Metabolic Reprogramming of Tumors: Induced Immunosuppression and Therapeutic Prospects of Nanoscale Drug Delivery Systems.

Authors: Li Q; State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Guangdong Key Lab of Traditional Chinese Medicine Informatization, International Science and Technology Cooperation Base of Guangdong Province, School of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China., Meng F; Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China., Yang L; Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China., Díaz García AM; Bioinorganic Laboratory, Faculty of Chemistry, University of Havana, Havana 1400, Cuba., Parkhats M; B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, 68-2 Nezavisimosti Avenue, Minsk 220072, Belarus., Lee J; College of Pharmacy, Korea University, Sejong 30019, Republic of Korea., Kusamori K; Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan., Nishikawa M; Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan., Gu H; Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China., Li Q; Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China., Williams GR; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, U.K., Yang Z; Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China., Cai Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Guangdong Key Lab of Traditional Chinese Medicine Informatization, International Science and Technology Cooperation Base of Guangdong Province, School of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.

Source: Molecular pharmaceutics [Mol Pharm] 2025 Sep 01; Vol. 22 (9), pp. 5193-5211. Date of Electronic Publication: 2025 Jul 31.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH Terms: Antineoplastic Agents*/administration & dosage , Metabolic Reprogramming*/drug effects , Metabolic Reprogramming*/immunology , Nanoparticle Drug Delivery System* , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology, Animals ; Humans

Facilitating microglial phagocytosis by which Jiawei Xionggui Decoction alleviates cognitive impairment via TREM2-mediated energy metabolic reprogramming.

Authors: Wen W; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Chen J; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Xiang J; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Zhang S; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Liu J; Division of Biosciences, University College London, London WC1E6BT, UK., Wang J; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Wang P; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: viviansector@aliyun.com., Xu S; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: xushijun@cdutcm.edu.cn.

Source: Chinese journal of natural medicines [Chin J Nat Med] 2025 Aug; Vol. 23 (8), pp. 909-919.

Publication Type: Journal Article

Journal Info: Publisher: Science Press Country of Publication: China NLM ID: 101504416 Publication Model: Print Cited Medium: Internet ISSN: 1875-5364 (Electronic) Linking ISSN: 18755364 NLM ISO Abbreviation: Chin J Nat Med Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Microglia*/drug effects , Phagocytosis* , Cognitive Dysfunction*/drug therapy , Metabolic Reprogramming* , Membrane Glycoproteins*/metabolism, Animals ; Mice ; Cell Line ; Receptors, Immunologic/metabolism ; Signal Transduction ; Amyloid beta-Peptides/metabolism ; Energy Metabolism

Liquiritin and L -Dopa mitigate gaseous elemental mercury toxicity in Tillandsia usneoides: Insights into metabolic reprogramming and phytoremediation potential.

Authors: Gao Y; Chongqing Key Laboratory of Innovative Application of Genetic Technology, College of Resources and Environment, Southwest University, Chongqing 400715, China., Xiong B; Chongqing Key Laboratory of Innovative Application of Genetic Technology, College of Resources and Environment, Southwest University, Chongqing 400715, China., Huang X; Chongqing Key Laboratory of Innovative Application of Genetic Technology, College of Resources and Environment, Southwest University, Chongqing 400715, China., Sun X; Center of Molecular Ecophysiology (CMEP), College of Resources and Environment, Southwest University, Chongqing 400715, China., Du H; Chongqing Key Laboratory of Innovative Application of Genetic Technology, College of Resources and Environment, Southwest University, Chongqing 400715, China. Electronic address: duhx@swu.edu.cn., Ma M; Center of Molecular Ecophysiology (CMEP), College of Resources and Environment, Southwest University, Chongqing 400715, China; Yibin Academy of Southwest University, Yibin, Sichuan 644005, China. Electronic address: maming@swu.edu.cn.

Source: Journal of hazardous materials [J Hazard Mater] 2025 Sep 15; Vol. 496, pp. 139237. Date of Electronic Publication: 2025 Jul 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE

MeSH Terms: Tillandsia*/drug effects , Tillandsia*/metabolism , Mercury*/metabolism , Mercury*/toxicity , Air Pollutants*/metabolism , Air Pollutants*/toxicity , Levodopa*/metabolism , Metabolic Reprogramming*, Arabidopsis ; Biodegradation, Environmental ; Antioxidants/metabolism ; Proof of Concept Study ; Glucosides ; Flavanones

ZnO-NPs Neurotoxicity to Caenorhabditis elegans : Disorders of Fatty Acid Synthesis and Glutathione Metabolism.

Authors: Han X; Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China., Teng J; Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China., Chen X; Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China., Yan F; Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.

Source: Environmental science & technology [Environ Sci Technol] 2025 Sep 09; Vol. 59 (35), pp. 18450-18467. Date of Electronic Publication: 2025 Aug 22.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE

MeSH Terms: Zinc Oxide*/toxicity , Nanoparticles*/toxicity , Lipid Metabolism*/drug effects , Metabolic Reprogramming*/drug effects , Behavior, Animal*/drug effects , Nervous System*/drug effects, Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/metabolism ; Animals ; Fatty Acids/biosynthesis ; Glutathione/metabolism ; Neurotoxins/toxicity ; Learning/drug effects ; Oxidative Stress/drug effects ; Gene Expression/drug effects

Metabolic reprogramming and interventions in angiogenesis.

Authors: Liu Y; College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Wu Z; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China., Li Y; College of Animal Science and Technology, Southwest University, Chongqing 400715, China; College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China., Chen Y; College of Animal Science and Technology, Southwest University, Chongqing 400715, China., Zhao X; College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: zhaoxuann@swu.edu.cn., Wu M; Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address: miaomiaowu0316@hunau.edu.cn., Xia Y; College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: yaoyaoxia20230750@swu.edu.cn.

Source: Journal of advanced research [J Adv Res] 2025 Apr; Vol. 70, pp. 323-338. Date of Electronic Publication: 2024 May 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

MeSH Terms: Metabolic Reprogramming*/physiology , Endothelial Cells*/metabolism , Angiogenesis*/physiology , Vascular Diseases*/metabolism , Vascular Diseases*/physiopathology, Humans ; Animals ; Blood Vessels/cytology ; Blood Vessels/growth & development ; Blood Vessels/metabolism ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/physiopathology

Deciphering molecular drivers of lactate metabolic shift in mammalian cell cultures.

Authors: Torres M; Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, UK; Department of Chemical Engineering, University of Manchester, Manchester, UK. Electronic address: mauro.torressebastian@manchester.ac.uk., Hawke E; Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, UK; Department of Chemical Engineering, University of Manchester, Manchester, UK., Hoare R; FUJIFILM Diosynth Biotechnologies, Billingham, TS23 1LH, UK., Scholey R; Bioinformatics Core Facility, University of Manchester, Manchester, UK., Pybus LP; FUJIFILM Diosynth Biotechnologies, Billingham, TS23 1LH, UK., Young A; FUJIFILM Diosynth Biotechnologies, Billingham, TS23 1LH, UK., Hayes A; Genomic Technologies Core Facility, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Dickson AJ; Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, UK; Department of Chemical Engineering, University of Manchester, Manchester, UK. Electronic address: alan.dickson@manchester.ac.uk.

Source: Metabolic engineering [Metab Eng] 2025 Mar; Vol. 88, pp. 25-39. Date of Electronic Publication: 2024 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: Belgium NLM ID: 9815657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-7184 (Electronic) Linking ISSN: 10967176 NLM ISO Abbreviation: Metab Eng Subsets: MEDLINE

MeSH Terms: CHO Cells* , Lactic Acid*/metabolism , Glutamine*/metabolism , Metabolic Reprogramming* , Biotechnology*/methods, Animals ; Cricetulus ; Principal Component Analysis ; Gene Expression Profiling ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Bioreactors

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer.

Authors: Bowen MB; Department of Gynecologic Oncology., Melendez B; Department of Genomic Medicine., Zhang Q; Department of Gynecologic Oncology., Moreno D; Department of Gynecologic Oncology., Peralta L; Department of Gynecologic Oncology., Chan WK; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology., Jeter C; Department of Epigenetics and Molecular Carcinogenesis., Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology., Zal MA; Department of Epigenetics and Molecular Carcinogenesis., Lorenzi PL; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology., Dunner K Jr; Department of Cancer Biology, and., Yang RK; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Broaddus RR; Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Celestino J; Department of Gynecologic Oncology., Gokul N; Department of Gynecologic Oncology., Whitley E; Department of Veterinary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Scoville DM; Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Kim TH; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri, USA., Jeong JW; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri, USA., Schmandt R; Department of Gynecologic Oncology., Lu K; Department of Gynecologic Oncology., Kim HE; Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas, USA.j., Yates MS; Department of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

Source: JCI insight [JCI Insight] 2025 Feb 18; Vol. 10 (6). Date of Electronic Publication: 2025 Feb 18.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH Terms: Disease Models, Animal* , Endometrial Neoplasms*/etiology , Endometrial Neoplasms*/metabolism , Colorectal Neoplasms, Hereditary Nonpolyposis*/complications , Colorectal Neoplasms, Hereditary Nonpolyposis*/metabolism , MutS Homolog 2 Protein*/deficiency , MutS Homolog 2 Protein*/genetics , Metabolic Reprogramming* , Mitochondrial Diseases*/etiology , Mitochondrial Diseases*/metabolism, Humans ; Female ; Animals ; Mice ; Middle Aged ; Aged ; Cell Line, Tumor ; Mitochondrial Turnover/genetics

Single-cell transcriptomic analysis reveals T cell heterogeneity and metabolic reprogramming in human immune-mediated glomerulonephritis.

Authors: Qing J; Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhao Y; Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Cheungpasitporn W; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Miao J; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Thongprayoon C; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Wu H; Department of Nephrology, Affiliated Hospital of Jiaxing University (The First Hospital of Jiaxing), Jiaxing, China., Wu J; Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Source: Autoimmunity [Autoimmunity] 2025 Dec 31; Vol. 58 (1), pp. 2582720. Date of Electronic Publication: 2025 Nov 16.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8900070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-842X (Electronic) Linking ISSN: 08916934 NLM ISO Abbreviation: Autoimmunity Subsets: MEDLINE

MeSH Terms: Glomerulonephritis*/immunology , Glomerulonephritis*/metabolism , Glomerulonephritis*/genetics , Transcriptome* , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , T-Lymphocyte Subsets*/immunology , T-Lymphocyte Subsets*/metabolism, Humans ; Single-Cell Analysis ; Gene Expression Profiling ; Lupus Nephritis/immunology ; Lupus Nephritis/metabolism ; Lupus Nephritis/genetics ; Male ; Female ; Glomerulonephritis, IGA/immunology ; Glomerulonephritis, IGA/metabolism ; Glomerulonephritis, IGA/genetics ; Metabolic Reprogramming

CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.

Authors: Hao J; The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Zheng J; The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Liu C; The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Lu J; Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, China., Tan M; Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, China., Li J; Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, China., Mao J; The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Yu Y; The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Wang H; The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Zhang Y; Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, China., Shen H; Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou, China. Electronic address: shenhl@lzu.edu.cn.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115594. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: CD36 Antigens*/metabolism , CD36 Antigens*/genetics , Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/pathology , Arthritis, Rheumatoid*/immunology , Fibroblasts*/metabolism , Fatty Acids*/metabolism , Synoviocytes*/metabolism , Synovial Membrane*/pathology, Humans ; Animals ; Male ; Disease Progression ; Signal Transduction ; Cells, Cultured ; Mice ; Female ; Cell Proliferation ; Middle Aged ; Cell Movement ; Apoptosis ; TOR Serine-Threonine Kinases/metabolism ; Metabolic Reprogramming

The interplay between extracellular matrix remodeling and cellular lipid metabolic reprogramming in cancer: a review.

Authors: Yin M; Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.; State Key Laboratory of Digestive Health, Beijing, 101100, China.; National Clinical Research Center for Digestive Disease, Beijing, 100069, China., Li X; Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.; State Key Laboratory of Digestive Health, Beijing, 101100, China.; National Clinical Research Center for Digestive Disease, Beijing, 100069, China.; Department of Gastroenterology and Hepatology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China., Zhang S; Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. zhangshutian@ccmu.edu.cn.; State Key Laboratory of Digestive Health, Beijing, 101100, China. zhangshutian@ccmu.edu.cn.; National Clinical Research Center for Digestive Disease, Beijing, 100069, China. zhangshutian@ccmu.edu.cn., Xie SA; Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. xiesian2022@mail.ccmu.edu.cn.; State Key Laboratory of Digestive Health, Beijing, 101100, China. xiesian2022@mail.ccmu.edu.cn.; National Clinical Research Center for Digestive Disease, Beijing, 100069, China. xiesian2022@mail.ccmu.edu.cn.

Source: Molecular biology reports [Mol Biol Rep] 2025 Dec 01; Vol. 53 (1), pp. 145. Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH Terms: Extracellular Matrix*/metabolism , Neoplasms*/metabolism , Neoplasms*/pathology , Lipid Metabolism*/physiology, Humans ; Tumor Microenvironment ; Animals ; Fatty Acids/metabolism ; Lipogenesis ; Signal Transduction ; Metabolic Reprogramming

Laminar double hydroxide-loaded miR-654-3p targets POU2F1-mediated metabolic reprogramming against colorectal cancer.

Authors: Shi J; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; Anhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials,Anhui 233030, China., Zhu C; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China., Xu S; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; The Third the Pople's Hospital of Bengbu, Anhui 233000, China., Ran R; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; Department of Life Sciences, Bengbu Medical University, Anhui 233030, China., Ye R; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; Department of Life Sciences, Bengbu Medical University, Anhui 233030, China., Xiao Y; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China., Ji Y; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China., Geng C; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; Department of Life Sciences, Bengbu Medical University, Anhui 233030, China., Tang G; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; Department of Life Sciences, Bengbu Medical University, Anhui 233030, China., Li R; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China; School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China., Ding Y; The Third the Pople's Hospital of Bengbu, Anhui 233000, China., Wang W; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China. Electronic address: wenrui-wang1983@163.com., Yang Q; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China. Electronic address: yqlmimi@163.com., Chen C; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, Anhui 233030, China. Electronic address: tochenchangjie@163.com.

Source: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109234. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: MicroRNAs*/metabolism , MicroRNAs*/genetics , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Hydroxides*/chemistry , Hydroxides*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Octamer Transcription Factor-1*/metabolism , Octamer Transcription Factor-1*/genetics , Octamer Transcription Factor-3*/metabolism , Octamer Transcription Factor-3*/genetics, Humans ; Animals ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Mice ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Metabolic Reprogramming

Tumor microenvironment and metabolic reprogramming: Unraveling the complex interplay in gastrointestinal tumor liver metastasis.

Authors: Wang S; Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China., Ma Z; Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China., Lv L; Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China., Yu Q; Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China., Liu S; Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: liushanglong@qdyy.cn., Lu Y; Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: luyun@qdu.edu.cn.

Source: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Dec; Vol. 216, pp. 105001. Date of Electronic Publication: 2025 Nov 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment* , Liver Neoplasms*/secondary , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Gastrointestinal Neoplasms*/pathology , Gastrointestinal Neoplasms*/metabolism, Humans ; Animals ; Metabolic Reprogramming

LncRNA HCP5: A key regulator of tumor metabolic reprogramming, signaling pathway modulation, and therapeutic resistance.

Authors: Peng C; Department of Otorhinolaryngology, Hengyang First People's Hospital, Hengyang, 421002, Hunan Province, China., Zhang F; Department of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, Hengyang, 421001, Hunan Province, China., Zhou F; Department of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, Hengyang, 421001, Hunan Province, China., Tan S; Department of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, Hengyang, 421001, Hunan Province, China. Electronic address: tansonghong2020@163.com., Xie W; Department of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, Hengyang, 421001, Hunan Province, China. Electronic address: doctorxie315@163.com.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 1), pp. 148606. Date of Electronic Publication: 2025 Oct 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Signal Transduction*/genetics , Drug Resistance, Neoplasm*/genetics , Neoplasms*/genetics , Neoplasms*/metabolism , Neoplasms*/therapy , Neoplasms*/pathology, Humans ; Gene Expression Regulation, Neoplastic ; Animals ; Metabolic Reprogramming

A metabolic reprogramming and trained immunity hydrogel mimic cluster missiles to eliminate infection and treat infected diabetic wounds.

Authors: Yu Z; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Chen Z; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Xie H; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou, 311300, China., Duan P; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Hu H; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Zhang H; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Ye X; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Yu Y; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Cheng Y; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Pan Z; Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. zn000382@whu.edu.cn.

Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Nov 28; Vol. 23 (1), pp. 749. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE

MeSH Terms: Hydrogels*/chemistry , Hydrogels*/pharmacology , Diabetes Mellitus, Experimental*/complications , Wound Infection*/therapy , Wound Infection*/drug therapy , Staphylococcal Infections*/drug therapy, Animals ; Rats ; Wound Healing/drug effects ; Rats, Sprague-Dawley ; Male ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Reactive Oxygen Species/metabolism ; Anti-Bacterial Agents/pharmacology ; Photothermal Therapy ; Bandages ; Metabolic Reprogramming ; Trained Immunity

Mitochondria-Targeted HA-Coated Nanosystem for ROS/CO Generation and Metabolic Reprogramming to Enhance Tumoricidal Macrophage Polarization.

Authors: Peng N; Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China.; Chia-Poland Belt and Road Joint Laboratory on Measurement and Control Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Song C; Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China., Liu X; Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China., Nowicki M; Institute of Metrology and Biomedical Engineering Faculty of Mechatronics, Warsaw University of Technology, 00-661 Warsaw, Poland., Szewczyk R; Institute of Metrology and Biomedical Engineering Faculty of Mechatronics, Warsaw University of Technology, 00-661 Warsaw, Poland., Wang Y; Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.; Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China., Liu Y; Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China.; School of Chemistry and Materials Sciences & School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.

Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 19; Vol. 17 (46), pp. 63041-63056. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

MeSH Terms: Reactive Oxygen Species*/metabolism , Mitochondria*/metabolism , Mitochondria*/drug effects , Hyaluronic Acid*/chemistry , Tumor-Associated Macrophages*/drug effects , Tumor-Associated Macrophages*/metabolism , Nanoparticles*/chemistry, Animals ; Mice ; Female ; Macrophages/drug effects ; Macrophages/metabolism ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Zirconium/chemistry ; Humans ; Organophosphorus Compounds/chemistry ; Metabolic Reprogramming

Multi-target synergistic anti-aging: QG extends Caenorhabditis elegans lifespan through DAF-16/FOXO pathways, mitochondrial homeostasis and metabolic reprogramming.

Authors: Wang J; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China., Li S; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China., Lei Z; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China., Xing Y; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China., Li J; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China., Guo J; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China., Duan B; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China. duanboshi@cicams-sz.org.cn., Liu Y; College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China. liuyg0228@163.com.

Source: Biogerontology [Biogerontology] 2025 Nov 18; Vol. 27 (1), pp. 6. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE

MeSH Terms: Caenorhabditis elegans*/drug effects , Caenorhabditis elegans*/metabolism , Longevity*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Aging*/drug effects, Animals ; Homeostasis/drug effects ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Metabolic Reprogramming

Multi-omics unravel heterogeneity of glucose metabolism reprogramming in gastric cancer.

Authors: Liang L; Department of General Surgery, Wuhan Xinzhou District People's Hospital, Wuhan, 431400, China. 13871168618@163.com., Jianming C; Department of General Surgery, Wuhan Xinzhou District People's Hospital, Wuhan, 431400, China., Xiaoan Q; Department of General Surgery, Wuhan Xinzhou District People's Hospital, Wuhan, 431400, China., Jinxi L; Department of General Surgery, Wuhan Xinzhou District People's Hospital, Wuhan, 431400, China.

Source: Clinical and experimental medicine [Clin Exp Med] 2025 Nov 18; Vol. 26 (1), pp. 21. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , Stomach Neoplasms*/pathology , Stomach Neoplasms*/mortality , Glucose*/metabolism, Humans ; Prognosis ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Transcriptome ; Metabolic Reprogramming ; Multiomics

The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming.

Authors: Grimmett ZW; Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, United States.; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States., Zhang R; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.; Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, United States., Zhou HL; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States., Chen Q; Department of Pharmacology, Weill Cornell Medicine, New York, United States., Miller D; Department of Pharmacology, Weill Cornell Medicine, New York, United States., Qian Z; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States., Lin J; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States., Kalra R; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States., Gross SS; Department of Pharmacology, Weill Cornell Medicine, New York, United States., Koch WJ; Department of Surgery, Duke University School of Medicine, Durham, United States.; Department of Medicine, Duke University School of Medicine, Durham, United States., Premont RT; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, United States., Stamler JS; Institute for Transformative Molecular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, United States.

Source: ELife [Elife] 2025 Nov 17; Vol. 14. Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH Terms: Myocardial Infarction*/metabolism , Myocardial Infarction*/pathology, Animals ; Mice ; Humans ; Mice, Knockout ; Disease Models, Animal ; Nitric Oxide/metabolism ; Metabolic Reprogramming

Radix Rehmanniae Praeparata Extract Enhances Liver Regeneration Through AMPK-Driven Metabolic Reprogramming.

Authors: Li C; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China., Zheng Q; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China., Li F; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China., Zhang Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Duan S; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China., Liu J; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Han Q; School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China., Liu R; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China.

Source: Nutrients [Nutrients] 2025 Nov 15; Vol. 17 (22). Date of Electronic Publication: 2025 Nov 15.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

MeSH Terms: Liver Regeneration*/drug effects , Rehmannia*/chemistry , AMP-Activated Protein Kinases*/metabolism , Plant Extracts*/pharmacology , Drugs, Chinese Herbal*/pharmacology, Animals ; Mice ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Cell Proliferation/drug effects ; Male ; Mice, Inbred C57BL ; Lipid Metabolism/drug effects ; Hepatectomy ; Liver/drug effects ; Liver/metabolism ; Cell Line ; Metabolic Reprogramming

Metabolic reprogramming of hippocampal endothelial cells contributes to blood-brain barrier dysfunction in perioperative neurocognitive disorder.

Authors: Qiu Y; Department of Anesthesiology, Zigong First People's Hospital, Zigong Academy of Medical Sciences, Zigong, 643000, Sichuan Province, China., Mo C; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: chunhengmo@gmail.com.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 14; Vol. 789, pp. 152857. Date of Electronic Publication: 2025 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/pathology , Blood-Brain Barrier*/physiopathology , Hippocampus*/metabolism , Hippocampus*/pathology , Endothelial Cells*/metabolism , Endothelial Cells*/pathology , Neurocognitive Disorders*/metabolism , Neurocognitive Disorders*/pathology , Neurocognitive Disorders*/etiology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Metabolic Reprogramming