Lambda restricted light chain as pathogenic cause of POEMS syndrome: a review of the hypothesis.

Authors: Troutman R; Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN, United States., Wagner A; Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN, United States., Delery E; Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN, United States.; Indiana Biosciences Research Institute, Indianapolis, IN, United States.; Department of Biochemistry, Molecular Biology and Pharmacology, Indiana University School of Medicine, Indianapolis, IN, United States.

Source: Frontiers in immunology [Front Immunol] 2026 Jul 06; Vol. 17, pp. 1865997. Date of Electronic Publication: 2026 Jul 06 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: POEMS Syndrome*/immunology , POEMS Syndrome*/etiology , Immunoglobulin lambda-Chains*/immunology , Immunoglobulin lambda-Chains*/metabolism, Plasma Cells/immunology ; Plasma Cells/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Humans ; Animals ; Molecular Mimicry

Defiance of stable lysogeny reveals hidden infection dynamics of phage Lambda.

Authors: Broux K; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium., Bäcker LE; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium., Oome D; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium.; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium., Baert F; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium.; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium., Vandenborre J; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium.; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium., Schoeters S; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium., Tran NHL; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium., Simoens K; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium., Waldherr S; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium.; Department of Functional and Evolutionary Ecology, University of Vienna, Vienna 1030, Austria., Bernaerts K; Department of Chemical Engineering, KU Leuven, Leuven 3001, Belgium., Aertsen A; Department of Microbial and Molecular Systems, KU Leuven, Leuven 3001, Belgium.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2600726123. Date of Electronic Publication: 2026 Jun 17.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Lysogeny*/genetics , Bacteriophage lambda*/genetics , Bacteriophage lambda*/physiology, Prophages/genetics

Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences.

Authors: Wang Y; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Respiratory Diseases, Institute of Pediatrics, Shenzhen Children's Hospital ＆ Shenzhen University Medical School, Shenzhen, China.; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China., Yang H; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China., Jiang L; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China., Ge Y; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China., Zhong Y; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China., Chu H; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China., Zhang K; Department of Respiratory Diseases, Institute of Pediatrics, Shenzhen Children's Hospital ＆ Shenzhen University Medical School, Shenzhen, China., Kuerban K; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China., Nong Y; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China., Gao H; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China., Xu C; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China., Li X; School of Bioengineering, Dalian University of Technology, Dalian, China., Chen S; Department of Gastroenterology, Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Disease, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China. shichen_2021@163.com.; Department of Critical Care Medicine, Intensive Care Unit, Shenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, Shenzhen University Medical School, The First Affiliated Hospital of Shenzhen University, Shenzhen, China. shichen_2021@163.com., Wang L; Department of Respiratory Diseases, Institute of Pediatrics, Shenzhen Children's Hospital ＆ Shenzhen University Medical School, Shenzhen, China. lianrong2008@gmail.com.

Source: Nature microbiology [Nat Microbiol] 2026 Aug; Vol. 11 (8), pp. 2187-2200. Date of Electronic Publication: 2026 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

MeSH Terms: Viral Proteins*/metabolism , Viral Proteins*/genetics , Bacteriophage lambda*/genetics , Bacteriophage lambda*/metabolism , DNA, Bacterial*/metabolism , DNA, Bacterial*/genetics , DNA, Bacterial*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry, DNA, Viral/metabolism ; DNA, Viral/genetics ; Escherichia coli/virology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Phosphorothioate Oligonucleotides/metabolism ; Iron-Sulfur Proteins/metabolism ; Iron-Sulfur Proteins/genetics ; Molecular Mimicry

A receptor-centered approach identifies Lom as a LamB-bound superinfection exclusion factor in bacteriophage λ.

Authors: Ge X; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China; Health and Wellness, City University of Macau, Macau 999078, P.R. China. Electronic address: gxf16@tsinghua.org.cn., Gu Z; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China., Wang J; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China. Electronic address: jwwang@tsinghua.edu.cn.

Source: Cell reports [Cell Rep] 2026 Jul 28; Vol. 45 (7), pp. 117691. Date of Electronic Publication: 2026 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH Terms: Bacteriophage lambda*/metabolism , Bacteriophage lambda*/physiology , Bacterial Outer Membrane Proteins*/metabolism , Bacterial Outer Membrane Proteins*/chemistry , Porins*/metabolism , Porins*/chemistry , Superinfection*, Viral Proteins/metabolism ; Escherichia coli/virology ; Escherichia coli/metabolism ; Protein Binding ; Receptors, Virus

Comparison of Igκ and Igλ binding toward influenza virus hemagglutinin and SARS-CoV-2 Spike protein during primary viral infections in humans, mice, and pigs.

Authors: Richardson RA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA., North JF; Department of Pathobiology, Auburn University, Auburn, AL, USA., Thomas MH; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA., Lynch A; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA., Kyriakis CS; Department of Pathobiology, Auburn University, Auburn, AL, USA., Sautto GA; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA., Ross TM; Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, USA; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA; Department of Infectious Diseases, University of Georgia, Athens, GA, USA. Electronic address: rosst7@ccf.org.

Source: Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2026 Jul; Vol. 128, pp. 102494. Date of Electronic Publication: 2026 Jun 23.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 7808924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1667 (Electronic) Linking ISSN: 01479571 NLM ISO Abbreviation: Comp Immunol Microbiol Infect Dis Subsets: MEDLINE

MeSH Terms: Spike Glycoprotein, Coronavirus*/immunology , Spike Glycoprotein, Coronavirus*/metabolism , Hemagglutinin Glycoproteins, Influenza Virus*/immunology , Hemagglutinin Glycoproteins, Influenza Virus*/metabolism , SARS-CoV-2*/immunology , Orthomyxoviridae Infections*/immunology , Orthomyxoviridae Infections*/virology , Influenza, Human*/immunology , Influenza, Human*/virology , Immunoglobulin lambda-Chains*/immunology , Immunoglobulin lambda-Chains*/metabolism , Coronavirus Infections*/immunology, Influenza A Virus, H3N2 Subtype/immunology ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Influenza A Virus, H1N1 Subtype/immunology ; Animals ; Swine ; Mice ; Humans ; Female

A CDR1 aggregation hotspot controls unfolding kinetics and multimolecular aggregation in IGLV2 light chains.

Authors: Gulyásová T; Department of Biophysics, Faculty of Science, Pavol Jozef Šafárik University, Jesenna 5, Košice 040 01, Slovakia; Center for Interdisciplinary Biosciences, Technology and Innovation Park, Pavol Jozef Šafárik University, Jesenna 5, Košice 040 01, Slovakia., Šipošová K; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, Košice 040 01, Slovakia., Džupponová V; Center for Interdisciplinary Biosciences, Technology and Innovation Park, Pavol Jozef Šafárik University, Jesenna 5, Košice 040 01, Slovakia. Electronic address: veronika.dzupponova@upjs.sk.

Source: Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2026 Jul 01; Vol. 1874 (4), pp. 141155. Date of Electronic Publication: 2026 May 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1454 (Electronic) Linking ISSN: 15709639 NLM ISO Abbreviation: Biochim Biophys Acta Proteins Proteom Subsets: MEDLINE

MeSH Terms: Immunoglobulin Light Chains*/chemistry , Immunoglobulin Light Chains*/genetics , Immunoglobulin Light Chains*/metabolism , Immunoglobulin lambda-Chains*/chemistry , Immunoglobulin lambda-Chains*/genetics , Protein Aggregates*, Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Kinetics ; Protein Unfolding ; Amino Acid Sequence ; Humans ; Calorimetry, Differential Scanning

Utility of ultrasensitive, US Food and Drug Administration-approved κ and λ dual in situ hybridization assay in the diagnosis of Hodgkin lymphomas.

Authors: Eltahir M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Young K; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Younes S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Zhao S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Silva O; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Natkunam Y; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States.

Source: American journal of clinical pathology [Am J Clin Pathol] 2026 Jun 04; Vol. 165 (6).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0370470 Publication Model: Print Cited Medium: Internet ISSN: 1943-7722 (Electronic) Linking ISSN: 00029173 NLM ISO Abbreviation: Am J Clin Pathol Subsets: MEDLINE

MeSH Terms: Hodgkin Disease*/diagnosis , In Situ Hybridization*/methods , Immunoglobulin kappa-Chains*/genetics , Immunoglobulin kappa-Chains*/analysis , Immunoglobulin lambda-Chains*/genetics , Immunoglobulin lambda-Chains*/analysis, B-Lymphocytes/pathology ; Biomarkers, Tumor/analysis ; Reed-Sternberg Cells/pathology ; Humans ; United States ; Female ; United States Food and Drug Administration ; Male ; Middle Aged ; Adult ; Aged ; Adolescent ; Aged, 80 and over ; Young Adult

Free light chain EQA: Analytical variability with clinical consequences - Data from 25 Italian EQA exercises (2021-2025).

Authors: Pasotti F; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy., Da Molin S; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy., Bosoni T; Laboratory of Clinical Analysis, IRCCS Policlinico San Matteo, Pavia, Italy., Azzarà G; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy., Liga G; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy., Moriello G; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy., Zaccaria B; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy., Buoro S; Regional Coordination Center for Laboratory Medicine of Lombardy Region, Milan, Italy.

Source: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2026 Aug 15; Vol. 590, pp. 121056. Date of Electronic Publication: 2026 May 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1302422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3492 (Electronic) Linking ISSN: 00098981 NLM ISO Abbreviation: Clin Chim Acta Subsets: MEDLINE

MeSH Terms: Immunoglobulin Light Chains*/blood , Immunoglobulin kappa-Chains*/blood , Immunoglobulin lambda-Chains*/blood, Paraproteinemias/diagnosis ; Paraproteinemias/blood ; Humans ; Italy ; Quality Control

Recurrent IgA1-λ-Type PGNMID Achieving Remission with Conventional Immunosuppressive Therapy.

Authors: Chida K; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Oura A; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Takahashi T; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Kiyohara M; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Matsumoto K; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Kyo T; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Ishizuka Y; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Kamei H; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Nakamura Y; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan., Nakaya I; Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan.

Source: Internal medicine (Tokyo, Japan) [Intern Med] 2026 Jun 15; Vol. 65 (12), pp. 1650-1656. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE

MeSH Terms: Immunosuppressive Agents*/therapeutic use , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/immunology , Immunoglobulin A* , Immunoglobulin lambda-Chains*, Mycophenolic Acid/therapeutic use ; Cyclophosphamide/therapeutic use ; Humans ; Male ; Middle Aged ; Remission Induction ; Recurrence

Validation and optimization of reference intervals for serum free light chains in Chinese patients with chronic kidney disease.

Authors: Xu W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Shen Y; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Huang J; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Xiong Y; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Pan B; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Wang B; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: wang.beili1@zs-hospital.sh.cn., Guo W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Laboratory Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China; Department of Laboratory Medicine, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Laboratory Medicine, Geriatric Medical Center, Shanghai, China. Electronic address: guo.wei@zs-hospital.sh.cn., Zhu J; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: zhu.jing@zs-hospital.sh.cn., Shao W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: shao.wenqi@zs-hospital.sh.cn.

Source: Clinical biochemistry [Clin Biochem] 2026 Jun; Vol. 143, pp. 111120. Date of Electronic Publication: 2026 Mar 23.

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0133660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2933 (Electronic) Linking ISSN: 00099120 NLM ISO Abbreviation: Clin Biochem Subsets: MEDLINE

MeSH Terms: Immunoglobulin kappa-Chains*/blood , Immunoglobulin lambda-Chains*/blood , Renal Insufficiency, Chronic*/blood, Aged ; Female ; Humans ; Male ; Middle Aged ; China ; Glomerular Filtration Rate ; Reference Values ; Retrospective Studies ; East Asian People

Transient expansion of peripheral Lambda-expressing plasma cells represents a distinctive phenotype associated with SFTSV infection.

Authors: Tang Y; Department of Flow Cytometry Center, the Second Hospital of Dalian Medical University, Dalian, China., Wu J; Department of Flow Cytometry Center, the Second Hospital of Dalian Medical University, Dalian, China., Tian Y; Department of Flow Cytometry Center, the Second Hospital of Dalian Medical University, Dalian, China., Wang J; Department of Flow Cytometry Center, the Second Hospital of Dalian Medical University, Dalian, China., Liu J; Department of Flow Cytometry Center, the Second Hospital of Dalian Medical University, Dalian, China., Chang Q; Pharmacy Department, Dalian Public Health Clinical Center, Dalian, China., Zhu J; Department of Flow Cytometry Center, the Second Hospital of Dalian Medical University, Dalian, China.

Source: Frontiers in immunology [Front Immunol] 2026 Apr 24; Vol. 17, pp. 1763231. Date of Electronic Publication: 2026 Apr 24 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Plasma Cells*/immunology , Plasma Cells*/metabolism , Phlebovirus*/immunology , Immunoglobulin lambda-Chains*/immunology , Immunoglobulin lambda-Chains*/metabolism , Severe Fever with Thrombocytopenia Syndrome*/immunology , Bunyaviridae Infections*/immunology, Humans ; Female ; Immunophenotyping ; Phenotype ; Male ; Middle Aged ; Aged ; Adult

[Construction and Efficacy Evaluation of a Highly Efficient Diagnostic Model for Neurosyphilis Driven by the Cerebrospinal Fluid/Serum Free Light Chain Index].

Transliterated Title: 脑脊液/血清游离轻链指数驱动神经梅毒高效诊断模型构建与效能评估.

Authors: Deng J; （ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.; （ 610041）Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China., Wu S; （ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China., Ye F; （ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China., Huang X; （ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China., Li D; （ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China., Liu J; （ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Source: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2026 Mar 20; Vol. 57 (2), pp. 448-454.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Sichuan da xue xue bao (yi xue ban) bian ji bu Country of Publication: China NLM ID: 101162609 Publication Model: Print Cited Medium: Print ISSN: 1672-173X (Print) Linking ISSN: 1672173X NLM ISO Abbreviation: Sichuan Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE

MeSH Terms: Neurosyphilis*/diagnosis , Neurosyphilis*/cerebrospinal fluid , Neurosyphilis*/blood , Immunoglobulin kappa-Chains*/blood , Immunoglobulin kappa-Chains*/cerebrospinal fluid , Immunoglobulin lambda-Chains*/blood , Immunoglobulin lambda-Chains*/cerebrospinal fluid , Immunoglobulin Light Chains*/blood , Immunoglobulin Light Chains*/cerebrospinal fluid, Humans ; Male ; Adult ; Female ; Middle Aged

Unraveling posttranscriptional regulatory networks in phage infection.

Authors: Velasco Gomariz M; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg 97080, Germany., Hör J; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg 97080, Germany; Institute of Molecular Infection Biology, University of Würzburg, Würzburg 97080, Germany. Electronic address: jens.hoer@helmholtz-hiri.de.

Source: Trends in microbiology [Trends Microbiol] 2026 Mar; Vol. 34 (3), pp. 230-231. Date of Electronic Publication: 2026 Feb 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 9310916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4380 (Electronic) Linking ISSN: 0966842X NLM ISO Abbreviation: Trends Microbiol Subsets: MEDLINE

MeSH Terms: Bacteriophage lambda*/genetics , Bacteriophage lambda*/physiology , Gene Regulatory Networks* , Gene Expression Regulation, Viral*, Host Factor 1 Protein/genetics ; Host Factor 1 Protein/metabolism ; Regulon

Single-phage profiling illuminates viral individuality during bacterial cell fate determination.

Authors: Homaee E; Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Zhu W; Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; NSF Science and Technology Center for Quantitative Cell Biology, Urbana, IL, USA., Yao T; Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA., Golding I; Department of Physics, University of Illinois Urbana-Champaign, Urbana, IL, USA. igolding@illinois.edu.; Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA. igolding@illinois.edu.; NSF Science and Technology Center for Quantitative Cell Biology, Urbana, IL, USA. igolding@illinois.edu.; Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA. igolding@illinois.edu.

Source: Nature communications [Nat Commun] 2026 May 30; Vol. 17 (1). Date of Electronic Publication: 2026 May 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Escherichia coli*/virology , Escherichia coli*/genetics , Bacteriophage lambda*/genetics , Bacteriophage lambda*/physiology, Lysogeny/genetics ; Bacteriolysis/genetics ; In Situ Hybridization, Fluorescence ; Genome, Viral ; Virus Replication ; Transcription, Genetic

Structures of λ-like phage A8 tail tip bound to OmpC provide insight into receptor recognition.

Authors: Deng T; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China., Ge X; Health and Wellness, City University of Macau, Macau 999078, P.R. China. Electronic address: gxf16@tsinghua.org.cn., Wang J; State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China. Electronic address: jwwang@tsinghua.edu.cn.

Source: Structure (London, England : 1993) [Structure] 2026 May 07; Vol. 34 (5), pp. 790-797.e3. Date of Electronic Publication: 2026 Feb 27.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

MeSH Terms: Porins*/metabolism , Porins*/chemistry , Porins*/genetics , Bacterial Outer Membrane Proteins*/metabolism , Bacterial Outer Membrane Proteins*/chemistry , Bacterial Outer Membrane Proteins*/genetics , Viral Tail Proteins*/metabolism , Viral Tail Proteins*/chemistry , Viral Tail Proteins*/genetics , Bacteriophage lambda*/metabolism , Bacteriophage lambda*/chemistry, Escherichia coli/metabolism ; Escherichia coli/virology ; Cryoelectron Microscopy ; Models, Molecular ; Protein Binding ; Binding Sites

A membrane-bound nuclease directly cleaves phage DNA during genome injection.

Authors: Saxton DS; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., DeWeirdt PC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA., Doering CR; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Roney IJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Laub MT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. laub@mit.edu.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. laub@mit.edu.

Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 861-869. Date of Electronic Publication: 2026 Feb 25.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH Terms: Bacteriophage lambda*/genetics , Bacteriophage lambda*/physiology , DNA, Viral*/metabolism , DNA, Viral*/genetics , Escherichia coli*/virology , Escherichia coli*/enzymology , Escherichia coli*/cytology , Escherichia coli*/metabolism, Cell Membrane/enzymology ; Cell Membrane/metabolism ; Escherichia coli Proteins/metabolism ; DNA Cleavage ; Genome, Viral

Sequential Phage Delivery Can Outperform Cocktails by Delaying Cross-Resistance Evolution.

Authors: Stuart EC; Department of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093, USA., Meyer JR; Department of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093, USA.

Source: Viruses [Viruses] 2026 Mar 25; Vol. 18 (4). Date of Electronic Publication: 2026 Mar 25.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH Terms: Phage Therapy*/methods , Escherichia coli K12*/virology , Escherichia coli K12*/genetics , Bacteriophage lambda*/physiology , Bacteriophage lambda*/genetics, Mutation ; Evolution, Molecular ; Bacteriophages

Investigating serum free light chains in patients with common variable immunodeficiency disorder in compare with other immunodeficiency diseases.

Authors: Bemanian MH; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Khoshmirsafa M; Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.; Department of immunology, school of medicine, Iran University of Medical Sciences, Tehran, Iran., Ahmadi M; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. mina.ahmadi65@yahoo.com., Nabavi M; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Arshi S; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Chavoshzadeh Z; Department Allergy and Clinical Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shokri S; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Fallahpour M; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Jafariaghdam N; Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran., Afrashteh F; Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran., Asefi S; Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Mesdaghi M; Department Allergy and Clinical Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Immunology and Allergy Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran., Sharafian S; Department Allergy and Clinical Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Source: Scientific reports [Sci Rep] 2026 Mar 13; Vol. 16 (1). Date of Electronic Publication: 2026 Mar 13.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Common Variable Immunodeficiency*/blood , Common Variable Immunodeficiency*/diagnosis , Common Variable Immunodeficiency*/immunology , Immunoglobulin kappa-Chains*/blood , Immunoglobulin lambda-Chains*/blood , Immunoglobulin Light Chains*/blood , Immunologic Deficiency Syndromes*/blood, Agammaglobulinemia/blood ; Agammaglobulinemia/diagnosis ; Biomarkers/blood ; Humans ; Female ; Male ; Adult ; Cross-Sectional Studies ; Middle Aged ; Young Adult ; Adolescent ; Child

Evaluation of Serum Kappa Free Light Chain Reference Interval Using a New Stabilized Calibrator.

Authors: Waggoner D; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, United States., Thoren K; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, United States., Maynard R; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, United States., Twum K; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States., Korpi-Steiner N; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Source: The journal of applied laboratory medicine [J Appl Lab Med] 2026 May 05; Vol. 11 (3), pp. 599-605.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101693884 Publication Model: Print Cited Medium: Print ISSN: 2576-9456 (Print) Linking ISSN: 24757241 NLM ISO Abbreviation: J Appl Lab Med Subsets: MEDLINE

MeSH Terms: Immunoglobulin kappa-Chains*/blood , Immunoglobulin lambda-Chains*/blood, Calibration/standards ; Electrophoresis, Capillary/standards ; Humans ; Reference Values ; Female ; Reproducibility of Results ; Adult

Leveraging Kappa-Lambda Signatures in a Multistage Machine Learning Pipeline for B-Cell Lymphoma Detection by Flow Cytometry.

Authors: Zhang I; Department of Biostatistics, School of Global Public Health, New York University, New York, New York., Chalise S; Memorial Sloan Kettering Cancer Center, New York, New York., Roshal M; Memorial Sloan Kettering Cancer Center, New York, New York., Gao Q; Memorial Sloan Kettering Cancer Center, New York, New York., Zhu M; Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: zhum1@mskcc.org., Feng Y; Department of Biostatistics, School of Global Public Health, New York University, New York, New York; Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: yf31@nyu.edu.

Source: The American journal of pathology [Am J Pathol] 2026 May; Vol. 196 (5), pp. 1158-1168. Date of Electronic Publication: 2026 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

MeSH Terms: Flow Cytometry*/methods , Lymphoma, B-Cell*/diagnosis , Lymphoma, B-Cell*/immunology , Immunoglobulin kappa-Chains*/metabolism , Immunoglobulin lambda-Chains*/metabolism , Machine Learning*, Immunophenotyping/methods ; Humans ; Classification Algorithms ; Boosting Machine Learning Algorithms ; Biomarkers, Tumor