Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury

Συγγραφείς: Ikbel Naouar, Andrei Pangan, Michelle Zuo, Syed Ali Raza, Kevin Champagne-Jorgensen, Jyot Patel, Angela Wang, Annie Pu, Lesley Ward, Jennifer S. Y. Ahn, Faizah N. Sayeed, Jingwen Zhu, Elisabeth Pössnecker, Shoshana Spring, John G. Sled, Bruno Cenni, Barbara Nuesslein-Hildesheim, Jeffrey L. Browning, Anne-Katrin Pröbstel, Daniel S. Reich, Jennifer L. Gommerman, Valeria Ramaglia

Πηγή: Nat Immunol
Nature immunology 27(1), 48-60 (2026). doi:10.1038/s41590-025-02359-5

Θεματικοί όροι: Male, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, TNFSF13B protein, human, Article, Tertiary Lymphoid Structures: immunology, Multiple Sclerosis: pathology, Mice, Chemokine CXCL13: immunology, Meninges, Cxcl13 protein, mouse, B-Cell Activating Factor, Gray Matter: immunology, Animals, Humans, Multiple Sclerosis: metabolism, B-Lymphocytes: immunology, Gray Matter, Encephalomyelitis, Autoimmune, Experimental: immunology, Th17 Cells: immunology, Lymphotoxin-alpha, B-Lymphocytes, B-Cell Activating Factor: immunology, CXCL13 protein, human, Multiple Sclerosis: immunology, Encephalomyelitis, Autoimmune, Experimental: pathology, Meninges: metabolism, Meninges: pathology, Chemokine CXCL13, Meninges: immunology, Mice, Inbred C57BL, Tertiary Lymphoid Structures: pathology, Tertiary Lymphoid Structures, Gray Matter: pathology, B-Cell Activating Factor: metabolism, Th17 Cells, Female, Chemokine CXCL13: metabolism, Gray Matter: metabolism, Lymphotoxin-alpha: metabolism

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41482555
https://pmc.ncbi.nlm.nih.gov/articles/PMC12915712/
https://doi.org/10.1038/s41590-025-02359-5
https://pubmed.ncbi.nlm.nih.gov/41482555/
https://pub.dzne.de/record/283126

Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury.

Συγγραφείς: Naouar, Ikbel, Pangan, Andrei, Sayeed, Faizah N, Zhu, Jingwen, Pössnecker, Elisabeth, Spring, Shoshana, Sled, John G, Cenni, Bruno, Nuesslein-Hildesheim, Barbara, Browning, Jeffrey L, Pröbstel, Anne-Katrin, Reich, Daniel S, Zuo, Michelle, Gommerman, Jennifer L, Ramaglia, Valeria, Raza, Syed Ali, Champagne-Jorgensen, Kevin, Patel, Jyot, Wang, Angela, Pu, Annie, Ward, Lesley, Ahn, Jennifer S Y

Πηγή: Nature immunology 27(1), 48 - 60 (2026). doi:10.1038/s41590-025-02359-5

Θεματικοί όροι: info:eu-repo/classification/ddc/610, Animals, Chemokine CXCL13: metabolism, Chemokine CXCL13: immunology, Gray Matter: immunology, Gray Matter: pathology, Gray Matter: metabolism, Humans, Mice, Encephalomyelitis, Autoimmune, Experimental: immunology, Experimental: pathology, Meninges: immunology, Meninges: metabolism, Meninges: pathology, B-Cell Activating Factor: metabolism, B-Cell Activating Factor: immunology, Multiple Sclerosis: immunology, Multiple Sclerosis: pathology, Multiple Sclerosis: metabolism, Female, Male, Inbred C57BL, Lymphotoxin-alpha: metabolism, Th17 Cells: immunology, Tertiary Lymphoid Structures: immunology, Tertiary Lymphoid Structures: pathology, B-Lymphocytes: immunology, Chemokine CXCL13

Θέμα γεωγραφικό: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1529-2916; info:eu-repo/semantics/altIdentifier/pmid/pmid:41482555; info:eu-repo/semantics/altIdentifier/issn/1529-2908; https://pub.dzne.de/record/283126

Διαθεσιμότητα: https://pub.dzne.de/record/283126
https://pub.dzne.de/search?p=id:%22DZNE-2026-00022%22

Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implications

Συγγραφείς: Wang, Xiaoxiao, Venet, David, Lifrange, Frédéric, Larsimont, Denis, Rediti, Mattia, Stenbeck, Linnea, Dupont, Floriane, Rouas, Ghizlane, Garcia, Andrea Joaquin, Craciun, Ligia, Buisseret, Laurence, Ignatiadis, Michail, Carausu, Marcela, Bhalla, Nayanika, Masarapu, Yuvarani, Villacampa, Eva Gracia, Franzén, Lovisa, Saarenpää, Sami, Kvastad, Linda, Thrane, Kim, Lundeberg, Joakim, Rothé, Françoise, Sotiriou, Christos

Συνεισφορές: BCRF - Breast Cancer Research Foundation, F.R.S.-FNRS - Fonds de la Recherche Scientifique, Cancerfonden

Πηγή: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Nature communications, 15 (1

Θεματικοί όροι: 0301 basic medicine, Tumor Microenvironment/genetics, Tertiary Lymphoid Structures/pathology, Oncologie, Triple Negative Breast Neoplasms/pathology, Triple Negative Breast Neoplasms, Gene Expression Profiling -- methods, Tumor Microenvironment, Cluster Analysis, Human health sciences, Triple Negative Breast Neoplasms -- genetics -- pathology -- therapy, 0303 health sciences, Tumor -- genetics -- metabolism, Chemistry (all), Sciences bio-médicales et agricoles, Middle Aged, Tertiary Lymphoid Structures/immunology, Gene Expression Regulation, Neoplastic, Oncology, Triple Negative Breast Neoplasms/therapy, Female, Immunotherapy, Biomarkers, Tumor/genetics, Adult, Tertiary Lymphoid Structures -- genetics -- pathology -- immunology, Science, Sciences de la santé humaine, Article, Physics and Astronomy (all), 03 medical and health sciences, Biomarkers, Tumor, Tumor Microenvironment/immunology, Humans, Tertiary Lymphoid Structures/genetics, Aged, Neoplastic, Biochemistry, Genetics and Molecular Biology (all), Gene Expression Profiling, Tumor Microenvironment -- genetics -- immunology, Tertiary Lymphoid Structures, Gene Expression Regulation, Biomarkers, Tumor/metabolism, Gene Expression Profiling/methods, Triple Negative Breast Neoplasms/genetics, Transcriptome, Biomarkers, Biomarkers, Tumor -- genetics -- metabolism

Περιγραφή αρχείου: 1 full-text file(s): application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39592577
https://doaj.org/article/ccc6eec04dde4ff3a3fd0330c0c3eaf5
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/387951
https://dipot.ulb.ac.be/dspace/bitstream/2013/387951/3/41467_2024_Article_54145.pdf

The effect of neoadjuvant therapy on PD-L1 expression and CD8 lymphocyte density in non-small cell lung cancer

Συγγραφείς: Philipp Zens, Corina Bello, Amina Scherz, Michael von Gunten, Adrian Ochsenbein, Ralph A. Schmid, Sabina Berezowska

Πηγή: Mod Pathol
Modern pathology, vol. 35, no. 12, pp. 1848-1859

Θεματικοί όροι: Lung Neoplasms, Humans, B7-H1 Antigen/analysis, Carcinoma, Non-Small-Cell Lung/drug therapy, CD8-Positive T-Lymphocytes/pathology, Lung Neoplasms/drug therapy, Lymphocytes, Tumor-Infiltrating/pathology, Neoadjuvant Therapy, Prognosis, Retrospective Studies, Tertiary Lymphoid Structures/pathology, CD8-Positive T-Lymphocytes, Article, B7-H1 Antigen, 3. Good health, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Tertiary Lymphoid Structures, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35915139
https://serval.unil.ch/notice/serval:BIB_F0F0181979B5
https://serval.unil.ch/resource/serval:BIB_F0F0181979B5.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F0F0181979B51

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products

Συγγραφείς: Suzanne M. Castenmiller, Nandhini Kanagasabesan, Aurélie Guislain, Benoît P. Nicolet, Marleen M. van Loenen, Kim Monkhorst, Alexander A.F.A. Veenhof, Egbert F. Smit, Koen J. Hartemink, John B.A.G. Haanen, Rosa de Groot, Monika C. Wolkers

Πηγή: Oncoimmunology
OncoImmunology, Vol 13, Iss 1 (2024)
Oncoimmunology, vol. 13, no. 1, pp. 2392898

Θεματικοί όροι: Male, 0301 basic medicine, B-Lymphocytes, 0303 health sciences, Lung Neoplasms, Humans, Carcinoma, Non-Small-Cell Lung/immunology, Carcinoma, Non-Small-Cell Lung/pathology, Lung Neoplasms/immunology, Lung Neoplasms/pathology, Tertiary Lymphoid Structures/immunology, Tertiary Lymphoid Structures/pathology, Lymphocytes, Tumor-Infiltrating/immunology, Immunotherapy, Adoptive/methods, Female, B-Lymphocytes/immunology, B-Lymphocytes/pathology, Middle Aged, Aged, Immune infiltrate, NSCLC, TIL therapy, TLS formation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, Immunotherapy, Adoptive, 3. Good health, 03 medical and health sciences, Tertiary Lymphoid Structures, Lymphocytes, Tumor-Infiltrating, Carcinoma, Non-Small-Cell Lung, Immunologic diseases. Allergy, RC254-282, Original Research

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39188755
https://doaj.org/article/765f3c5d599a4883af3b95a3fce40f0d
https://hdl.handle.net/1887/4094260
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4F0F8DC467FB5
https://serval.unil.ch/resource/serval:BIB_4F0F8DC467FB.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_4F0F8DC467FB

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

Συγγραφείς: Nayar, S, Campos, J, Smith, CG, Iannizzotto, V, Gardner, DH, Mourcin, F, Roulois, D, Turner, J, Sylvestre, M, Asam, S, Glaysher, B, Bowman, SJ, Fearon, DT, Filer, A, Tarte, K, Luther, SA, Fisher, BA, Buckley, CD, Coles, MC, Barone, F

Συνεισφορές: Jonchère, Laurent

Πηγή: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America.-2019
Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 27, pp. 13490-13497

Θεματικοί όροι: Interleukin-13, Interleukins, autoimmunity, Fluorescent Antibody Technique, Autoimmunity, Fibroblasts, Flow Cytometry, Interleukin-22, Salivary Glands, Animals, Disease Models, Animal, Fibroblasts/pathology, Humans, Interleukin-13/metabolism, Interleukins/metabolism, Lymphocytes/pathology, Mice, Salivary Glands/pathology, Tertiary Lymphoid Structures/pathology, Sjögren's syndrome, fibroblasts, tertiary lymphoid structures, 3. Good health, Tertiary Lymphoid Structures, [SDV.CAN] Life Sciences [q-bio]/Cancer, PNAS Plus, Tertiary lymphoid, Lymphocytes, Structures

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.pnas.org/content/pnas/116/27/13490.full.pdf
https://pubmed.ncbi.nlm.nih.gov/31213547
https://sonar.ch/global/documents/68398
https://serval.unil.ch/resource/serval:BIB_89AC1F96DED4.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_89AC1F96DED49
https://serval.unil.ch/notice/serval:BIB_89AC1F96DED4

Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes

Συγγραφείς: Korpos, Eva, KADRI, Nadir, Loismann, Sophie, Findeisen, Clais Raphael, Arfuso, Frank, Burke, George William, Richardson, Sarah, Morgan, Noel, Marika, Pugliese, Alberto, Sorokin, Lydia

Πηγή: http://lobid.org/resources/99370676916506441#!, 64(7):1626-1641.

Θεματικοί όροι: Microscopy, Fluorescence [MeSH], Aged, 80 and over [MeSH], Tertiary Lymphoid Structures/pathology [MeSH], Aged [MeSH], Tertiary Lymphoid Structures/blood [MeSH], Pancreas/pathology [MeSH], Type 1 diabetes, Fibroblastic reticular cells, Autoimmunity, Male [MeSH], Basement membrane, High endothelial venules, Child [MeSH], Diabetes Mellitus, Type 1/blood [MeSH], Type 1/pathology [MeSH], Adolescent [MeSH], Female [MeSH], Reticular fibres, Transplantation, Tertiary Lymphoid Structures/immunology [MeSH], Adult [MeSH], Autoantibodies/blood [MeSH], Humans [MeSH], Middle Aged [MeSH], Mice, Inbred NOD [MeSH], Animals [MeSH]

Relation: https://repository.publisso.de/resource/frl:6451910; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187221/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6451910
https://doi.org/10.1007/s00125-021-05453-z
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187221/

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice

Συγγραφείς: Delvecchio, Fincham, Kocher, Spear, Clear, Roy-Luzarraga, Balkwill, Gribben, Bombardieri, Hodivala-Dilke, Capasso, Melania

Πηγή: Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023

Θεματικοί όροι: Pancreatic Neoplasms: metabolism, Tumor Microenvironment: drug effects, Carcinoma, Pancreatic Ductal: immunology, Mice, Transgenic, Antineoplastic Agents: pharmacology, Tertiary Lymphoid Structures: immunology, Mice, Carcinoma, Pancreatic Ductal: pathology, Cell Line, Tumor, T-Lymphocytes: pathology, Animals, Humans, Tertiary Lymphoid Structures: drug therapy, B-Lymphocytes: immunology, Dendritic Cells: metabolism, Antigen Presentation, Pancreatic Neoplasms: drug therapy, T-Lymphocytes: immunology, Dendritic Cells: immunology, Germinal Center, Immunohistochemistry, Xenograft Model Antitumor Assays, T-Lymphocytes: metabolism, B-Lymphocytes: pathology, Cytokines: metabolism, Disease Models, Animal, Tertiary Lymphoid Structures: pathology, Treatment Outcome, Tumor Microenvironment: immunology, Carcinoma, Pancreatic Ductal: metabolism, Pancreatic Neoplasms: immunology, B-Lymphocytes: metabolism, Pancreatic Neoplasms: pathology, Carcinoma, Pancreatic Ductal: drug therapy, Biomarkers, Antineoplastic Agents: therapeutic use

Σύνδεσμος πρόσβασης: https://pub.dzne.de/record/157917

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures

Συγγραφείς: Saba Nayar, Joana Campos, Ming May Chung, Leyre Navarro-Núñez, Menka Chachlani, Nathalie Steinthal, David H Gardner, Philip Rankin, Thomas Cloake, Jorge H Caamaño, Helen M McGettrick, Steve P Watson, Sanjiv Luther, Christopher D Buckley, Francesca Barone

Πηγή: J Immunol
Journal of immunology (Baltimore, Md. : 1950).-2016
Journal of immunology, vol. 197, no. 5, pp. 1957-1967

Θεματικοί όροι: Inflammation, 0301 basic medicine, 0303 health sciences, Interleukin-7, Lymphotoxin alpha1, beta2 Heterotrimer, Mucosal Immunology, Salivary Glands, Mice, 03 medical and health sciences, Tertiary Lymphoid Structures, Gene Expression Regulation, Animals, Interleukin-7/genetics, Interleukin-7/immunology, Interleukin-7/metabolism, Lymphangiogenesis, Lymphatic Vessels/immunology, Lymphatic Vessels/metabolism, Lymphotoxin alpha1, beta2 Heterotrimer/genetics, Lymphotoxin alpha1, beta2 Heterotrimer/immunology, Lymphotoxin alpha1, beta2 Heterotrimer/metabolism, Salivary Glands/immunology, Signal Transduction/genetics, Signal Transduction/immunology, Tertiary Lymphoid Structures/immunology, Tertiary Lymphoid Structures/pathology, Lymphatic Vessels, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.jimmunol.org/content/jimmunol/197/5/1957.full.pdf
https://pubmed.ncbi.nlm.nih.gov/27474071
https://sonar.ch/global/documents/172692
https://serval.unil.ch/notice/serval:BIB_390335AE2228
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_390335AE22282
https://serval.unil.ch/resource/serval:BIB_390335AE2228.P001/REF.pdf

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products.

Συγγραφείς: Castenmiller, S.M., Kanagasabesan, N., Guislain, A., Nicolet, B.P., van Loenen, M.M., Monkhorst, K., Veenhof, AAFA, Smit, E.F., Hartemink, K.J., Haanen, JBAG, de Groot, R., Wolkers, M.C.

Θεματικοί όροι: Humans, Carcinoma, Non-Small-Cell Lung/immunology, Non-Small-Cell Lung/pathology, Lung Neoplasms/immunology, Lung Neoplasms/pathology, Tertiary Lymphoid Structures/immunology, Tertiary Lymphoid Structures/pathology, Lymphocytes, Tumor-Infiltrating/immunology, Immunotherapy, Adoptive/methods, Female, Male, B-Lymphocytes/immunology, B-Lymphocytes/pathology, Middle Aged, Aged, Immune infiltrate, NSCLC, TIL therapy, TLS formation

Περιγραφή αρχείου: application/pdf

Relation: OncoImmunology; https://iris.unil.ch/handle/iris/50545; serval:BIB_4F0F8DC467FB; 001296385300001

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/50545
https://doi.org/10.1080/2162402X.2024.2392898

The effect of neoadjuvant therapy on PD-L1 expression and CD8+lymphocyte density in non-small cell lung cancer.

Συγγραφείς: Zens, P., Bello, C., Scherz, A., von Gunten, M., Ochsenbein, A., Schmid, R.A., Berezowska, S.

Θεματικοί όροι: Humans, B7-H1 Antigen/analysis, Carcinoma, Non-Small-Cell Lung/drug therapy, CD8-Positive T-Lymphocytes/pathology, Lung Neoplasms/drug therapy, Lymphocytes, Tumor-Infiltrating/pathology, Neoadjuvant Therapy, Prognosis, Retrospective Studies, Tertiary Lymphoid Structures/pathology

Περιγραφή αρχείου: application/pdf

Relation: Modern Pathology; https://iris.unil.ch/handle/iris/250229; serval:BIB_F0F0181979B5; 000834747000001

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/250229
https://doi.org/10.1038/s41379-022-01139-y