Spatial transcriptomics reveals tumor microenvironment–driven subtypes of invasive lobular carcinoma

Συγγραφείς: Matteo Serra, Mattia Rediti, Laetitia Collet, Frédéric Lifrange, David Venet, Nicola Occelli, Andreas Papagiannis, Delphine Vincent, Ghizlane Rouas, Denis Larsimont, Miikka Vikkula, Francois P. Duhoux, Françoise Rothé, Christos Sotiriou

Συνεισφορές: UCL - SSS/DDUV/GEHU - Génétique, UCL - (SLuc) Service d'oncologie médicale, Institute of Molecular Oncology - Italian Association for Cancer Research, Institut Jules Bordet - Breast Cancer Translational Research Laboratory J-C Heuson, Centre hospitalier universitaire de Liège - Department of Pathology, Institut Jules Bordet - Department of Pathology

Πηγή: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences, Vol. 123, no.6, p. e2517567123 (2026)
Proceedings of the National Academy of Sciences of the United States of America, 123 (6

Θεματικοί όροι: molecular subtypes, Biomarkers, Tumor -- genetics, spatial transcriptomics, Gene Expression Profiling, Transcriptome -- genetics, Breast Neoplasms, Sciences bio-médicales et agricoles, Biological Sciences, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Breast Neoplasms -- genetics -- pathology -- metabolism -- classification, Carcinoma, Lobular, Carcinoma, Lobular -- genetics -- pathology -- metabolism -- classification, Tumor Microenvironment -- genetics, invasive lobular carcinoma, Tumor Microenvironment, Biomarkers, Tumor, tumor microenvironment, Humans, Female, Transcriptome

Περιγραφή αρχείου: 1 full-text file(s): application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41637449
https://pubmed.ncbi.nlm.nih.gov/41637449/
https://doi.org/10.1073/pnas.2517567123
https://pmc.ncbi.nlm.nih.gov/articles/PMC12890879/
https://hdl.handle.net/2078.1/311857
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/402803
https://dipot.ulb.ac.be/dspace/bitstream/2013/402803/3/serra-et-al-2026-41637449.pdf

Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders

Συγγραφείς: Pierre Solomon, Lalit Kaurani, Monika Budde, Jean-Baptiste Guiné, Dennis Manfred Krüger, Kevin Riquin, Tonatiuh Pena, Susanne Burkhardt, Cynthia Fourgeux, Kristina Adorjan, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Bernhardt T. Baune, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Christian Figge, Georg Juckel, Carsten Konrad, Jens Reimer, Eva Z. Reininghaus, Max Schmauß, Carsten Spitzer, Jens Wiltfang, Jörg Zimmermann, Anna-Lena Schütz, Farahnaz Sananbenesi, Anne Sauvaget, Peter Falkai, Thomas G. Schulze, André Fischer, Urs Heilbronner, Jeremie Poschmann

Συνεισφορές: KERANDEL-DION, Céline, Solomon, Pierre, Kaurani, Lalit, Budde, Monika, Guiné, Jean-Baptiste, Krüger, Dennis Manfred, Riquin, Kevin, Pena, Tonatiuh, Burkhardt, Susanne, Fourgeux, Cynthia, Adorjan, Kristina, Poschmann, Jeremie, Fischer, André

Πηγή: Molecular psychiatry 30(9), 4364-4383 (2025). doi:10.1038/s41380-025-03018-9
Molecular psychiatry

Θεματικοί όροι: Male, Adult, Bipolar Disorder, Transcriptome: genetics, Psychotic Disorders: genetics, Bipolar Disorder: genetics, MicroRNAs: genetics, Schizophrenia: genetics, Humans, Gene Regulatory Networks, Schizophrenia: metabolism, Mental Disorders: genetics, Genome-Wide Association Study: methods, Mental Disorders, Gene Expression Profiling, Gene Expression Profiling: methods, MicroRNAs: metabolism, Middle Aged, Gene Regulatory Networks: genetics, [SDV] Life Sciences [q-bio], MicroRNAs, Psychotic Disorders, Schizophrenia, Female, Transcriptome, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40263528
https://pub.dzne.de/record/280292
https://inserm.hal.science/inserm-05117288v1
https://doi.org/10.1038/s41380-025-03018-9
https://inserm.hal.science/inserm-05117288v1/document
https://resolver.sub.uni-goettingen.de/purl?gro-2/148933
https://hdl.handle.net/21.11116/0000-0011-1BED-5

Translational genomics of osteoarthritis in 1,962,069 individuals

Συγγραφείς: Hatzikotoulas, Konstantinos, Southam, Lorraine, Stefansdottir, Lilja, Boer, Cindy G, McDonald, Merry-Lynn, Pett, J Patrick, Park, Young-Chan, Tuerlings, Margo, Mulders, Rick, Barysenka, Andrei, Arruda, Ana Luiza, Tragante, Vinicius, Rocco, Alison, Bittner, Norbert, Chen, Shibo, Horn, Susanne, Srinivasasainagendra, Vinodh, To, Ken, Katsoula, Georgia, Kreitmaier, Peter, Tenghe, Amabel MM, Gilly, Arthur, Arbeeva, Liubov, Chen, Lane G, de Pins, Agathe M, Dochtermann, Daniel, Henkel, Cecilie, Höijer, Jonas, Ito, Shuji, Lind, Penelope A, Lukusa-Sawalena, Bitota, Minn, Aye Ko Ko, Mola-Caminal, Marina, Narita, Akira, Nguyen, Chelsea, Reimann, Ene, Silberstein, Micah D, Skogholt, Anne-Heidi, Tiwari, Hemant K, Yau, Michelle S, Yue, Ming, Zhao, Wei, Zhou, Jin J, Alexiadis, George, Banasik, Karina, Brunak, Søren, Campbell, Archie, Cheung, Jackson TS, Dowsett, Joseph, Faquih, Tariq, Faul, Jessica D, Fei, Lijiang, Fenstad, Anne Marie, Funayama, Takamitsu, Gabrielsen, Maiken E, Gocho, Chinatsu, Gromov, Kirill, Hansen, Thomas, Hudjashov, Georgi, Ingvarsson, Thorvaldur, Johnson, Jessica S, Jonsson, Helgi, Kakehi, Saori, Karjalainen, Juha, Kasbohm, Elisa, Lemmelä, Susanna, Lin, Kuang, Liu, Xiaoxi, Loef, Marieke, Mangino, Massimo, McCartney, Daniel, Millwood, Iona Y, Richman, Joshua, Roberts, Mary B, Ryan, Kathleen A, Samartzis, Dino, Shivakumar, Manu, Skou, Søren T, Sugimoto, Sachiyo, Suzuki, Ken, Takuwa, Hiroshi, Teder-Laving, Maris, Thomas, Laurent, Tomizuka, Kohei, Turman, Constance, Weiss, Stefan, Wu, Tian T, Zengini, Eleni, Zhang, Yanfei, arcOGEN Consortium, ARGO Consortium, DBDS Genomic Consortium, Estonian Biobank Research Team, FinnGen, Genes & Health Research Team, HUNT All-In Pain, Million Veteran Program, Regeneron Genetics Center, Ferreira, Manuel Allen Revez, Babis, George, Baras, Aris, Barker, Tyler, Carey, David J, Cheah, Kathryn SE, Chen, Zhengming, Cheung, Jason Pui-Yin, Daly, Mark, de Mutsert, Renée, Eaton, Charles B, Erikstrup, Christian, Furnes, Ove Nord, Golightly, Yvonne M, Gudbjartsson, Daniel F, Hailer, Nils P, Hayward, Caroline, Hochberg, Marc C, Homuth, Georg, Huckins, Laura M, Hveem, Kristian, Ikegawa, Shiro, Ishijima, Muneaki, Isomura, Minoru, Jones, Marcus, Kang, Jae H, Kardia, Sharon LR, Kloppenburg, Margreet, Kraft, Peter, Kumahashi, Nobuyuki, Kuwata, Suguru, Lee, Ming Ta Michael, Lee, Phil H, Lerner, Robin, Li, Liming, Lietman, Steve A, Lotta, Luca, Lupton, Michelle K, Mägi, Reedik, Martin, Nicholas G, McAlindon, Timothy E, Medland, Sarah E, Michaëlsson, Karl, Mitchell, Braxton D, Mook-Kanamori, Dennis O, Morris, Andrew P, Nabika, Toru, Nagami, Fuji, Nelson, Amanda E, Ostrowski, Sisse Rye, Palotie, Aarno, Pedersen, Ole Birger, Rosendaal, Frits R, Sakurai-Yageta, Mika, Schmidt, Carsten Oliver, Sham, Pak Chung, Singh, Jasvinder A, Smelser, Diane T, Smith, Jennifer A, Song, You-Qiang, Sørensen, Erik, Tamiya, Gen, Tamura, Yoshifumi, Terao, Chikashi, Thorleifsson, Gudmar, Troelsen, Anders, Tsezou, Aspasia, Uchio, Yuji, Uitterlinden, AG, Ullum, Henrik, Valdes, Ana M, van Heel, David A, Walters, Robin G, Weir, David R, Wilkinson, J Mark, Winsvold, Bendik S, Yamamoto, Masayuki, Zwart, John-Anker, Stefansson, Kari, Meulenbelt, Ingrid, Teichmann, Sarah A, van Meurs, Joyce BJ, Styrkarsdottir, Unnur, Zeggini, Eleftheria

Συνεισφορές: Apollo - University of Cambridge Repository

Πηγή: Nature
Hatzikotoulas, K, Southam, L, Stefansdottir, L, Boer, C G, McDonald, M L, Pett, J P, Park, Y C, Tuerlings, M, Mulders, R, Barysenka, A, Arruda, A L, Tragante, V, Rocco, A, Bittner, N, Chen, S, Horn, S, Srinivasasainagendra, V, To, K, Katsoula, G, Kreitmaier, P, Tenghe, A M M, Gilly, A, Arbeeva, L, Chen, L G, de Pins, A M, Dochtermann, D, Henkel, C, Höijer, J, Ito, S, Lind, P A, Lukusa-Sawalena, B, Minn, A K K, Mola-Caminal, M, Narita, A, Nguyen, C, Reimann, E, Silberstein, M D, Skogholt, A H, Tiwari, H K, Banasik, K, Brunak, S, Dowsett, J, Gromov, K, Hansen, T, Skou, S T, Ostrowski, S R, Pedersen, O B, Sørensen, E, Troelsen, A, Ullum, H, arcOGEN Consortium, ARGO Consortium, DBDS Genomic Consortium, Estonian Biobank Research Team, FinnGen, Genes & Health Research Team, HUNT All-In Pain, Million Veteran Program & Regeneron Genetics Center 2025, ' Translational genomics of osteoarthritis in 1,962,069 individuals ', Nature, vol. 641, pp. 1217–1224 . https://doi.org/10.1038/s41586-025-08771-z
Hatzikotoulas, K, Southam, L, Stefansdottir, L, Boer, C G, McDonald, M-L, Pett, J P, Park, Y-C, Tuerlings, M, Mulders, R, Barysenka, A, Arruda, A L, Tragante, V, Rocco, A, Bittner, N, Chen, S, Horn, S, Srinivasasainagendra, V, To, K, Katsoula, G, Kreitmaier, P, Tenghe, A M M, Gilly, A, Arbeeva, L, Chen, L G, de Pins, A M, Dochtermann, D, Henkel, C, Höijer, J, Ito, S, Lind, P A, Lukusa-Sawalena, B, Minn, A K K, Mola-Caminal, M, Narita, A, Nguyen, C, Reimann, E, Silberstein, M D, Skogholt, A-H, Tiwari, H K, Yau, M S, Yue, M, Zhao, W, Zhou, J J, Alexiadis, G, Banasik, K, Brunak, S, Campbell, A, Cheung, J T S, Skou, S T, arcOGEN Consortium, ARGO Consortium, Danish Blood Donor Study Genomic Consortium, Estonian Biobank Research Team, FinnGen, Genes & Health Research Team, HUNT All-In Pain, Million Veteran Program, Regeneron Genetics Center, Pedersen, O B & Zeggini, E 2025, 'Translational genomics of osteoarthritis in 1,962,069 individuals', Nature, vol. 641, no. 8065, 30, pp. 1217-1224. https://doi.org/10.1038/s41586-025-08771-z
2025, 'Translational genomics of osteoarthritis in 1,962,069 individuals', Nature, vol. 641, no. 8065, 30, pp. 1217-1224. https://doi.org/10.1038/s41586-025-08771-z
arcOGEN Consortium, ARGO Consortium, DBDS Genomic Consortium, Estonian Biobank Research Team, FinnGen, Genes & Health Research Team, HUNT All-In Pain, Million Veteran Program & Regeneron Genetics Center 2025, 'Translational genomics of osteoarthritis in 1,962,069 individuals', Nature, vol. 641, no. 8065, 30, pp. 1217-1224. https://doi.org/10.1038/s41586-025-08771-z

Θεματικοί όροι: Male, Estonian Biobank Research Team, Neuroglia/metabolism, Proteome, Article, Medical Genetics and Genomics, Translational Research, Biomedical, Epigenome, SDG 3 - Good Health and Well-being, ARGO Consortium, Osteoarthritis, Humans, Genes & Health Research Team, HUNT All-In Pain, Osteoarthritis/genetics, Million Veteran Program, DBDS Genomic Consortium, Genomics, Transcriptome/genetics, Regeneron Genetics Center, Medicinsk genetik och genomik, FinnGen, Proteome/genetics, Case-Control Studies, Signal Transduction/genetics, Female, Single-Cell Analysis, Transcriptome, Epigenome/genetics, Neuroglia, arcOGEN Consortium, Genome-Wide Association Study, Signal Transduction

Περιγραφή αρχείου: application/pdf; application/zip; text/xml

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40205036
https://pure.eur.nl/en/publications/2d3436a6-ec60-4659-a5b7-cbf5497b5f37
https://doi.org/10.1038/s41586-025-08771-z
https://hdl.handle.net/1887/4249389
https://ora.ox.ac.uk/objects/uuid:db6e7bf5-7f61-4fa9-8543-c7ffacc449a7
https://doi.org/10.1038/s41586-025-08771-z
https://researchprofiles.ku.dk/da/publications/424ad1bc-f27e-4811-b122-4eee596c1926
https://curis.ku.dk/ws/files/537594760/s41586-025-08771-z.pdf
https://doi.org/10.1038/s41586-025-08771-z
https://portal.findresearcher.sdu.dk/da/publications/b36b46c0-7cfc-44fe-ad62-96ce5ba66698
https://doi.org/10.1038/s41586-025-08771-z
https://findresearcher.sdu.dk/ws/files/290965201/s41586-025-08771-z.pdf
https://portal.findresearcher.sdu.dk/da/publications/b36b46c0-7cfc-44fe-ad62-96ce5ba66698
https://doi.org/10.1038/s41586-025-08771-z
https://www.pure.ed.ac.uk/ws/files/498387282/GO2_paper_1738061965.pdf
https://www.nature.com/articles/s41586-025-08771-z
https://hdl.handle.net/20.500.11820/07ffc24b-811a-4e84-bd2b-710ecf3c2c70
https://www.pure.ed.ac.uk/ws/files/498648686/Translational_genomics_of_osteoarthritis_in_1_962_069_individuals.pdf
https://www.research.ed.ac.uk/en/publications/07ffc24b-811a-4e84-bd2b-710ecf3c2c70
https://doi.org/10.1038/s41586-025-08771-z
https://www.repository.cam.ac.uk/handle/1810/384851
https://doi.org/10.1038/s41586-025-08771-z
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-569111
https://eprints.whiterose.ac.uk/id/eprint/225424/
https://www.scopus.com/pages/publications/105002481309
https://pure.au.dk/portal/en/publications/17cff414-a72d-4533-9f86-23e015cb3260
https://doi.org/10.1038/s41586-025-08771-z

The landscape of N6-methyladenosine in localized primary prostate cancer

Συγγραφείς: Xin Xu, Helen Zhu, Rupert Hugh-White, Julie Livingstone, Stefan Eng, Nicole Zeltser, Yujuan Wang, Kinga Pajdzik, Sujun Chen, Kathleen E. Houlahan, Wenqin Luo, Shun Liu, Xi Xu, Minzhi Sheng, Wang Yuan Guo, Jaron Arbet, Yuxi Song, Miranda Wang, Yong Zeng, Shiyan Wang, Guanghui Zhu, Tingxiao Gao, Wei Chen, Xinpei Ci, Wenjie Xu, Kexin Xu, Michele Orain, Valerie Picard, Helene Hovington, Alain Bergeron, Louis Lacombe, Bernard Têtu, Yves Fradet, Mathieu Lupien, Gong-Hong Wei, Marianne Koritzinsky, Robert G. Bristow, Neil E. Fleshner, Xue Wu, Yang Shao, Chuan He, Alejandro Berlin, Theodorus van der Kwast, Hon Leong, Paul C. Boutros, Housheng Hansen He

Πηγή: Nat Genet
Xu, X, Zhu, H, Hugh-White, R, Livingstone, J, Eng, S, Zeltser, N, Wang, Y, Pajdzik, K, Chen, S, Houlahan, K E, Luo, W, Liu, S, Xu, X, Sheng, M, Guo, W Y, Arbet, J, Song, Y, Wang, M, Zeng, Y, Wang, S, Zhu, G, Gao, T, Chen, W, Ci, X, Xu, W, Xu, K, Orain, M, Picard, V, Hovington, H, Bergeron, A, Lacombe, L, Têtu, B, Fradet, Y, Lupien, M, Wei, G-H, Koritzinsky, M, Bristow, R G, Fleshner, N E, Wu, X, Shao, Y, He, C, Berlin, A, van der Kwast, T, Leong, H, Boutros, P C & He, H H 2025, 'The landscape of N 6-methyladenosine in localized primary prostate cancer.', Nature Genetics, vol. 57, no. 4, pp. 934-948. https://doi.org/10.1038/s41588-025-02128-y

Θεματικοί όροι: Male, Adenosine, Prostatic Neoplasms/genetics, Prostatic Neoplasms, Transcriptome/genetics, Prognosis, Article, Gene Expression Regulation, Neoplastic, Mutation, Biomarkers, Tumor, Humans, Adenosine/analogs & derivatives, Biomarkers, Tumor/genetics, Transcriptome

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40128621
https://research.manchester.ac.uk/en/publications/e26621d7-1388-456c-b3f3-e4b46da8cfa8
https://doi.org/10.1038/s41588-025-02128-y

Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study

Συγγραφείς: Ugalde-Morales, E., Wilf, R., Pluta, J., Ploner, A., Fan, M., Damra, M., Aben, K.K.H., Anson-Cartwright, L., Chen, C., Cortessis, V.K., Daneshmand, S., Ferlin, A., Gamulin, M., Gietema, J.A., Gonzalez-Niera, A., Grotmol, T., Hamilton, R.J., Harland, M., Haugen, T.B., Hauser, R., Hildebrandt, M.A., Karlsson, R., Kiemeney, B., Kim, Jung, Lessel, D., Lothe, R.A., Loveday, C., Chanock, S.J., McGlynn, K.A., Meijer, C., Nead, K.T., Nsengimana, J., Popovic, M., Rafnar, T., Richiardi, L., Rocca, M.S., Schwartz, S.M., Skotheim, R.I., Stefansson, K., Stewart, D.R., Turnbull, C., Vaughn, D.J., Winge, S.B., Zheng, T., Monteiro, Ana, Almstrup, K., Kanetsky, P.A., Nathanson, K.L., Wiklund, F.

Συνεισφορές: University of Zagreb. University of Zagreb, School of Medicine. Department of Clinical Oncology

Πηγή: Am J Hum Genet
American Journal of Human Genetics, 112, 3, pp. 630-643
Ugalde-Morales, E, Wilf, R, Pluta, J, Ploner, A, Fan, M, Damra, M, Aben, K K, Anson-Cartwright, L, Chen, C, Cortessis, V K, Daneshmand, S, Ferlin, A, Gamulin, M, Gietema, J A, Gonzalez-Niera, A, Grotmol, T, Hamilton, R J, Harland, M, Haugen, T B, Hauser, R, Hildebrandt, M A T, Karlsson, R, Kiemeney, L A, Kim, J, Lessel, D, Lothe, R A, Loveday, C, Chanock, S J, McGlynn, K A, Meijer, C, Nead, K T, Nsengimana, J, Popovic, M, Rafnar, T, Richiardi, L, Rocca, M S, Schwartz, S M, Skotheim, R I, Stefansson, K, Stewart, D R, Turnbull, C, Vaughn, D J, Winge, S B, Zheng, T, Monteiro, A N, Almstrup, K, Kanetsky, P A, Nathanson, K L, Wiklund, F & The Testicular Cancer Consortium 2025, ' Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study ', American Journal of Human Genetics, vol. 112, no. 3, pp. 630-643 . https://doi.org/10.1016/j.ajhg.2025.01.022

Θεματικοί όροι: Male, Primary and Community Care - Radboud University Medical Center, colocalization analysis, testicular germ cell tumors, transcriptome-wide association study, Polymorphism, Single Nucleotide, Article, Testicular Neoplasms / genetics, Testicular Neoplasms, Neoplasms, Germ Cell and Embryonal / genetics, Clinical Medical Sciences, IQ health - Radboud University Medical Center, Humans, Genetic Predisposition to Disease, Biomedicine and Health Sciences, Gene Expression Profiling, Neoplasms, Germ Cell and Embryonal, onkologija, Transcriptome / genetics, Kliničke medicinske znanosti, Gene Expression Regulation, Neoplastic, Oncology, Biomedicina i zdravstvo, Urology - Radboud University Medical Center, Transcriptome, Polymorphism, Single Nucleotide / genetics, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39999848
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/317614
https://doi.org/10.1016/j.ajhg.2025.01.022
https://hdl.handle.net/11370/b6938e82-8f31-4cb3-b558-d341748fad39
https://research.rug.nl/en/publications/b6938e82-8f31-4cb3-b558-d341748fad39
https://doi.org/10.1016/j.ajhg.2025.01.022
https://repository.ubn.ru.nl//bitstream/handle/2066/317614/317614.pdf
https://hdl.handle.net/2066/317614
https://urn.nsk.hr/urn:nbn:hr:105:918624
https://doi.org/10.1016/j.ajhg.2025.01.022

Human-correlated genetic models identify precision therapy for liver cancer

Συγγραφείς: Miryam Müller, Stephanie May, Holly Hall, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Anastasia Georgakopoulou, Thomas Jamieson, Narisa Phinichkusolchit, Sandeep Dhayade, Toshiyasu Suzuki, Júlia Huguet-Pradell, Ian R. Powley, Leah Officer-Jones, Rachel L. Pennie, Roger Esteban-Fabró, Albert Gris-Oliver, Roser Pinyol, George L. Skalka, Jack Leslie, Matthew Hoare, Joep Sprangers, Gaurav Malviya, Agata Mackintosh, Emma Johnson, Misti McCain, John Halpin, Christos Kiourtis, Colin Nixon, Graeme Clark, William Clark, Robin Shaw, Ann Hedley, Thomas M. Drake, Ee Hong Tan, Matt Neilson, Daniel J. Murphy, David Y. Lewis, Helen L. Reeves, John Le Quesne, Derek A. Mann, Leo M. Carlin, Karen Blyth, Josep M. Llovet, Markus H. Heim, Owen J. Sansom, Crispin J. Miller, Thomas G. Bird

Συνεισφορές: Apollo - University of Cambridge Repository

Πηγή: Nature
Müller, M, May, S, Hall, H, Kendall, T J, McGarry, L C, Blukacz, L, Nuciforo, S, Georgakopoulou, A, Jamieson, T, Phinichkusolchit, N, Dhayade, S, Suzuki, T, Huguet-Pradell, J, Powley, I R, Officer-Jones, L, Pennie, R L, Gris-Oliver, A, Pinyol, R, Skalka, G L, Leslie, J, Hoare, M, Sprangers, J, Malviya, G, Mackintosh, A, Johnson, E, McCain, M, Halpin, J, Kiourtis, C, Nixon, C, Clark, G, Clark, W, Shaw, R, Hedley, A, Drake, T, Tan, E H, Neilson, M, Murphy, D J, Lewis, D, Reeves, H L, Le Quesne, J, Mann, D A, Carlin, L M, Blyth, K, Llovet, J M, Heim, M H, J. Sansom, O, Miller, C J & Bird, T G 2025, 'Human-correlated genetic models identify precision therapy for liver cancer', Nature, vol. 639, 67, pp. 754-764. https://doi.org/10.1038/s41586-025-08585-z

Θεματικοί όροι: Male, Carcinoma, Hepatocellular, Models, Genetic, Carcinoma, Hepatocellular/genetics, Liver Neoplasms, Transcriptome/genetics, Article, Mice, Disease Models, Animal, Cell Line, Tumor, Mutation, Humans, Animals, Female, Precision Medicine, Transcriptome, Liver Neoplasms/genetics

Περιγραφή αρχείου: application/pdf; application/zip; text/xml

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39972137

The Quick Guide to RNA-Seq: From Data Acquisition to Functional Analysis

Συγγραφείς: Solaiman, Morjina

Πηγή: Journal of Scientific Reports. 10:37-51

Θεματικοί όροι: RNA seq, RNA-Seq, Transcriptome/genetics, Sequence Analysis, RNA/methods

Characterization of human melanoma skin cancer models: A step towards model-based melanoma research: A step towards model-based melanoma research

Συγγραφείς: Nicoline Dorothea Daugaard, Rikke Tholstrup, Jakob Rask Tornby, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Daniela De Zio, Mike Bogetofte Barnkob, Kim Ravnskjaer, Jonathan R. Brewer

Πηγή: Daugaard, N D, Tholstrup, R, Tornby, J R, Bendixen, S M, Larsen, F T, De Zio, D, Barnkob, M B, Ravnskjaer, K & Brewer, J R 2025, 'Characterization of human melanoma skin cancer models : A step towards model-based melanoma research', Acta Biomaterialia, vol. 191, pp. 308-324. https://doi.org/10.1016/j.actbio.2024.11.018

Θεματικοί όροι: Neoplastic, Tumor, Skin Neoplasms, Transcriptome/genetics, RNAseq, Biological, Bioimaging, Models, Biological, Skin Neoplasms/pathology, Cell Line, 3D skin models, Vemurafenib/pharmacology, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Vemurafenib, Models, Melanoma skin model, Cell Line, Tumor, Melanoma/pathology, Humans, Transcriptome, Melanoma

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39549863
https://findresearcher.sdu.dk/ws/files/280843182/1-s2.0-S1742706124006731-main.pdf
https://doi.org/10.1016/j.actbio.2024.11.018
https://portal.findresearcher.sdu.dk/da/publications/34907b36-7ce1-405b-938d-ad57c3c3df55

Twin pairs discordant for incident coronary artery disease reveal epigenetic and transcriptomic differences by gene region

Συγγραφείς: Asmus Cosmos Skovgaard, Mikael Thinggaard, Jacob vB. Hjelmborg, Afsaneh M. Nejad, Hans Christian Beck, Qihua Tan, Mette Soerensen

Πηγή: Mol Genet Genomics
Skovgaard, A C, Thinggaard, M, Hjelmborg, J VB, Nejad, A M, Beck, H C, Tan, Q & Soerensen, M 2025, 'Twin pairs discordant for incident coronary artery disease reveal epigenetic and transcriptomic differences by gene region', Molecular Genetics and Genomics, vol. 301, no. 1, pp. 6. https://doi.org/10.1007/s00438-025-02325-8

Θεματικοί όροι: Male, Epigenomics, Denmark, Twins, Twins, Monozygotic/genetics, Coronary Artery Disease, Epigenesis, Genetic, Promoter Regions, Genetic, Humans, Promoter Regions, Genetic, Genetic/genetics, Aged, Coronary Artery Disease/genetics, Gene Expression Profiling, Epigenesis, Genetic/genetics, Twins, Monozygotic, Transcriptome/genetics, DNA Methylation, Middle Aged, Denmark/epidemiology, CpG Islands/genetics, Original Article, Female, CpG Islands, Transcriptome, DNA Methylation/genetics, Epigenesis, Monozygotic/genetics

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41381984
https://pubmed.ncbi.nlm.nih.gov/41381984/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12698802/
https://doi.org/10.1007/s00438-025-02325-8
https://findresearcher.sdu.dk/ws/files/302295368/Twin_pairs_discordant_for_incident_coronary_artery_disease_reveal_epigenetic_and_transcriptomic_differences_by_gene_region.pdf
https://doi.org/10.1007/s00438-025-02325-8
https://portal.findresearcher.sdu.dk/da/publications/f54d48da-bbab-4cb5-bf80-b4028830a3bd

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease

Συγγραφείς: Anushree Ray, Paulo Alabarse, Rainer Malik, Muralidharan Sargurupremraj, Jürgen Bernhagen, Martin Dichgans, Sebastian-Edgar Baumeister, Marios K. Georgakis

Πηγή: Am J Hum Genet
The American journal of human genetics 112(7), 1597-1609 (2025). doi:10.1016/j.ajhg.2025.06.001

Θεματικοί όροι: Transcriptome: genetics, Quantitative Trait Loci, Coronary Artery Disease, Polymorphism, Single Nucleotide, drug target, Article, immune cells, Mendelian Randomization Analysis: methods, cardiovascular disease, Mendelian randomization, Humans, colocalization analysis, Genetic Predisposition to Disease, Cardiovascular Diseases: genetics, expression quantitative trait loci, Quantitative Trait Loci: genetics, Atherosclerosis: genetics, RNA sequencing, Mendelian Randomization Analysis, Atherosclerosis, Single-Cell Analysis: methods, Cardiovascular Diseases, Atherosclerosis: pathology, atherosclerosis, Single-Cell Analysis, Transcriptome, Polymorphism, Single Nucleotide: genetics, Coronary Artery Disease: genetics, Genome-Wide Association Study

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40555237
https://pub.dzne.de/record/279452
https://epub.ub.uni-muenchen.de/128269/

Transcriptomic Signatures of Nitrate Response in Rapeseed Genotypes With Distinct Root System Sizes.

Συγγραφείς: Haelterman, Loïc, Qi, Run, Sargar, Pramod Ramchandra, Kupcsik, Laszlo, Xu, Jiajia, Chiodi, Claudia, Inzé, Dirk, Hermans, Christian

Πηγή: Physiologia Plantarum, 178 (3

Θεματικοί όροι: Sciences bio-médicales et agricoles, Nitrates -- metabolism -- pharmacology, Plant Roots -- genetics -- drug effects -- metabolism -- growth & development -- anatomy & histology, Brassica napus -- genetics -- metabolism -- drug effects, Genotype, Transcriptome -- genetics, Gene Expression Regulation, Plant -- drug effects, Gene Expression Profiling, global transcriptome, mineral nutrition, nitrogen, rapeseed, root morphology

Περιγραφή αρχείου: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1111/ppl.70908; uri/info:pmid/42083833; uri/info:scp/105037887045; https://dipot.ulb.ac.be/dspace/bitstream/2013/408745/3/Haelterman_et_al_2026.pdf

Διαθεσιμότητα: https://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/408745
https://dipot.ulb.ac.be/dspace/bitstream/2013/408745/3/Haelterman_et_al_2026.pdf

Spatial transcriptomics reveals tumor microenvironment-driven subtypes of invasive lobular carcinoma.

Συγγραφείς: Serra, Matteo, Rediti, Mattia, Collet, Laetitia, Lifrange, Frédéric, Venet, David, Occelli, Nicola, Papagiannis, Andreas, Vincent, Delphine, Rouas, Ghizlane, Larsimont, Denis, Vikkula, Miikka, Duhoux, Francois P, Rothé, Françoise, Sotiriou, Christos

Πηγή: Proceedings of the National Academy of Sciences of the United States of America, 123 (6

Θεματικοί όροι: Sciences bio-médicales et agricoles, Tumor Microenvironment -- genetics, Humans, Female, Breast Neoplasms -- genetics -- pathology -- metabolism -- classification, Carcinoma, Lobular -- genetics -- pathology -- metabolism -- classification, Transcriptome -- genetics, Gene Expression Regulation, Neoplastic, Gene Expression Profiling, Prognosis, Middle Aged, Biomarkers, Tumor -- genetics, invasive lobular carcinoma, molecular subtypes, spatial transcriptomics, tumor microenvironment

Περιγραφή αρχείου: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1073/pnas.2517567123; uri/info:pmid/41637449; uri/info:scp/105029526418; uri/info:pmcid/PMC12890879

Διαθεσιμότητα: https://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/402803
https://dipot.ulb.ac.be/dspace/bitstream/2013/402803/3/serra-et-al-2026-41637449.pdf

Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system

Συγγραφείς: Wang, Fei, Ren, Jilong, Zhou, Yaqi, Huo, Wuqiang, Liu, Huichao, Qin, Mumu, Jing, Yi, Yin, Zhongtao, Shi, Tao, Shan, Huiquan, Tan, Guanghui, Wang, Haoping, Guo, Xi, Mei, Junpu, Yue, Zhen, Hou, Zhuocheng, Zhou, Huaijun, Song, Jiuzhou, Degn, Søren Egedal, Lin, Lin, Luo, Yonglun, Meng, Feilong, Fang, Xiaodong, Zhang, Haihan, He, Xi, Fang, Lingzhao, Jiang, Yu

Πηγή: Wang, F, Ren, J, Zhou, Y, Huo, W, Liu, H, Qin, M, Jing, Y, Yin, Z, Shi, T, Shan, H, Tan, G, Wang, H, Guo, X, Mei, J, Yue, Z, Hou, Z, Zhou, H, Song, J, Degn, S E, Lin, L, Luo, Y, Meng, F, Fang, X, Zhang, H, He, X, Fang, L & Jiang, Y 2026, 'Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system', Nature Communications, vol. 17, no. 1, 6031. https://doi.org/10.1038/s41467-026-72642-y

Θεματικοί όροι: Animals, Chickens/genetics, Transcriptome/genetics, Single-Cell Analysis, Immune System/metabolism, Single-Cell Gene Expression Analysis, Turtles/genetics, Chick Embryo, B-Lymphocytes/immunology, Humans, Species Specificity, Biological Evolution, Bursa of Fabricius/immunology, Evolution, Molecular, Dendritic Cells/immunology

Relation: info:eu-repo/semantics/altIdentifier/pmid/42086564; info:eu-repo/semantics/altIdentifier/pissn/2041-1723; info:eu-repo/semantics/altIdentifier/eissn/2041-1723

Διαθεσιμότητα: https://pure.au.dk/portal/en/publications/451e25a2-8f9f-41cb-a110-26e899550844
https://doi.org/10.1038/s41467-026-72642-y
https://www.scopus.com/pages/publications/105044275197

Scale:unsupervised multiscale domain identification in spatial omics data

Συγγραφείς: Yousefi, Behnam, Schaub, Darius P, Khatri, Robin, Kaiser, Nico, Kuehl, Malte, Ly, Cedric, Puelles, Victor G, Huber, Tobias B, Prinz, Immo, Krebs, Christian F, Panzer, Ulf, Bonn, Stefan

Πηγή: Yousefi, B, Schaub, D P, Khatri, R, Kaiser, N, Kuehl, M, Ly, C, Puelles, V G, Huber, T B, Prinz, I, Krebs, C F, Panzer, U & Bonn, S 2026, 'Scale : unsupervised multiscale domain identification in spatial omics data', Nucleic Acids Research, vol. 54, no. 1, gkaf1456. https://doi.org/10.1093/nar/gkaf1456

Θεματικοί όροι: Animals, Mice, Single-Cell Analysis/methods, Algorithms, Brain/metabolism, Humans, Transcriptome/genetics, Kidney/metabolism, Deep Learning, Gene Expression Profiling/methods, Unsupervised Machine Learning, Computational Biology/methods

Relation: info:eu-repo/semantics/altIdentifier/pmid/41495880; info:eu-repo/semantics/altIdentifier/pissn/0305-1048; info:eu-repo/semantics/altIdentifier/eissn/1362-4962

Διαθεσιμότητα: https://pure.au.dk/portal/en/publications/c2af6265-aaf3-47be-87ef-b93ef2dde62a
https://doi.org/10.1093/nar/gkaf1456
https://www.scopus.com/pages/publications/105026840510

Large-scale analysis of temporal gene expression variation in peripheral blood

Συγγραφείς: Mishra, Neha, Kimmig, Franziska, Vandeputte, Doris, Talevi, Valentina, De Commer, Lindsey, Verspecht, Chloe, Vich Vila, Arnau, El-Sayed Moustafa, Julia S, Kreft, Lukasz, Botzki, Alexander, El Darzi, Youssef, Proost, Sebastian, Devolder, Lindsay, Wang, Dongmeng, Bernardes, Joana P, Aziz, N Ahmad, Franke, Andre, Schreiber, Stefan, Dermitzakis, Emmanouil T, Vieira-Silva, Sara, Falony, Gwen, Small, Kerrin S, Breteler, Monique M B, Schultze, Joachim L, Raes, Jeroen, Rosenstiel, Philip, Andersen, Vibeke

Πηγή: Mishra, N, Kimmig, F, Vandeputte, D, Talevi, V, De Commer, L, Verspecht, C, Vich Vila, A, El-Sayed Moustafa, J S, Kreft, L, Botzki, A, El Darzi, Y, Proost, S, Devolder, L, Wang, D, Bernardes, J P, Aziz, N A, Franke, A, Schreiber, S, Dermitzakis, E T, Vieira-Silva, S, Falony, G, Small, K S, Breteler, M M B, Schultze, J L, Raes, J, Rosenstiel, P, SYSCID Consortium & Andersen, V 2026, 'Large-scale analysis of temporal gene expression variation in peripheral blood', Nature Communications, vol. 17, 6992 . https://doi.org/10.1038/s41467-026-73218-6

Θεματικοί όροι: Humans, Female, Gene Expression Profiling/methods, Male, Transcriptome/genetics, Twins, Monozygotic/genetics, Cross-Sectional Studies, Dizygotic/genetics, Gene Expression Regulation, Adult, Genetic Variation

Περιγραφή αρχείου: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/42215465; info:eu-repo/semantics/altIdentifier/pissn/2041-1723; info:eu-repo/semantics/altIdentifier/eissn/2041-1723

Διαθεσιμότητα: https://portal.findresearcher.sdu.dk/da/publications/3a3b9ab5-a59d-4765-bcaf-3ea0cc78dc00
https://doi.org/10.1038/s41467-026-73218-6
https://findresearcher.sdu.dk/ws/files/315407444/s41467-026-73218-6.pdf

Single-cell transcriptomic integrated with machine learning reveals human retinal cell-specific biomarkers in diabetic retinopathy

Συγγραφείς: Lin, Sen, Yang, Luning, Tao, Yiwen, Pan, Qi, Cai, Tengda, Ye, Yunyan, Liu, Jianhui, Zhou, Yang, Shao, Yongqing, Yi, Quanyong, Lu, Zen H., Chen, Lie, McKay, Gareth, Rankin, Richard, Li, Fan, Meng, Weihua

Πηγή: Lin, S, Yang, L, Tao, Y, Pan, Q, Cai, T, Ye, Y, Liu, J, Zhou, Y, Shao, Y, Yi, Q, Lu, Z H, Chen, L, McKay, G, Rankin, R, Li, F & Meng, W 2026, 'Single-cell transcriptomic integrated with machine learning reveals human retinal cell-specific biomarkers in diabetic retinopathy', Human Molecular Genetics, vol. 35, no. 16. https://doi.org/10.1093/hmg/ddag069

Θεματικοί όροι: Humans, Diabetic Retinopathy/genetics, Machine Learning, Biomarkers/metabolism, Single-Cell Analysis/methods, Single-Cell Gene Expression Analysis, Retina/metabolism, Transcriptome/genetics, Female, Male, Gene Expression Profiling, Middle Aged, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

Relation: info:eu-repo/semantics/altIdentifier/pmid/42531047; info:eu-repo/semantics/altIdentifier/pissn/0964-6906; info:eu-repo/semantics/altIdentifier/eissn/1460-2083

Διαθεσιμότητα: https://pure.qub.ac.uk/en/publications/f1a7339b-7a8f-4c60-b9be-a78409592603
https://doi.org/10.1093/hmg/ddag069

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Συγγραφείς: Morsy, Sarah, Scifo, Enzo, Xie, Kan, Schaaf, Kristina, Russ, Jenny, Paulusch, Stefan, De Domenico, Elena, Salomoni, Paolo, Bano, Daniele, Ehninger, Dan

Πηγή: Aging cell 25(2), e70357 (2026). doi:10.1111/acel.70357

Θεματικοί όροι: info:eu-repo/classification/ddc/610, Animals, Aging: genetics, Transcriptome: genetics, Mice, Male, Inbred C57BL, Organ Specificity: genetics, Gene Expression Profiling

Θέμα γεωγραφικό: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1474-9728; info:eu-repo/semantics/altIdentifier/issn/1474-9718; info:eu-repo/semantics/altIdentifier/pmid/pmid:41508419; info:eu-repo/semantics/altIdentifier/issn/1474-9726; https://pub.dzne.de/record/283153

Διαθεσιμότητα: https://pub.dzne.de/record/283153
https://pub.dzne.de/search?p=id:%22DZNE-2026-00049%22

Transcriptome- and Epigenome-Wide Association Studies of Tic Spectrum Disorder in Discordant Monozygotic Twins

Συγγραφείς: Dalsberg, Jonas, Jespersgaard, Cathrine, Levy, Amanda M, Asplund, Anna Maria, Bagger, Frederik Otzen, Debes, Nanette M, Tan, Qihua, Tümer, Zeynep, Hildonen, Mathis

Πηγή: Dalsberg , J , Jespersgaard , C , Levy , A M , Asplund , A M , Bagger , F O , Debes , N M , Tan , Q , Tümer , Z & Hildonen , M 2026 , ' Transcriptome- and Epigenome-Wide Association Studies of Tic Spectrum Disorder in Discordant Monozygotic Twins ' , Genes , vol. 17 , no. 1 , 97 . https://doi.org/10.3390/genes17010097

Θεματικοί όροι: Humans, Twins, Monozygotic/genetics, DNA Methylation/genetics, Male, Female, Transcriptome/genetics, Epigenome/genetics, Child, Genome-Wide Association Study, Epigenesis, Genetic, Adolescent, Tourette Syndrome/genetics, Adult, Tic Disorders/genetics

Περιγραφή αρχείου: application/pdf

Διαθεσιμότητα: https://researchprofiles.ku.dk/da/publications/6937977e-4cd0-4aba-a052-982d8b17166f
https://doi.org/10.3390/genes17010097
https://curis.ku.dk/ws/files/533897431/genes-17-00097.pdf

Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy

Συγγραφείς: Mengyu Liao, Zhisheng Ye, Yumeng Zhao, Jiaying Nan, Yuming Liu, Xueming Yao, Tianjing Yang, Ju Guo, Xin Jin, Hong Zhang, Caiyun You, Heping Xu, Jinguo Yu, Yupeng Chen, Xiaohong Wang, Hua Yan

Πηγή: Proc Natl Acad Sci U S A
Liao, M, Ye, Z, Zhao, Y, Nan, J, Liu, Y, Yao, X, Yang, T, Guo, J, Jin, X, Zhang, H, You, C, Xu, H, Yu, J, Chen, Y, Wang, X & Yan, H 2025, 'Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy', Proceedings of the National Academy of Sciences of the United States of America, vol. 122, no. 37, e2424487122. https://doi.org/10.1073/pnas.2424487122

Θεματικοί όροι: Fibroblasts/metabolism, Retinal Pigment Epithelium/metabolism, Epithelial-Mesenchymal Transition, Fibrosis/genetics, Single-Cell Analysis/methods, Vitreoretinopathy, Proliferative, Vitreoretinopathy, Proliferative/pathology, Retinal Pigment Epithelium, Transcriptome/genetics, Biological Sciences, Fibroblasts, Fibrosis, Thrombospondin 1, Mice, Thrombospondin 1/genetics, Epithelial-Mesenchymal Transition/genetics, Animals, Humans, Single-Cell Analysis, Transcriptome

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40920930
https://pureadmin.qub.ac.uk/ws/files/654923131/sing.pdf
https://pure.qub.ac.uk/en/publications/756c00b1-da54-484d-9506-825248dfb31b
https://doi.org/10.1073/pnas.2424487122

Multiomic Analyses Direct Hypotheses for Creutzfeldt-Jakob Disease Risk Genes

Συγγραφείς: Fahri Küçükali, Elizabeth Hill, Tijs Watzeels, Holger Hummerich, Tracy Campbell, Lee Darwent, Steven Collins, Christiane Stehmann, Gabor G Kovacs, Michael D Geschwind, Karl Frontzek, Herbert Budka, Ellen Gelpi, Adriano Aguzzi, Sven J van der Lee, Cornelia M van Duijn, Pawel P Liberski, Miguel Calero, Pascual Sanchez-Juan, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Stéphane Haïk, Jean-Phillipe Brandel, Angela Mammana, Sabina Capellari, Anna Poleggi, Anna Ladogana, Dorina Tiple, Saima Zafar, Stephanie Booth, Gerard H Jansen, Aušrinė Areškevičiūtė, Eva Løbner Lund, Katie Glisic, Piero Parchi, Peter Hermann, Inga Zerr, Jiri Safar, Pierluigi Gambetti, Brian S Appleby, John Collinge, Kristel Sleegers, Simon Mead

Συνεισφορές: Küçükali, Fahri, Hill, Elizabeth, Watzeels, Tijs, Hummerich, Holger, Campbell, Tracy, Darwent, Lee, Collins, Steven, Stehmann, Christiane, Kovacs, Gabor G, Geschwind, Michael D, Mead, Simon

Πηγή: Brain
Brain 148(9), 3350-3363 (2025). doi:10.1093/brain/awaf032
medRxiv
Küçükali, F, Hill, E, Watzeels, T, Hummerich, H, Campbell, T, Darwent, L, Collins, S, Stehmann, C, Kovacs, G G, Geschwind, M D, Frontzek, K, Budka, H, Gelpi, E, Aguzzi, A, van der Lee, S J, van Duijn, C M, Liberski, P P, Calero, M, Sanchez-Juan, P, Bouaziz-Amar, E, Laplanche, J-L, Haïk, S, Brandel, J-P, Mammana, A, Capellari, S, Poleggi, A, Ladogana, A, Tiple, D, Zafar, S, Booth, S, Jansen, G H, Areškevičiūtė, A, Lund, E L, Glisic, K, Parchi, P, Hermann, P, Zerr, I, Safar, J, Gambetti, P, Appleby, B S, Collinge, J, Sleegers, K & Mead, S 2025, ' Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes ', Brain : a journal of neurology, vol. 148, no. 9, pp. 3350-3363 . https://doi.org/10.1093/brain/awaf032

Θεματικοί όροι: multiomics, neurodegeneration, proteome-wide association studies (PWAS), sporadic Creutzfeldt-Jakob disease (sCJD), transcriptome-wide association studies (TWAS), Transcriptome: genetics, Brain, Genetic Predisposition to Disease: genetics, Creutzfeldt-Jakob Syndrome: genetics, Creutzfeldt-Jakob Syndrome, SDG 3 - Good Health and Well-being, Risk Factors, Creutzfeldt-Jakob Syndrome: metabolism, Humans, Original Article, Genetic Predisposition to Disease, Human medicine, Brain: metabolism, Transcriptome, Biology, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf; application/zip

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39865733
https://pub.dzne.de/record/281103
https://ora.ox.ac.uk/objects/uuid:0ffef7a4-0ab7-4800-aa7e-54be50577a24
https://doi.org/10.1093/brain/awaf032
https://resolver.sub.uni-goettingen.de/purl?gro-2/147627
https://repository.uantwerpen.be/docstore/d:irua:30339
https://hdl.handle.net/10067/2161800151162165141
https://hdl.handle.net/10067/2090790151162165141
https://repository.uantwerpen.be/docstore/d:irua:25786