Comparison of Streptococcus mutans growth-phase-dependent transcriptome changes in two different simulated microgravity models.

Authors: Davis KAT; Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, 32611, USA.; Present address: Health Sciences (Biotechnology), Central Georgia Technical College, 12 Macon, GA 31206, USA., Rice KC; Department of Microbiology and Cell Science, IFAS, University of Florida, Gainesville, Florida, 32611, USA.

Source: Microbiology (Reading, England) [Microbiology (Reading)] 2026 Oct; Vol. 172 (10).

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Microbiology Society Country of Publication: England NLM ID: 9430468 Publication Model: Print Cited Medium: Internet ISSN: 1465-2080 (Electronic) Linking ISSN: 13500872 NLM ISO Abbreviation: Microbiology (Reading) Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/genetics , Streptococcus mutans*/growth & development , Streptococcus mutans*/metabolism , Transcriptome* , Weightlessness Simulation*, Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biofilms/growth & development ; Gene Expression Regulation, Bacterial ; Weightlessness ; Gene Expression Profiling

Bioabsorbable Cold Plasma-Generated Nitric Oxide Gas and Plasma-Activated Nitric Oxide Water: Inactivation of Oral Planktonic and Biofilm-Forming Streptococcus mutans.

Authors: Ashokkumar S; Department of Bio-Nano Technology, Gachon University, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea., Bhatnagar A; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea., Acharya TR; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea.; GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Nottingham, UK., Shin YO; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea., Choi EH; Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul, Republic of Korea., Lee YC; Department of Bio-Nano Technology, Gachon University, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea.

Source: ChemPlusChem [Chempluschem] 2026 Oct; Vol. 91 (10), pp. e70257.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101580948 Publication Model: Print Cited Medium: Internet ISSN: 2192-6506 (Electronic) Linking ISSN: 21926506 NLM ISO Abbreviation: Chempluschem Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Nitric Oxide*/chemistry , Nitric Oxide*/pharmacology , Biofilms*/drug effects , Plasma Gases*/chemistry , Plasma Gases*/pharmacology , Water*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry, Staphylococcus aureus/drug effects ; Hydrogen Peroxide/chemistry

Regulation of Streptococcus mutans biofilm virulence by dietary sugars: Mechanistic basis of sucralose-mediated suppression.

Authors: Nesa SR; Department of Food Safety and Regulatory Science, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea; GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea., Meghla NS; Department of Food Safety and Regulatory Science, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea; GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea., Lee H; Department of Food Safety and Regulatory Science, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea; GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea., Kang I; Department of Animal Science, California Polytechnic State University, San Luis Obispo, CA, 93407, USA., Chun KA; Department of Conservative Dentistry, Korea University Anam Hospital, Koreadaero 73, Seoul, Sungbuk-Gu, Republic of Korea., Mizan MFR; Department of Food Safety and Regulatory Science, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea; GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea. Electronic address: rahaman4162@cau.ac.kr., Ha SD; Department of Food Safety and Regulatory Science, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea; GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, Gyeonggido, 17546, Republic of Korea. Electronic address: sangdoha@cau.ac.kr.

Source: Microbial pathogenesis [Microb Pathog] 2026 Oct; Vol. 219, pp. 108772. Date of Electronic Publication: 2026 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE

MeSH Terms: Biofilms*/drug effects , Biofilms*/growth & development , Sucrose*/analogs & derivatives , Sucrose*/pharmacology , Sucrose*/metabolism , Streptococcus mutans*/drug effects , Streptococcus mutans*/pathogenicity , Streptococcus mutans*/genetics , Streptococcus mutans*/growth & development , Streptococcus mutans*/metabolism , Streptococcus mutans*/physiology , Dietary Sucrose*/pharmacology, Virulence/drug effects ; Gene Expression Regulation, Bacterial/drug effects ; Bacterial Adhesion/drug effects ; Sweetening Agents/pharmacology ; Microbial Viability/drug effects ; Glucose/pharmacology ; Bacterial Proteins/genetics ; Microscopy, Electron, Scanning

Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems.

Authors: Snigdha NT; Department of Dental Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.; Department of Orthodontics, Pedodontics, and Preventive Dentistry, Faculty of Dentistry, Ibn Al-Nafis University, Sanaa, Republic of Yemen., Alamoudi RA; Professor and Consultant of Endodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia., Alghamdi NS; Department Restorative Dental Science, College of Dentistry, King Khalid University, Abha, Saudi Arabia., Kader MA; Department Restorative Dental Science, College of Dentistry, King Khalid University, Abha, Saudi Arabia., Basheer SN; Department of Restorative Dental Sciences, College Of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia., Mulla M; Associate Professor, Department of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia., Mulla M; Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India., Mathur A; Department of Dental Research Cell, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, India., Karobari MI; Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.; Faculty of Dentistry, University of Puthisastra, Phnom Penh, Cambodia.

Source: Molecular oral microbiology [Mol Oral Microbiol] 2026 Oct; Vol. 41 (5), pp. 241-257. Date of Electronic Publication: 2026 Jun 24.

Publication Type: Journal Article; Review

Journal Info: Publisher: John Wiley & Sons Country of Publication: Denmark NLM ID: 101524770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1014 (Electronic) Linking ISSN: 20411006 NLM ISO Abbreviation: Mol Oral Microbiol Subsets: MEDLINE

MeSH Terms: Biofilms*/growth & development , Streptococcus mutans*/genetics , Streptococcus mutans*/pathogenicity , Streptococcus mutans*/physiology , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism, Virulence/genetics ; Signal Transduction/genetics ; Dental Caries/microbiology ; Gene Expression Regulation, Bacterial ; Humans ; Oxidative Stress

Artemisinins inhibited the synergistic cariogenic effect between Candida albicans and Streptococcus mutans.

Authors: Zhou J; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.; West China Lecheng Hospital, Sichuan University, Boao, Hainan, China., Zhou Z; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Shen J; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Lin Y; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Lei L; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Gou L; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Meng Z; Department of Clinical Laboratory, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Zhou Y; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China., Liao B; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Cheng L; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Cariology and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Zhou X; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.; Department of Cariology and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China., Ren B; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 Sep 08; Vol. 16, pp. 1950360. Date of Electronic Publication: 2026 Sep 08 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

MeSH Terms: Candida albicans*/drug effects , Candida albicans*/growth & development , Candida albicans*/physiology , Artemisinins*/pharmacology , Streptococcus mutans*/drug effects , Streptococcus mutans*/growth & development , Streptococcus mutans*/genetics , Dental Caries*/microbiology , Dental Caries*/prevention & control , Dental Caries*/drug therapy , Microbial Interactions*/drug effects, Biofilms/drug effects ; Biofilms/growth & development ; Virulence/drug effects ; Hyphae/drug effects ; Hyphae/growth & development ; Anti-Bacterial Agents/pharmacology ; Animals ; Drug Synergism ; Disease Models, Animal ; Rats ; Microbial Sensitivity Tests

A biomimetic urchin-like photothermal nanoplatform for the efficient eradication of Streptococcus mutans and biofilm dispersion.

Authors: Wang Y; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Mi J; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Cao X; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China., Wang M; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.; Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Feng H; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Kong F; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China., Zhang X; Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Tianjin Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin, China., Liu X; Department of Cariology and Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Clinical Research Center for Oral Diseases, Tianjin Stomatological Hospital, Tianjin, China.

Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2026 Sep 03; Vol. 16, pp. 1917604. Date of Electronic Publication: 2026 Sep 03 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

MeSH Terms: Biofilms*/drug effects , Biofilms*/growth & development , Biofilms*/radiation effects , Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Anti-Bacterial Agents*/pharmacology , Biomimetics*/methods , Biomimetic Materials*/pharmacology, Gold/chemistry ; Microbial Viability/drug effects ; Dental Caries/microbiology ; Dental Caries/therapy ; Metal Nanoparticles/chemistry ; Humans ; Animals

Antibacterial and antibiofilm effects of immobilized hydrogen on pathogenic oral bacteria.

Authors: Sato K; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Akizuki M; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Enggardipta RA; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan.; Department of Conservative Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia., Kido R; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Inagaki Y; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Sumitomo T; Department of Oral Microbiology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan., Nambu K; Acche Corporation, Tokyo, 105-0001, Japan., Yumoto H; Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan.

Source: Journal of applied microbiology [J Appl Microbiol] 2026 Sep 02; Vol. 137 (9).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9706280 Publication Model: Print Cited Medium: Internet ISSN: 1365-2672 (Electronic) Linking ISSN: 13645072 NLM ISO Abbreviation: J Appl Microbiol Subsets: MEDLINE

MeSH Terms: Biofilms*/drug effects , Hydrogen*/pharmacology , Hydrogen*/chemistry , Enterococcus faecalis*/drug effects , Enterococcus faecalis*/genetics , Enterococcus faecalis*/physiology , Streptococcus mutans*/drug effects , Streptococcus mutans*/genetics , Streptococcus mutans*/physiology , Anti-Bacterial Agents*/pharmacology , Porphyromonas gingivalis*/drug effects , Porphyromonas gingivalis*/genetics , Porphyromonas gingivalis*/physiology , Mouth*/microbiology, Calcium Carbonate/pharmacology ; Calcium Carbonate/chemistry ; Humans ; Animals

Promotive effect of cold brew coffee on the maturation of S. mutans biofilms during the post-initiation stage.

Authors: Kim U; Department of Food and Nutrition, Kookmin University, Seoul, Republic of Korea., Oh SW; Department of Food and Nutrition, Kookmin University, Seoul, Republic of Korea. Electronic address: swoh@kookmin.ac.kr.

Source: International journal of food microbiology [Int J Food Microbiol] 2026 Sep 02; Vol. 458, pp. 111873. Date of Electronic Publication: 2026 May 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8412849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3460 (Electronic) Linking ISSN: 01681605 NLM ISO Abbreviation: Int J Food Microbiol Subsets: MEDLINE

MeSH Terms: Biofilms*/growth & development , Biofilms*/drug effects , Streptococcus mutans*/physiology , Streptococcus mutans*/drug effects , Streptococcus mutans*/growth & development , Coffee*/chemistry, Stainless Steel ; Food Microbiology ; Microscopy, Electron, Scanning

Quorum sensing rewires membrane vesicle protein cargo to promote antibiotic persistence in Streptococcus mutans.

Authors: Dufour D; Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada., Leiva-Sabadini C; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile., Aguayo S; Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile.; School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Lévesque CM; Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Source: Journal of bacteriology [J Bacteriol] 2026 Aug 20; Vol. 208 (8), pp. e0032326. Date of Electronic Publication: 2026 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

MeSH Terms: Quorum Sensing*/physiology , Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Streptococcus mutans*/genetics , Streptococcus mutans*/metabolism , Anti-Bacterial Agents*/pharmacology , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Membrane Proteins*/metabolism

Novel 1,2,3-Thiadiazole-based Hydrazone and 1,3,4-Oxadiazole hybrids as promising agents against Streptococcus mutans: Synthesis, biological evaluation, and molecular modeling studies.

Authors: Kurtuluş İG; Faculty of Engineering, Department of Chemistry, Organic Chemistry Division, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey., Başpınar Küçük H; Faculty of Engineering, Department of Chemistry, Organic Chemistry Division, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey. Electronic address: baspinar@iuc.edu.tr., Kahya SE; School of Pharmacy, Department of Pharmacognosy, Istanbul Medipol University, Istanbul 34810, Türkiye., Karadağ AE; School of Pharmacy, Department of Pharmacognosy, Istanbul Medipol University, Istanbul 34810, Türkiye., Ghazy S; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçesehir University, Istanbul 34353, Türkiye; Lab for Innovative Drugs (Lab4IND), Computational Drug Design Center (HİTMER), Bahçesehir University, İstanbul 34353, Türkiye., Durdağı S; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçesehir University, Istanbul 34353, Türkiye; Lab for Innovative Drugs (Lab4IND), Computational Drug Design Center (HİTMER), Bahçesehir University, İstanbul 34353, Türkiye; Systems Biology Lab, Biruni University Scientific Research Center, Biruni University, İstanbul, Turkiye; Molecular Therapy Lab, Department of Pharmaceutical Chemistry, School of Pharmacy, Bahçesehir University, Istanbul 34353, Türkiye. Electronic address: serdar.durdagi@bau.edu.tr.

Source: Bioorganic chemistry [Bioorg Chem] 2026 Aug 05; Vol. 177, pp. 109935. Date of Electronic Publication: 2026 Apr 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/drug effects , Streptococcus mutans*/enzymology , Hydrazones*/pharmacology , Hydrazones*/chemistry , Hydrazones*/chemical synthesis , Oxadiazoles*/pharmacology , Oxadiazoles*/chemistry , Oxadiazoles*/chemical synthesis , Thiadiazoles*/chemistry , Thiadiazoles*/pharmacology , Thiadiazoles*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry, Antioxidants/pharmacology ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Biphenyl Compounds/antagonists & inhibitors ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Quantitative Structure-Activity Relationship ; Models, Molecular ; Dose-Response Relationship, Drug ; Structure-Activity Relationship

Zinc tolerance through glutathione import strikes a fine balance between protection and damage in Streptococcus mutans.

Authors: Carter MC; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA., Womack E; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA., Khatib M; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA., Peterson AM; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA., Saengpet IS; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA., Lemos JA; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.

Source: Microbiology (Reading, England) [Microbiology (Reading)] 2026 Aug; Vol. 172 (8).

Publication Type: Journal Article

Journal Info: Publisher: Microbiology Society Country of Publication: England NLM ID: 9430468 Publication Model: Print Cited Medium: Internet ISSN: 1465-2080 (Electronic) Linking ISSN: 13500872 NLM ISO Abbreviation: Microbiology (Reading) Subsets: MEDLINE

MeSH Terms: Glutathione*/metabolism , Streptococcus mutans*/metabolism , Streptococcus mutans*/genetics , Streptococcus mutans*/drug effects , Streptococcus mutans*/growth & development , Zinc*/metabolism , Zinc*/toxicity, Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Gene Deletion ; Stress, Physiological ; Biological Transport

Comparative Analysis of Chlorhexidine Derivatives and Alternative Agents on Streptococcus mutans Viability, Biofilm Formation, and Gene Expression.

Authors: Kamalloo H; Department of Microbiology, Science and Research Branch, Islamic Azad University, Tehran, Iran., Moeininejad M; School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran., Golshoui MK; Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Samadyar F; Department of Microbiology, Faculty of Basic Science, Karaj Branch, Islamic Azad University Karaj, Karaj, Iran., Shivaee A; Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kalani BS; Department of Medical Microbiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.; Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.

Source: MicrobiologyOpen [Microbiologyopen] 2026 Aug; Vol. 15 (4), pp. e70360.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101588314 Publication Model: Print Cited Medium: Internet ISSN: 2045-8827 (Electronic) Linking ISSN: 20458827 NLM ISO Abbreviation: Microbiologyopen Subsets: MEDLINE

MeSH Terms: Biofilms*/drug effects , Biofilms*/growth & development , Chlorhexidine*/pharmacology , Chlorhexidine*/analogs & derivatives , Streptococcus mutans*/drug effects , Streptococcus mutans*/physiology , Streptococcus mutans*/genetics , Microbial Viability*/drug effects , Anti-Bacterial Agents*/pharmacology , Gene Expression Regulation, Bacterial*/drug effects, Fibroblasts/drug effects ; Humans ; Microbial Sensitivity Tests ; Gene Expression Profiling ; Biguanides

GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1-cAMP/PKA Pathway in the Cross-Kingdom Biofilms.

Authors: Zhang B; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Center of Oral Public Health, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China., Hou S; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China., Zhang A; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Center of Oral Public Health, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China., Yang J; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Center of Oral Public Health, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China., Zhang W; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Center of Oral Public Health, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China., Zhu S; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Center of Oral Public Health, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China., Chen H; Department of Endodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China.; Key Laboratory of Oral Diseases and Biomedical Sciences, Stomatological Hospital of Chongqing Medical University, Chongqing, China., Huang R; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Center of Oral Public Health, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Source: Molecular oral microbiology [Mol Oral Microbiol] 2026 Aug; Vol. 41 (4), pp. 188-200. Date of Electronic Publication: 2026 Apr 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley & Sons Country of Publication: Denmark NLM ID: 101524770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1014 (Electronic) Linking ISSN: 20411006 NLM ISO Abbreviation: Mol Oral Microbiol Subsets: MEDLINE

MeSH Terms: Biofilms*/growth & development , Candida albicans*/genetics , Candida albicans*/growth & development , Candida albicans*/physiology , Candida albicans*/pathogenicity , Candida albicans*/metabolism , Streptococcus mutans*/genetics , Streptococcus mutans*/metabolism , Streptococcus mutans*/physiology , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism, Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics ; ras Proteins/metabolism ; ras Proteins/genetics ; Signal Transduction ; Microscopy, Electron, Scanning ; Microscopy, Confocal ; Animals ; Gene Expression Regulation, Bacterial ; Polysaccharides, Bacterial

The impact of Streptococcus mutans biofilms on the color stability and topographical features of three lithium disilicate ceramics.

Authors: Balhaddad AA; Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Al Otaibi AM; Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alotaibi KS; College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Al-Zain AO; Restorative Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia., Ismail EH; Department of Clinical Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Al-Dulaijan YA; Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alalawi H; Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Al-Thobity AM; Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Source: Journal of prosthodontics : official journal of the American College of Prosthodontists [J Prosthodont] 2026 Oct; Vol. 35 (8), pp. 1304-1311. Date of Electronic Publication: 2024 Aug 31.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9301275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-849X (Electronic) Linking ISSN: 1059941X NLM ISO Abbreviation: J Prosthodont Subsets: MEDLINE

MeSH Terms: Biofilms*/growth & development , Streptococcus mutans*/physiology , Streptococcus mutans*/growth & development , Dental Porcelain*/chemistry , Ceramics*/chemistry, Surface Properties ; Color ; Microscopy, Electron, Scanning ; Materials Testing ; Humans ; Spectrophotometry

Synthesis and characterization of chitosan nanoparticles and their inhibitory effects against Streptococcus mutans: role of concentration and exposure time.

Authors: Costa BP; Graduate Program in Dentistry, Universidade Federal da Paraíba (UFPB), Cidade Universitária, Castelo Branco III, João Pessoa, PB, 58051-900, Brazil., Reis RM; Departamento de Saúde Coletiva, Odontopediatria E Ortodontia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (FOP/UNICAMP), Av. Limeira, 901, Areião, Piracicaba, SP, 13414-903, Brazil., de Castro Bernardino K; Department of Pediatric Dentistry-Dental School, Universidade Federal de Uberlândia-Campus Umuarama, Bloco UMU2G. Av. Pará, 1720, Umuarama, Uberlândia, MG, 38405-320, Brazil., Aguiar RT; Graduate Program in Dentistry, Universidade Federal da Paraíba (UFPB), Cidade Universitária, Castelo Branco III, João Pessoa, PB, 58051-900, Brazil., Carlo HL; Department of Pediatric Dentistry-Dental School, Universidade Federal de Uberlândia-Campus Umuarama, Bloco UMU2G. Av. Pará, 1720, Umuarama, Uberlândia, MG, 38405-320, Brazil., Dos Santos RL; Department of Dentistry, Universidade Federal de Juiz de Fora, Avenida Doutor Raimundo Rezende N. 330, Centro, Governador Valadares, Juiz de Fora, MG, 35012-140, Brazil., de Carvalho FG; Department of Pediatric Dentistry-Dental School, Universidade Federal de Uberlândia-Campus Umuarama, Bloco UMU2G. Av. Pará, 1720, Umuarama, Uberlândia, MG, 38405-320, Brazil. fabiola.carlo@ufu.br.

Source: Odontology [Odontology] 2026 Oct; Vol. 114 (4), pp. 1955-1965. Date of Electronic Publication: 2025 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Tokyo Country of Publication: Japan NLM ID: 101134822 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1255 (Electronic) Linking ISSN: 16181247 NLM ISO Abbreviation: Odontology Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/drug effects , Chitosan*/pharmacology , Chitosan*/chemical synthesis , Chitosan*/chemistry , Nanoparticles*/chemistry , Anti-Bacterial Agents*/pharmacology, Biofilms/drug effects ; Bacterial Adhesion/drug effects ; Microscopy, Electron, Transmission ; Spectroscopy, Fourier Transform Infrared ; Microbial Sensitivity Tests ; Time Factors

Inhibitory effects of surface pre-reacted glass-ionomer eluate on Candida albicans and commensal oral streptococci dual-species biofilm.

Authors: Fujishima K; Department of Preventive Dentistry, Kagoshima University Graduate School of Medicine and Dental Sciences., Hoshika T; Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medicine and Dental Sciences., Watanabe A; Department of Oral Health Care and Rehabilitation, Tokushima University Graduate School of Biomedical Sciences., Oku Y; Department of Preventive Dentistry, Kagoshima University Graduate School of Medicine and Dental Sciences., Kudo Y; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences., Nishitani Y; Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medicine and Dental Sciences., Tamaki N; Department of Preventive Dentistry, Kagoshima University Graduate School of Medicine and Dental Sciences.

Source: Dental materials journal [Dent Mater J] 2026 Sep 25; Vol. 45 (5), pp. 633-638. Date of Electronic Publication: 2026 Aug 26.

Publication Type: Journal Article

Journal Info: Publisher: Japanese Society for Dental Materials and Devices Country of Publication: Japan NLM ID: 8309299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1361 (Electronic) Linking ISSN: 02874547 NLM ISO Abbreviation: Dent Mater J Subsets: MEDLINE

MeSH Terms: Biofilms*/drug effects , Candida albicans*/drug effects , Streptococcus mutans*/drug effects , Acrylic Resins*/pharmacology , Acrylic Resins*/chemistry , Streptococcus*/drug effects, Oxidative Stress/drug effects ; Surface Properties ; Humans ; Silicon Dioxide

Monounsaturated fatty acid biosynthesis is critical for streptococcal envelope homeostasis and stress tolerance.

Authors: Baker JL; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Biomedical Engineering, OHSU School of Medicine, Portland, Oregon, USA., Tang J; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; KCGIP, Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, Oregon, USA., Guo M; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA., Farias-da-Silva FF; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Public Health, Pediatric Dentistry and Orthodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil., Barbisan M; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA., Burnside M; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA., Crofton K; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Biology, Rollins College, Winter Park, Florida, USA., Williams S; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Rao S; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Statistics, Santa Clara University, Santa Clara, California, USA., Lee M; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Biology, Oregon State University, Corvallis, Oregon, USA., Drucker SG; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Biology, Scripps College, Claremont, California, USA., Kim D; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA., Higashi D; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA., Merritt J; Department of Biomaterial & Biomedical Sciences, OHSU School of Dentistry, Portland, Oregon, USA.; Department of Molecular Microbiology and Immunology, OHSU School of Medicine, Portland, Oregon, USA., Hirose Y; Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan., Veening J-W; Department of Fundamental Microbiology, Faculty of Biology & Medicine, University of Lausanne, Lausanne, Switzerland., Nizet V; Department of Pediatrics, UC San Diego School of Medicine, La Jolla, California, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.

Source: Journal of bacteriology [J Bacteriol] 2026 Sep 17; Vol. 208 (9), pp. e0002626. Date of Electronic Publication: 2026 Aug 07.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/metabolism , Streptococcus mutans*/genetics , Streptococcus mutans*/physiology , Fatty Acids, Monounsaturated*/metabolism , Streptococcus pneumoniae*/metabolism , Streptococcus pneumoniae*/genetics , Streptococcus pneumoniae*/physiology , Streptococcus pneumoniae*/pathogenicity , Streptococcus pyogenes*/metabolism , Streptococcus pyogenes*/genetics , Streptococcus pyogenes*/physiology , Streptococcus pyogenes*/pathogenicity , Homeostasis* , Stress, Physiological*, Cell Membrane/metabolism ; Humans ; Virulence ; Gene Deletion

An XRE-type regulator in Streptococcus mutans plays an important role in brpA expression and oxidative stress tolerance response.

Authors: Wen ZT; Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.; Department of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Ellepola K; Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Guillot LC; Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Dhaked HPS; Department of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Wu H; Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, Portland, Oregon, USA.

Source: Microbiology spectrum [Microbiol Spectr] 2026 Sep; Vol. 14 (9), pp. e0011626. Date of Electronic Publication: 2026 Jul 21.

Publication Type: Journal Article

Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/genetics , Streptococcus mutans*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Oxidative Stress*, Hydrogen Peroxide/pharmacology ; Biofilms/growth & development ; Gene Expression Regulation, Bacterial ; Promoter Regions, Genetic ; Response Elements

Effects of Ultrasound-Mediated Treatments on Dental Biofilm Attachment and Viability.

Authors: De Grandi D; Institute of Biomedical Engineering (IBME), Department of Engineering Science, University of Oxford, Oxford, UK., LuTheryn G; Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK., Stoffels M; Philips Oral Healthcare, Eindhoven, The Netherlands., Born M; Philips Oral Healthcare, Eindhoven, The Netherlands., Gottenbos B; Philips Oral Healthcare, Eindhoven, The Netherlands., Carugo D; Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK. Electronic address: dario.carugo@ndorms.ox.ac.uk., Stride E; Institute of Biomedical Engineering (IBME), Department of Engineering Science, University of Oxford, Oxford, UK.

Source: Ultrasound in medicine & biology [Ultrasound Med Biol] 2026 Sep; Vol. 52 (9), pp. 1900-1911. Date of Electronic Publication: 2026 Jun 25.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0410553 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-291X (Electronic) Linking ISSN: 03015629 NLM ISO Abbreviation: Ultrasound Med Biol Subsets: MEDLINE

MeSH Terms: Biofilms*/radiation effects , Biofilms*/growth & development , Streptococcus mutans*/physiology , Ultrasonic Therapy*/methods , Bacterial Adhesion*/radiation effects, Chlorhexidine/pharmacology ; Microbubbles ; Microbial Viability ; Humans

On-demand caries prevention: on-site generated slightly acidic electrolyzed water as a potent and biocompatible anti- Streptococcus mutans agent.

Authors: Luan M; Department of Stomatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China.; The First School of Clinical Medicine, Anhui Medical University, Hefei, 230032, P. R. China., Gao X; Department of Stomatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China.; The First School of Clinical Medicine, Anhui Medical University, Hefei, 230032, P. R. China., Cao Q; Department of Stomatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China.; The First School of Clinical Medicine, Anhui Medical University, Hefei, 230032, P. R. China., Lv N; Department of Stomatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China. lvna@ahmu.edu.cn.; The First School of Clinical Medicine, Anhui Medical University, Hefei, 230032, P. R. China. lvna@ahmu.edu.cn.

Source: BMC oral health [BMC Oral Health] 2026 Aug 08; Vol. 26 (1). Date of Electronic Publication: 2026 Aug 08.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE

MeSH Terms: Streptococcus mutans*/drug effects , Dental Caries*/prevention & control , Dental Caries*/microbiology , Anti-Bacterial Agents*/pharmacology , Water*/pharmacology , Water*/chemistry, Biofilms/drug effects ; Animals ; Rats ; Rats, Sprague-Dawley ; Humans ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; Electrolysis ; Microscopy, Confocal