Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy

Συγγραφείς: Christian Schinke, Smilla K. Maierhof, Lois Hew, Valeria Fernandez Vallone, Silke Frahm, Narasimha Swamy Telugu, Sebastian Diecke, Andranik Ivanov, Richard Kovács, Dieter Beule, Marieluise Kirchner, Philipp Mertins, Ulrike Brüning, Jennifer A. Kirwan, Harald Stachelscheid, Matthias Endres, Petra Huehnchen, Wolfgang Boehmerle

Πηγή: Cell Death Dis
Cell death & disease 17(1), 211 (2026). doi:10.1038/s41419-026-08445-2

Θεματικοί όροι: Sensory Receptor Cells: metabolism, Paclitaxel, Topic 3: Integrative Biomedicine, Topic 1: Genes, Cells and Cell-Based Medicine, Peripheral Nervous System Diseases: metabolism, Cell Survival: drug effects, Sensory Receptor Cells: pathology, Paclitaxel: adverse effects, Multiomics, Article, Peripheral Nervous System Diseases: pathology, Humans, Sensory Receptor Cells: drug effects, Induced Pluripotent Stem Cells: metabolism, Induced Pluripotent Stem Cells: drug effects, Technology Platforms, Peripheral Nervous System Diseases: genetics, Paclitaxel: pharmacology, Peripheral Nervous System Diseases: chemically induced, Topic 2: Molecular Processes and Therapies

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41667428/
https://doi.org/10.1038/s41419-026-08445-2
https://pmc.ncbi.nlm.nih.gov/articles/PMC12921266/
https://pub.dzne.de/record/285355

Green and Ecofriendly Mycosynthesis of Nanocomposite Based on Zinc and Magnesium Oxide Nanoparticles Using Endophytic Sarocladium kiliense : Characterization, Anticancer Activity, Antimicrobial and Antibiofilm Activities: Characterization, Anticancer Activity, Antimicrobial and Antibiofilm Activities

Συγγραφείς: Samy Selim, Fathy M. Elkady, Ebrahim Saied, Amr H. Hashem, Amer M. Abdelaziz, Mohammed S. Abdulrahman, Faisal Alsenani, Omar Awad Alsaidan, Sami I. Alzarea, Yousef Alhaj Hamoud, Hiba Shaghaleh, Mohammed Aufy

Πηγή: Microbiologyopen

Θεματικοί όροι: Microbial Sensitivity Tests, anticancer, Pseudomonas aeruginosa/drug effects, biofilm, Cell Line, Anti-Bacterial Agents/pharmacology, Nanocomposites/chemistry, Anti-Infective Agents/metabolism, Magnesium Oxide/metabolism, Biofilms/drug effects, ZnO-MgO NCs, SDG 3 - Good Health and Well-being, Humans, Spectroscopy, 106022 Mikrobiologie, Tumor, Sarocladium kiliense, Green Chemistry Technology, Endophytes/metabolism, mycosynthesis, Antineoplastic Agents/metabolism, Fourier Transform Infrared, SDG 3 – Gesundheit und Wohlergehen, 106022 Microbiology, Zinc Oxide/metabolism, Original Article, Nanoparticles/chemistry, Cell Survival/drug effects

Σύνδεσμος πρόσβασης: https://pmc.ncbi.nlm.nih.gov/articles/PMC12918420/
https://pubmed.ncbi.nlm.nih.gov/41711410/
https://doi.org/10.1002/mbo3.70235
https://ucrisportal.univie.ac.at/de/publications/2dae96d8-f971-4205-9a47-74e5b4dcebc6
https://doi.org/10.1002/mbo3.70235

Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment: in vitro and in vivo assessment: in vitro and in vivo assessment

Συγγραφείς: Prashant Pandey, Dilip Kumar Arya, Anit Kumar, Ajeet Kaushik, Yogendra Kumar Mishra, P. S. Rajinikanth

Πηγή: Pandey, P, Arya, D K, Kumar, A, Kaushik, A, Mishra, Y K & Rajinikanth, P S 2025, 'Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment : in vitro and in vivo assessment', Journal of Materials Chemistry B, vol. 13, no. 8, pp. 2682-2694. https://doi.org/10.1039/d4tb02570a

Θεματικοί όροι: Folic Acid/chemistry, Breast Neoplasms, Antineoplastic Agents, Apoptosis, Drug Screening Assays, Ligands, Cell Proliferation/drug effects, Rats, Sprague-Dawley, Folic Acid, Breast Neoplasms/drug therapy, Cell Movement, Antineoplastic Agents/chemistry, Humans, Animals, Particle Size, Cell Proliferation, Apoptosis/drug effects, Antitumor, Hydrogen-Ion Concentration, Rats, Drug Liberation, Liposomes, Fluorouracil/pharmacology, MCF-7 Cells, Female, Sprague-Dawley, Fluorouracil, Drug Screening Assays, Antitumor, Liposomes/chemistry, Oligopeptides, Cell Survival/drug effects

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39841132
https://portal.findresearcher.sdu.dk/da/publications/10377c9f-8091-462f-9771-97b9a1cf3a66
https://doi.org/10.1039/d4tb02570a

Enhancing the CuAAC efficiency of a Cu(i)–NHC complex in biological media by encapsulation

Συγγραφείς: A. P. Prakasham, Harshit Singh, Anja R. A. Palmans

Πηγή: Chem Commun (Camb)
Chemical Communications

Θεματικοί όροι: Cycloaddition Reaction, Cell Survival, Antineoplastic Agents, Coordination Complexes/chemistry, Glutathione, Catalysis, Chemistry, Coordination Complexes, Antineoplastic Agents/chemistry, Copper/chemistry, Humans, Glutathione/chemistry, Copper, Cell Survival/drug effects, HeLa Cells

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40468768

Electrochemotherapy impacts the viability, functionality and phenotype of murine dendritic cells in voltage-dependent manner

Συγγραφείς: Bendix, Maura B, Baker, Kevin J, Forde, Patrick F, Houston, Aileen, Brint, Elizabeth

Θεματικοί όροι: Animals, Dendritic Cells/cytology, Cell Survival/drug effects, Mice, Electrochemotherapy/methods, Inbred C57BL, Toll-Like Receptors/metabolism, Phenotype, Cytokines/metabolism, [Medicine]

Περιγραφή αρχείου: application/pdf

Relation: 109263; Baker, Kevin J; Forde, Patrick F; Bioelectrochemistry; https://hdl.handle.net/10468/18682; 170

Διαθεσιμότητα: https://hdl.handle.net/10468/18682
https://doi.org/10.1016/j.bioelechem.2026.109263

Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma

Συγγραφείς: Kocherlakota, Sai, Nicol, Alan, Locri, Filippo, Stebbins, Karin J, Lorrain, Daniel S, Tribble, James R, Williams, Pete A

Πηγή: Kocherlakota, S, Nicol, A, Locri, F, Stebbins, K J, Lorrain, D S, Tribble, J R & Williams, P A 2026, 'Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma', Translational Vision Science and Technology, vol. 15, no. 1, 11. https://doi.org/10.1167/tvst.15.1.11

Θεματικοί όροι: Animals, Ocular Hypertension/drug therapy, Receptors, Lysophosphatidic Acid/antagonists & inhibitors, Rats, Disease Models, Animal, Intraocular Pressure/drug effects, Retinal Ganglion Cells/drug effects, Glaucoma/drug therapy, Male, Neuroprotective Agents/pharmacology, Neuroprotection/drug effects, Sprague-Dawley, Cell Survival/drug effects

Περιγραφή αρχείου: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/41533855

Διαθεσιμότητα: https://kclpure.kcl.ac.uk/portal/en/publications/d9b97cd7-ff9f-4bd5-85ea-2efd6da16a5b
https://doi.org/10.1167/tvst.15.1.11
https://kclpure.kcl.ac.uk/ws/files/363026969/Pharmacological_Blockade_of_LPAR1_Does_Not_Provide_Neuroprotection_Version_of_Record.pdf
https://www.scopus.com/pages/publications/105027617972

Mechanically reinforced hydrogel vehicle delivering angiogenic factor for beta cell therapy

Συγγραφείς: Mette Steen Toftdal, Natasja Porskjær Christensen, Firoz Babu Kadumudi, Alireza Dolatshahi-Pirouz, Lars Groth Grunnet, Menglin Chen

Πηγή: Toftdal, M S, Christensen, N P, Kadumudi, F B, Dolatshahi-Pirouz, A, Grunnet, L G & Chen, M 2024, 'Mechanically reinforced hydrogel vehicle delivering angiogenic factor for beta cell therapy', Journal of Colloid and Interface Science, vol. 667, pp. 54-63. https://doi.org/10.1016/j.jcis.2024.04.050

Θεματικοί όροι: Vascular Endothelial Growth Factor A, 0301 basic medicine, Gelatin/chemistry, Alginates, Cell Survival, Surface Properties, Polyesters, 03 medical and health sciences, Insulin-Secreting Cells/metabolism, Insulin-Secreting Cells, Animals, Humans, name=SDG 3 - Good Health and Well-being, Polyesters/chemistry, 0303 health sciences, Electrospinning, Vascular Endothelial Growth Factor A/metabolism, Hydrogels, Drug release, Hydrogels/chemistry, VEGF, Angiogenesis Inducing Agents/chemistry, Rats, 3. Good health, Beta cell, Hydrogel, Diabetes Mellitus, Type 1, Alginates/chemistry, Gelatin, Methacrylates, Methacrylates/chemistry, Angiogenesis Inducing Agents, Diabetes Mellitus, Type 1/therapy, Cell Survival/drug effects

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38615623
https://pure.au.dk/portal/en/publications/1e686ff3-3e90-408a-8e56-eef983c9545d
https://doi.org/10.1016/j.jcis.2024.04.050
https://www.scopus.com/pages/publications/85190250014
https://pure.au.dk/ws/files/420364146/1-s2.0-S0021979724007628-main.pdf

Systemic semaglutide provides a mild vasoprotective and antineuroinflammatory effect in a rat model of ocular hypertensive glaucoma

Συγγραφείς: Mouhammad, Zaynab A, Rombaut, Anne, Bermúdez, Mariana Yolotzin García, Vohra, Rupali, Tribble, James R, Williams, Pete A, Kolko, Miriam

Πηγή: Mol Brain
Mouhammad, Z A, Rombaut, A, Bermudez, M Y G, Vohra, R, Tribble, J R, Williams, P A & Kolko, M 2025, ' Systemic semaglutide provides a mild vasoprotective and antineuroinflammatory effect in a rat model of ocular hypertensive glaucoma ', Molecular Brain, vol. 18, no. 1, 54 . https://doi.org/10.1186/s13041-025-01224-8
Mouhammad, Z A, Rombaut, A, Bermúdez, M Y G, Vohra, R, Tribble, J R, Williams, P A & Kolko, M 2025, 'Systemic semaglutide provides a mild vasoprotective and antineuroinflammatory effect in a rat model of ocular hypertensive glaucoma', Molecular brain, vol. 18, no. 1, 54. https://doi.org/10.1186/s13041-025-01224-8

Θεματικοί όροι: Retinal Ganglion Cells, Male, Glaucoma/drug therapy, Cell Survival, Glucagon-Like Peptides, Anti-Inflammatory Agents, Retina, Micro Report, Intraocular Pressure/drug effects, Neuroinflammation, Glucagon-Like Peptide 1, Rats, Inbred BN, Retinal Ganglion Cells/drug effects, Animals, Anti-Inflammatory Agents/pharmacology, Retinal ganglion cell, Neurodegeneration, Intraocular Pressure, Inflammation, GLP-1 receptor agonists, Semaglutide, Glaucoma, Neuroprotection, Rats, Glucagon-Like Peptides/pharmacology, Astrocytes/drug effects, Disease Models, Animal, Neuroprotective Agents, Astrocytes, Ocular Hypertension, Neuroprotective Agents/pharmacology, Ocular Hypertension/drug therapy, Inflammation/pathology, Cell Survival/drug effects

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40597179
https://curis.ku.dk/ws/files/455897625/s13041-025-01224-8.pdf
https://doi.org/10.1186/s13041-025-01224-8
https://researchprofiles.ku.dk/da/publications/b0585401-0c96-40dd-a470-954b8696c4f9
https://www.scopus.com/pages/publications/105009795411
https://doi.org/10.1186/s13041-025-01224-8
https://kclpure.kcl.ac.uk/portal/en/publications/1eabbd8b-2b45-4d13-a90f-0c4097a76ee9
https://kclpure.kcl.ac.uk/ws/files/361569385/s13041-025-01224-8.pdf

Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs

Συγγραφείς: Jasmijn Janssen, Nino Chirico, Madison J. Ainsworth, Gerardo Cedillo-Servin, Martina Viola, Inge Dokter, Tina Vermonden, Pieter A. Doevendans, Margarida Serra, Ilja K. Voets, Jos Malda, Miguel Castilho, Linda W. van Laake, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Alain van Mil

Πηγή: Biomater Sci
Biomaterials Science

Θεματικοί όροι: Cryopreservation, 0301 basic medicine, Myocytes, 0303 health sciences, Cultured, Tissue Engineering, Tissue Scaffolds, Cell Survival, Cells, Induced Pluripotent Stem Cells, Hydrogels, Hydrogels/chemistry, Tissue Scaffolds/chemistry, Chemistry, 03 medical and health sciences, Induced Pluripotent Stem Cells/cytology, Cardiac/cytology, Humans, Myocytes, Cardiac, Cells, Cultured, Cell Survival/drug effects

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38910521
https://research.tue.nl/en/publications/ea25cd0d-48d3-453e-bafa-1ae9c4028904
https://doi.org/10.1039/d3bm01908j
https://research-portal.uu.nl/en/publications/6b4d7f85-b28f-4d9a-ab24-2ee0933fa9ca
https://doi.org/10.1039/d3bm01908j

Assembly-enhanced indocyanine green nanoparticles for fluorescence imaging-guided photothermal therapy

Συγγραφείς: Shukun Li, Yudong Li, Mengqian Shi, Ruirui Xing, Jan C. M. Van Hest, Xuehai Yan

Πηγή: Journal of Materials Chemistry B. 12:10915-10922

Θεματικοί όροι: Indocyanine Green, Mice, Inbred BALB C, Photothermal Therapy, Cell Survival, Optical Imaging, Antineoplastic Agents, Theranostic Nanomedicine, Mice, Indocyanine Green/chemistry, Antineoplastic Agents/chemistry, Nanoparticles, Humans, Animals, Fluorescent Dyes/chemistry, Nanoparticles/chemistry, Particle Size, Inbred BALB C, Cell Survival/drug effects, Fluorescent Dyes

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39347558

Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria

Συγγραφείς: Ronni A. G. da Silva, Claudia J. Stocks, Guangan Hu, Kimberly A. Kline, Jianzhu Chen

Πηγή: ACS Infect Dis

Θεματικοί όροι: Cell Survival / drug effects, antibiotic resistance, Antibiotic resistance, Cell Survival, Wound infection, Macrophages / drug effects, immunomodulation, NF-kappa B / metabolism, Immunomodulation, Aniline Compounds / pharmacology, Mice, Phagocytosis, Nitriles, Enterococcus faecalis, Animals, Humans, Enterococcus faecalis / drug effects, Gram-Positive Bacterial Infections, Aniline Compounds, Macrophages, NF-kappa B, Gram-Positive Bacterial Infections / drug therapy, Reactive Oxygen Species / metabolism, phagocytosis, 2725 Infectious Diseases, Anti-Bacterial Agents / pharmacology, macrophages, Src kinases targeting, Anti-Bacterial Agents, 3. Good health, Mice, Inbred C57BL, Quinolines, Nitriles / pharmacology, wound infection, Phagocytosis / drug effects, Reactive Oxygen Species, Quinolines / pharmacology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38602352
https://api.library.uq.edu.au/view/UQ:edd5faa
https://espace.library.uq.edu.au/view/UQ:edd5faa

The Importance of Coating Surface and Composition for Attachment and Survival of Neuronal Cells Under Mechanical Stimulation

Συγγραφείς: Pascal A. M. M. Vroemen, Adrián Seijas‐Gamardo, Roy Palmen, Paul A. Wieringa, Carroll A. B. Webers, Lorenzo Moroni, Theo G. M. F. Gorgels

Πηγή: Journal of Biomedical Materials Research Part A. 113

Θεματικοί όροι: Retinal Ganglion Cells, Neurons, Cell Survival, Surface Properties, PC-12, Coated Materials, coating, Retinal Ganglion Cells/cytology metabolism drug effects, Stress, Mechanical, PC12 Cells, Rats, neuronal cells, Biocompatible/pharmacology chemistry, Neurons/cytology, glaucoma, laminin, Coated Materials, Biocompatible, Cell Adhesion, Animals, Cell Adhesion/drug effects, Stress, Mechanical, mechanical stimulation, retinal ganglion cell, Cell Survival/drug effects

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40285752
https://cris.maastrichtuniversity.nl/en/publications/18f94409-d4c6-4bd6-9ac9-efeb98c0ee28
https://doi.org/10.1002/jbm.a.37919

Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival

Συγγραφείς: Komza, M., Khatun, J., Gelles, J.D., Trotta, A.P., Abraham-Enachescu, I., Henao, J., Elsaadi, A., Kotini, A.G., Clementelli, C., Arandela, J., Ghaity-Beckley, S.E., Barua, A., Chen, Y., Berisa, M., Marcellino, B.K., Papapetrou, E.P., Poyurovsky, M.V., Chipuk, J.E.

Πηγή: Cell Commun Signal
Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-23 (2025)
Cell communication and signaling, vol. 23, no. 1, pp. 47

Θεματικοί όροι: Adaptations, Leukemia, QH573-671, Cell Survival, Research, Humans, Mitochondria/metabolism, Mitochondria/drug effects, Glucose/metabolism, Cell Survival/drug effects, Leukemia, Myeloid, Acute/pathology, Leukemia, Myeloid, Acute/metabolism, Leukemia, Myeloid, Acute/genetics, Leukemia, Myeloid, Acute/drug therapy, Cell Respiration/drug effects, Glycolysis/drug effects, Oxidative Phosphorylation/drug effects, Cell Line, Tumor, Adaptation, Physiological, Bioenergetics, Cancer, Chemotherapy, Glucose, Metabolism, Mitochondria, Oncogenes, Stem cells, Cell Respiration, Oxidative Phosphorylation, Leukemia, Myeloid, Acute, Medicine, Cytology, Glycolysis

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39863913
https://doaj.org/article/1ee0edd56afb478b807dd13d66caf1ab
https://serval.unil.ch/resource/serval:BIB_903FD8FB36B8.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_903FD8FB36B8
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_903FD8FB36B84

Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells

Συγγραφείς: Adhish S. Walvekar, Marc Warmoes, Dean Cheung, Tim Sikora, Najmesadat Seyedkatouli, Gemma Gomez-Giro, Sebastian Perrone, Lisa Dengler, François Unger, Bruno F. R. Santos, Floriane Gavotto, Xiangyi Dong, Julia Becker-Kettern, Yong-Jun Kwon, Christian Jäger, Jens C. Schwamborn, Nicole J. Van Bergen, John Christodoulou, Carole L. Linster

Πηγή: Cell Mol Biol Lett
Cellular & Molecular Biology Letters, Vol 30, Iss 1, Pp 1-40 (2025)
Cellular and Molecular Biology Letters, 30 (1), 3 (2025-01-09)

Θεματικοί όροι: NAXE protein, human, Cell Survival, Racemases and Epimerases, Metabolite damage and repair, Inborn errors of metabolism, Serine biosynthesis, Biochimie, biophysique & biologie moléculaire, Biochemistry, Sciences de la santé humaine, Cell Line, NAD(P)H hydration, Mitochondria/metabolism, Serine, Humans, 3-Phosphoglycerate dehydrogenase, Human health sciences, Molecular Biology, NAXD, Serine/metabolism, QH573-671, Cell Biology, NADP/metabolism, NAD, Life sciences, Inosine, Mitochondria/drug effects, Nicotinamide riboside, Mitochondria, Sciences du vivant, NAD/metabolism, Cytology, NADP, Cell Survival/drug effects, Biochemistry, biophysics & molecular biology, Research Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39789421
https://doaj.org/article/d0b260fa47e44d809b279ae3873a1f18
https://orbilu.uni.lu/handle/10993/65234
https://orbilu.uni.lu/bitstream/10993/65234/1/s11658-024-00681-8.pdf

Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines

Συγγραφείς: Verhees, Femke, Demers, Imke, Legemaate, Dion, Jacobs, Robin, Hoeben, Ann, Kremer, Bernd, Speel, Ernst-Jan

Πηγή: Int J Oncol

Θεματικοί όροι: Pyridines, Cell Survival, Aminopyridines, Apoptosis, Head and Neck Neoplasms/drug therapy virology metabolism, cell survival, Piperazines, Cell Line, Cell Proliferation/drug effects, Phosphatidylinositol 3-Kinases, Papillomavirus Infections/drug therapy virology, Signal Transduction/drug effects, Cell Line, Tumor, Phosphoinositide-3 Kinase Inhibitors/pharmacology, Thiazoles/pharmacology, Proto-Oncogene Proteins c-akt/metabolism, Humans, Piperazines/pharmacology, human papillomavirus, Protein Kinase Inhibitors, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Pyridines/pharmacology, Tumor, Squamous Cell Carcinoma of Head and Neck, TOR Serine-Threonine Kinases, Apoptosis/drug effects, Papillomavirus Infections, apoptosis, Cyclin-Dependent Kinase 4, Human Papillomavirus Viruses, cell line, Articles, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase 6/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism antagonists & inhibitors, Aminopyridines/pharmacology, Protein Kinase Inhibitors/pharmacology therapeutic use, Head and Neck Neoplasms, Purines, Squamous Cell Carcinoma of Head and Neck/drug therapy virology metabolism pathology, cell cycle, head and neck cancer, Cyclin-Dependent Kinase 4/antagonists & inhibitors metabolism, Phosphatidylinositol 3-Kinases/metabolism, Proto-Oncogene Proteins c-akt, Purines/pharmacology, Cell Survival/drug effects, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39791215

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

Συγγραφείς: Stevenson, Leanne, Cairns, Lauren, Li, Xiaodun, Jammula, Sriganesh, Taylor, Harriet, Douglas, Rosalie, McCabe, Niamh, Gavory, Gerald, Jacq, Xavier, Fitzgerald, Rebecca C., Kennedy, Richard D., Harrison, Timothy, Turkington, Richard C.

Συνεισφορές: Apollo - University of Cambridge Repository

Πηγή: Sci Rep
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Stevenson, L, Cairns, L, Li, X, Jammula, S, Taylor, H, Douglas, R, McCabe, N, Gavory, G, Jacq, X, Fitzgerald, R C, Kennedy, R D, Harrison, T & Turkington, R C 2024, 'Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma', Scientific Reports, vol. 14, 32121 . https://doi.org/10.1038/s41598-024-83912-4

Θεματικοί όροι: 0301 basic medicine, tumor, Esophageal Neoplasms, Cell Survival, Science, Apoptosis, Antineoplastic Agents, Adenocarcinoma, inhibitor of apoptosis proteins - metabolism - antagonists & inhibitors, Article, Inhibitor of Apoptosis Proteins, apoptosis - drug effects, proto-oncogene proteins c-akt - metabolism, 03 medical and health sciences, Cell Line, Tumor, cell survival - drug effects, Humans, cell proliferation - drug effects, humans, Cell Proliferation, drug synergism, 0303 health sciences, drug resistance, neoplasm - drug effects, drug resistance, neoplasm - drug effects, Drug Synergism, cell line, adenocarcinoma - drug therapy - metabolism - pathology, cell line, tumor, signal transduction - drug effects, Drug Resistance, Neoplasm, Medicine, Proto-Oncogene Proteins c-akt, antineoplastic Agents - pharmacology, esophageal neoplasms - drug therapy - metabolism - pathology, Signal Transduction

Περιγραφή αρχείου: application/pdf; application/zip; text/xml

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39739112
https://doaj.org/article/fef048df10404b758cee606c430aea71

Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties

Συγγραφείς: Vermeulen, Stephanie, Ernst, Sam, Blondeel, Eva, Xia, Zihan, Rappu, Pekka, Heino, Jyrki, Dedeyne, Sandor, Denys, Hannelore, Sys, Gwen, Gijsels, Stefanie, Depypere, Herman, Tummers, Philippe, Ceelen, Wim, Craciun, Ligia, Demetter, Pieter, Raes, Olivier, Hendrix, An, Van der Eycken, Johan, De Wever, Olivier

Πηγή: Sci Rep
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Scientific reports, 14 (1
SCIENTIFIC REPORTS

Θεματικοί όροι: Paclitaxel, Cell Survival, Science, Antineoplastic Agents, TUBULIN ACETYLATION, Paclitaxel -- pharmacology, Tubulin Modulators -- pharmacology -- chemistry, Microtubules, DISEASE, Article, MECHANISMS, Lactones, Breast cancer, Ovarian cancer, Tubulin, Cell Line, Tumor, Medicine and Health Sciences, Humans, Animals, Tubulin -- metabolism, Biology and Life Sciences, SITE, Sarcoma, Sciences bio-médicales et agricoles, Antineoplastic Agents -- pharmacology -- chemistry, Pelophen B, Cell Survival -- drug effects, Tubulin Modulators, PELORUSIDE-A, Microtubule-stabilizing agent, G2 Phase Cell Cycle Checkpoints, G2 Phase Cell Cycle Checkpoints -- drug effects, Lactones -- pharmacology -- chemistry -- metabolism, CELL-DEATH, Drug Resistance, Neoplasm, GROWTH, Medicine, BETA-TUBULIN, SENSITIVITY, TAXANE, Microtubules -- metabolism -- drug effects, Drug Resistance, Neoplasm -- drug effects

Περιγραφή αρχείου: 1 full-text file(s): application/pdf; application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39633082
https://doaj.org/article/45ac459d71fb40c5a53b49a155765449
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/395755
https://dipot.ulb.ac.be/dspace/bitstream/2013/395755/3/41598_2024_Article_80672.pdf
https://biblio.ugent.be/publication/01JEBJ6FTBJM9FXP5G71BQQQ7M/file/01JEBJ7PAGZBXX7AM438DZ759A
http://hdl.handle.net/1854/LU-01JEBJ6FTBJM9FXP5G71BQQQ7M
http://doi.org/10.1038/s41598-024-80672-z
https://biblio.ugent.be/publication/01JEBJ6FTBJM9FXP5G71BQQQ7M

Decellularised Cartilage-Based Hydrogels Functionalised With Chondroitin Sulphate and Quercetin: The Impact on Chondrogenesis

Συγγραφείς: Rosa, NDS, Neves, N, Gelinsky, M, Santos, SG, Bernhardt, A, Barbosa, MA

Συνεισφορές: Instituto de Investigação e Inovação em Saúde

Θεματικοί όροι: Animals, Cartilage / chemistry, Cell Differentiation / drug effects, Cell Survival / drug effects, Chondrocytes / cytology, Chondrogenesis / drug effects, Chondroitin Sulfates / chemistry, Decellularized Extracellular Matrix / chemistry Humans, Humans, Hydrogels / chemistry, Quercetin / chemistry, Chondrocytes / drug effects, Chondrocytes / metabolism, Chondroitin Sulfates / pharmacology, Hydrogels / pharmacology, Quercetin / pharmacology

Περιγραφή αρχείου: application/pdf

Relation: Journal of Biomedical Materials Research - Part A, vol.113(10):e37999; https://hdl.handle.net/10216/173786; https://isni.org/isni/0000000458971141; https://ror.org/04wjk1035

Διαθεσιμότητα: https://hdl.handle.net/10216/173786
https://doi.org/10.1002/jbm.a.37999
https://isni.org/isni/0000000458971141
https://ror.org/04wjk1035

Kerstinginone, a new flavanone derivative from Commiphora kerstingii Engl. (Burseraceae) with potent apoptosis-inducing activity and inhibition of AKT/mTOR signaling pathway in non-sensitive prostate cancer cells.

Συγγραφείς: Yaya, Joël Abel Gbaweng, Zingue, Stephane, Offermann, Anne, Feunaing Toko, Roméo, Kang, Duan, Bapong, Elisée, Henoumont, Céline, Laurent, Sophie, Sailer, Verena-Wilbeth, Kirfef, Jutta, Talla, Emmanuel, Perner, Sven

Συνεισφορές: CMMI - Centre de Recherche en Microscopie et Imagerie Médicale, M108 - Chimie générale, organique et biomédicale, R550 - Institut des Sciences et Technologies de la Santé, R100 - Institut des Biosciences

Πηγή: Journal of Ethnopharmacology, 338 (Pt 2), 119073 (2025-02-10)

Θεματικοί όροι: Apoptosis, Cell growth, Commiphora kerstingii, Kerstingilactone, Kerstinginone, Prostate cancer, Proto-Oncogene Proteins c-akt, Plant Extracts, TOR Serine-Threonine Kinases, Antineoplastic Agents, Phytogenic, Flavanones, Humans, Male, Cell Line, Tumor, Cell Proliferation/drug effects, Phytogenic/pharmacology, Phytogenic/isolation & purification, Phytogenic/chemistry, Cell Survival/drug effects, Cell Movement/drug effects, Flavanones/pharmacology, Flavanones/isolation & purification, Plant Leaves/chemistry, Plant Bark/chemistry, PC-3 Cells, Apoptosis/drug effects, Prostatic Neoplasms/drug therapy, Prostatic Neoplasms/pathology

Relation: https://api.elsevier.com/content/article/PII:S0378874124013722?httpAccept=text/xml; urn:issn:0378-8741; urn:issn:1872-7573; https://orbi.umons.ac.be/handle/20.500.12907/53640; info:hdl:20.500.12907/53640; info:pmid:39522846

Διαθεσιμότητα: https://orbi.umons.ac.be/handle/20.500.12907/53640
https://hdl.handle.net/20.500.12907/53640
https://orbi.umons.ac.be/bitstream/20.500.12907/53640/1/1-s2.0-S0378874124013722-main.pdf
https://doi.org/10.1016/j.jep.2024.119073

An Evaluation of the Potential Radiosensitization Effect of Spherical Gold Nanoparticles to Induce Cellular Damage Using Different Radiation Qualities

Συγγραφείς: Engelbrecht-Roberts, Monique, Miles, Xanthene, Vandevoorde, Charlot, de Kock, Maryna

Πηγή: Molecules 30(5), 1038 (2025). doi:10.3390/molecules30051038

Θεματικοί όροι: info:eu-repo/classification/ddc/540, Gold: chemistry, Gold: pharmacology, Humans, Metal Nanoparticles: chemistry, Radiation-Sensitizing Agents: pharmacology, Radiation-Sensitizing Agents: chemistry, Cell Survival: drug effects, Cell Survival: radiation effects, Animals, DNA Breaks, Double-Stranded: radiation effects, Double-Stranded: drug effects, X-Rays, MCF-7 Cells, Cell Proliferation: drug effects, Cell Proliferation: radiation effects, CHO Cells, Lymphocytes: drug effects, Lymphocytes: radiation effects, Cricetulus, DNA Damage, Cell Cycle: drug effects, Cell Cycle: radiation effects, dose enhancement effect, gold nanoparticles (AuNPs), linear energy transfer (LET), nanomedicine, radiation therapy, radiosensitizer interaction indices

Θέμα γεωγραφικό: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1420-3049; info:eu-repo/semantics/altIdentifier/wos/WOS:001442490800001; info:eu-repo/semantics/altIdentifier/pmid/pmid:40076263; info:eu-repo/semantics/altIdentifier/issn/1431-5157; https://repository.gsi.de/record/363331

Διαθεσιμότητα: https://repository.gsi.de/record/363331
https://repository.gsi.de/search?p=id:%22GSI-2025-01348%22