Breaking the Bonds of Aging: The Underappreciated Roles of Aberrant Cysteine Crosslinks and Protective Thiol Interventions.

Authors: Duong SN; Laboratories of Molecular Recognition, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, USA., Barnes KM; Lento Bio, Syracuse, New York, USA., Frederich JH; Laboratories of Molecular Recognition, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, USA.

Source: Rejuvenation research [Rejuvenation Res] 2026 Aug; Vol. 29 (4), pp. 193-210. Date of Electronic Publication: 2026 Feb 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Mary Ann Liebert Inc Country of Publication: United States NLM ID: 101213381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8577 (Electronic) Linking ISSN: 15491684 NLM ISO Abbreviation: Rejuvenation Res Subsets: MEDLINE

MeSH Terms: Aging*/metabolism , Cysteine*/metabolism , Cysteine*/chemistry , Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/pharmacology, Glycation End Products, Advanced/metabolism ; Humans ; Animals ; Oxidation-Reduction

Sustained mucosal delivery of SAMT-247 via an intravaginal ring reduces the risk of SIVmac251 acquisition in vaccinated macaques.

Authors: Rahman MA; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: mohammadarif.rahman@nih.gov., Woode EK; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Moss JA; Oak Crest Institute of Science, Monrovia, CA, USA., Bissa M; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Gunawardana M; Oak Crest Institute of Science, Monrovia, CA, USA., Gutowska A; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Schifanella L; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Silva de Castro I; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Brown S; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Stamos JD; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Sarkis S; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Robello M; Synthetic Bioactive Molecules Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Castonguay AE; Oak Crest Institute of Science, Monrovia, CA, USA., Butkyavichene I; Oak Crest Institute of Science, Monrovia, CA, USA., Pise-Masison CA; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Choo-Wosoba H; Office of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Doster M; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Alilin AN; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA., Killoran KE; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA., Kramer J; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA., Breed MW; Laboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA; Clemson University, Clemson, SC, USA., Cardozo T; New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA., Appella DH; Synthetic Bioactive Molecules Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Baum MM; Oak Crest Institute of Science, Monrovia, CA, USA., Franchini G; Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: franchig@mail.nih.gov.

Source: Cell reports. Medicine [Cell Rep Med] 2026 Jul 21; Vol. 7 (7), pp. 102877. Date of Electronic Publication: 2026 Jun 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

MeSH Terms: Simian Immunodeficiency Virus*/immunology , Simian Immunodeficiency Virus*/drug effects , Simian Acquired Immunodeficiency Syndrome*/prevention & control , Simian Acquired Immunodeficiency Syndrome*/immunology , Simian Acquired Immunodeficiency Syndrome*/virology , Benzamides*/administration & dosage , Benzamides*/pharmacology , Sulfhydryl Compounds*/administration & dosage , Sulfhydryl Compounds*/pharmacology , SAIDS Vaccines*/immunology, Immunity, Mucosal/drug effects ; Vagina/virology ; Vagina/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/drug effects ; Mucous Membrane/drug effects ; Mucous Membrane/immunology ; Animals ; Female ; Administration, Intravaginal ; Macaca mulatta ; Vaccination

Altered Thiol-Disulfide Homeostasis in Sarcoidosis: A Case-Control Study.

Authors: Uzdogan EA; Department of Medical Biochemistry, Ankara Bilkent City Hospital, 06800 Ankara, Turkey., Kocaer ZH; Department of Pulmonary Disease, Bingol State Hospital, 12000 Bingol, Turkey., Neselioglu S; Department of Medical Biochemistry, Ankara Bilkent City Hospital, 06800 Ankara, Turkey.; Faculty of Medicine, Ankara Yildirim Beyazit University, 06800 Ankara, Turkey., Karalezli A; Faculty of Medicine, Ankara Yildirim Beyazit University, 06800 Ankara, Turkey.; Department of Pulmonary Disease, Ankara Bilkent City Hospital, 06800 Ankara, Turkey., Erel O; Department of Medical Biochemistry, Ankara Bilkent City Hospital, 06800 Ankara, Turkey.; Faculty of Medicine, Ankara Yildirim Beyazit University, 06800 Ankara, Turkey.

Source: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2026 Jul 20; Vol. 62 (7). Date of Electronic Publication: 2026 Jul 20.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

MeSH Terms: Sulfhydryl Compounds*/blood , Sulfhydryl Compounds*/analysis , Disulfides*/blood , Disulfides*/analysis , Homeostasis*/physiology , Sarcoidosis*/blood , Sarcoidosis*/physiopathology, Oxidative Stress/physiology ; Biomarkers/blood ; Biomarkers/analysis ; Humans ; Female ; Cross-Sectional Studies ; Middle Aged ; Case-Control Studies ; Adult ; Male ; ROC Curve

Composite Dissolvable Microneedle-Enabled Local High-Dose Delivery of Endogenous Thiols for Efficient Allergic Dermatitis Treatment.

Authors: Wang L; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Fang Z; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Wu Z; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Wang W; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Li X; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Shi X; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Lv L; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Lu X; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China., Li J; State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (Nanjing Tech), Nanjing, China.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2026 Jul 14; Vol. 27 (13), pp. e70455.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH Terms: Cysteine*/administration & dosage , Cysteine*/chemistry , Cysteine*/therapeutic use , Sulfhydryl Compounds*/administration & dosage , Sulfhydryl Compounds*/chemistry , Dermatitis, Allergic Contact*/drug therapy , Drug Delivery Systems*, Hyaluronic Acid/chemistry ; Animals ; Microneedle Drug Delivery ; Mice ; Female ; Needles ; Humans

Novel mercapto conjugates of oleanolic acid as potential antifungal agents.

Authors: Sofi ZI; Bioorganic Chemistry Division, CSIR Indian Institute of Integrative Medicine, Srinagar, J&K, 190005, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Kantroo HA; Clinical Microbiology and PK-PD Division, CSIR Indian Institute of Integrative Medicine, Srinagar, J&K, 190005, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Wani ZA; Clinical Microbiology and PK-PD Division, CSIR Indian Institute of Integrative Medicine, Srinagar, J&K, 190005, India., Shah MU; Bioorganic Chemistry Division, CSIR Indian Institute of Integrative Medicine, Srinagar, J&K, 190005, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Bhat KA; Bioorganic Chemistry Division, CSIR Indian Institute of Integrative Medicine, Srinagar, J&K, 190005, India. kabhat@iiim.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. kabhat@iiim.res.in., Ahmad Z; Clinical Microbiology and PK-PD Division, CSIR Indian Institute of Integrative Medicine, Srinagar, J&K, 190005, India. zap@iiim.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. zap@iiim.res.in.

Source: Archives of microbiology [Arch Microbiol] 2026 Jul 11; Vol. 208 (10). Date of Electronic Publication: 2026 Jul 11.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE

MeSH Terms: Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Candida albicans*/drug effects , Candida albicans*/growth & development , Oleanolic Acid*/pharmacology , Oleanolic Acid*/chemistry , Oleanolic Acid*/analogs & derivatives , Sulfhydryl Compounds*/chemistry , Sulfhydryl Compounds*/pharmacology, Biofilms/drug effects ; Biofilms/growth & development ; Hyphae/drug effects ; Hyphae/growth & development ; Ergosterol/metabolism ; Virulence/drug effects ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Animals ; Humans

AlphaFold reveals how pathogenic Leptospira use cross-kingdom thiol-disulfide exchange to evade the complement membrane attack complex.

Authors: Hinds A; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Johnson E; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.; Computational Biology Facility, LIV-SRF, MerseyBio, University of Liverpool, Liverpool, United Kingdom., Staton G; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Njume FN; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Crosby-Durrani HE; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Nally JE; Infectious Bacterial Disease Research Unit, National Animal Disease Centre, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa, USA., Carter S; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom., Rigden DJ; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Evans NJ; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Leahurst Campus, Chester, Neston, United Kingdom.

Source: MBio [mBio] 2026 Jul 08; Vol. 17 (7), pp. e0087826. Date of Electronic Publication: 2026 Jun 15.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH Terms: Disulfides*/metabolism , Disulfides*/chemistry , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/immunology , Leptospira*/pathogenicity , Leptospira*/immunology , Leptospira*/genetics , Leptospira*/metabolism , Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Complement C8*/metabolism , Complement C8*/immunology , Immune Evasion*, Leptospirosis/microbiology ; Leptospirosis/immunology ; Lipoproteins/metabolism ; Lipoproteins/genetics ; Lipoproteins/chemistry ; Protein Binding ; Humans ; Animals ; Models, Molecular ; Bacterial Adhesion

Thiolated Chitosan-Stearic Acid Thiol-Linked Biomimetic Hydrogels for Axonal Regrowth and Neuronal Tissue Regeneration.

Authors: Bhatt M; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India., Das B; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.

Source: ACS applied bio materials [ACS Appl Bio Mater] 2026 Jul 06; Vol. 9 (13), pp. 5557-5573. Date of Electronic Publication: 2026 Jun 08.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE

MeSH Terms: Chitosan*/chemistry , Chitosan*/pharmacology , Hydrogels*/chemistry , Hydrogels*/pharmacology , Hydrogels*/chemical synthesis , Sulfhydryl Compounds*/chemistry , Sulfhydryl Compounds*/pharmacology , Biocompatible Materials*/chemistry , Biocompatible Materials*/pharmacology , Biocompatible Materials*/chemical synthesis , Stearic Acids*/chemistry , Stearic Acids*/pharmacology , Biomimetic Materials*/chemistry , Biomimetic Materials*/pharmacology , Biomimetic Materials*/chemical synthesis , Axons*/drug effects , Nerve Regeneration*/drug effects, Cell Proliferation/drug effects ; Neurons/drug effects ; Animals ; Materials Testing ; Mice ; Particle Size

Thiol-Based Neuroprotective Copolymers Acutely Restore Redox Metabolism and Mediate Vasogenic Edema in a Mouse Model of Traumatic Brain Injury.

Authors: Curtis ET; Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., McDonald BZ; Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Tarudji AW; Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA., Priester AM; Department of Material Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri, USA., Convertine AJ; Department of Material Science and Engineering, Missouri University of Science and Technology, Rolla, Missouri, USA., Kievit FM; Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

Source: Macromolecular bioscience [Macromol Biosci] 2026 Jul; Vol. 26 (7), pp. e00642.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101135941 Publication Model: Print Cited Medium: Internet ISSN: 1616-5195 (Electronic) Linking ISSN: 16165187 NLM ISO Abbreviation: Macromol Biosci Subsets: MEDLINE

MeSH Terms: Brain Injuries, Traumatic*/drug therapy , Brain Injuries, Traumatic*/metabolism , Brain Injuries, Traumatic*/pathology , Brain Injuries, Traumatic*/complications , Brain Injuries, Traumatic*/diagnostic imaging , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Polymers*/pharmacology , Polymers*/chemistry , Sulfhydryl Compounds*/chemistry , Sulfhydryl Compounds*/pharmacology , Brain Edema*/drug therapy , Brain Edema*/metabolism , Brain Edema*/pathology, Oxidation-Reduction/drug effects ; Nanoparticles/chemistry ; Reactive Oxygen Species/metabolism ; Antioxidants/pharmacology ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Lipid Peroxidation/drug effects ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/drug effects ; Glial Fibrillary Acidic Protein/metabolism ; Animals ; Mice ; Disease Models, Animal ; Male ; Mice, Inbred C57BL

Simultaneous Determination and Enantiomeric Separation of Five DL-Thiol Compounds Using UHPLC-HRMS With Chiral Derivatization in Sake: Dynamic Monitoring of Human Urine After Drinking.

Authors: Xiao S; Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Department of Pharmacy of Tianjin Children's Hospital, Children's Hospital, Tianjin University, Tianjin, China., Shi H; Pharmaceutical Analysis, College of Pharmacy, Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, Jilin Province, China., Song S; Pharmaceutical Analysis, College of Pharmacy, Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, Jilin Province, China., Min JZ; Pharmaceutical Analysis, College of Pharmacy, Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, Jilin Province, China.

Source: Chirality [Chirality] 2026 Jul; Vol. 38 (7), pp. e70112.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8914261 Publication Model: Print Cited Medium: Internet ISSN: 1520-636X (Electronic) Linking ISSN: 08990042 NLM ISO Abbreviation: Chirality Subsets: MEDLINE

MeSH Terms: Sulfhydryl Compounds*/urine , Sulfhydryl Compounds*/chemistry , Sulfhydryl Compounds*/isolation & purification , Liquid Chromatography-Mass Spectrometry*/methods , Alcoholic Beverages*/analysis, Chromatography, High Pressure Liquid/methods ; Mass Spectrometry/methods ; Cysteine/urine ; Stereoisomerism ; Humans

Comparative Effects of Laparotomy and Laparoscopy-Assisted Embryo Transfer on Oxidative Stress and Thiol-Disulphide Homeostasis in Tuj Ewes.

Authors: Demir MC; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Demir MS; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Makav M; Department of Physiology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Kaya S; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Gökdemir T; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Önder NT; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Kuru M; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye., Kaçar C; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye.

Source: Veterinary medicine and science [Vet Med Sci] 2026 Jul; Vol. 12 (4), pp. e71023.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101678837 Publication Model: Print Cited Medium: Internet ISSN: 2053-1095 (Electronic) Linking ISSN: 20531095 NLM ISO Abbreviation: Vet Med Sci Subsets: MEDLINE

MeSH Terms: Laparoscopy*/veterinary , Disulfides*/blood , Disulfides*/metabolism , Sulfhydryl Compounds*/blood , Sulfhydryl Compounds*/metabolism , Embryo Transfer*/veterinary , Embryo Transfer*/methods , Laparotomy*/veterinary , Oxidative Stress*, Sheep/physiology ; Glutathione/blood ; Animals ; Female ; Homeostasis

ReDisulphID: A discovery platform for thiol redox sensors identifies a druggable site regulating p53 activation.

Authors: Coleman P; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK. Electronic address: pierre.coleman@kcl.ac.uk., Laddach A; Nervous System Development and Homeostasis Laboratory, the Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Anderson R; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK., Yang X; Proteomics Facility, Centre of Excellence for Mass Spectrometry, King's College London, The James Black Centre, Denmark Hill Campus, London, SE5 9NU, UK., Kumar R; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, The British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK., Shah A; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, The British Heart Foundation Centre of Excellence, James Black Centre, 125 Coldharbour Lane, London, SE5 9NU, UK., Fraternali F; Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK; Research Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK; Department of Biological Sciences, Birkbeck, University of London, London, WC1E 7HX, UK., Burgoyne JR; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK. Electronic address: joseph.r.burgoyne@kcl.ac.uk.

Source: Redox biology [Redox Biol] 2026 Jul; Vol. 94, pp. 104196. Date of Electronic Publication: 2026 Apr 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

MeSH Terms: Tumor Suppressor Protein p53*/metabolism , Tumor Suppressor Protein p53*/chemistry , Tumor Suppressor Protein p53*/genetics , Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Disulfides*/chemistry , Disulfides*/metabolism, Computational Biology/methods ; Oxidation-Reduction ; Humans ; Signal Transduction ; Drug Discovery

The Thiol-Redox Biochemistry of Trypanosomatids: A New Perspective Based on Known and New Actors.

Authors: Comini MA; Institut Pasteur de Montevideo, Mataojo 2020, CP 11400 Montevideo, Uruguay., Graña M; Institut Pasteur de Montevideo, Mataojo 2020, CP 11400 Montevideo, Uruguay., Manta B; Institut Pasteur de Montevideo, Mataojo 2020, CP 11400 Montevideo, Uruguay.

Source: Biochemistry [Biochemistry] 2026 Jun 16; Vol. 65 (12), pp. 1873-1899. Date of Electronic Publication: 2026 May 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

MeSH Terms: Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Glutathione*/analogs & derivatives , Glutathione*/metabolism , Glutathione*/chemistry , Trypanosomatina*/metabolism , Protozoan Proteins*/metabolism , Protozoan Proteins*/chemistry, Thioredoxins/metabolism ; Thioredoxins/chemistry ; Spermidine/analogs & derivatives ; Spermidine/metabolism ; Spermidine/chemistry ; Glutaredoxins/metabolism ; Glutaredoxins/chemistry ; Oxidation-Reduction ; Animals

Visualizing nanoplastic-metal ion co-exposure stress with an NIR biothiol responsive fluorescent probe.

Authors: Wei S; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhang L; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China., Tan J; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu S; College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China., Arabi M; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn., Ostovan A; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn., Zhuang X; College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China., Chen L; Shandong Key Laboratory of Coastal Zone Environmental Processes and Ecological Security, Shandong Engineering Research Center for Coastal Zone Ecological & Environmental Monitoring Technologies and Equipment, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. liangweizhang@yic.ac.cn.; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao 266237, China.; University of Chinese Academy of Sciences, Beijing 100049, China.

Source: The Analyst [Analyst] 2026 Jun 02; Vol. 151 (11), pp. 3291-3297. Date of Electronic Publication: 2026 Jun 02.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 0372652 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-5528 (Electronic) Linking ISSN: 00032654 NLM ISO Abbreviation: Analyst Subsets: MEDLINE

MeSH Terms: Fluorescent Dyes*/chemistry , Fluorescent Dyes*/toxicity , Fluorescent Dyes*/chemical synthesis , Sulfhydryl Compounds*/analysis , Sulfhydryl Compounds*/chemistry , Mercury*/chemistry , Mercury*/toxicity , Glutathione*/analysis, Oxidative Stress/drug effects ; Polymethyl Methacrylate/chemistry ; Polymethyl Methacrylate/toxicity ; Naphthalimides/chemistry ; Naphthalimides/toxicity ; Naphthalimides/radiation effects ; Naphthalimides/chemical synthesis ; Cysteine/analysis ; Zebrafish ; Animals ; Fluorescent Chemosensor Compounds ; Humans ; HeLa Cells ; Limit of Detection ; Infrared Rays

MccB-catalyzed C-terminal Thioesterification for Protein Bioconjugation.

Authors: Yang D; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Weeks AM; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.

Source: Current protocols [Curr Protoc] 2026 Jun; Vol. 6 (6), pp. e70398.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101773894 Publication Model: Print Cited Medium: Internet ISSN: 2691-1299 (Electronic) Linking ISSN: 26911299 NLM ISO Abbreviation: Curr Protoc Subsets: MEDLINE

MeSH Terms: Esters*/chemistry , Esters*/metabolism , Proteins*/chemistry , Proteins*/metabolism , Sulfhydryl Compounds*/chemistry , Sulfhydryl Compounds*/metabolism, Esterification

Analysis of ligand recognition by choline O-acetyltransferase reveals thiol-reactive assay interference and weak ligand affinity in solution.

Authors: Forsgren N; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Jonsson F; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Carlsson M; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Sander RA; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Larsson A; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Lindén P; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Linusson A; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden; Department of Chemistry, Umeå University, Umeå, Sweden., Engdahl CS; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Wiktelius D; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden., Ekström F; CBRN Defence and Security, Swedish Defence Research Agency, Umeå, Sweden. Electronic address: fredrik.ekstrom@foi.se.

Source: The Journal of biological chemistry [J Biol Chem] 2026 Jun; Vol. 302 (6), pp. 113115. Date of Electronic Publication: 2026 May 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH Terms: Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Choline O-Acetyltransferase*/metabolism , Choline O-Acetyltransferase*/chemistry, Ligands ; Crystallography, X-Ray ; Models, Molecular ; Solutions

Electroconvulsive therapy in the manic phase of bipolar disorder: examining oxidative stress and effects of thiol-disulfide homeostasis.

Authors: Angın KM; Department of Psychiatry, Bursa City Hospital, Bursa, Türkiye., Önen S; Department of Psychiatry, University of Health Sciences Bursa Yuksek Ihtisas Training And Research Hospital, Bursa, Turkey., Neşelioglu S; Department of Biochemistry, Ankara Bilkent City Hospital, Ankara, Turkey.; Department of Biochemistry, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey., Erel Ö; Department of Biochemistry, Ankara Bilkent City Hospital, Ankara, Turkey.; Department of Biochemistry, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Source: International journal of psychiatry in clinical practice [Int J Psychiatry Clin Pract] 2026 Jun; Vol. 30 (2), pp. 164-171. Date of Electronic Publication: 2026 Jan 08.

Publication Type: Journal Article; Observational Study

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9709509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1788 (Electronic) Linking ISSN: 13651501 NLM ISO Abbreviation: Int J Psychiatry Clin Pract Subsets: MEDLINE

MeSH Terms: Oxidative Stress*/physiology , Bipolar Disorder*/therapy , Bipolar Disorder*/metabolism , Bipolar Disorder*/blood , Sulfhydryl Compounds*/blood , Sulfhydryl Compounds*/metabolism , Disulfides*/blood , Disulfides*/metabolism , Homeostasis*/physiology , Mania*/therapy , Mania*/metabolism , Electroconvulsive Therapy*, Humans ; Female ; Male ; Adult ; Case-Control Studies ; Cross-Sectional Studies ; Middle Aged

Recent advances in the catalytic removal of gaseous methyl mercaptan.

Authors: Liu X; Fujian Provincial Key Laboratory of Resources and Environmental Monitoring and Sustainable Management and Utilization, Sanming University, Sanming 365004, China; Center for Excellence in Regional Atmospheric Environment, Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; School of Resources & Chemical Engineering, Sanming University, Sanming 365004, China. Electronic address: xiaofengliu@fjsmu.edu.cn., Liu D; Fujian Provincial Key Laboratory of Resources and Environmental Monitoring and Sustainable Management and Utilization, Sanming University, Sanming 365004, China; School of Resources & Chemical Engineering, Sanming University, Sanming 365004, China., Peng L; School of Resources & Chemical Engineering, Sanming University, Sanming 365004, China., Lu Y; Center for Excellence in Regional Atmospheric Environment, Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China., Zhao J; Fujian Provincial Key Laboratory of Resources and Environmental Monitoring and Sustainable Management and Utilization, Sanming University, Sanming 365004, China; School of Resources & Chemical Engineering, Sanming University, Sanming 365004, China., Xiao W; School of Resources & Chemical Engineering, Sanming University, Sanming 365004, China; Sanming Research Institute for Fluorine Chemical Industry Technology, Sanming University, Sanming 365004, China. Electronic address: xwc@fjsmu.edu.cn.

Source: Journal of environmental sciences (China) [J Environ Sci (China)] 2026 Jun; Vol. 164, pp. 676-695. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

MeSH Terms: Sulfhydryl Compounds*/chemistry , Sulfhydryl Compounds*/analysis , Air Pollutants*/chemistry , Air Pollutants*/analysis , Air Pollution*/prevention & control, Catalysis ; Oxidation-Reduction

The competitive interplay of 12-oxophytodienoic acid (OPDA), protein thiols, and glutathione.

Authors: Knieper M; Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Germany., Schwarz R; Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Germany., Vogelsang L; Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Germany., Sproß J; Industrial Organic Chemistry and Biotechnology, Faculty of Chemistry, Bielefeld University, Germany., Kaya A; Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Germany.; Department of Engineering Basic Sciences, Faculty of Engineering, Alanya Alaaddin Keykubat University, Turkey., Bittmann M; Industrial Organic Chemistry and Biotechnology, Faculty of Chemistry, Bielefeld University, Germany., Gröger H; Industrial Organic Chemistry and Biotechnology, Faculty of Chemistry, Bielefeld University, Germany., Viehhauser A; Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Germany., Dietz KJ; Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Germany.

Source: The FEBS journal [FEBS J] 2026 Jun; Vol. 293 (12), pp. 3683-3705. Date of Electronic Publication: 2026 Feb 05.

Publication Type: Journal Article

Journal Info: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

MeSH Terms: Glutathione*/metabolism , Glutathione*/chemistry , Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Fatty Acids, Unsaturated*/metabolism , Fatty Acids, Unsaturated*/chemistry , Thioredoxins*/metabolism , Thioredoxins*/chemistry, Oxidation-Reduction ; Kinetics

Characterization and mechanism probe of enzymatic extraction and thiolation modification of wheat bran arabinoxylan.

Authors: Jin C; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Zhu L; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Shandong Key Laboratory of Food Resources and Healthy, Shandong 256600, China. Electronic address: zhuling@jiangnan.edu.cn., Tang J; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Xiao Y; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Wan J; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China., Zhang H; National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Shandong Key Laboratory of Food Resources and Healthy, Shandong 256600, China. Electronic address: zhanghui@jiangnan.edu.cn.

Source: Food research international (Ottawa, Ont.) [Food Res Int] 2026 Aug 31; Vol. 238, pp. 119424. Date of Electronic Publication: 2026 May 10.

Publication Type: Journal Article

Journal Info: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

MeSH Terms: Xylans*/chemistry , Xylans*/isolation & purification , Sulfhydryl Compounds*/chemistry , Dietary Fiber*/analysis, Antioxidants/analysis ; Antioxidants/chemistry ; Hydrophobic and Hydrophilic Interactions ; Spectroscopy, Fourier Transform Infrared

4-Mercaptobenzenesulfonic acid-functionalized SiO2@Au nanoshells for specific enrichment and SALDI-MS detection of quaternary ammonium compounds.

Authors: Du M; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China; College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, China., Chen X; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Sun Y; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Hu J; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Wen W; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Xu H; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Electronic address: hhxu@scau.edu.cn., Yin Z; Institute of Advanced Light Source Facilities, Shenzhen 518107, China. Electronic address: yinzhibin@mail.iasf.ac.cn., Wu X; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Electronic address: wuxz@scau.edu.cn.

Source: Journal of chromatography. A [J Chromatogr A] 2026 Aug 30; Vol. 1783, pp. 467136. Date of Electronic Publication: 2026 May 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE

MeSH Terms: Silicon Dioxide*/chemistry , Quaternary Ammonium Compounds*/analysis , Quaternary Ammonium Compounds*/isolation & purification , Quaternary Ammonium Compounds*/chemistry , Gold*/chemistry , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*/methods , Sulfhydryl Compounds*/chemistry, Nanocomposites/chemistry ; Adsorption ; Limit of Detection ; Reproducibility of Results ; Hydrogen-Ion Concentration ; Linear Models ; Benzoates