An Rcs Stress-Based High-Throughput Screen Reveals Novel Gyrase Inhibitors as Indirect Inducers of Cell Envelope Stress in Gram-Negative Bacteria

Συγγραφείς: Cleenewerk, Laurence^aff1, Otto, Alexandra^aff1, Wouters, Willemijn^aff2, Willemse, Joost^aff3, Gao, Meiling^aff4, Lysenko, Vladyslav^aff4, Punt, Jeroen M.^aff5, van der Stelt, Mario^aff5, Martin, Nathaniel I.^aff4, van Ulsen, Peter^aff1, Luirink, Joen^aff1

Πηγή: ACS Infectious Diseases. 11(9):2577-2592

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00445

A Quantitative High-Throughput Screen Identifies Compounds that Upregulate the p53 Isoform Δ133p53α and Inhibit Cellular Senescence

Συγγραφείς: Lissa, Delphine^aff1, Joruiz, Sebastien M.^aff1, Dranchak, Patricia K.^aff2, Ungerleider, Kyra^aff1, Yamada, Leo^aff1, Horikawa, Izumi^aff1, Oliphant, Erin^aff2, Manubag, Rebecca^aff2, Von Muhlinen, Natalia^aff1, Beck, Jessica^aff1, Harris, Brent T.^aff3, Inglese, James^{aff2, aff4}, Harris, Curtis^aff1

Πηγή: ACS Pharmacology & Translational Science. 8(7):2061-2074

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acsptsci.5c00186

Automated Strain Construction for Biosynthetic Pathway Screening in Yeast

Συγγραφείς: Astolfi, Maria C. T.^{aff1, aff2, aff3}, Yoder, Sam D.^{aff2, aff3}, Delfa-Lalaguna, Marina^{aff4, aff2}, Winegar, Peter H.^{aff2, aff3, aff5}, Holm, Sara K. F.^{aff6, aff2}, Lei, Mengziang^aff2, Zhao, Xixi^{aff2, aff3, aff5}, Tan, Stephen E.^{aff2, aff3}, Louie, Randy^{aff2, aff3}, Hillson, Nathan J.^{aff2, aff3}, Hudson, Graham A.^{aff2, aff3, aff5}, Keasling, Jay D.^{aff1, aff2, aff3, aff5, aff6, aff7}

Πηγή: ACS Synthetic Biology. 14(10):4143-4151

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acssynbio.5c00554

Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors

Συγγραφείς: Scott, Louis, 1987, Author, Wigglesworth, Mark J., Author, Siewers, Verena, 1976, Author, Davis, Andy M., Author, David, Florian, 1981, Author

Συνεισφορές: Scott, Louis, 1987, Author, Wigglesworth, Mark J., Author, Siewers, Verena, 1976, Author, Davis, Andy M., Author, David, Florian, 1981, Author

Πηγή: ACS Synthetic Biology. 11(10):3182-3189

Θεματικοί όροι: biosensor, high-throughput screen, genetic circuit, new modality, drug discovery, directed evolution

Περιγραφή αρχείου: electronic

Σύνδεσμος πρόσβασης: https://research.chalmers.se/publication/532766
https://research.chalmers.se/publication/532745
https://research.chalmers.se/publication/532766/file/532766_Fulltext.pdf

High-throughput nutrient optimisation of microalgae cultivation for sustainable post-mining land use

Συγγραφείς: Renna Eliana Warjoto, Robert Chapman, Ben Hankamer, Juliane Wolf

Πηγή: Cleaner Engineering and Technology, Vol 33, Iss , Pp 101250- (2026)

Θεματικοί όροι: Microalgae, High-throughput screen, Lobochlamys, Brackish water, Mine-impacted water, Post-mining land use, Renewable energy sources, TJ807-830, Environmental engineering, TA170-171

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666790826001096; https://doaj.org/toc/2666-7908

Σύνδεσμος πρόσβασης: https://doaj.org/article/86715ddf6bfe4c79b9e52539c7541d62

Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action

Συγγραφείς: Schum, Dominik^aff1, Elsen, Franziska A. V.^aff1, Ruddell, Stuart^aff1, Schorpp, Kenji^aff2, Junca, Howard^aff3, Müsken, Mathias^aff4, Chen, Shu-Yu^aff5, Fiedler, Michaela K.^aff1, Pickl, Thomas^aff6, Pieper, Dietmar H.^aff3, Hadian, Kamyar^aff2, Zacharias, Martin^aff5, Sieber, Stephan A.^aff1

Πηγή: JACS Au. 4(8):3125-3134

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/jacsau.4c00449

Electrochemiluminescence Imaging for In Situ Electrocatalysis Characterization: Recent Progress and Mechanistic Insights

Συγγραφείς: Zhang, Shiyu^aff1, Wang, Hongye^aff2, Salem, Alaa A.^aff3, Liu, Yang^aff1

Πηγή: Chemical & Biomedical Imaging. 4(8):1646-1664

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/cbmi.5c00283

AI-driven identification of Zika virus inhibitors

Συγγραφείς: Otsuka, Yuka ^a, Shumate, Justin ^a, Rye, Teresa Findley ^b, Goldberg, Ilya ^b, Clement, Amanda ^c, Scampavia, Louis ^a, Chung, Donghoon ^d, Spicer, Timothy P. ^{a, ⁎}

Πηγή: In SLAS Discovery October 2026 43

A high-throughput screen to identify potential inhibitors of HSV-2

Συγγραφείς: Hao, Hongping ^a, Roy, Anuradha ^b, Johnson, David K. ^c, Davido, David J. ^{a, ⁎}

Πηγή: In Antiviral Research October 2026 254

Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

Συγγραφείς: Hippman, Ryan S.^aff1, Snead, Amanda M.^aff2, Petros, Zoe A.^aff1, Korkmaz-Vaisys, Melissa A.^aff1, Patel, Sruchi^aff2, Sotelo, Daniel^aff1, Dobria, Andrew^aff1, Salkovski, Maryna^aff1, Nguyen, Thu T. A.^aff1, Linares, Ricardo^aff2, Cologna, Stephanie M.^aff1, Gowrishankar, Swetha^aff2, Aldrich, Leslie N.^aff1

Πηγή: ACS Chemical Neuroscience. 14(24):4363-4382

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acschemneuro.3c00573

High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression

Συγγραφείς: Gulcan Semra Sahin, Paul J. Guyett, Kaiping Xu, Jennifer Kouznetsova, Wei Zheng, Michael Hendrickson

Πηγή: SLAS Discovery, Vol 40, Iss , Pp 100303- (2026)

Θεματικοί όροι: Amyotrophic lateral sclerosis, Induced pluripotent stem cells, motor neurons, quantitative high throughput screen, Drug discovery, Drug metabolism and pharmacokinetics, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555226000092; https://doaj.org/toc/2472-5552

Σύνδεσμος πρόσβασης: https://doaj.org/article/dad7d8924b8f4cb3aaf09115d0ea9bf5

Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3)

Συγγραφείς: Vora, Bianca, Author, Green, Elizabeth A. E., Author, Khuri, Natalia, Author, Bällgren, Frida, Author, Sirota, Marina, Author, Giacomini, Kathleen M., Author

Συνεισφορές: Vora, Bianca, Author, Green, Elizabeth A. E., Author, Khuri, Natalia, Author, Bällgren, Frida, Author, Sirota, Marina, Author, Giacomini, Kathleen M., Author

Πηγή: American Journal of Clinical Nutrition. 111(1):110-121

Θεματικοί όροι: drug-nutrient interactions, vitamin B1, transporters, vitamin deficiency, clinical data, high-throughput screen, electronic health records, machine learning

Περιγραφή αρχείου: electronic

Σύνδεσμος πρόσβασης: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403259
https://doi.org/10.1093/ajcn/nqz255

Early Reduction of Glucose Consumption Is a Biomarker of Kinase Inhibitor Efficacy Which Can Be Reversed with GLUT1 Overexpression in Lung Cancer Cells

Συγγραφείς: Ghezzi, Chiara, Perez, Stefani, Ryan, Kaitlin, Wong, Alicia, Chen, Bao Ying, Damoiseaux, Robert, Clark, Peter M

Πηγή: Molecular Imaging and Biology. 25(3)

Θεματικοί όροι: 32 Biomedical and Clinical Sciences (for-2020), 3202 Clinical Sciences (for-2020), 3211 Oncology and Carcinogenesis (for-2020), Lung (rcdc), Precision Medicine (rcdc), Cancer (rcdc), Lung Cancer (rcdc), Biomedical Imaging (rcdc), 5.1 Pharmaceuticals (hrcs-rac), 6.1 Pharmaceuticals (hrcs-rac), 4.1 Discovery and preclinical testing of markers and technologies (hrcs-rac), Cancer (hrcs-hc), Humans (mesh), Lung Neoplasms (mesh), Carcinoma, Non-Small-Cell Lung (mesh), Fluorodeoxyglucose F18 (mesh), Glucose (mesh), Glucose Transporter Type 1 (mesh), Positron-Emission Tomography (mesh), Protein Kinase Inhibitors (mesh), Antineoplastic Agents (mesh), Biomarkers (mesh), Cell Line, Tumor (mesh), Positron emission tomography, Biomarker, [F-18]FDG, Tumor imaging, Lung cancer, Glucose consumption, High-throughput screen, Cell Line, Tumor (mesh), Humans (mesh), Carcinoma, Non-Small-Cell Lung (mesh), Lung Neoplasms (mesh), Fluorodeoxyglucose F18 (mesh), Glucose (mesh), Antineoplastic Agents (mesh), Protein Kinase Inhibitors (mesh), Positron-Emission Tomography (mesh), Glucose Transporter Type 1 (mesh), Biomarkers (mesh), Biomarker, Glucose consumption, High-throughput screen, Lung cancer, Positron emission tomography, Tumor imaging, [18F]FDG, Humans (mesh), Lung Neoplasms (mesh), Carcinoma, Non-Small-Cell Lung (mesh), Fluorodeoxyglucose F18 (mesh), Glucose (mesh), Glucose Transporter Type 1 (mesh), Positron-Emission Tomography (mesh), Protein Kinase Inhibitors (mesh), Antineoplastic Agents (mesh), Biomarkers (mesh), Cell Line, Tumor (mesh), 0606 Physiology (for), 1103 Clinical Sciences (for), Nuclear Medicine & Medical Imaging (science-metrix), 3202 Clinical sciences (for-2020)

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/33g7095j
https://escholarship.org/content/qt33g7095j/qt33g7095j.pdf

Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening

Συγγραφείς: Qin, Songkang, Li, Kuan-Hao, Liu, Ben-Jin, Cao, Cun, Yu, De-Bin, Jiang, Zhi-Gang, Wang, Jun, Han, Yu-Xin, Wang, Fang, Qi, Ying-Lin, Sun, Chao, Yu, Li, Chang, Ji-Tao, Yin, Xin

Πηγή: Virol Sin

Θεματικοί όροι: Rotavirus, Rotavirus/drug effects, High-throughput screen, Immunology, Green Fluorescent Proteins, Drug Evaluation, Preclinical, Small chemical compound, Genome, Viral, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Green Fluorescent Proteins/genetics, Rotavirus Infections, Cell Line, Veterinary medicine & animal health, Reverse Genetics/methods, NSP3 protein, Rotavirus, Virology, Cricetinae, Animals, Bovine rotavirus (BRV), Rotavirus Infections/virology, Plasmids/genetics, Virus Replication/drug effects, Reporter virus, Life sciences, Médecine vétérinaire & santé animale, Reverse Genetics, Viral Nonstructural Proteins/genetics, Infectious Diseases, Optimized reverse genetics system, Rotavirus/genetics, Sciences du vivant, Molecular Medicine, Cattle, Drug Evaluation, Preclinical/methods, Research Article, Plasmids

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39349279

A value-based approach for training of classifiers with high-throughput small molecule screening data

Συγγραφείς: Khuri, Natalia, Parsons, Sarah

Πηγή: Proceedings of the 12th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. :1-10

Διαθεσιμότητα: http://dl.acm.org/doi/10.1145/3459930.3469514

Rickettsia Aglow: A Fluorescence Assay and Machine Learning Model to Identify Inhibitors of Intracellular Infection

Συγγραφείς: Lemenze, Alexander^aff1, Mittal, Nisha^aff2, Perryman, Alexander L.^aff2, Daher, Samer S.^aff2, Ekins, Sean^aff3, Occi, James^aff1, Ahn, Yong-Mo^aff2, Wang, Xin^aff2, Russo, Riccardo^aff1, Patel, Jimmy S.^aff2, Daugherty, Robin M.^aff4, Wood, David O.^aff4, Connell, Nancy^aff1, Freundlich, Joel S.^{aff1, aff2}

Πηγή: ACS Infectious Diseases. 8(7):1280-1290

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acsinfecdis.2c00014

Functional Nanopore Screen: A Versatile High-Throughput Assay to Study and Engineer Protein Nanopores in Escherichia coli

Συγγραφείς: Weber, Wadim^{aff1, aff2}, Roeder, Markus^aff1, Probanowski, Tobias^{aff1, aff2}, Yang, Jie^aff3, Abujubara, Helal^aff3, Koeppl, Heinz^{aff2, aff4}, Tietze, Alesia^aff3, Stein, Viktor^{aff1, aff2}

Πηγή: ACS Synthetic Biology. 11(6):2070-2079

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acssynbio.1c00635

Discovery of an Effective Small-Molecule Allosteric Inhibitor of New Delhi Metallo-β-lactamase (NDM)

Συγγραφείς: Thomas, Pei W.^aff1, Cho, Eun Jeong^{aff1, aff2}, Bethel, Christopher R.^aff3, Smisek, Thomas^aff1, Ahn, Yeong-Chan^aff1, Schroeder, John M.^aff1, Thomas, Caitlyn A.^aff5, Dalby, Kevin N.^{aff1, aff2}, Beckham, Josh T.^aff4, Crowder, Michael W.^aff5, Bonomo, Robert A.^{aff3, aff6, aff7, aff9, aff10}, Fast, Walter^{aff1, aff11}

Πηγή: ACS Infectious Diseases. 8(4):811-824

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acsinfecdis.1c00577

Identification of BET inhibitors (BETi) against solitary fibrous tumor (SFT) through high-throughput screening (HTS)

Συγγραφείς: Mondaza-Hernandez, Jose L. ^{a, b, †}, Moura, David S. ^{a, b, †}, Li, Yi ^{c, d, †}, Marti, Jesus L. ^a, Gomez-Puertas, Paulino ^e, Nguyen, John T. ^{c, d}, Wei, Shuguang ^f, Posner, Bruce A. ^f, Meyer, Clark A. ^c, Bleris, Leonidas ^{c, d, g, ⁎⁎}, Martin-Broto, Javier ^{a, b, h, ⁎}, Hayenga, Heather N. ^{c, ⁎⁎⁎}

Πηγή: In Neoplasia December 2025 70

High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms

Συγγραφείς: Woodford, Colin R., Frank, Kristine E., Zhu, Haizhong, Dionne, Gilman, Schrimpf, Michael R., Gopalakrishnan, Sujatha M., Elsen, Nathaniel L. ^⁎

Πηγή: In SLAS Discovery December 2025 37