kennedy, Kienan I. Savage, Simon McDade, Adam Carie, Jim Pankovich, Mark Bazett, Sandra Van Schaeybroeck

Source: Mol Cancer Res
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium drug BOLD-100 regulates BRAFmt colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151
Griffin, D, Carson, R, Moss, D, Sessler, T, Lavin, D, Tiwari, V K, Karelia, S, Kennedy, R, Savage, K I, McDade, S, Carie, A, Pankovich, J, Bazett, M & Van Schaeybroeck, S 2024, 'Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation', Molecular Cancer Research, vol. 22, no. 12, pp. 1088-1101. https://doi.org/10.1158/1541-7786.MCR-24-0151

Subject Terms: Proto-Oncogene Proteins B-raf, Basic Helix-Loop-Helix Proteins, Ataxia Telangiectasia Mutated Proteins/metabolism, name=Oncology, name=Cancer Research, colorectal cancer, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Cancer Genes and Networks, Receptors, Aryl Hydrocarbon/metabolism, Cell Line, ruthenium drug, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects, Cell Line, Tumor, Proto-Oncogene Proteins B-raf/genetics, Receptors, Basic Helix-Loop-Helix Transcription Factors, Humans, name=SDG 3 - Good Health and Well-being, Tumor, cell apoptosis, Apoptosis/drug effects, Colorectal Neoplasms/drug therapy, 3. Good health, Receptors, Aryl Hydrocarbon, Aryl Hydrocarbon/metabolism, BOLD-100, BRAFMT, Colorectal Neoplasms, Reactive Oxygen Species, Signal Transduction

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39083088
https://pure.qub.ac.uk/en/publications/357b4c8d-d077-4033-8c9a-433d6c961788
https://doi.org/10.1158/1541-7786.MCR-24-0151
https://pureadmin.qub.ac.uk/ws/files/611793665/Ruthenium_drug.pdf
https://findresearcher.sdu.dk/ws/files/279240332/mcr-24-0151.pdf
https://doi.org/10.1158/1541-7786.MCR-24-0151
https://portal.findresearcher.sdu.dk/da/publications/3d27516f-a3d5-4134-9523-74594c733a9f

Combinational studies of BOLD-100/KP1339 with established chemotherapeutics in gastrointestinal multicellular tumor spheroids

Authors: Wenisch, Dominik^Aff1, Ždravac, Slavica^Aff1, Jakupec, Michael A.^{Aff1, Aff2, IDs0028002604902z_cor1}, Jirsa, Franz^Aff3, Keppler, Bernhard K.^{Aff1, Aff2}

Source: Cancer Chemotherapy and Pharmacology. 96(1)

Frontiers of metal-coordinating drug design

Authors: Palermo, Giulia, Spinello, Angelo, Saha, Aakash, Magistrato, Alessandra

Source: Expert Opinion on Drug Discovery. 16(5)

Subject Terms: 3214 Pharmacology and Pharmaceutical Sciences (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 5.1 Pharmaceuticals (hrcs-rac), Generic health relevance (hrcs-hc), Antineoplastic Agents (mesh), Chemistry, Pharmaceutical (mesh), Computer Simulation (mesh), Coordination Complexes (mesh), Drug Design (mesh), Drug Discovery (mesh), Humans (mesh), Ligands (mesh), Metals (mesh), Metallodrug, metal-binding inhibitors, molecular dynamics, QM, MM, CYP450, ruthenium drug, breast cancer, prostate cancer, RAPTA, metallo-beta-lacatamases, aromatase, Humans (mesh), Metals (mesh), Antineoplastic Agents (mesh), Ligands (mesh), Drug Design (mesh), Chemistry, Pharmaceutical (mesh), Computer Simulation (mesh), Drug Discovery (mesh), Coordination Complexes (mesh), CYP450, Metallodrug, QM/MM, RAPTA, aromatase, breast cancer, metal-binding inhibitors, metallo-beta-lacatamases, molecular dynamics, prostate cancer, ruthenium drug, Antineoplastic Agents (mesh), Chemistry, Pharmaceutical (mesh), Computer Simulation (mesh), Coordination Complexes (mesh), Drug Design (mesh), Drug Discovery (mesh), Humans (mesh), Ligands (mesh), Metals (mesh), 1115 Pharmacology and Pharmaceutical Sciences (for), Pharmacology & Pharmacy (science-metrix), 3214 Pharmacology and pharmaceutical sciences (for-2020)

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Access URL: https://escholarship.org/uc/item/1r22p1jt
https://escholarship.org/content/qt1r22p1jt/qt1r22p1jt.pdf

Differences in the Cellular Response and Signaling Pathways between Cisplatin and Monodentate Organometallic Ru(II) Antitumor Complexes Containing a Terphenyl Ligand
Organometallic Ru(II) antitumor complex

Authors: Kisova, Anna^aff1, Zerzankova, Lenka^aff1, Habtemariam, Abraha^aff2, Sadler, Peter J.^aff2, Brabec, Viktor^aff3, Kasparkova, Jana^aff1

Source: Molecular Pharmaceutics. 8(3):949-957

Availability: https://pubs.acs.org/doi/10.1021/mp200105d