Detection and Quantification of Spreading Depolarization in Drosophila melanogaster Using High-Throughput, Wide-Field Brain Imaging.

Συγγραφείς: Stein W; School of Biological Sciences, Illinois State University, Normal, Illinois.; These authors contributed equally to this work., Harris AL; Department of Physics, Illinois State University, Normal, Illinois.; These authors contributed equally to this work.

Πηγή: Current protocols [Curr Protoc] 2026 Oct; Vol. 6 (10), pp. e70475.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101773894 Publication Model: Print Cited Medium: Internet ISSN: 2691-1299 (Electronic) Linking ISSN: 26911299 NLM ISO Abbreviation: Curr Protoc Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Drosophila melanogaster*/physiology , Brain*/diagnostic imaging , Brain*/physiology , Optical Imaging*/methods , Cortical Spreading Depression*/physiology , High-Throughput Screening Assays*/methods, Animals ; Larva

Vasopressin 1A and 1B receptor-mediated antinociception in a mouse model of cortical spreading depolarization.

Συγγραφείς: Kwamo T; Boston University, Boston, MA, United States., Hancock M; Boston University, Boston, MA, United States., Kaya MZ; Neurovascular Research Unit, Massachusetts General Hospital, Boston, MA, United States., Olagundoye F; Boston University, Boston, MA, United States., Harriott AM; Neurovascular Research Unit, Massachusetts General Hospital, Boston, MA, United States.

Πηγή: Pain [Pain] 2026 Sep 01; Vol. 167 (9), pp. 2062-2072. Date of Electronic Publication: 2026 Jun 22.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Vasopressin*/metabolism , Cortical Spreading Depression*/drug effects , Cortical Spreading Depression*/physiology , Migraine Disorders*/drug therapy, Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Antidiuretic Hormone Receptor Antagonists/pharmacology ; Hyperalgesia/drug therapy ; Animals ; Male ; Mice ; Disease Models, Animal ; Female ; Mice, Inbred C57BL ; Mice, Transgenic ; Indoles

EA1-linked Kv1.1 dysfunction enhances susceptibility to cerebellar spreading depression and a transient cerebellar refractory state.

Συγγραφείς: Servettini I; Department of Medicine and Health Science 'V. Tiberio', University of Molise, Campobasso, Italy; Department of Medicine and Surgery, University of Perugia, 06156, Perugia, Italy. Electronic address: ilenio.servettini@unimol.it., Megaro A; Department of Medicine and Surgery, University of Perugia, 06156, Perugia, Italy., Caramia M; Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Largo Rosanna Benzi 10, 16132, Genova, Italy; Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy., Sforna L; Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy., Michelucci A; Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy., Catacuzzeno L; Department of Chemistry, Biology and Biotechnology, University of Perugia, Italy. Electronic address: luigi.catacuzzeno@unipg.it.

Πηγή: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2026 Oct; Vol. 1872 (7), pp. 168302. Date of Electronic Publication: 2026 May 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Kv1.1 Potassium Channel*/genetics , Kv1.1 Potassium Channel*/metabolism , Cerebellum*/metabolism , Cerebellum*/pathology , Cerebellum*/physiopathology , Ataxia*/genetics , Ataxia*/metabolism , Ataxia*/pathology , Ataxia*/physiopathology , Cortical Spreading Depression*, Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL ; Female ; Myokymia

SCR Disease Name: Episodic Ataxia, Type 1

Multifocal Initiation of Spreading Depolarization by Generalized Tonic-Clonic Seizures.

Συγγραφείς: Smirnova M; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia., Karan A; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia., Medvedeva T; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia., Vinogradova L; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova Street 5A, 117485 Moscow, Russia.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Sep 21; Vol. 27 (18). Date of Electronic Publication: 2026 Sep 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Seizures*/physiopathology , Seizures*/chemically induced , Cortical Spreading Depression*/physiology , Hippocampus*/physiopathology, Cerebral Cortex/physiopathology ; Animals ; Male ; Rats ; Pentylenetetrazole ; Electroencephalography ; Disease Models, Animal ; Rats, Sprague-Dawley

Alteration of the cortical spreading depolarization in the mouse defective in translocator protein 18 kDa.

Συγγραφείς: Hattori M; Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Zhang Q; Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Handa T; Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Kikutani K; Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Kasaragod DK; Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Matsumata M; Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Ota K; Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Shime N; Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Aizawa H; Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan. Electronic address: haizawa@hiroshima-u.ac.jp.

Πηγή: Brain research [Brain Res] 2026 Sep 15; Vol. 1887, pp. 150386. Date of Electronic Publication: 2026 May 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Receptors, GABA*/genetics , Receptors, GABA*/metabolism , Receptors, GABA*/deficiency , Cerebral Cortex*/metabolism, Blood-Brain Barrier/metabolism ; Neurons/metabolism ; Inflammation/metabolism ; Animals ; Mice, Knockout ; Mice ; Male ; Mice, Inbred C57BL

An astro-neural-field model with application to cortical spreading depolarization.

Συγγραφείς: Baspinar E; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France. emre.baspinar@inria.fr., Avitabile D; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France.; Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience - System and Network Neuroscience, Amsterdam, The Netherlands., Nouveau C; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France., Desroches M; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France., Campillo F; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France. fabien.campillo@inria.fr., Mantegazza M; Université Côte d'Azur, Valbonne-Sophia Antipolis, France.; CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France.; Inserm U1323, Valbonne-Sophia Antipolis, France.

Πηγή: Journal of computational neuroscience [J Comput Neurosci] 2026 Sep; Vol. 54 (3), pp. 559-576. Date of Electronic Publication: 2026 Jul 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer US Country of Publication: United States NLM ID: 9439510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6873 (Electronic) Linking ISSN: 09295313 NLM ISO Abbreviation: J Comput Neurosci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Astrocytes*/physiology , Neurons*/physiology , Models, Neurological* , Cerebral Cortex*, Potassium/metabolism ; Membrane Potentials/physiology ; Migraine Disorders/physiopathology ; Humans ; Animals ; Nonlinear Dynamics

Bridging the Gap: Translating Microemboli-Induced Spreading Depolarization Into Clinical Practice.

Συγγραφείς: Brammer Kreiberg MP; Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Denmark., Hamann S; Department of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Denmark.; Department of Clinical Medicine, University of Copenhagen, Denmark.; Rothschild Foundation Hospital, Paris, France., Rosenbaum S; Department of Neurology, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Denmark., Rossing K; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Denmark., Gall MA; Medical & Translational Science, Diabetes, Cardiovascular, Liver & Rare Disease, Novo Nordisk A/S, Soeborg, Denmark; and., Ayata C; Neurovascular Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown., Hougaard A; Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Denmark.; Department of Clinical Medicine, University of Copenhagen, Denmark.

Πηγή: Neurology [Neurology] 2026 Oct 13; Vol. 107 (7), pp. e218484. Date of Electronic Publication: 2026 Aug 28.

Τύπος έκδοσης: Case Reports; Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intracranial Embolism*/complications , Intracranial Embolism*/physiopathology , Intracranial Embolism*/diagnostic imaging , Cortical Spreading Depression*/physiology , Migraine with Aura*/etiology , Migraine with Aura*/physiopathology , Migraine with Aura*/diagnostic imaging, Humans ; Female ; Aged ; Ultrasonography, Doppler, Transcranial

Computer models predict differential dendritic vulnerability with ischemia and spreading depression.

Συγγραφείς: Newton AJH; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, United States of America.; Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, New York, United States of America., Lytton WW; Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, New York, United States of America.; Department of Neurology, Kings County Hospital Center, Brooklyn, New York, United States of America., DiStasio M; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America.; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, United States of America.; Wu Tsai Institute, Yale University, New Haven, Connecticut, United States of America., McDougal RA; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, United States of America.; Wu Tsai Institute, Yale University, New Haven, Connecticut, United States of America.; Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut, United States of America.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America.; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, United States of America.

Πηγή: PLoS computational biology [PLoS Comput Biol] 2026 Sep 08; Vol. 22 (9), pp. e1014701. Date of Electronic Publication: 2026 Sep 08 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural

Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Dendrites*/physiology , Dendrites*/metabolism , Cortical Spreading Depression*/physiology , Brain Ischemia*/physiopathology , Brain Ischemia*/metabolism , Models, Neurological*, Pyramidal Cells/physiology ; Calcium/metabolism ; Potassium/metabolism ; CA1 Region, Hippocampal/physiopathology ; Animals ; Computer Simulation ; Computational Biology ; Humans

Behavioral Deficits and Cortical Network Dysfunction Following Repeated Mild Traumatic Brain Injuries.

Συγγραφείς: Pinkowski NJ; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Hess BR; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Pacheco JM; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.; Department of Neurology, Thomas Jefferson, Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA., Hatcher DS; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., McDonald M; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Swindle AN; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Laboy Ramirez R; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Situ M; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Abdeljawad T; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Mehos CJ; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Mayer AR; Mind Research Network/Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico, USA.; Department of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA., McKenzie S; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Morton RA; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.; Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.

Πηγή: Journal of neurotrauma [J Neurotrauma] 2026 Sep; Vol. 43 (17-18), pp. 1506-1519. Date of Electronic Publication: 2026 Mar 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Brain Concussion*/physiopathology , Brain Concussion*/complications , Brain Concussion*/psychology , Nerve Net*/physiopathology , Cerebral Cortex*/physiopathology , Cortical Spreading Depression*/physiology , Behavior, Animal*/physiology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Optogenetics

Dual role of spreading depolarization in an epileptic focus.

Συγγραφείς: Vinokurova D; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia., Tukhvatullina K; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia., Khazipov R; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.; Aix-Marseille University, L'Institut de Neurobiologie de la Méditerranée (INMED), Institut national de la santé et de la recherche médicale (Inserm), Marseille, France., Nasretdinov A; Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.

Πηγή: Epilepsia [Epilepsia] 2026 Jul; Vol. 67 (7), pp. 3815-3828. Date of Electronic Publication: 2026 Apr 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Epilepsy*/physiopathology , Parietal Lobe*/physiopathology , Parietal Lobe*/drug effects, Seizures/physiopathology ; Potassium Channel Blockers/pharmacology ; Animals ; Electrocorticography ; Rats ; Male ; Rats, Sprague-Dawley ; 4-Aminopyridine

Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit.

Συγγραφείς: Balança B; Lyon Neuroscience Research Centre, CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron, France; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France. Electronic address: baptiste.balanca@chu-lyon.fr., Ghibaudo V; Lyon Neuroscience Research Centre, CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron, France., Bado J; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Berthiller J; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Ritzenthaler T; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Gobert F; Lyon Neuroscience Research Centre, CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron, France; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Bapteste L; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Carrillon R; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Bodonian C; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Contard F; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Percevault G; Lyon Neuroscience Research Centre, CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron, France., Marinesco S; Lyon Neuroscience Research Centre, CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron, France., Dreier JP; Centre for stroke research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitépl. 1, 10117 Berlin, Germany; Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitépl. 1, 10117 Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitépl. 1, 10117 Berlin, Germany; Bernstein Center for Computational Neuroscience Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Einstein Centre for Neurosciences Berlin, Charitépl. 1, 10117 Berlin, Germany., Woitzik J; Universitätsklinik für Neurochirurgie, Oldenburg, Steinweg 13 - 17, 26122 Oldenburg, Germany., Haegelen C; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Rheims S; Lyon Neuroscience Research Centre, CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron, France; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Dumot C; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Dailler F; Hospices Civils de Lyon, Hôpital Pierre Wertheimer, 59 Bd Pinel, 69500 Bron, France., Berhouma M; University Hospital of Dijon Burgundy, 2 Bd Maréchal de Lattre de Tassigny, 21000 Dijon, France; ICMUB - CNRS 6302 - University of Burgundy Europe, Dijon, France.

Πηγή: Anaesthesia, critical care & pain medicine [Anaesth Crit Care Pain Med] 2026 Jul; Vol. 45 (4), pp. 101669. Date of Electronic Publication: 2025 Nov 13.

Τύπος έκδοσης: Journal Article; Observational Study

Στοιχεία περιοδικού: Publisher: Published by Elsevier Masson SAS on behalf of the Société française d'anesthésie et de réanimation (Sfar) Country of Publication: France NLM ID: 101652401 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-5568 (Electronic) Linking ISSN: 23525568 NLM ISO Abbreviation: Anaesth Crit Care Pain Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Electrocorticography*/methods , Electrocorticography*/adverse effects , Cortical Spreading Depression*/physiology , Subarachnoid Hemorrhage*/physiopathology , Brain Injuries*/physiopathology , Brain Injuries, Traumatic*/physiopathology, Monitoring, Physiologic/methods ; Critical Care/methods ; Humans ; Prospective Studies ; Female ; Feasibility Studies ; Male ; Intensive Care Units ; Middle Aged ; Adult ; Aged

Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.

Συγγραφείς: Pensato U; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.; Department of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Ospel JM; Department of Radiology, University of Calgary, Calgary, AB, Canada., Lemale CL; Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Experimental Neurology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Hartings JA; Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Romoli M; Department of Neurosciences, Bufalini Hospital, Cesena, Italy., Sacco S; Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy., Dreier JP; Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Experimental Neurology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Neurology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Berlin, Germany.

Πηγή: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2026 Jul; Vol. 46 (7), pp. 1759-1781. Date of Electronic Publication: 2026 Mar 21.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Brain Ischemia*/physiopathology , Brain Ischemia*/pathology , Cell Death*/physiology , Cortical Spreading Depression*/physiology , Neuroprotection*/physiology, Neurons/pathology ; Humans ; Animals

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.

Συγγραφείς: Liu J; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA., Gluckman BJ; Neural Engineering Center, Pennsylvania State University, University Park, Pennsylvania, USA.; Engineering Science and Mechanics Department, Pennsylvania State University, University Park, Pennsylvania, USA.; Neurosurgery Department, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.; Biomedical Engineering Department, Pennsylvania State University, University Park, Pennsylvania, USA.

Πηγή: Epilepsia [Epilepsia] 2026 Jun; Vol. 67 (6), pp. 3171-3184. Date of Electronic Publication: 2026 Mar 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Seizures*/physiopathology , Seizures*/metabolism , Hippocampus*/metabolism , Hippocampus*/physiopathology , Cortical Spreading Depression*/physiology , Oxygen*/metabolism , Brain*/physiopathology , Brain*/metabolism, Extracellular Space/metabolism ; Animals ; Male ; Female ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal

Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model.

Συγγραφείς: Bennett MC; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: michael.bennett@umontreal.ca., Morton RA; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: ramorton@salud.unm.edu., Carlson AP; Department of Neurosurgery, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: EQB2TS@uvahealth.org., Shuttleworth CW; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: bshuttleworth@salud.unm.edu.

Πηγή: Experimental neurology [Exp Neurol] 2026 May; Vol. 399, pp. 115671. Date of Electronic Publication: 2026 Jan 27.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Stroke*/physiopathology , Stroke*/pathology , Infarction, Middle Cerebral Artery*/physiopathology , Infarction, Middle Cerebral Artery*/pathology, Potassium Chloride/toxicity ; Animals ; Male ; Mice ; Disease Models, Animal ; Mice, Inbred C57BL ; Optogenetics

Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques.

Συγγραφείς: Díaz-Pérez A; Department of Pharmacology, Therapeutics, and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.; Institute of Neurosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain., de Eulate NA; Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), Campus UAB, Bellaterra, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Masvidal-Codina E; Institute of Neurosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Spain., Illa X; Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), Campus UAB, Bellaterra, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Navarro X; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.; Institute of Neurosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Red Española de Terapias Avanzadas (RED-TERAV), Instituto de Salud Carlos III, Madrid, Spain., Guimerà-Brunet A; Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), Campus UAB, Bellaterra, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Jiménez-Altayó F; Department of Pharmacology, Therapeutics, and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Francesc.jimenez@uab.cat.; Institute of Neurosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Francesc.jimenez@uab.cat.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Francesc.jimenez@uab.cat., Penas C; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Clara.Penas@uab.cat.; Institute of Neurosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Clara.Penas@uab.cat.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Clara.Penas@uab.cat.; Red Española de Terapias Avanzadas (RED-TERAV), Instituto de Salud Carlos III, Madrid, Spain. Clara.Penas@uab.cat.; Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain. Clara.Penas@uab.cat.

Πηγή: GeroScience [Geroscience] 2026 Apr; Vol. 48 (2), pp. 2123-2151. Date of Electronic Publication: 2025 Nov 26.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Stroke*/physiopathology, Cerebrovascular Circulation/physiology ; Humans ; Neuroprotection

Spreading depolarization and its influence on epileptiform activity.

Συγγραφείς: Lévesque M; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Quebec, Canada., Köhling R; Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany., Avoli M; Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Quebec, Canada.; Department of Physiology, McGill University, Quebec, Canada.

Πηγή: Epilepsia [Epilepsia] 2026 Mar; Vol. 67 (3), pp. 1078-1089. Date of Electronic Publication: 2025 Nov 08.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Epilepsy*/physiopathology , Cortical Spreading Depression*/physiology , Cortical Spreading Depression*/drug effects, Neurons/physiology ; Humans ; Animals

Intranasal hybrid nanoparticles encapsulating rizatriptan enhance antimigraine efficacy in an optogenetic spreading depression model.

Συγγραφείς: Kaya MZ; Neurovascular Research Unit, Massachusetts General Hospital, Boston, MA, USA; Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey., Gultekin Y; Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey., Celebier M; Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey., Soyseven M; Anadolu University, Yunus Emre SHMYO, Department of Analytical Chemistry, Eskisehir, Turkey., Vural I; Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey., Oner L; Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey., Ayata C; Neurovascular Research Unit, Massachusetts General Hospital, Boston, MA, USA., Pehlivan SB; Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. Electronic address: sbozdag@hacettepe.edu.tr., Harriott AM; Neurovascular Research Unit, Massachusetts General Hospital, Boston, MA, USA.

Πηγή: International journal of pharmaceutics [Int J Pharm] 2026 Apr 10; Vol. 694, pp. 126743. Date of Electronic Publication: 2026 Mar 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Tryptamines*/administration & dosage , Tryptamines*/pharmacokinetics , Tryptamines*/chemistry , Tryptamines*/pharmacology , Cortical Spreading Depression*/drug effects , Migraine Disorders*/drug therapy , Migraine Disorders*/physiopathology, Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Calcitonin Gene-Related Peptide/administration & dosage ; Calcitonin Gene-Related Peptide/chemistry ; Hyperalgesia/drug therapy ; Brain/metabolism ; Brain/drug effects ; Animals ; Administration, Intranasal ; Male ; Mice ; Drug Liberation ; Disease Models, Animal ; Mice, Inbred C57BL ; Delayed-Action Preparations ; Triazoles

Action Potential Dynamics During Spreading Depolarization.

Συγγραφείς: Vinokurova D; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Mingazov B; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Burkhanova-Zakirova G; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia., Khazipov R; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.; Institut de Neurobiologie de la Méditerranée (INMED), L'Institut National de la Santé et de la Recherche Médicale (INSERM), Aix-Marseille University, 13273 Marseille, France., Nasretdinov A; Laboratory of Neurobiology, Kazan Federal University, 420008 Kazan, Russia.

Πηγή: Cells [Cells] 2026 Mar 28; Vol. 15 (7). Date of Electronic Publication: 2026 Mar 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Action Potentials*/physiology , Cortical Spreading Depression*/physiology, Neurons/physiology ; Somatosensory Cortex/physiology ; Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Patch-Clamp Techniques

Sex-dependent cognitive and behavioral outcomes induced by repetitive cortical spreading depression in mice.

Συγγραφείς: An Y; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.; Medical School of Chinese PLA, Beijing, 100853, China., Wang Y; Beijing Institute of Basic Medical Sciences, Beijing, 100850, China., Yuan H; Xinqiao Hospital and the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China., Pi C; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China., Yuan C; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China., Na W; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.; School of Medicine, Nankai University, Tianjin, 300071, China., He Z; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.; Medical School of Chinese PLA, Beijing, 100853, China., Lin X; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.; Medical School of Chinese PLA, Beijing, 100853, China., Ma Z; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.; Medical School of Chinese PLA, Beijing, 100853, China., Yu S; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. yusy1963@126.com., Li Y; Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. leeyj_317@163.com.

Πηγή: The journal of headache and pain [J Headache Pain] 2026 Mar 20; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Cognition*/physiology , Migraine with Aura*/physiopathology , Migraine with Aura*/psychology , Behavior, Animal*/physiology , Sex Characteristics*, Anxiety/physiopathology ; Hyperalgesia/physiopathology ; Hippocampus/physiopathology ; Neurogenesis/physiology ; Photophobia/physiopathology ; Animals ; Female ; Male ; Mice ; Disease Models, Animal ; Mice, Inbred C57BL

The metabolic consequences of evoked spreading depolarization in brain slices.

Συγγραφείς: Grech O; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Mugo C; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Hill LJ; Biomedical Sciences, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Heaselgrave SR; Center of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390- 9077, USA., Alimajstorovic Z; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Yiangou A; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, B15 2WB, UK., Lyons HS; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Mitchell J; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK., Lavery GG; Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Clifton Campus, Nottingham, NG11 8NS, UK., Fulton D; Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.; Birmingham Centre for Neurogenetics, University of Birmingham, Birmingham, B15 2TT, UK., Sinclair AJ; Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK. a.b.sinclair@bham.ac.uk.

Πηγή: Scientific reports [Sci Rep] 2026 Feb 11; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Brain*/metabolism, Glucose/metabolism ; Glucose/deficiency ; Mitochondria/metabolism ; Ubiquinone/analogs & derivatives ; Ubiquinone/pharmacology ; Ubiquinone/metabolism ; Neurons/metabolism ; Carbon/metabolism ; Animals ; Glycolysis ; Male ; Calcium Signaling ; Energy Metabolism