Ultrasound-assisted 1,2,4-triazole Schiff bases: synthesis, characterization, docking, and dual inhibition of urease and α-glucosidase.

Authors: Gültekin E; Science-Technology Research and Application Center, Artvin Coruh University, Artvin, Türkiye.

Source: Future medicinal chemistry [Future Med Chem] 2026 Jul; Vol. 18 (13), pp. 1701-1711. Date of Electronic Publication: 2026 May 19.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , Urease*/antagonists & inhibitors , Urease*/metabolism , alpha-Glucosidases*/metabolism , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Ultrasonic Waves*, Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Schiff Bases/chemical synthesis ; Molecular Docking Simulation ; Structure-Activity Relationship ; Molecular Structure

Synthesis of thiosemicarbazone derivatives of thiophene-2-carboxylic acid as potent urease inhibitors: in vitro evaluation, molecular docking, and density functional theory analysis.

Authors: Khan W; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Laiba; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Ahmad I; Programa de Pós-Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Pelotas, Brazil., Elhenawy AA; Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt., Shah SAA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA Puncak Alam Campus, Bandar Puncak Alam, Malaysia.; Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Malaysia., Alanazi AS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Shakoor A; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Alam A; Department of Chemistry, Rawalpindi Women University, Rawalpindi, Pakistan., Khan M; Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan., Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Source: Future medicinal chemistry [Future Med Chem] 2026 Aug; Vol. 18 (16), pp. 2147-2159. Date of Electronic Publication: 2026 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/chemical synthesis , Thiosemicarbazones*/pharmacology , Thiophenes*/chemistry , Thiophenes*/pharmacology , Thiophenes*/chemical synthesis , Density Functional Theory*, Molecular Docking Simulation ; Structure-Activity Relationship ; Molecular Structure ; Molecular Dynamics Simulation ; Carboxylic Acids

Unraveling Structural Changes and the Reaction Mechanism in Urease upon Infrared Physical Inactivation.

Authors: Shen T; School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China., Liu Y; School of Food Science and Engineering, Chongqing Technology and Business University, 19 Xuefu Avenue, Nan'an District, Chongqing 400010, PR China., Qu W; School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.; Institute of Food Physical Processing, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China., Ma H; School of Food Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China.; Institute of Food Physical Processing, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, PR China., Jiang Q; Zhenjiang Meibo Infrared Technology Co., Ltd, Dingmao Technology New Town, Zhenjiang, Jiangsu 212013, PR China., Huang Y; Taizhou Agricultural Machinery Technology Promotion Station, Taizhou, Jiangsu 225300, PR China.

Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jul 22; Vol. 74 (28), pp. 22172-22186. Date of Electronic Publication: 2026 Jul 09.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

MeSH Terms: Urease*/chemistry , Urease*/metabolism, Protein Conformation/radiation effects ; Kinetics ; Hydrophobic and Hydrophilic Interactions ; Molecular Dynamics Simulation ; Infrared Rays ; Hydrogen Bonding ; Hot Temperature

Urease inhibitors: current advances, therapeutic potentials, and clinical challenges.

Authors: Alzoubi OH; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Khamees A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.; Princess Basma Teaching Hospital, Ministry of Health, Irbid, Jordan., Alzu'bi MB; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Freihat SF; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Attar A; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Abo Sameed H; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alzubi R; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Alsamarah AA; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Yassin RY; Faculty of Pharmacy, Yarmouk University, Irbid, Jordan., Al-Shami K; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan., Al-Trad B; Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia., Al-Zoubi RM; Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.; Department of Chemistry, Jordan University of Science and Technology, Irbid, Jordan.; Department of Biomedical Sciences, QU-Health, College of Health Sciences, Qatar University, Doha, Qatar., Al Zoubi MS; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Source: Future medicinal chemistry [Future Med Chem] 2026 Jul; Vol. 18 (14), pp. 1907-1923. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/therapeutic use, Helicobacter pylori/drug effects ; Helicobacter pylori/enzymology ; Helicobacter Infections/drug therapy ; Humans ; Animals

Mechanistic insights into Helicobacter pylori urease inhibition by poplar propolis ethanol extract.

Authors: Yuan J; College of Agriculture and Biology, Liaocheng University, Liaocheng, People's Republic of China; Institut for Advanced Studies, Universiti Malaya, Kuala Lumpur, Malaysia., Li T; College of Agriculture and Biology, Liaocheng University, Liaocheng, People's Republic of China., Gao S; College of Agriculture and Biology, Liaocheng University, Liaocheng, People's Republic of China., Tang Y; College of Agriculture and Biology, Liaocheng University, Liaocheng, People's Republic of China., Ma S; College of Agriculture and Biology, Liaocheng University, Liaocheng, People's Republic of China., Lee HY; Tropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address: leehaiyen@um.edu.my., Chin KL; Institut for Advanced Studies, Universiti Malaya, Kuala Lumpur, Malaysia; Department of Medical Microbiology, Universiti Malaya, Kuala Lumpur, Malaysia. Electronic address: chinkimling@um.edu.my., Xuan H; College of Agriculture and Biology, Liaocheng University, Liaocheng, People's Republic of China. Electronic address: xuanhongzhuan@lcu.edu.cn.

Source: Journal of ethnopharmacology [J Ethnopharmacol] 2026 Jun 28; Vol. 365, pp. 121596. Date of Electronic Publication: 2026 Mar 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Urease*/genetics , Propolis*/pharmacology , Propolis*/chemistry , Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Helicobacter pylori*/growth & development , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/isolation & purification , Anti-Bacterial Agents*/chemistry , Populus*/chemistry , Enzyme Inhibitors*/pharmacology, Ethanol/chemistry ; Molecular Docking Simulation

Engineering Escherichia coli for Urease-Driven Synthesis of Metal Oxide Nanomaterials.

Authors: Wu ZY; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Lin AYW; The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Müller IE; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Zhao Z; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Mouncey NJ; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Ercius P; The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Yoshikuni Y; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; U.S. Department of Energy Center for Bioenergy and Bioproducts Innovation (CABBI), Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Energy and Biosciences Institute, University of California, Berkeley, Berkeley, California 94720, United States.; Global Institution for Collaborative Research and Education, Hokkaido University, Hokkaido 060-8589, Japan.

Source: ACS synthetic biology [ACS Synth Biol] 2026 Jun 19; Vol. 15 (6), pp. 2264-2273. Date of Electronic Publication: 2026 Jun 08.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE

MeSH Terms: Escherichia coli*/genetics , Escherichia coli*/metabolism , Urease*/metabolism , Urease*/genetics , Metal Nanoparticles*/chemistry , Nanostructures*/chemistry, Titanium/chemistry ; Titanium/metabolism ; Sporosarcina/genetics ; Sporosarcina/enzymology ; Ferric Compounds/chemistry ; Ferric Compounds/metabolism ; Calcium Carbonate/metabolism ; Calcium Carbonate/chemistry ; Calcium Phosphates/metabolism ; Calcium Phosphates/chemistry ; Oxides/chemistry ; Oxides/metabolism

SCR Organism: Sporosarcina pasteurii

Sporosarcina pasteurii urease gene expression regulation mechanism overcomes urease inhibition by hydrocarbons.

Authors: Comadran-Casas C; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK. Electronic address: Carla.ComadranCasas@glasgow.ac.uk., Cholet F; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK., Ogundero A; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK., Poursat BAJ; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK., Smith CJ; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK., Sloan WT; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK., Bass AM; School of Geographical & Earth Sciences, College of Science and Engineering, University of Glasgow, Glasgow, UK., MacDonald J; School of Geographical & Earth Sciences, College of Science and Engineering, University of Glasgow, Glasgow, UK., Unluer C; Department of Civil Engineering and Management, University of Manchester, Manchester, UK., Gauchotte-Lindsay C; James Watt School of Engineering, College of Science and Engineering, Department of Infrastructure and Environment, the University of Glasgow, Glasgow, UK.

Source: Journal of hazardous materials [J Hazard Mater] 2026 Jun 15; Vol. 511, pp. 142148. Date of Electronic Publication: 2026 Apr 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE

MeSH Terms: Sporosarcina*/genetics , Sporosarcina*/drug effects , Sporosarcina*/enzymology , Sporosarcina*/growth & development , Urease*/genetics , Urease*/antagonists & inhibitors , Urease*/metabolism , Hydrocarbons*/pharmacology , Hydrocarbons*/toxicity , Gene Expression Regulation, Bacterial*/drug effects , Gene Expression Regulation, Enzymologic*/drug effects

SCR Organism: Sporosarcina pasteurii

Inhibition of urease by urea/thiourea-derived heterocycles: IC50 profiling and structure-activity relationship.

Authors: Bağ A; Institute of Science, Kafkas University, 36100, Kars, Turkey., Uluçay O; Department of Bioengineering, Faculty of Engineering and Architecture, Kafkas University, 36100, Kars, Turkey. Electronic address: orhanulucay@gmail.com.

Source: Biochimie [Biochimie] 2026 Jun; Vol. 245, pp. 160-167. Date of Electronic Publication: 2026 Mar 23.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/chemistry , Thiourea*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Urea*/chemistry , Heterocyclic Compounds*/chemistry , Heterocyclic Compounds*/pharmacology, Canavalia/enzymology ; Structure-Activity Relationship ; Inhibitory Concentration 50

Structure-activity studies reveal efficient inactivation of urease by Ebsulfur-based compounds.

Authors: Mazzei L; Laboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, I-40138 Bologna, Italy. Electronic address: luca.mazzei2@unibo.it., Paul A; Laboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, I-40138 Bologna, Italy. Electronic address: arundhati.paul2@unibo.it., Cianci M; Department of Agricultural, Food and Environmental Sciences, Polytechnic University of Marche, I-60131 Ancona, Italy. Electronic address: m.cianci@staff.univpm.it., Pizzi A; Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, I-20131 Milano, Italy. Electronic address: andrea.pizzi@polimi.it., Resnati G; Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, I-20131 Milano, Italy. Electronic address: giuseppe.resnati@polimi.it., Ciurli S; Laboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, I-40138 Bologna, Italy. Electronic address: stefano.ciurli@unibo.it.

Source: Journal of inorganic biochemistry [J Inorg Biochem] 2026 Jun; Vol. 279, pp. 113272. Date of Electronic Publication: 2026 Feb 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/chemistry , Sporosarcina*/enzymology , Azoles*/chemistry , Azoles*/pharmacology , Organoselenium Compounds*/chemistry , Organoselenium Compounds*/pharmacology , Canavalia*/enzymology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Isoindoles ; Structure-Activity Relationship ; Crystallography, X-Ray

SCR Organism: Sporosarcina pasteurii

Double-site rapid urease test versus histopathology for the diagnosis of Helicobacter pylori among patients with dyspepsia on proton pump inhibitors-A diagnostic accuracy study.

Authors: Yadav AI; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Jearth V; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India. vaneet.jearth@gmail.com., Sharma AK; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Singh AK; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Chauhan P; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Patial P; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Sekar A; Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Shah J; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Mandavdhare H; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Rana SS; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India., Dutta U; Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India.

Source: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2026 Aug; Vol. 45 (4), pp. 706-714. Date of Electronic Publication: 2025 Jun 12.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Springer India Country of Publication: India NLM ID: 8409436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0975-0711 (Electronic) Linking ISSN: 02548860 NLM ISO Abbreviation: Indian J Gastroenterol Subsets: MEDLINE

MeSH Terms: Helicobacter Infections*/diagnosis , Helicobacter Infections*/pathology , Helicobacter Infections*/complications , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/genetics , Proton Pump Inhibitors*/adverse effects , Proton Pump Inhibitors*/administration & dosage , Dyspepsia*/etiology , Dyspepsia*/microbiology , Dyspepsia*/drug therapy , Urease*/analysis, Humans ; Prospective Studies ; Female ; Biopsy ; Sensitivity and Specificity ; Polymerase Chain Reaction ; Male ; Predictive Value of Tests ; Middle Aged ; Rapid Diagnostic Tests ; Adult

Risk-benefit ranking of nitrification and urease inhibitors applied to agricultural soils using the PROMETHEE method.

Authors: Wang X; School of Biosystems and Food Engineering, Agriculture and Food Science Centre, University College Dublin, Belfield, Ireland., Forrestal P; Teagasc, Soils, Environment and Land Use Department, Crops Environment and Land Use Programme, Johnstown Castle, Co., Wexford, Ireland., Richards K; Teagasc, Soils, Environment and Land Use Department, Crops Environment and Land Use Programme, Johnstown Castle, Co., Wexford, Ireland., Matse DT; Teagasc, Soils, Environment and Land Use Department, Crops Environment and Land Use Programme, Johnstown Castle, Co., Wexford, Ireland., Cummins E; School of Biosystems and Food Engineering, Agriculture and Food Science Centre, University College Dublin, Belfield, Ireland.

Source: Integrated environmental assessment and management [Integr Environ Assess Manag] 2026 Jul 01; Vol. 22 (4), pp. 1159-1168.

Publication Type: Journal Article

Journal Info: Publisher: Society of Environmental Toxicology and Chemistry (SETAC) Country of Publication: England NLM ID: 101234521 Publication Model: Print Cited Medium: Internet ISSN: 1551-3793 (Electronic) Linking ISSN: 15513777 NLM ISO Abbreviation: Integr Environ Assess Manag Subsets: MEDLINE

MeSH Terms: Nitrification*/drug effects , Urease*/antagonists & inhibitors , Agriculture*/methods , Enzyme Inhibitors*/toxicity, Soil/chemistry ; Fertilizers ; Risk Assessment ; Nitrogen ; Organophosphorus Compounds

Synthesis, crystal structures and urease inhibition of Ni(II) complexes constructed from Schiff bases with 2,2'-bipyridine as co-ligands.

Authors: Liu WY; Department of Pharmacy, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou, Henan, 450003, China. SJun@zzu.edu.cn., Li HL; Department of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, 222000, China., Jia JS; Department of Pharmacy, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou, Henan, 450003, China. SJun@zzu.edu.cn., Zhao WM; Department of Pharmacy, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou, Henan, 450003, China. SJun@zzu.edu.cn., Sun J; Department of Pharmacy, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou, Henan, 450003, China. SJun@zzu.edu.cn.

Source: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2026 Jun 02; Vol. 55 (21), pp. 8258-8271. Date of Electronic Publication: 2026 Jun 02.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9234 (Electronic) Linking ISSN: 14779226 NLM ISO Abbreviation: Dalton Trans Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , 2,2'-Dipyridyl*/chemistry , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Coordination Complexes*/pharmacology , Nickel*/chemistry , Nickel*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology, Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Ligands ; Crystallography, X-Ray ; Molecular Structure ; Models, Molecular ; Molecular Docking Simulation

Urease-coated polydopamine nanomotors as self-propelled biosensors for non-invasive diagnosis: detection of prostate cancer-associated miR-141 in urine.

Authors: Özcan Özseven S; Suleyman Demirel University, Graduate School of Natural and Applied Sciences, Bioengineering, 32260 Isparta, Turkey., Yurdabak Karaca G; Suleyman Demirel University, Isparta Health Services Vocational School, Medical Services and Techniques, 32260 Isparta, Turkey., Öksüz L; Suleyman Demirel University, Faculty of Engineering and Natural Sciences, Department of Physics, 32260 Isparta, Turkey.; PLAZMATEK, Süleyman Demirel University Technokent, No: 105, 32000 Isparta, Turkey., Wang J; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA., Uygun Öksüz A; Suleyman Demirel University, Faculty of Engineering and Natural Sciences, Department of Chemistry, 32260 Isparta, Turkey. ayseguluygun@sdu.edu.tr.

Source: Analytical methods : advancing methods and applications [Anal Methods] 2026 Jul 09; Vol. 18 (26), pp. 5523-5535. Date of Electronic Publication: 2026 Jul 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: RSC Pub Country of Publication: England NLM ID: 101519733 Publication Model: Electronic Cited Medium: Internet ISSN: 1759-9679 (Electronic) Linking ISSN: 17599660 NLM ISO Abbreviation: Anal Methods Subsets: MEDLINE

MeSH Terms: MicroRNAs*/urine , Polymers*/chemistry , Biosensing Techniques*/methods , Prostatic Neoplasms*/urine , Prostatic Neoplasms*/diagnosis , Indoles*/chemistry , Urease*/chemistry , Urease*/metabolism, Biomarkers, Tumor/urine ; Humans ; Male

Antimicrobial peptide SAAP-148 inhibits Helicobacter pylori and is associated with membrane disruption, biofilm suppression, and reduced cell-associated urease activity.

Authors: Wang Y; National Center for Clinical Laboratories, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China., Zhang R; National Center for Clinical Laboratories, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China., Gao Z; National Center for Clinical Laboratories, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China., Liu X; Department of Gastroenterology, Emergency General Hospital, Beijing 100028, China., Pian Y; National Center for Clinical Laboratories, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.

Source: Journal of applied microbiology [J Appl Microbiol] 2026 Jun 03; Vol. 137 (6).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9706280 Publication Model: Print Cited Medium: Internet ISSN: 1365-2672 (Electronic) Linking ISSN: 13645072 NLM ISO Abbreviation: J Appl Microbiol Subsets: MEDLINE

MeSH Terms: Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Helicobacter pylori*/physiology , Helicobacter pylori*/genetics , Biofilms*/drug effects , Urease*/metabolism , Anti-Bacterial Agents*/pharmacology , Antimicrobial Peptides*/pharmacology , Antimicrobial Cationic Peptides*/pharmacology, Epithelial Cells/drug effects ; Helicobacter Infections/microbiology ; Cell Membrane/drug effects ; Microbial Sensitivity Tests ; Humans

Diamide-based sulfonamide derivatives as new urease inhibitors: Synthesis, biological evaluation, and computational studies.

Authors: Mohammadi Oshnari A; Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P.O. Box 14335-186, Tehran, Iran., Mohammadi AA; Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P.O. Box 14335-186, Tehran, Iran. Electronic address: aliamohammadi@yahoo.com., Ahmad I; Division of Computer-Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India; Department of Pharmaceutical Chemistry, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, 424002, Maharashtra, India., Ekhtiari Z; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Tahmasebi E; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Mohammadi-Khanaposhtani M; Pharmaceutical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Amanlou M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Source: Bioorganic chemistry [Bioorg Chem] 2026 Sep 15; Vol. 180, pp. 110240. Date of Electronic Publication: 2026 Jul 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Sulfonamides*/chemistry , Sulfonamides*/pharmacology , Sulfonamides*/chemical synthesis , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Molecular Dynamics Simulation ; Dose-Response Relationship, Drug

Chalcogenated phosphine derivatives as urease inhibitors for agricultural: soil application and biophysical studies.

Authors: Enes KB; Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Santos EFA; Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió 57072-900, AL, Brazil., Viana LPS; Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Júnior MMO; Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió 57072-900, AL, Brazil., Batista PHJ; Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; Instituto Nacional de Pesquisas da Amazônia, Manaus 69067-375, AM, Brazil., Modolo LV; Departamento de Botânica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; Department of Agricultural Biotechnology, Faculty of Agriculture, Ataturk University, Erzurum, Türkiye., Santos JCC; Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió 57072-900, AL, Brazil; National Institute of Science and Technology in Bioanalytics Lauro Kubota (INCTBio-LK), Instituto de Química, Universidade Estadual de Campinas (Unicamp), PO Box 6154, Campinas 13083-970, SP, Brazil. Electronic address: josue@iqb.ufal.br., de Fátima Â; Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Türkiye. Electronic address: adefatima@qui.ufmg.br.

Source: Bioorganic chemistry [Bioorg Chem] 2026 Sep 05; Vol. 179, pp. 110009. Date of Electronic Publication: 2026 May 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Phosphines*/chemistry , Phosphines*/pharmacology , Phosphines*/chemical synthesis , Chalcogens*/chemistry , Chalcogens*/pharmacology , Soil*/chemistry, Canavalia/enzymology ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Kinetics

Fundamental study on the germination, revival of urease activity, and bio-deposition behaviors of Bacillus sphaericus spores for microbial self-healing concrete.

Authors: Hou F; Department of Civil Engineering, School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an, 710049, China., Shen D; Department of Civil Engineering, School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an, 710049, China; General Contracting and Operation Branch, China Communications Construction Corporation, Beijing, 100088, China., Wang J; Department of Civil Engineering, School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address: jianyun.wang@xjtu.edu.cn.

Source: Environmental research [Environ Res] 2026 Sep 01; Vol. 305 (Pt 2), pp. 125075. Date of Electronic Publication: 2026 Jun 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE

MeSH Terms: Bacillus*/enzymology , Bacillus*/physiology , Urease*/metabolism , Spores, Bacterial*/physiology , Spores, Bacterial*/enzymology , Construction Materials*/microbiology, Hydrogen-Ion Concentration ; Temperature ; Bacillaceae

SCR Organism: Lysinibacillus sphaericus

Green-synthesized silver nanoparticles optimized by Taguchi method inhibit urease activity in antibiotic-resistant helicobacter pylori.

Authors: Ghanbari R; Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran., Yazdinezhad A; Department of Pharmacognosy and Traditional Pharmacy, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran., Danafar H; Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran., Asadi S; Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran., Salehabadi H; Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran. hsalehabadi@zums.ac.ir.

Source: Scientific reports [Sci Rep] 2026 May 18; Vol. 16 (1). Date of Electronic Publication: 2026 May 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Metal Nanoparticles*/chemistry , Helicobacter pylori*/drug effects , Helicobacter pylori*/enzymology , Silver*/chemistry , Silver*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Drug Resistance, Bacterial*/drug effects , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry, Green Chemistry Technology/methods ; Plant Extracts/chemistry ; Citrus/chemistry ; Spectroscopy, Fourier Transform Infrared ; Particle Size

Circular biocementation via waste-derived urease: maize root residue as a sustainable enzyme source for EICP.

Authors: Absalan P; Faculty of Architecture and Urban Planning, Shahid Beheshti University, Velenjak, Tehran, Iran., Parniaei N; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Velenjak, Tehran, Iran., Mirzajani F; Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Velenjak, Tehran, Iran.; Department of Medical Laboratory Science, College of Science, Knowledge University, Kirkuk Road, 44001, Erbil, Iraq., Shafaat A; Faculty of Architecture and Urban Planning, Shahid Beheshti University, Velenjak, Tehran, Iran. shafaat@outlook.com.

Source: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2026 May; Vol. 33 (19), pp. 9816-9829. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE

MeSH Terms: Urease* , Zea mays*, Carbonates/chemistry ; Plant Roots ; Soil

Synthesis and Evaluation of Isatin Analogs as Potential Urease and Tyrosinase Inhibitors: An Approach of Molecular Docking.

Authors: Ma G; School of Chemistry & Materials Engineering, Xinxiang University, Xinxiang, Henan, China., Li Y; School of Pharmacy, Xinxiang University, Xinxiang, Henan, China., Xu S; School of Pharmacy, Xinxiang University, Xinxiang, Henan, China., Javid MT; Department of Chemistry, University of Layyah, Layyah, Punjab, Pakistan., Ahmed N; Department of Chemistry, PMAS-Aid Agriculture University, Rawalpindi, Pakistan., Farooq U; Miami College of Henan University, Kaifeng, Henan, China.

Source: Chemistry & biodiversity [Chem Biodivers] 2026 May; Vol. 23 (5), pp. e71285.

Publication Type: Journal Article

Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH Terms: Urease*/antagonists & inhibitors , Urease*/metabolism , Isatin*/chemical synthesis , Isatin*/chemistry , Isatin*/pharmacology , Isatin*/analogs & derivatives , Monophenol Monooxygenase*/antagonists & inhibitors , Monophenol Monooxygenase*/metabolism , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Molecular Docking Simulation*, Schiff Bases/chemistry ; Schiff Bases/chemical synthesis ; Schiff Bases/pharmacology ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug