Mast cells regulate the brain-dura interface and CSF dynamics.

Authors: Mamuladze T; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Immunology Graduate Program, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: t.mamuladze@wustl.edu., Zaninelli TH; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Smyth LCD; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Wu Y; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St Louis, MO 63130, USA., Abramishvili D; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Silva R; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Imbiakha B; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Verhaege D; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Du S; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Immunology Graduate Program, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Papadopoulos Z; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Gu X; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Lee D; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Storck S; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Perrin RJ; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurologic Disorders, Washington University in St. Louis, St. Louis, MO, USA., Smirnov I; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Dong X; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Hu S; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St Louis, MO 63130, USA., Diamond MS; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Pinho-Ribeiro FA; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA., Kipnis J; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; Immunology Graduate Program, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: kipnis@wustl.edu.

Source: Cell [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5487-5498.e16. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

MeSH Terms: Mast Cells*/immunology , Mast Cells*/metabolism , Brain*/immunology , Brain*/metabolism , Cerebrospinal Fluid*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Meninges/immunology ; Histamine/metabolism ; Neutrophils/immunology ; Meningitis, Bacterial/immunology ; Meningitis, Bacterial/cerebrospinal fluid ; Meningitis, Bacterial/microbiology ; Female ; Male ; Cell Degranulation

Redefining CNS immune privilege.

Authors: Smyth LCD; Brain Immunology and Glia Center, Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Kipnis J; Brain Immunology and Glia Center, Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. kipnis@wustl.edu.

Source: Nature reviews. Immunology [Nat Rev Immunol] 2025 Oct; Vol. 25 (10), pp. 766-775. Date of Electronic Publication: 2025 May 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1741 (Electronic) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol Subsets: MEDLINE

MeSH Terms: Central Nervous System*/immunology , Immune Privilege*/immunology, Humans ; Animals ; Neuroimmunomodulation/immunology ; Meninges/immunology

Amyloidosis of bridging veins is a pathologic feature of Alzheimer's disease.

Authors: Smyth LCD; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA.; Department of Physiology, Monash University, Clayton, Victoria, Australia.; Biomedicine Discovery Institute, Monash University , Clayton, Victoria, Australia., Verhaege D; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Standen-Bloom E; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Wu Y; Department of Biomedical Engineering, Danforth Campus, Washington University in St Louis, St. Louis, MO, USA., Gan Y; Department of Mechanical Engineering, University of Rochester, Rochester, NY, USA., Storck SE; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Boskovic P; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Plog BA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Mamuladze T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Mazzitelli JA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA., Wang Z; Department of Biomedical Engineering, Danforth Campus, Washington University in St Louis, St. Louis, MO, USA., Lee DD; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Randolph GJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Drieu A; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266 , Paris, France., Schwetye KE; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Hu S; Department of Biomedical Engineering, Danforth Campus, Washington University in St Louis, St. Louis, MO, USA., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kelley DH; Department of Mechanical Engineering, University of Rochester, Rochester, NY, USA., Mehta RI; Rush Alzheimer's Disease Center, Rush University Medical Center , Chicago, IL, USA.; Department of Pathology, Rush University Medical Center, Chicago, IL, USA., Kipnis J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine , St. Louis, MO, USA.

Source: The Journal of experimental medicine [J Exp Med] 2026 Feb 02; Vol. 223 (2). Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article

Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/pathology , Alzheimer Disease*/cerebrospinal fluid , Amyloidosis*/pathology , Amyloidosis*/cerebrospinal fluid , Cerebral Veins*/pathology, Humans ; Animals ; Mice ; Mice, Transgenic ; Male ; Female ; Aged ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal ; Aged, 80 and over

Correction: ADAPT-3D:accelerated deep adaptable processing of tissue for 3-dimensional fluorescence tissue imaging for research and clinical settings.

Authors: Lee DD; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. ldaniel@wustl.edu.; Department of Pathology and Immunology, 425 S. Euclid Avenue, Campus Box 8118-86-10, Saint Louis, MO, 63105, USA. ldaniel@wustl.edu., Telfer KA; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Davis DL; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Smyth LCD; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Ravindran R; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Czepielewski RS; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Huckstep CG; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Du S; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Kurashima K; Department of Pediatrics, Saint Louis University, Saint Louis, MO, USA., Jain AK; Department of Pediatrics, Saint Louis University, Saint Louis, MO, USA., Kipnis J; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Zinselmeyer BH; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. bzinselmeyer@wustl.edu.; Department of Pathology and Immunology, 425 S. Euclid Avenue, Campus Box 8118-86-10, Saint Louis, MO, 63105, USA. bzinselmeyer@wustl.edu., Randolph GJ; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. gjrandolph@wustl.edu.; Department of Pathology and Immunology, 425 S. Euclid Avenue, Campus Box 8118-86-10, Saint Louis, MO, 63105, USA. gjrandolph@wustl.edu.

Source: Scientific reports [Sci Rep] 2025 Sep 22; Vol. 15 (1), pp. 32625. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Published Erratum

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: In Process; MEDLINE

Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain.

Authors: Smyth LCD; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, Missouri 63110, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110, USA., Beschorner N; Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark., Nedergaard M; Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark maiken.nedergaard@sund.ku.dk kipnis@wustl.edu.; Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, Missouri 63110, USA maiken.nedergaard@sund.ku.dk kipnis@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

Source: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2025 Sep 02; Vol. 17 (9). Date of Electronic Publication: 2025 Sep 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101513680 Publication Model: Electronic Cited Medium: Internet ISSN: 1943-0264 (Electronic) Linking ISSN: 19430264 NLM ISO Abbreviation: Cold Spring Harb Perspect Biol Subsets: MEDLINE

MeSH Terms: Glymphatic System*/physiology , Brain*/physiology , Brain*/metabolism , Lymphatic System*/physiology , Cerebrospinal Fluid*, Humans ; Animals ; Meninges

The night shift: norepinephrine drives glymphatics.

Authors: Plog BA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. bplog@wustl.edu.; Department of Neurosurgery, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. bplog@wustl.edu., Smyth LCD; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. kipnis@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. kipnis@wustl.edu.

Source: Cell research [Cell Res] 2025 Sep; Vol. 35 (9), pp. 621-622.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: In Process; MEDLINE

ADAPT-3D:accelerated deep adaptable processing of tissue for 3-dimensional fluorescence tissue imaging for research and clinical settings.

Authors: Lee DD; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. ldaniel@wustl.edu.; Department of Pathology and Immunology, 425 S. Euclid Avenue, Campus Box 8118-86-10, Saint Louis, MO, 63105, USA. ldaniel@wustl.edu., Telfer KA; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Davis DL; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Smyth LCD; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Ravindran R; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Czepielewski RS; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Huckstep CG; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Du S; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Kurashima K; Department of Pediatrics, Saint Louis University, Saint Louis, MO, USA., Jain AK; Department of Pediatrics, Saint Louis University, Saint Louis, MO, USA., Kipnis J; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA., Zinselmeyer BH; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. bzinselmeyer@wustl.edu.; Department of Pathology and Immunology, 425 S. Euclid Avenue, Campus Box 8118-86-10, Saint Louis, MO, 63105, USA. bzinselmeyer@wustl.edu., Randolph GJ; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. gjrandolph@wustl.edu.; Department of Pathology and Immunology, 425 S. Euclid Avenue, Campus Box 8118-86-10, Saint Louis, MO, 63105, USA. gjrandolph@wustl.edu.

Source: Scientific reports [Sci Rep] 2025 Aug 29; Vol. 15 (1), pp. 31841. Date of Electronic Publication: 2025 Aug 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Imaging, Three-Dimensional*/methods , Brain*/diagnostic imaging , Optical Imaging*/methods, Animals ; Mice ; Humans ; Microscopy, Fluorescence/methods

Age-related meningeal extracellular matrix remodeling compromises CNS lymphatic function.

Authors: Hitpass Romero K; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Stevenson TJ; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Smyth LCD; Brain Immunology and Glia Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Watkin B; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., McCullough SJC; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Vinnell L; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Smith AM; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Schweder P; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.; Auckland City Hospital, Auckland, 1023, New Zealand., Correia JA; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.; Auckland City Hospital, Auckland, 1023, New Zealand., Kipnis J; Brain Immunology and Glia Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Dragunow M; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand., Rustenhoven J; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand. justin.rustenhoven@auckland.ac.nz.; Centre for Brain Research, The University of Auckland, Auckland, New Zealand. justin.rustenhoven@auckland.ac.nz.

Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Apr 17; Vol. 22 (1), pp. 109. Date of Electronic Publication: 2025 Apr 17.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE

MeSH Terms: Extracellular Matrix*/metabolism , Extracellular Matrix*/pathology , Meninges*/metabolism , Meninges*/pathology , Aging*/pathology , Aging*/metabolism, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Male ; Female ; Fibroblasts/metabolism ; Lymphatic Vessels ; Cells, Cultured

ADAPT-3D: Accelerated Deep Adaptable Processing of Tissue for 3-Dimensional Fluorescence Tissue Imaging for Research and Clinical Settings.

Authors: Lee DD; Washington University School of Medicine., Davis DL; Washington University School of Medicine., Smyth LCD; Washington University School of Medicine., Telfer KA; Washington University School of Medicine., Ravindran R; Washington University School of Medicine., Czepielewski RS; Washington University School of Medicine., Huckstep CG; Washington University School of Medicine., Du S; Washington University School of Medicine., Kurashima K; Saint Louis University., Jain AK; Saint Louis University., Kipnis J; Washington University School of Medicine., Zinselmeyer BH; Washington University School of Medicine., Randolph GJ; Washington University School of Medicine.

Source: Research square [Res Sq] 2025 Mar 24. Date of Electronic Publication: 2025 Mar 24.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

Rest and rinse: sleeping rhythms drive brain detox.

Authors: Smyth LCD; Brain Immunology and Glia (BIG) Center, Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA. Electronic address: l.c.smyth@wustl.edu., Plog BA; Brain Immunology and Glia (BIG) Center, Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA. Electronic address: kipnis@wustl.edu.

Source: Trends in immunology [Trends Immunol] 2025 Mar; Vol. 46 (3), pp. 189-191. Date of Electronic Publication: 2025 Feb 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4981 (Electronic) Linking ISSN: 14714906 NLM ISO Abbreviation: Trends Immunol Subsets: MEDLINE

MeSH Terms: Sleep*/physiology , Brain*/physiology , Brain*/metabolism, Animals ; Humans ; Norepinephrine/metabolism ; Mice

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis.

Authors: Papadopoulos Z; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis , St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Neuroscience Graduate Program, School of Medicine, Washington University in St. Louis , St. Louis, MO, USA., Smyth LCD; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis , St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Smirnov I; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis , St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Gibson DA; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis , St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Herz J; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis , St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis , St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Neuroscience Graduate Program, School of Medicine, Washington University in St. Louis , St. Louis, MO, USA.

Source: The Journal of experimental medicine [J Exp Med] 2025 Feb 03; Vol. 222 (2). Date of Electronic Publication: 2025 Jan 08.

Publication Type: Journal Article

Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

MeSH Terms: Homeostasis* , Cerebrospinal Fluid*/metabolism , Cerebrospinal Fluid*/physiology , Lymph Nodes*, Animals ; Male ; Intracranial Pressure/physiology ; Mice ; Lymphatic Vessels/physiology ; Central Nervous System/metabolism ; Central Nervous System/physiology ; Lymphatic System/physiology ; Mice, Inbred C57BL

Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability.

Authors: Featherston T; Mātai Hāora - Centre for Redox Biology and Medicine, Department of Pathology and Biomedical Science, University of Otago Christchurch, Ōtautahi Christchurch, Aotearoa New Zealand., Helem S; Mātai Hāora - Centre for Redox Biology and Medicine, Department of Pathology and Biomedical Science, University of Otago Christchurch, Ōtautahi Christchurch, Aotearoa New Zealand., Smyth LCD; Mātai Hāora - Centre for Redox Biology and Medicine, Department of Pathology and Biomedical Science, University of Otago Christchurch, Ōtautahi Christchurch, Aotearoa New Zealand., Hampton MB; Mātai Hāora - Centre for Redox Biology and Medicine, Department of Pathology and Biomedical Science, University of Otago Christchurch, Ōtautahi Christchurch, Aotearoa New Zealand., Paumann-Page M; Mātai Hāora - Centre for Redox Biology and Medicine, Department of Pathology and Biomedical Science, University of Otago Christchurch, Ōtautahi Christchurch, Aotearoa New Zealand.

Source: Toxicology mechanisms and methods [Toxicol Mech Methods] 2024 Oct; Vol. 34 (8), pp. 886-896. Date of Electronic Publication: 2024 Jun 18.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE

MeSH Terms: Cell Proliferation*/drug effects , Cell Survival*/drug effects , Microscopy, Fluorescence*, Humans ; Flow Cytometry ; Fluorescent Dyes/chemistry ; Cell Line, Tumor ; Tetrazolium Salts/chemistry

DALT: the brain's border patrol.

Authors: Park JH; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Alexander JF; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Smyth LCD; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University in St. Louis, St. Louis, MO, USA. kipnis@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. kipnis@wustl.edu.

Source: Cell research [Cell Res] 2024 Sep; Vol. 34 (9), pp. 603-604.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: PubMed not MEDLINE; MEDLINE

An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination.

Authors: Barclay KM; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Abduljawad N; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Cheng Z; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA., Kim MW; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Immunology Graduate Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA., Zhou L; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Yang J; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Rustenhoven J; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Mazzitelli JA; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA., Smyth LCD; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Kapadia D; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Brioschi S; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Beatty W; Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, School of Medicine, St. Louis, MO 63110, USA., Hou J; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Saligrama N; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine in St. Louis, St. Louis, MO 63112, USA., Colonna M; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Yu G; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA., Kipnis J; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA., Li Q; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Brain Immunology and Glia (BIG) Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine in St. Louis, School of Medicine, St. Louis, MO 63110, USA. Electronic address: qingyunli@wustl.edu.

Source: Immunity [Immunity] 2024 Jun 11; Vol. 57 (6), pp. 1394-1412.e8. Date of Electronic Publication: 2024 May 30.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

MeSH Terms: Microglia*/physiology , Remyelination* , Cell Plasticity*/genetics, Animals ; Mice ; Demyelinating Diseases/genetics ; Mice, Inbred C57BL ; Mice, Transgenic ; Disease Models, Animal ; Brain ; Myelin Sheath/metabolism ; White Matter/pathology

Identification of direct connections between the dura and the brain.

Authors: Smyth LCD; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. l.c.smyth@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA. l.c.smyth@wustl.edu., Xu D; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Okar SV; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Dykstra T; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Rustenhoven J; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Papadopoulos Z; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Neuroscience Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Bhasiin K; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Kim MW; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Drieu A; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Mamuladze T; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Blackburn S; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Gu X; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Gaitán MI; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Nair G; Quantitative MRI Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Storck SE; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Du S; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA., White MA; Department of Genetics, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA., Bayguinov P; Washington University Center for Cellular Imaging, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA., Smirnov I; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Dikranian K; Department of Neuroscience, Washington University School of Medicine, Washington University in St Louis, St Louis, MO, USA., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Neuroscience Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Immunology Graduate Program, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.

Source: Nature [Nature] 2024 Mar; Vol. 627 (8002), pp. 165-173. Date of Electronic Publication: 2024 Feb 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

MeSH Terms: Arachnoid*/anatomy & histology , Arachnoid*/blood supply , Arachnoid*/immunology , Arachnoid*/metabolism , Brain*/anatomy & histology , Brain*/blood supply , Brain*/immunology , Brain*/metabolism , Dura Mater*/anatomy & histology , Dura Mater*/blood supply , Dura Mater*/immunology , Dura Mater*/metabolism, Animals ; Humans ; Mice ; Biological Transport ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Gene Expression Profiling ; Magnetic Resonance Imaging ; Mice, Transgenic ; Subarachnoid Space/anatomy & histology ; Subarachnoid Space/blood supply ; Subarachnoid Space/immunology ; Subarachnoid Space/metabolism ; Cerebrospinal Fluid/metabolism ; Veins/metabolism

Skull bone marrow channels as immune gateways to the central nervous system.

Authors: Mazzitelli JA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA.; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO, USA., Pulous FE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Smyth LCD; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA., Kaya Z; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Rustenhoven J; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand., Moskowitz MA; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kipnis J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany. mnahrendorf@mgh.harvard.edu.

Source: Nature neuroscience [Nat Neurosci] 2023 Dec; Vol. 26 (12), pp. 2052-2062. Date of Electronic Publication: 2023 Nov 23.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

MeSH Terms: Bone Marrow* , Central Nervous System*, Meninges ; Skull ; Head

The amyotrophic lateral sclerosis-linked protein TDP-43 regulates interleukin-6 cytokine production by human brain pericytes.

Authors: Scotter EL; Centre for Brain Research, University of Auckland, New Zealand; School of Biological Sciences, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: emma.scotter@auckland.ac.nz., Cao MC; Centre for Brain Research, University of Auckland, New Zealand; School of Biological Sciences, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: m.cao@auckland.ac.nz., Jansson D; Centre for Brain Research, University of Auckland, New Zealand; School of Biological Sciences, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: d.macveigh@auckland.ac.nz., Rustenhoven J; Centre for Brain Research, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: justin.rustenhoven@auckland.ac.nz., Smyth LCD; Centre for Brain Research, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: l.c.smyth@wustl.edu., Aalderink MC; Centre for Brain Research, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: m.aalderink@auckland.ac.nz., Siemens A; Centre for Brain Research, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: siemensa894@ohsu.edu., Fan V; Bioinformatics Institute, University of Auckland, Auckland, New Zealand. Electronic address: v.fan@auckland.ac.nz., Wu J; Centre for Brain Research, University of Auckland, New Zealand; Department of Anatomy and Medical Imaging, University of Auckland, New Zealand. Electronic address: jane.wu@auckland.ac.nz., Mee EW; Department of Neurosurgery, Auckland City Hospital, Auckland, New Zealand. Electronic address: edwardm@adhb.govt.nz., Faull RLM; Centre for Brain Research, University of Auckland, New Zealand; Department of Anatomy and Medical Imaging, University of Auckland, New Zealand. Electronic address: rlm.faull@auckland.ac.nz., Dragunow M; Centre for Brain Research, University of Auckland, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, New Zealand. Electronic address: m.dragunow@auckland.ac.nz.

Source: Molecular and cellular neurosciences [Mol Cell Neurosci] 2022 Dec; Vol. 123, pp. 103768. Date of Electronic Publication: 2022 Aug 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9100095 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9327 (Electronic) Linking ISSN: 10447431 NLM ISO Abbreviation: Mol Cell Neurosci Subsets: MEDLINE

MeSH Terms: Amyotrophic Lateral Sclerosis*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Interleukin-6*/metabolism , Pericytes*/metabolism , Pericytes*/pathology, Humans ; Brain/metabolism ; Cytokines/metabolism ; Gene Expression ; Spinal Cord/metabolism

Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress.

Authors: Stevenson TJ; Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand., Johnson RH; Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand., Savistchenko J; Alternative Energies and Atomic Energy Commission and Laboratory of Neurodegenerative Diseases, Molecular Imaging Research Center, Francois Jacob Institute, National Center for Scientific Research, Fontenay-Aux-Roses, France., Rustenhoven J; Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand., Woolf Z; Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand., Smyth LCD; Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand., Murray HC; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand., Faull RLM; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand., Correia J; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Auckland City Hospital, 2 Park Road, Auckland, 1010, New Zealand., Schweder P; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Auckland City Hospital, 2 Park Road, Auckland, 1010, New Zealand., Heppner P; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Starship Children's Hospital, 2 Park Road, Auckland, 1010, New Zealand., Turner C; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Department of Anatomical Pathology, Lab Plus, Auckland City Hospital, 2 Park Road, Auckland, New Zealand., Melki R; Alternative Energies and Atomic Energy Commission and Laboratory of Neurodegenerative Diseases, Molecular Imaging Research Center, Francois Jacob Institute, National Center for Scientific Research, Fontenay-Aux-Roses, France., Dieriks BV; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand., Curtis MA; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand. m.curtis@auckland.ac.nz.; Department of Anatomy and Medical Imaging, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. m.curtis@auckland.ac.nz., Dragunow M; Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. m.dragunow@auckland.ac.nz.; Centre for Brain Research, University of Auckland, Private Bag 920139, Auckland, 1142, New Zealand. m.dragunow@auckland.ac.nz.

Source: Scientific reports [Sci Rep] 2022 Oct 15; Vol. 12 (1), pp. 17314. Date of Electronic Publication: 2022 Oct 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Parkinson Disease*/metabolism , alpha-Synuclein*/metabolism, Apoptosis ; Cytokines/metabolism ; Humans ; Pericytes/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/metabolism ; Proteome/metabolism ; Reactive Oxygen Species/metabolism ; Ubiquitin/metabolism

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels.

Authors: Mazzitelli JA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA.; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO, USA., Smyth LCD; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA., Cross KA; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Dykstra T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA., Sun J; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA., Du S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.; Immunology Graduate Program, Washington University School of Medicine, St. Louis, MO, USA., Mamuladze T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.; Immunology Graduate Program, Washington University School of Medicine, St. Louis, MO, USA., Smirnov I; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA., Rustenhoven J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. rustenhoven@wustl.edu.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA. rustenhoven@wustl.edu.; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand. rustenhoven@wustl.edu., Kipnis J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Neuroscience Graduate Program, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.; Immunology Graduate Program, Washington University School of Medicine, St. Louis, MO, USA. kipnis@wustl.edu.

Source: Nature neuroscience [Nat Neurosci] 2022 May; Vol. 25 (5), pp. 555-560. Date of Electronic Publication: 2022 Mar 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

MeSH Terms: Bone Marrow*/physiology , Skull*, Cerebrospinal Fluid ; Head ; Meninges ; Myeloid Cells/metabolism

Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.

Authors: Smyth LCD; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand. l.c.smyth@wustl.edu.; Department of Pathology and Biomedical Science, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand. l.c.smyth@wustl.edu.; Department of Pathology and Immunology, Center for Brain Immunology and Glia, Washington University in St. Louis, Campus, Box 8118, St. Louis, MO, USA. l.c.smyth@wustl.edu., Murray HC; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Anatomy With Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Hill M; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand.; Department of Pathology and Biomedical Science, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand., van Leeuwen E; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand.; Department of Pathology and Biomedical Science, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand., Highet B; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Anatomy With Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Magon NJ; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand.; Department of Pathology and Biomedical Science, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand., Osanlouy M; Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand., Mathiesen SN; Department of Psychology, University of Otago, Dunedin, New Zealand.; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Mockett B; Department of Psychology, University of Otago, Dunedin, New Zealand., Singh-Bains MK; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Anatomy With Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Morris VK; School of Biological Science, University of Canterbury, Canterbury, New Zealand., Clarkson AN; Department of Anatomy, University of Otago, Dunedin, New Zealand., Curtis MA; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Anatomy With Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Abraham WC; Department of Psychology, University of Otago, Dunedin, New Zealand., Hughes SM; Department of Biochemistry, University of Otago, Dunedin, New Zealand., Faull RLM; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Anatomy With Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Kettle AJ; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand.; Department of Pathology and Biomedical Science, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand., Dragunow M; Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. m.dragunow@auckland.ac.nz.; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. m.dragunow@auckland.ac.nz., Hampton MB; Centre for Free Radical Research, University of Otago, Christchurch, New Zealand. mark.hampton@otago.ac.nz.; Department of Pathology and Biomedical Science, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand. mark.hampton@otago.ac.nz.

Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Mar 24; Vol. 10 (1), pp. 38. Date of Electronic Publication: 2022 Mar 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/metabolism , Extracellular Traps*/metabolism, Animals ; Brain/metabolism ; Humans ; Mice ; Neutrophils/metabolism ; Peroxidase/metabolism