Leptin mediates the effects of sulfur amino acid restriction on food intake and body weight in mice.

Συγγραφείς: Cooke D; Orentreich Foundation for the Advancement of Science, Inc., Cold Spring, New York, USA., Ouattara A; Orentreich Foundation for the Advancement of Science, Inc., Cold Spring, New York, USA., Ables GP; Orentreich Foundation for the Advancement of Science, Inc., Cold Spring, New York, USA. Electronic address: gables@orentreich.org.

Πηγή: The Journal of nutritional biochemistry [J Nutr Biochem] 2026 Oct; Vol. 156, pp. 110396. Date of Electronic Publication: 2026 May 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Leptin*/blood , Leptin*/genetics , Amino Acids, Sulfur*/deficiency , Eating* , Body Weight*, Hypothalamus/metabolism ; Obesity/metabolism ; Obesity/etiology ; Receptors, Leptin/genetics ; Receptors, Leptin/metabolism ; Uncoupling Protein 1/metabolism ; Adipose Tissue, Brown/metabolism ; Animals ; Male ; Mice ; Iodothyronine Deiodinase Type II ; Mice, Inbred C57BL ; Mice, Obese ; Weight Loss

Circuit Mechanisms Underlying the Contribution of Leptin Receptor-Expressing Neurons in the Nucleus Tractus Solitarius to Ventilatory Homeostasis.

Συγγραφείς: Hao Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.; Experimental Center for Teaching, Hebei Medical University, Shijiazhuang, 050017, China., Zhu M; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.; Department of Laboratory Diagnostics, Hebei Medical University, Shijiazhuang, 050017, China., Yu H; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Zhang X; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Shi Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Sun L; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Hao Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Huang Y; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Yu L; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China., Wang S; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.; Hebei Key Laboratory of Brain Science and Brain-Inspired Intelligence, Shijiazhuang, 050017, China.; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, 050017, China., Zhao D; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510162, China. rieast@163.com., Yuan F; Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. yuanfang@hebmu.edu.cn.; Hebei Key Laboratory of Brain Science and Brain-Inspired Intelligence, Shijiazhuang, 050017, China. yuanfang@hebmu.edu.cn.; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, 050017, China. yuanfang@hebmu.edu.cn.

Πηγή: Neuroscience bulletin [Neurosci Bull] 2026 Oct; Vol. 42 (10), pp. 2199-2218. Date of Electronic Publication: 2026 Apr 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Solitary Nucleus*/metabolism , Neurons*/metabolism , Receptors, Leptin*/metabolism , Receptors, Leptin*/genetics , Homeostasis*/physiology , Sleep Apnea Syndromes*/physiopathology , Sleep Apnea Syndromes*/metabolism , Respiration*, Leptin/metabolism ; Neural Pathways/metabolism ; Animals ; Mice, Inbred C57BL ; Male ; Mice

FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance.

Συγγραφείς: Shen Q; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China., Zou H; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China., Jin L; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China., Liu J; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China., Wang S; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou 510005, Guangdong Province, China; Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China., Li N; The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Centre for Stem Cell Translational Biology, The University of Hong Kong, Hong Kong SAR, China., Zhou R; AIDS Institute and Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Yue M; AIDS Institute and Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Wang B; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China., Yang R; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China., Song E; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Institute of Metabolic Science, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510005, Guangdong Province, China., Lin Y; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China., Liao S; The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Centre for Stem Cell Translational Biology, The University of Hong Kong, Hong Kong SAR, China., Chen Z; AIDS Institute and Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Xiao Y; National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China; Furong Laboratory, Central South University, Changsha 410008, Hunan Province, China., Chan YS; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou 510005, Guangdong Province, China; The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China., Tse HF; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Centre for Stem Cell Translational Biology, The University of Hong Kong, Hong Kong SAR, China., Xu A; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, The University of Hong Kong, Hong Kong SAR, China; Guangdong-Hong Kong Joint Laboratory for Metabolic Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: amxu@hku.hk.

Πηγή: Cell metabolism [Cell Metab] 2026 Sep 01; Vol. 38 (9), pp. 1815-1834.e8. Date of Electronic Publication: 2026 Jul 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Leptin*/agonists , Fibroblast Growth Factors*/metabolism , Fibroblast Growth Factors*/pharmacology , Obesity*/metabolism , Obesity*/complications , Liver*/metabolism , Liver*/drug effects, Receptors, Leptin/metabolism ; Adiponectin/metabolism ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Fatty Liver/metabolism ; Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Insulin Resistance

Genetic burden of rare leptin-melanocortin variants in pediatric nonsyndromic obesity: Evidence from a Taiwanese cohort.

Συγγραφείς: Chang YM; Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan., Hwang DY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan., Chou YY; Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan., Pan YW; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan., Weng YH; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan., Tsai MC; Department of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan; Department of Medical Humanities and Social Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: mengchets@gs.ncku.edu.tw.

Πηγή: Obesity research & clinical practice [Obes Res Clin Pract] 2026 Sep-Oct; Vol. 20 (5), pp. 401-408. Date of Electronic Publication: 2026 Aug 03.

Τύπος έκδοσης: Journal Article; Observational Study

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101303911 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1871-403X (Print) Linking ISSN: 1871403X NLM ISO Abbreviation: Obes Res Clin Pract Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/genetics , Pediatric Obesity*/genetics, Receptors, Leptin/genetics ; Humans ; Child ; Taiwan ; Female ; Child, Preschool ; Male ; Prospective Studies ; Adolescent ; Genetic Variation ; Genetic Predisposition to Disease

Vascular Endothelial Growth Factor Receptors 1 and 3 Mediate Placental Trophoblast Leptin Production in Preeclampsia, Inducing Vascular Dysfunction.

Συγγραφείς: Elgazzaz M; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Ogbi S; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Moronge D; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Mellott E; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Cooper G; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Backer K; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Brawley A; Department of Obstetrics and Gynecology (A.B., P.C.W., J.M., J.L.F.), Medical College of Georgia at Augusta University., Hernendez G; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Hitchings J; Department of Pathology (J.H., L.V.Z., S.K.), Medical College of Georgia at Augusta University., Valesquez Zarate L; Department of Pathology (J.H., L.V.Z., S.K.), Medical College of Georgia at Augusta University., Kavuri S; Department of Pathology (J.H., L.V.Z., S.K.), Medical College of Georgia at Augusta University., Lee TJ; Department of Cellular Biology and Anatomy (T.J.L.), Medical College of Georgia at Augusta University., Ilatovskaya DV; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University., Woodham PC; Department of Obstetrics and Gynecology (A.B., P.C.W., J.M., J.L.F.), Medical College of Georgia at Augusta University., Maher J; Department of Obstetrics and Gynecology (A.B., P.C.W., J.M., J.L.F.), Medical College of Georgia at Augusta University., Annex BH; Vascular Biology Center and Department of Medicine (B.H.A.), Medical College of Georgia at Augusta University., Faulkner JL; Department of Physiology (M.E., S.O., D.M., E.M., G.C., K.B., G.H., D.V.I., J.L.F.), Medical College of Georgia at Augusta University.; Department of Obstetrics and Gynecology (A.B., P.C.W., J.M., J.L.F.), Medical College of Georgia at Augusta University.

Πηγή: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2026 Sep; Vol. 46 (9), pp. e324143. Date of Electronic Publication: 2026 Jul 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Pre-Eclampsia*/physiopathology , Pre-Eclampsia*/metabolism , Vascular Endothelial Growth Factor Receptor-1*/metabolism , Vascular Endothelial Growth Factor Receptor-1*/administration & dosage , Trophoblasts*/metabolism , Trophoblasts*/drug effects, Receptors, Leptin/metabolism ; Pregnancy Proteins/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/pharmacology ; Female ; Animals ; Pregnancy ; Humans ; Placenta Growth Factor ; Cells, Cultured ; Mice, Inbred C57BL ; Disease Models, Animal ; Mice ; Signal Transduction

Curcumin Improves Redox Status and Insulin Sensitivity in the Periphery and Decreases Leptin Receptor Expression in the Arcuate Nucleus in Obese Diabetic Mice.

Συγγραφείς: Flores-Cortez YA; Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico., Mendoza-Bello JM; Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico., Salinas-Bautista E; Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico., Cortes-Sarabia K; Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico., Ramirez M; SECIHTI-Faculty of Chemical and Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico., Lamas M; Department of Pharmacobiology, Cinvestav Sede Sur, Mexico City, Mexico., Calvario-Pino RY; Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico., Sánchez-Alavez M; Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Baja California, Mexico.; Department of Molecular and Cellular Biology, The Scripps Research Institute, San Diego, California, USA., Espinoza-Rojo M; Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo, Guerrero, Mexico.

Πηγή: Molecular nutrition & food research [Mol Nutr Food Res] 2026 May; Vol. 70 (10), pp. e70499.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Leptin*/metabolism , Receptors, Leptin*/genetics , Curcumin*/pharmacology , Arcuate Nucleus of Hypothalamus*/metabolism , Arcuate Nucleus of Hypothalamus*/drug effects , Obesity*/metabolism , Obesity*/drug therapy , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/drug therapy , Insulin Resistance*, Leptin/blood ; Leptin/metabolism ; Oxidative Stress/drug effects ; Antioxidants/pharmacology ; Diet, High-Fat/adverse effects ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/drug effects ; Intra-Abdominal Fat/metabolism ; Intra-Abdominal Fat/drug effects ; Protein Carbonylation/drug effects ; Insulin/blood ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Glutathione Peroxidase/metabolism ; Animals ; Male ; Mice, Inbred C57BL ; Oxidation-Reduction ; Mice

[Role of leptin receptor in the dorsal vagal complex in the inhibition of food intake in obese mice by electroacupuncture at "Zusanli" (ST36)].

Συγγραφείς: Li K; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029., Wang YL; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China., Xiao WH; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China., Lu LQ; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China., Lu MJ; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China., Xu TC; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China., Xu B; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China., Bao C; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029. drbaochao@163.com., Yu Z; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. yuzhi@njucm.edu.cn.

Πηγή: Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2026 Jul 25; Vol. 51 (7), pp. 858-865.

Τύπος έκδοσης: English Abstract; Journal Article

Στοιχεία περιοδικού: Publisher: Institute Of Acupuncture And Moxibustion Country of Publication: China NLM ID: 8507710 Publication Model: Print Cited Medium: Print ISSN: 1000-0607 (Print) Linking ISSN: 10000607 NLM ISO Abbreviation: Zhen Ci Yan Jiu Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Leptin*/metabolism , Receptors, Leptin*/genetics , Obesity*/therapy , Obesity*/metabolism , Obesity*/genetics , Obesity*/physiopathology , Vagus Nerve*/metabolism , Electroacupuncture* , Eating* , Acupuncture Points*, Leptin/metabolism ; Insulin/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Proto-Oncogene Proteins c-fos/genetics ; Animals ; Mice ; Male ; Mice, Inbred C57BL ; Humans ; Mice, Obese

Leptin-driven microglial activation in fibromyalgia: mechanistic insights and therapeutic implications.

Συγγραφείς: Abdelrheem NM; Postgraduate program in Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Giza, Egypt., Ahmed MAE; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Giza, Egypt., Mohamed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt., Shalaby HN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address: heba.nasr@pharma.cu.edu.eg., El Sayed NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Faculty of Pharmacy, Al Ryada University for Science and Technology, Sadat City, Menoufia 16504, Egypt.

Πηγή: International immunopharmacology [Int Immunopharmacol] 2026 Jul 01; Vol. 180, pp. 116657. Date of Electronic Publication: 2026 Apr 19.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Leptin*/immunology , Microglia*/immunology , Microglia*/metabolism , Fibromyalgia*/immunology , Fibromyalgia*/metabolism , Fibromyalgia*/drug therapy, Receptors, Leptin/metabolism ; Neuroinflammatory Diseases/immunology ; Humans ; Animals ; Signal Transduction ; Nociplastic Pain

Genetic variability in the leptin-melanocortin pathway and its role in weight loss.

Συγγραφείς: Santos-Pereira M; Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4050-313, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal., Guimarães M; Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4050-313, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal; Department of General Surgery, Hospital São Sebastião, Unidade Local de Saúde de Entre o Douro e Vouga, Rua Dr. Cândido Pinho, 4050-220, Santa Maia da Feira, Portugal., Monteiro MP; Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4050-313, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal., Pereira SS; Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4050-313, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal. Electronic address: sspereira@icbas.up.pt., Azevedo L; Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4050-313, Porto, Portugal; Laboratory for Integrative and Translational Research in Population Health (ITR), University of Porto, Rua das Taipas, n° 135, 4050-600, Porto, Portugal. Electronic address: lazevedo@icbas.up.pt.

Πηγή: Molecular metabolism [Mol Metab] 2026 Jun; Vol. 108, pp. 102377. Date of Electronic Publication: 2026 Apr 28.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Weight Loss*/genetics , Leptin*/genetics , Leptin*/metabolism , Obesity*/genetics , Obesity*/metabolism , Melanocortins*/metabolism , Melanocortins*/genetics, Signal Transduction/genetics ; Energy Metabolism/genetics ; Receptors, Leptin/genetics ; Receptors, Leptin/metabolism ; Pro-Opiomelanocortin/genetics ; Receptor, Melanocortin, Type 4/genetics ; Humans ; Genetic Variation ; Animals ; Bariatric Surgery

Leptin Receptor Fibroblasts Are Preferential Contributors to Cardiac Fibrosis.

Συγγραφείς: Larcher V; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.)., Fischer A; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.)., Zhang L; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA (L.Z., S.M.E.)., Almolla O; Centro Cardiologico Monzino IRCCS, Milan, Italy (O.A., M.C., F.A., C.W., P.C., N.G.-C.)., Chiesa M; Centro Cardiologico Monzino IRCCS, Milan, Italy (O.A., M.C., F.A., C.W., P.C., N.G.-C.).; Department of Electronics, Information and Biomedical Engineering, Politecnico di Milano, Milan, Italy (M.C.)., Andriani F; Centro Cardiologico Monzino IRCCS, Milan, Italy (O.A., M.C., F.A., C.W., P.C., N.G.-C.)., Wernet C; Centro Cardiologico Monzino IRCCS, Milan, Italy (O.A., M.C., F.A., C.W., P.C., N.G.-C.)., Serio S; IRCCS Humanitas Research Hospital, Rozzano, Italy (S.S.).; Institute of Genetic and Biomedical Research (IRGB), Milan Unit, National Research Council, Milan, Italy (S.S.)., Tombor LS; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.)., Peruzzo S; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.)., Mukherjee D; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.)., Bussani R; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (R.B., S.Z.)., Zacchigna S; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (R.B., S.Z.).; International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy (S.Z.)., Adams RH; Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany (R.H.A.)., Dimmeler S; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.)., Evans SM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA (L.Z., S.M.E.).; Department of Medicine and Department of Pharmacology, University of California San Diego, La Jolla, CA (S.M.E.)., Cattaneo P; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Centro Cardiologico Monzino IRCCS, Milan, Italy (O.A., M.C., F.A., C.W., P.C., N.G.-C.).; Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy (P.C.)., Guimarães-Camboa N; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany (V.L., A.F., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; German Centre for Cardiovascular Research (DZHK), Partner Site Rhein Main, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Cardiopulmonary Institute, Frankfurt am Main, Germany (V.L., L.S.T., S.P., D.M., S.D., P.C., N.G.-C.).; Centro Cardiologico Monzino IRCCS, Milan, Italy (O.A., M.C., F.A., C.W., P.C., N.G.-C.).

Πηγή: Circulation research [Circ Res] 2026 May 22; Vol. 138 (11), pp. e327701. Date of Electronic Publication: 2026 Apr 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Leptin*/metabolism , Receptors, Leptin*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Myocardium*/pathology , Myocardium*/metabolism , Myocardial Infarction*/pathology , Myocardial Infarction*/metabolism , Myocardial Infarction*/genetics, Leptin/metabolism ; Animals ; Fibrosis ; Humans ; Mice ; Signal Transduction ; Male ; Mice, Inbred C57BL ; Cell Proliferation ; Disease Models, Animal ; Cells, Cultured

The perineurium integrates leptin with its sympathetic outflow to protect against obesity.

Συγγραφείς: Sarker G; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Haberman E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Chandran A; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Monfeuga T; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Maroteau C; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Lundh S; Department of Pathology and Imaging, Global Drug Discovery, Novo Nordisk, Måløv, Denmark., Oliveira DS; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Raimondi A; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ziegler K; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Gomes T; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal., Cordeiro TN; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal., Parekh K; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Schmid E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Fernández-Sanmartín P; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain., Griebel A; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany., Martinez-Sanchez N; Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK., Arús BA; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Department of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Cheung SW; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Zhu Y; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Shaked M; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Knowles SCL; Department of Biology, University of Oxford, Oxford, UK., Engelhardt SH; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany., Iannacone M; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scherer PE; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., López M; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain., Toledo EM; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Domingos AI; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. ana.domingos@dpag.ox.ac.uk.

Πηγή: Nature metabolism [Nat Metab] 2026 Jul; Vol. 8 (7), pp. 1563-1582. Date of Electronic Publication: 2026 Jul 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Obesity*/metabolism , Obesity*/prevention & control , Obesity*/genetics , Peripheral Nerves*/metabolism , Sympathetic Nervous System*, Receptors, Leptin/metabolism ; Receptors, Leptin/genetics ; Receptors, Adrenergic, beta-2/genetics ; Receptors, Adrenergic, beta-2/metabolism ; Ganglia, Sympathetic/metabolism ; Animals ; Male ; Mice ; Energy Metabolism ; Humans ; Mice, Knockout ; Thermogenesis

Serum Leptin Exacerbates Osteoarthritis by Promoting Subchondral Bone H-Type Vessel Angiogenesis via Activation of the PI3K/AKT Pathway.

Συγγραφείς: Li R; University Town Hospital of Chongqing Medical University, Chongqing, China., Xi Z; University Town Hospital of Chongqing Medical University, Chongqing, China., Luo S; University Town Hospital of Chongqing Medical University, Chongqing, China., Qin J; University Town Hospital of Chongqing Medical University, Chongqing, China., Liu T; University Town Hospital of Chongqing Medical University, Chongqing, China., Zhang J; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Πηγή: Journal of cellular and molecular medicine [J Cell Mol Med] 2026 Jul; Vol. 30 (13), pp. e71232.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/blood , Phosphatidylinositol 3-Kinases*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Osteoarthritis*/pathology , Osteoarthritis*/blood , Neovascularization, Pathologic*/pathology , Neovascularization, Pathologic*/blood , Bone and Bones*/pathology , Bone and Bones*/blood supply , Bone and Bones*/metabolism , Angiogenesis*, Mesenchymal Stem Cells/metabolism ; Receptors, Leptin/metabolism ; Animals ; Humans ; Signal Transduction ; Mice ; Male ; Mice, Knockout ; Osteogenesis ; Mice, Inbred C57BL ; Female

Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity.

Συγγραφείς: Liang X; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Pan S; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Ji J; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Deng Y; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Chen M; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Huang Z; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Deng J; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Chen M; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Xiong T; Department of Occupational Health, Shenzhen Bao'an District Public Health Center, Shenzhen, China‌‌., Liang J; Department of School Health, Guangzhou Health Care Promotion Center for Primary and Middle Schools, Guangzhou, China., Liu L; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Πηγή: PloS one [PLoS One] 2026 May 15; Vol. 21 (5), pp. e0348694. Date of Electronic Publication: 2026 May 15 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/genetics , Leptin*/metabolism , Pediatric Obesity*/genetics , Melanocortins*/genetics , Melanocortins*/metabolism , Exercise*, Receptors, Leptin/genetics ; Receptor, Melanocortin, Type 4/genetics ; Pro-Opiomelanocortin/genetics ; Humans ; Child ; Case-Control Studies ; Female ; Adolescent ; Male ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Sleep Duration ; Genetic Risk Score ; Genetic Variation ; Risk Factors ; Sleep

Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.

Συγγραφείς: Hall JE; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Clinical and Translational Research, University of Mississippi Medical Center, Jackson, MS, U.S.A., Omoto ACM; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A., do Carmo JM; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A., da Silva AA; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A., Mouton AJ; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A., Wang Z; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A., Hall ME; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Mississippi Center for Clinical and Translational Research, University of Mississippi Medical Center, Jackson, MS, U.S.A.; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, U.S.A.

Πηγή: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2026 Jul 15; Vol. 140 (7), pp. 1473-1496.

Τύπος έκδοσης: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Brain*/metabolism , Receptor, Melanocortin, Type 4*/metabolism , Adipocytes*/metabolism , Melanocortins*/metabolism, Receptors, Leptin/metabolism ; Obesity/metabolism ; Obesity/physiopathology ; Sympathetic Nervous System/physiopathology ; Sympathetic Nervous System/metabolism ; Humans ; Animals ; Signal Transduction

Genotype-Phenotype Spectrum of Non-Syndromic Monogenic Obesity in a National Paediatric Cohort.

Συγγραφείς: Kahveci A; Department of Paediatric Endocrinology, Marmara University Faculty of Medicine, Istanbul, Türkiye., Karauzum SU; Department of Paediatric Endocrinology, Ege University Faculty of Medicine, Izmir, Türkiye., Manyas H; Department of Paediatric Endocrinology, Sanliurfa Eyyubiye Training and Research Hospital, Sanliurfa, Türkiye., Ozdemir BS; Department of Paediatric Endocrinology, Ankara Etlik City Hospital, Ankara, Türkiye., Orbak Z; Department of Paediatric Endocrinology, Ataturk University Faculty of Medicine, Erzurum, Türkiye., Tercan U; Department of Paediatric Endocrinology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Yildirim R; Department of Paediatric Endocrinology, Diyarbakir Children Hospital, Diyarbakir, Türkiye., Hatipoglu N; Department of Paediatric Endocrinology, Erciyes University Faculty of Medicine, Kayseri, Türkiye., Kilci F; Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Türkiye., Nursoy H; Department of Paediatric Endocrinology, Uludag University Faculty of Medicine, Bursa, Türkiye., Ozalkak S; Department of Paediatric Endocrinology, Diyarbakir Children Hospital, Diyarbakir, Türkiye., Kolbasi B; Department of Paediatric Endocrinology, Dicle University Faculty of Medicine, Diyarbakir, Türkiye., Cetinkaya S; Department of Paediatric Endocrinology, Dr. Sami Ulus Training and Research Hospital, Ankara, Türkiye., Ozdemir HC; Department of Paediatric Endocrinology, Antalya Training and Research Hospital, Antalya, Türkiye., Parlak M; Department of Paediatric Endocrinology, Akdeniz University Faculty of Medicine, Antalya, Türkiye., Kokenli FT; Department of Paediatric Endocrinology, Trakya University Faculty of Medicine, Edirne, Türkiye., Camtosun E; Department of Paediatric Endocrinology, Inonu University Faculty of Medicine, Malatya, Türkiye., Dibeklioglu SE; Department of Paediatric Endocrinology, Konya City Hospital, Konya, Türkiye., Buyukyilmaz G; Department of Paediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Türkiye., Bulus AD; Department of Paediatric Endocrinology, Ankara Ataturk Sanatory Education and Research Hospital, Ankara, Türkiye., Balki HG; Department of Paediatric Endocrinology, Necip Fazil City Hospital, Kahramanmaras, Türkiye., Ozden A; Department of Paediatric Endocrinology, Ataturk University Faculty of Medicine, Erzurum, Türkiye., Gonc EN; Department of Paediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Türkiye., Ozsu E; Department of Paediatric Endocrinology, Ankara University Faculty of Medicine, Ankara, Türkiye., Demirbilek H; Department of Paediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Türkiye., Yildiz M; Department of Paediatric Endocrinology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Ozen S; Department of Paediatric Endocrinology, Ege University Faculty of Medicine, Izmir, Türkiye., Bereket A; Department of Paediatric Endocrinology, Marmara University Faculty of Medicine, Istanbul, Türkiye., Haliloglu B; Department of Paediatric Endocrinology, Marmara University Faculty of Medicine, Istanbul, Türkiye.

Πηγή: Pediatric obesity [Pediatr Obes] 2026 Jun; Vol. 21 (6), pp. e70121.

Τύπος έκδοσης: Journal Article; Multicenter Study

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell for the International Association for the Study of Obesity Country of Publication: England NLM ID: 101572033 Publication Model: Print Cited Medium: Internet ISSN: 2047-6310 (Electronic) Linking ISSN: 20476302 NLM ISO Abbreviation: Pediatr Obes Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Leptin*/genetics , Receptor, Melanocortin, Type 4*/genetics , Pediatric Obesity*/genetics , Pediatric Obesity*/epidemiology, Pro-Opiomelanocortin/genetics ; Leptin/genetics ; Turkey/epidemiology ; Proprotein Convertase 1/genetics ; Adenylyl Cyclases/genetics ; Humans ; Female ; Child ; Retrospective Studies ; Male ; Genetic Association Studies ; Phenotype ; Adolescent ; Genotype ; Child, Preschool ; Body Mass Index

Leptin Receptor b (LEPRb) Mutations Disrupt Hypothalamic Control of the Reproductive Axis.

Συγγραφείς: Zikopoulos A; Department of Reproductive Medicine and Surgery, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK., Moustakli E; Department of Nursing, School of Health Sciences, University of Ioannina, 4th Kilometer National Highway Str. Ioannina-Athens, 45500 Ioannina, Greece., Katopodis P; Laboratory of Medical Genetics in Clinical Practice, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece., Paraschos VS; Department of Obstetrics and Gynecology, Corewell Health Hospital, 4700 Schaefer Road Suite 310, Dearborn, MI 48126, USA., Potiris A; Third Department of Obstetrics and Gynecology, University General Hospital 'ATTIKON', Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Anagnostaki I; Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece., Vogiatzoglou AL; Third Department of Obstetrics and Gynecology, University General Hospital 'ATTIKON', Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Zacharis K; Department of Obstetrics and Gynecology, General Hospital of Lamia, 35100 Lamia, Greece., Karampitsakos T; Third Department of Obstetrics and Gynecology, University General Hospital 'ATTIKON', Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece., Zikopoulos K; Department of Obstetrics & Gynecology, University Hospital of Ioannina, 45500 Ioannina, Greece., Stavros S; Third Department of Obstetrics and Gynecology, University General Hospital 'ATTIKON', Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Mar 08; Vol. 27 (5). Date of Electronic Publication: 2026 Mar 08.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Leptin*/genetics , Receptors, Leptin*/metabolism , Hypothalamus*/metabolism , Reproduction*/genetics , Mutation*, Leptin/metabolism ; Gonadotropin-Releasing Hormone/metabolism ; Kisspeptins/metabolism ; Hypogonadism/genetics ; Hypogonadism/metabolism ; Humans ; Animals ; Hypothalamic-Pituitary-Gonadal Axis ; Signal Transduction

Leptin: 30 Years Later.

Συγγραφείς: Ahima RS; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Flier JS; Department of Physiology and Department of Medicine, Harvard Medical School, Boston, Masschusetts, USA; email: Jeffrey_Flier@hms.harvard.edu.

Πηγή: Annual review of physiology [Annu Rev Physiol] 2026 Feb; Vol. 88 (1), pp. 229-250. Date of Electronic Publication: 2025 Oct 03.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Annual Reviews Country of Publication: United States NLM ID: 0370600 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-1585 (Electronic) Linking ISSN: 00664278 NLM ISO Abbreviation: Annu Rev Physiol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/physiology , Leptin*/deficiency , Leptin*/genetics , Leptin*/metabolism , Leptin*/therapeutic use, Obesity/physiopathology ; Obesity/metabolism ; Signal Transduction/physiology ; Receptors, Leptin/physiology ; Energy Metabolism/physiology ; Humans ; Animals ; Mice ; History, 21st Century

Adipocyte Leptin Signaling Regulates Glycemia and Cardiovascular Function by Enhancing Brown Adipose Tissue Thermogenesis in Obese Male Mice.

Συγγραφείς: Ono Y; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA., Kennard S; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA., Wall BT; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA., Ma J; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA., Belin de Chantemèle EJ; Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA.; Division of Cardiology, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA.

Πηγή: Diabetes [Diabetes] 2026 Mar 01; Vol. 75 (3), pp. 441-453.

Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Adipose Tissue, Brown*/metabolism , Leptin*/metabolism , Thermogenesis*/physiology , Obesity*/metabolism , Adipocytes*/metabolism , Blood Glucose*/metabolism, Receptors, Leptin/metabolism ; Receptors, Leptin/genetics ; Signal Transduction/physiology ; Energy Metabolism/physiology ; Animals ; Male ; Mice ; Mice, Knockout ; Female ; Mice, Obese

Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection.

Συγγραφείς: Omoto ACM; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Vechetti I; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE (I.V.)., do Carmo JM; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Wang Z; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Mouton AJ; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Young JC; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Dai X; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Ladnier EC; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Zenum SC; School of Medicine, Centro Universitario Barao de Maua, Ribeirao Preto, SP, Brazil (S.C.Z., O.E.S.T., L.R.)., Tosta OES; School of Medicine, Centro Universitario Barao de Maua, Ribeirao Preto, SP, Brazil (S.C.Z., O.E.S.T., L.R.)., Romeiro L; School of Medicine, Centro Universitario Barao de Maua, Ribeirao Preto, SP, Brazil (S.C.Z., O.E.S.T., L.R.)., Hamby M; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Li X; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Spitz RW; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Richards AM; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN (A.M.R., C.H.J., C.J.G.)., Johns CH; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN (A.M.R., C.H.J., C.J.G.)., Goergen CJ; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN (A.M.R., C.H.J., C.J.G.)., da Silva AA; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.)., Hall JE; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS (A.C.M.O., J.M.d.C., Z.W., A.J.M., J.C.Y., X.D., E.C.L., M.H., X.L., R.W.S., A.A.d.S., J.E.H.).

Πηγή: Circulation research [Circ Res] 2026 Feb 27; Vol. 138 (5), pp. e326878. Date of Electronic Publication: 2026 Feb 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/administration & dosage , Leptin*/pharmacology , Adipose Tissue, Brown*/metabolism , Adipose Tissue, Brown*/innervation , Adipose Tissue, Brown*/drug effects , Brain*/metabolism , Brain*/drug effects , Myocardial Reperfusion Injury*/metabolism , Myocardial Reperfusion Injury*/prevention & control , Myocardial Reperfusion Injury*/physiopathology , Myocardial Reperfusion Injury*/pathology , Myocardium*/metabolism , Myocardium*/pathology, Receptors, Leptin/metabolism ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/drug effects ; Myocardial Infarction/metabolism ; Animals ; Rats, Sprague-Dawley ; Male ; Rats ; Mice

The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition.

Συγγραφείς: Hadley CK; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA.; Weill Cornell/Rockefeller/Sloan Kettering Tri-institutional MD-PhD Program, New York, NY, USA., Galgano L; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.; Scuola Universitaria Superiore, IUSS, Pavia, Italy.; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gui Y; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Carvalho da Silva AM; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Porter DT; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Wu Y; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Lai Y; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China., Torti M; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Çakır I; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. cakiri@pitt.edu.; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. cakiri@pitt.edu.

Πηγή: Nature communications [Nat Commun] 2026 Feb 05; Vol. 17 (1), pp. 1212. Date of Electronic Publication: 2026 Feb 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leptin*/metabolism , Leptin*/pharmacology , Histone Deacetylases*/metabolism , Focal Adhesion Kinase 2*/metabolism , Focal Adhesion Kinase 2*/genetics , Histone Deacetylase Inhibitors*/pharmacology , Focal Adhesion Kinase 1*/metabolism , Focal Adhesion Kinase 1*/genetics , Weight Loss*/drug effects, Histone Deacetylase 6/antagonists & inhibitors ; Hydroxamic Acids/pharmacology ; Indoles/pharmacology ; Receptors, Leptin/metabolism ; Hypothalamus/metabolism ; Hypothalamus/drug effects ; Signal Transduction/drug effects ; STAT3 Transcription Factor/metabolism ; Obesity/metabolism ; Obesity/drug therapy ; Obesity/genetics ; Animals ; Male ; Mice ; Mice, Knockout ; Phosphorylation ; Mice, Inbred C57BL