Small-molecule dissolution of stress granules by redox modulation benefits ALS models

Συγγραφείς: Hiroyuki Uechi, Sindhuja Sridharan, Jik Nijssen, Jessica Bilstein, Juan M. Iglesias-Artola, Satoshi Kishigami, Virginia Casablancas-Antras, Ina Poser, Eduardo J. Martinez, Edgar Boczek, Michael Wagner, Nadine Tomschke, António M. de Jesus Domingues, Arun Pal, Thom Doeleman, Sukhleen Kour, Eric Nathaniel Anderson, Frank Stein, Hyun O. Lee, Xiaojie Zhang, Anatol W. Fritsch, Marcus Jahnel, Julius Fürsch, Anastasia C. Murthy, Simon Alberti, Marc Bickle, Nicolas L. Fawzi, André Nadler, Della C. David, Udai B. Pandey, Andreas Hermann, Florian Stengel, Benjamin G. Davis, Andrew J. Baldwin, Mikhail M. Savitski, Anthony A. Hyman, Richard J. Wheeler

Πηγή: Nat Chem Biol
Nature chemical biology 21(10), 1577-1588 (2025). doi:10.1038/s41589-025-01893-5
Nature chemical biology
Uechi, H, Sridharan, S, Nijssen, J, Bilstein, J, Iglesias-Artola, J M, Kishigami, S, Casablancas-Antras, V, Poser, I, Martinez, E J, Boczek, E, Wagner, M, Tomschke, N, de Jesus Domingues, A M, Pal, A, Doeleman, T, Kour, S, Anderson, E N, Stein, F, Lee, H O, Zhang, X, Fritsch, A W, Jahnel, M, Fürsch, J, Murthy, A C, Alberti, S, Bickle, M, Fawzi, N L, Nadler, A, David, D C, Pandey, U B, Stengel, F, Davis, B G, Baldwin, A J, Savitski, M M, Hyman, A A & Wheeler, R J 2025, 'Small-molecule dissolution of stress granules by redox modulation benefits ALS models', Nature Chemical Biology, vol. 21, no. 10, pp. 1577-1588. https://doi.org/10.1038/s41589-025-01893-5

Θεματικοί όροι: Amyotrophic Lateral Sclerosis: genetics, Small Molecule Libraries: pharmacology, Stress Granules: drug effects, Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis: pathology, Stress Granules: metabolism, Small Molecule Libraries: chemistry, Article, Stress Granules, Small Molecule Libraries, Mice, Disease Models, Animal, Amyotrophic Lateral Sclerosis: drug therapy, Oxidation-Reduction: drug effects, Humans, Animals, Amyotrophic Lateral Sclerosis: metabolism, Oxidation-Reduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40369342
https://pubmed.ncbi.nlm.nih.gov/40369342/
https://doi.org/10.1038/s41589-025-01893-5
https://pmc.ncbi.nlm.nih.gov/articles/PMC12463676/
https://pub.dzne.de/record/281502
https://hdl.handle.net/21.11116/0000-0012-17B6-5

Support Vector Machine Identification of Small Molecule Binders to an Understudied Allosteric Site of SARS‐CoV‐2 Mpro for Next‐Generation PROTAC‐Based Therapeutics

Συγγραφείς: Fassi, Enrico Mario Alessandro, Mekni, Nedra, Albani, Marco, Maehrlein, Sabine, Weldert, Annabelle Carolin, Schirmeister, Tanja, Langer, Thierry, Giovanni Grazioso

Πηγή: Arch Pharm (Weinheim)

Θεματικοί όροι: Support Vector Machine, Full Paper, SARS-CoV-2, 3CL protease, Mpro, PROTAC, covid‐19, drug design, machine learning, Antiviral Agents/pharmacology, Molecular Dynamics Simulation, 301207 Pharmazeutische Chemie, Protease Inhibitors/pharmacology, Antiviral Agents, COVID-19 Drug Treatment, Molecular Docking Simulation, Small Molecule Libraries, Small Molecule Libraries/pharmacology, Coronavirus 3C Proteases/metabolism, Humans, Allosteric Site/drug effects, Protease Inhibitors, SARS-CoV-2/drug effects, Coronavirus 3C Proteases, Allosteric Site, 301207 Pharmaceutical chemistry

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41388974
https://pmc.ncbi.nlm.nih.gov/articles/PMC12701685/
https://doi.org/10.1002/ardp.70169
https://pubmed.ncbi.nlm.nih.gov/41388974/
https://ucrisportal.univie.ac.at/de/publications/3e14d597-c8eb-459c-827c-b852b7c6168c
https://doi.org/10.1002/ardp.70169

Traversing chemical space with active deep learning for low-data drug discovery

Συγγραφείς: Derek van Tilborg, Francesca Grisoni

Πηγή: Nature Computational Science

Θεματικοί όροι: Small Molecule Libraries, Deep Learning, Small Molecule Libraries/pharmacology, Drug Discovery, Humans, Drug Discovery/methods

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39333789
https://research.tue.nl/en/publications/2959fdf3-ccda-465f-af64-ef1c74576b2c
https://doi.org/10.1038/s43588-024-00697-2

Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors

Συγγραφείς: Pellattiero, Anna, Quirin, Charlotte, Magrin, Federico, Sturlese, Mattia, Fracasso, Alberto, Biris, Nikolaos, Herkenne, Stéphanie, Cendron, Laura, Gavathiotis, Evripidis, Moro, Stefano, Mattarei, Andrea, Scorrano, Luca

Πηγή: Sci Adv

Θεματικοί όροι: Pyrazoles/pharmacology, Small Molecule Libraries/chemistry, Pyrazoles/chemistry, Apoptosis, Antineoplastic Agents, OPA1 protein, human, GTP Phosphohydrolases/antagonists & inhibitors, Drug Resistance, Neoplasm/drug effects, Biochimie, biophysique & biologie moléculaire, GTP Phosphohydrolases, Cytochromes c/metabolism, Enzyme Inhibitors/chemistry, Small Molecule Libraries, Structure-Activity Relationship, Cell Line, Tumor, Mitochondria/metabolism, Antineoplastic Agents/chemistry, Small Molecule Libraries/pharmacology, Humans, Enzyme Inhibitors, Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors, Enzyme Inhibitors/pharmacology, Apoptosis/drug effects, Cytochromes c, GTP Phosphohydrolases/chemistry, Life sciences, Mitochondria/drug effects, Mitochondria, Proto-Oncogene Proteins c-bcl-2, Drug Resistance, Neoplasm, Sciences du vivant, Pyrazoles, Proto-Oncogene Proteins c-bcl-2/metabolism, Biomedicine and Life Sciences, GTP Phosphohydrolases/metabolism, Antineoplastic Agents/pharmacology, Biochemistry, biophysics & molecular biology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40614185

SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina

Συγγραφείς: Bugnon, Marine, Röhrig, Ute F, Goullieux, Mathilde, Perez, Marta A S, Daina, Antoine, Michielin, Olivier, Zoete, Vincent

Πηγή: Nucleic Acids Res
Nucleic acids research, vol. 52, no. W1, pp. W324-W332

Θεματικοί όροι: 0301 basic medicine, Molecular Docking Simulation, Ligands, Software, Drug Discovery/methods, User-Computer Interface, Internet, Proteins/chemistry, Proteins/metabolism, Small Molecule Libraries/chemistry, Small Molecule Libraries/pharmacology, Protein Binding, Binding Sites, 0303 health sciences, Proteins, Small Molecule Libraries, 03 medical and health sciences, Web Server Issue, Drug Discovery

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38686803
https://archive-ouverte.unige.ch/unige:189256
https://doi.org/10.1093/nar/gkae300
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A9197F3939908
https://serval.unil.ch/notice/serval:BIB_A9197F393990
https://serval.unil.ch/resource/serval:BIB_A9197F393990.P001/REF.pdf

Small molecule inhibitors of hnRNPA2B1–RNA interactions reveal a predictable sorting of RNA subsets into extracellular vesicles

Συγγραφείς: Corsi, Jessica, Semnani, Pouriya Sharbatian, Peroni, Daniele, Belli, Romina, Morelli, Alessia, Lassandro, Michelangelo, Sidarovich, Viktoryia, Adami, Valentina, Valentini, Chiara, Cavallerio, Paolo, Grosskreutz, Julian, Fabbiano, Fabrizio, Grossmann, Dajana, Hermann, Andreas, Tell, Gianluca, Basso, Manuela, D’Agostino, Vito Giuseppe

Πηγή: Nucleic Acids Res
Nucleic acids research 53(5), gkaf176 (2025). doi:10.1093/nar/gkaf176

Θεματικοί όροι: Proteomics, Proteomics: methods, Extracellular Vesicles: genetics, Extracellular Vesicles: drug effects, Heterogeneous-Nuclear Ribonucleoprotein Group A-B: antagonists & inhibitors, Small Molecule Libraries, Extracellular Vesicles, Heterogeneous-Nuclear Ribonucleoprotein Group A-B: metabolism, RNA: metabolism, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, RNA and RNA-protein complexes, Humans, hnRNP A2, Protein Binding: drug effects, Small Molecule Libraries: pharmacology, RNA-Binding Proteins: metabolism, NF-kappa B, RNA-Binding Proteins, Extracellular Vesicles: metabolism, Heterogeneous-Nuclear Ribonucleoprotein Group A-B: genetics, HEK293 Cells, NF-kappa B: metabolism, RNA, RNA: genetics, Protein Binding

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40103230
https://pub.dzne.de/record/277552

Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges

Συγγραφείς: Renaudin, Xavier, Campalans, Anna

Συνεισφορές: Stabilité génétique, cellules souches et radiations (SGCSR (U_1274 / UMR_E_008)), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Campalans lab has received financial support from the Agence Nationale de la recherche (ANR-OXIREPTRA and ANR-TIROX), La Ligue contre le Cancer, the graduate school Life sciences and Health (GS-LSH) from the Université Paris-Saclay, Electricité de France and the CEA., ANR-23-CE12-0025,OxiREPTRA,Les dommages oxydatifs de l'ADN et OGG1 à l'interface entre réparation de l'ADN et régulation de la transcription(2023), ANR-24-CE12-2431,Tirox,Blessures transcriptionnelles et rétablissement en réponse au stress oxidatif(2024)

Πηγή: ISSN: 1568-7864.

Θεματικοί όροι: Transcriptional regulation, Small molecules, Oxidative DNA damage, OGG1 modulators, Inflammation, Cancer, Base excision repair, MESH: Animals, DNA Damage, DNA Glycosylases* / antagonists & inhibitors, DNA Glycosylases* / metabolism, DNA Repair* / drug effects, Enzyme Inhibitors* / pharmacology, Humans, Neoplasms / drug therapy, Neoplasms / genetics, Oxidative Stress, Small Molecule Libraries* / pharmacology, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/40120404; PUBMED: 40120404

Διαθεσιμότητα: https://u-paris.hal.science/hal-05110034
https://u-paris.hal.science/hal-05110034v1/document
https://u-paris.hal.science/hal-05110034v1/file/1-s2.0-S1568786425000230-main.pdf
https://doi.org/10.1016/j.dnarep.2025.103827

Accelerating CAR-T Cell Therapies with Small-Molecule Inhibitors

Συγγραφείς: Mestermann, Katrin, Garitano-Trojaola, Andoni, Hudecek, Michael

Πηγή: http://lobid.org/resources/99370678147706441#!, 39(1):33-51.

Θεματικοί όροι: T-Lymphocytes/drug effects [MeSH], T-Lymphocytes/immunology [MeSH], Humans [MeSH], Neoplasms/immunology [MeSH], Receptors, Chimeric Antigen/immunology [MeSH], Tumor Microenvironment/drug effects [MeSH], Review Article, Animals [MeSH], Small Molecule Libraries/pharmacology [MeSH], Neoplasms/drug therapy [MeSH], Neoplasms/therapy [MeSH], Small Molecule Libraries/therapeutic use [MeSH], Immunotherapy, Adoptive/methods [MeSH]

Relation: https://repository.publisso.de/resource/frl:6502087; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750903/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6502087
https://doi.org/10.1007/s40259-024-00688-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750903/

Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay

Συγγραφείς: Rezaei Adariani, Soheila, Agne, Daya, Koska, Sandra, Burhop, Annina, Seitz, Carina, Warmers, Jens, Janning, Petra, Metz, Malte, Pahl, Axel, Sievers, Sonja, Waldmann, Herbert, Ziegler, Slava

Πηγή: http://lobid.org/resources/99370676049806441#!, 67(15):13252-13270.

Θεματικοί όροι: Small Molecule Libraries/chemistry [MeSH], Cell Line, Tumor [MeSH], Article, Stress, Physiological/drug effects [MeSH], Mitochondria/metabolism [MeSH], Mitochondria/drug effects [MeSH], Humans [MeSH], Small Molecule Libraries/pharmacology [MeSH]

Relation: https://repository.publisso.de/resource/frl:6486328; https://doi.org/10.1021/acs.jmedchem.4c01183; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320566/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6486328
https://doi.org/10.1021/acs.jmedchem.4c01183
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320566/

Illuminating Dark Chemical Matter Using the Cell Painting Assay

Συγγραφείς: Pahl, Axel, Liu, Jie, PATIL, SOHAN, Rezaei Adariani, Soheila, Schölermann, Beate, Warmers, Jens, Bonowski, Jana, Koska, Sandra, Akbulut, Yasemin, Seitz, Carina, Sievers, Sonja, Ziegler, Slava, Waldmann, Herbert

Πηγή: http://lobid.org/resources/99370676049806441#!, 67(11):8862-8876.

Θεματικοί όροι: Small Molecule Libraries/chemistry [MeSH], Pyrimidines/pharmacology [MeSH], Pyrimidines/chemistry [MeSH], Cell Line, Tumor [MeSH], Article, DNA/chemistry [MeSH], Pyrimidines/chemical synthesis [MeSH], Humans [MeSH], Microtubules/drug effects [MeSH], Small Molecule Libraries/pharmacology [MeSH], Microtubules/metabolism [MeSH]

Relation: https://repository.publisso.de/resource/frl:6485910; https://doi.org/10.1021/acs.jmedchem.4c00160; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181314/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6485910
https://doi.org/10.1021/acs.jmedchem.4c00160
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181314/

A drug discovery platform to identify compounds that inhibit EGFR triple mutants

Συγγραφείς: Punit Saraon, Jamie Snider, Yannis Kalaidzidis, Leanne E. Wybenga-Groot, Konstantin Weiss, Ankit Rai, Nikolina Radulovich, Luka Drecun, Nika Vučković, Adriana Vučetić, Victoria Wong, Brigitte Thériault, Nhu-An Pham, Jin H. Park, Alessandro Datti, Jenny Wang, Shivanthy Pathmanathan, Farzaneh Aboualizadeh, Anna Lyakisheva, Zhong Yao, Yuhui Wang, Babu Joseph, Ahmed Aman, Michael F. Moran, Michael Prakesch, Gennady Poda, Richard Marcellus, David Uehling, Miroslav Samaržija, Marko Jakopović, Ming-Sound Tsao, Frances A. Shepherd, Adrian Sacher, Natasha Leighl, Anna Akhmanova, Rima Al-awar, Marino Zerial, Igor Stagljar

Συνεισφορές: Sub Cell Biology, Cell Biology, Neurobiology and Biophysics

Πηγή: Nature chemical biology

Θεματικοί όροι: Lung Neoplasms, Carcinoma, Non-Small-Cell Lung/drug therapy, Drug Resistance, Drug Resistance, Neoplasm/genetics, Non-Small-Cell Lung/drug therapy, Cell Line, Small Molecule Libraries, Genes, Reporter, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Taverne, ErbB Receptors/antagonists & inhibitors, Small Molecule Libraries/pharmacology, Drug Discovery, High-Throughput Screening Assays/methods, Humans, Luciferases/genetics, Phosphorylation, Lung Neoplasms/drug therapy, Luciferases, Reporter, Protein Kinase Inhibitors, Tumor, Neoplasm/genetics, Carcinoma, Phosphorylation/drug effects, Reproducibility of Results, Staurosporine, High-Throughput Screening Assays, 3. Good health, ErbB Receptors, Genes, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, DNA Nucleotidyltransferases/genetics, DNA Nucleotidyltransferases, Mutation, Staurosporine/analogs & derivatives

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123931
https://pubmed.ncbi.nlm.nih.gov/32094923
https://research-portal.uu.nl/en/publications/8c84db43-d226-43a0-8d45-c8c22e72ac39
https://doi.org/10.1038/s41589-020-0484-2
https://hdl.handle.net/21.11116/0000-0008-A238-2
https://dspace.library.uu.nl/handle/1874/410302

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

Συγγραφείς: Montanari S., Mahmoud A. M., Pruccoli L., Rabbito A., Naldi M., Petralla S., Moraleda I., Bartolini M., Monti B., Iriepa I., Belluti F., Gobbi S., Di Marzo V., Bisi A., Tarozzi A., Ligresti A., Rampa A.

Πηγή: European journal of medicinal chemistry 178 (2019): 243–258. doi:10.1016/j.ejmech.2019.05.080
info:cnr-pdr/source/autori:Montanari, Serena; Mahmoud, Ali Mokhtar; Pruccoli, Letizia; Rabbito, Alessandro; Naldi, Marina; Petralla, Sabrina; Moraleda, Ignacio; Bartolini, Manuela; Monti, Barbara; Iriepa, Isabel; Belluti, Federica; Gobbi, Silvia; Di Marzo, Vincenzo; Bisi, Alessandra; Tarozzi, Andrea; Ligresti, Alessia; Rampa, Angela/titolo:Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment/doi:10.1016%2Fj.ejmech.2019.05.080/rivista:European journal of medicinal chemistry/anno:2019/pagina_da:243/pagina_a:258/intervallo_pagine:243–258/volume:178
European Journal of Medicinal Chemistry

Θεματικοί όροι: Neuroprotective agents - chemical synthesis, 0301 basic medicine, Benzofurans - chemistry, Anti-inflammatory M2 phenotype, Aβ peptide, Benzofuran scaffold, CB receptors, MTDL, Neuroprotection, Acetylcholinesterase, Alzheimer Disease, Amyloid beta-Peptides, Animals, Benzofurans, Butyrylcholinesterase, CHO Cells, Catalytic Domain, Cell Line, Tumor, Cholinesterase Inhibitors, Cricetulus, Drug Design, Humans, Immunologic Factors, Mice, Microglia, Molecular Docking Simulation, Neuroprotective Agents, Peptide Fragments, Protein Binding, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Small Molecule Libraries, Neuroprotective agents - chemistry, Cholinesterase inhibitors - chemistry, Neuroprotective agents - pharmacology, Molecular docking simulation, Small molecule libraries - chemical synthesis, Benzofurans - pharmacology, 0303 health sciences, Small molecule libraries - pharmacology, CHO cells, Neuroprotective agents - metabolism, cannabinoid, 3. Good health, Alzheimer disease - drug therapy, Acetylcholinesterase - metabolism, CB2 - metabolism, CB1 - metabolism, Receptor, tumor, Small molecule libraries - metabolism, Benzofurans - metabolism, Cholinesterase inhibitors - chemical synthesis, 03 medical and health sciences, Protein binding, Butyrylcholinesterase - chemistry, A beta peptide, Small molecule libraries - chemistry, Benzofurans - chemical synthesis, Amyloid beta-peptides - antagonists & inhibitors, Microglia - drug effects, Catalytic domain, Peptide fragments - antagonists & inhibitors, Cholinesterase inhibitors - pharmacology, Cholinesterase inhibitors - metabolism, Cell line

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://cris.unibo.it/bitstream/11585/700770/5/benzo%20AM%20.pdf
https://pubmed.ncbi.nlm.nih.gov/31185414
https://hdl.handle.net/20.500.14243/366587
https://doi.org/10.1016/j.ejmech.2019.05.080

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

Συγγραφείς: Antoine Daina, Olivier Michielin, Vincent Zoete

Πηγή: Nucleic Acids Res
Nucleic acids research.-2019
Nucleic acids research, vol. 47, no. W1, pp. W357-W364

Θεματικοί όροι: Protein Conformation, alpha-Helical, 0301 basic medicine, Internet, 0303 health sciences, Binding Sites, Datasets as Topic, Proteins, Amino Acid Sequence, Animals, Databases, Chemical, Drug Discovery/methods, Humans, Ligands, Mice, Protein Binding, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Proteins/agonists, Proteins/antagonists & inhibitors, Proteins/chemistry, Proteins/metabolism, Rats, Small Molecule Libraries/chemistry, Small Molecule Libraries/pharmacology, Software, 3. Good health, Small Molecule Libraries, 03 medical and health sciences, Web Server Issue, Drug Discovery

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://academic.oup.com/nar/article-pdf/47/W1/W357/28880175/gkz382.pdf
https://pubmed.ncbi.nlm.nih.gov/31106366
https://sonar.ch/global/documents/297720
https://serval.unil.ch/resource/serval:BIB_37625953AF4B.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_37625953AF4B
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_37625953AF4B2

Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)

Συγγραφείς: Shah, Dilip, Das, Pragnya, Acharya, Suchismita, Agarwal, Beamon, Christensen, Dale J., Robertson, Stella M., Bhandari, Vineet

Πηγή: International Journal of Molecular Sciences

Θεματικοί όροι: Avr-25, Avr-48, acute lung injury, lung inflammation, pulmonary edema, sepsis, Acute Lung Injury / drug therapy, Animals, Chitin / pharmacology, Disease Models, Animal, Female, Immunologic Factors / pharmacology, Lipopolysaccharides / pharmacology, Lung / drug effects, Male, Mice, Inbred C57BL, Pneumonia / drug therapy, Pulmonary Edema / drug therapy, Rats, Sprague-Dawley, Respiratory Distress Syndrome / drug therapy, Sepsis / drug therapy, Small Molecule Libraries / pharmacology

Περιγραφή αρχείου: application/pdf

Relation: https://doi.org/10.3390/ijms22052573; Shah, D., Das, P., Acharya, S., Agarwal, B., Christensen, D. J., Robertson, S. M., & Bhandari, V. (2021). Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). International journal of molecular sciences, 22(5), 2573. https://doi.org/10.3390/ijms22052573; https://hdl.handle.net/20.500.12503/31592; 22

Διαθεσιμότητα: https://hdl.handle.net/20.500.12503/31592

Analysis of pharmaceuticals and small molecules in aqueous humor

Συγγραφείς: Karolina Pietrowska, Diana Anna Dmuchowska, Pawel Krasnicki, Zofia Mariak, Adam Kretowski, Michal Ciborowski

Πηγή: Journal of Pharmaceutical and Biomedical Analysis. 159:23-36

Θεματικοί όροι: Small molecule libraries - metabolism, Intraocular pressure - physiology, Biosimilar pharmaceuticals - metabolism, Small molecule libraries - analysis, Antihypertensive agents - metabolism, Aqueous humor - drug effects, 01 natural sciences, Chemistry Techniques, Analytical, analytical - methods, Aqueous Humor, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Anti-bacterial agents - analysis, Biosimilar pharmaceuticals - analysis, Animals, Humans, Biosimilar Pharmaceuticals, Antihypertensive Agents, Intraocular Pressure, Biosimilar pharmaceuticals - pharmacology, Small molecule libraries - pharmacology, Aqueous humor - metabolism, Antihypertensive agents - analysis, Anti-bacterial agents - pharmacology, Anti-Bacterial Agents, 3. Good health, 0104 chemical sciences, Aqueous humor - chemistry, Anti-bacterial agents - metabolism, Antihypertensive agents - pharmacology, Intraocular pressure - drug effects, Chemistry techniques

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/29980016

Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin Inhibitors

Συγγραφείς: Alireza Jorkesh, Sylvia Rothenberger, Laura Baldassar, Birute Grybaite, Povilas Kavaliauskas, Vytautas Mickevicius, Monica Dettin, Filippo Vascon, Laura Cendron, Antonella Pasquato

Συνεισφορές: MDPI AG (Basel, Switzerland)

Πηγή: Int J Mol Sci
International Journal of Molecular Sciences
Volume 25
Issue 10
Pages: 5079
International journal of molecular sciences, vol. 25, no. 10

Θεματικοί όροι: Furin, 0301 basic medicine, 0303 health sciences, SARS-CoV-2, exosite, Drug Evaluation, Preclinical, envelope glycoprotein, COVID-19, in vitro, protease, virus, Antiviral Agents, peptide, Article, 3. Good health, Furin/antagonists & inhibitors, Furin/metabolism, SARS-CoV-2/drug effects, SARS-CoV-2/metabolism, Humans, Small Molecule Libraries/pharmacology, Small Molecule Libraries/chemistry, Antiviral Agents/pharmacology, Antiviral Agents/chemistry, COVID-19/virology, Spike Glycoprotein, Coronavirus/metabolism, Spike Glycoprotein, Coronavirus/antagonists & inhibitors, Spike Glycoprotein, Coronavirus/chemistry, Spike Glycoprotein, Coronavirus/genetics, Drug Evaluation, Preclinical/methods, HTS, cleavage, inhibitor, Small Molecule Libraries, 03 medical and health sciences, Spike Glycoprotein, Coronavirus

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38791119
https://serval.unil.ch/resource/serval:BIB_9F00CF02496F.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_9F00CF02496F
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_9F00CF02496F5
https://hdl.handle.net/11577/3516956
https://doi.org/10.3390/ijms25105079

A Staphylococcus aureus Virulence Inhibitor Identified by SaeRS Refactoring and Screening in Bacillus subtilis

Συγγραφείς: Ekness, Felix, Wold, Eric A, Leasure, Catherine S, Musteata, Elena, Monteith, Andrew J, Laut, Clare

Πηγή: MaineHealth Maine Medical Center

Θεματικοί όροι: Bacillus subtilis, Staphylococcus aureus, bacterial two-component system, inhibitor screen, sensor histidine kinase, virulence, Bacillus subtilis (genetics, metabolism, drug effects), Bacterial Proteins (genetics, antagonists & inhibitors), Staphylococcus aureus (drug effects, pathogenicity, genetics, metabolism), Virulence (drug effects), Anti-Bacterial Agents (pharmacology), Signal Transduction (drug effects), Histidine Kinase (metabolism, Gene Expression Regulation, Bacterial (drug effects), Phosphorylation (drug effects), Small Molecule Libraries (pharmacology), Protein Kinases, Transcription Factors

Relation: https://knowledgeconnection.mainehealth.org/mmc/3992

Διαθεσιμότητα: https://knowledgeconnection.mainehealth.org/mmc/3992

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor

Συγγραφείς: Jana Ylva Tretter, Kenji Schorpp, Elke Luxenburger, Johannes Trambauer, Harald Steiner, Kamyar Hadian, Olivier Gires, Dierk Niessing

Πηγή: The journal of biological chemistry 293(23), 8994-9005 (2018). doi:10.1074/jbc.RA118.002776
J. Biol. Chem. 293, 8994-9005 (2018)

Θεματικοί όροι: 0301 basic medicine, Small Molecule Libraries: pharmacology, Transcription, Genetic, Drug Evaluation, Preclinical, Epithelial Cell Adhesion Molecule: metabolism, Transcription, Genetic: drug effects, Epithelial Cell Adhesion Molecule, Signal Transduction: drug effects, Small Molecule Libraries: chemistry, High-Throughput Screening Assays, Small Molecule Libraries, 03 medical and health sciences, High-Throughput Screening Assays: methods, HEK293 Cells, 0302 clinical medicine, Epithelial Cell Adhesion Molecule: antagonists & inhibitors, Drug Evaluation, Preclinical: methods, Cell Proliferation: drug effects, Humans, Anticancer Drug, Cell Signaling, Epithelial Cell Adhesion Molecule (epcam), High-throughput Screening (hts), Intramembrane Proteolysis, Cell Proliferation, Signal Transduction

Σύνδεσμος πρόσβασης: http://www.jbc.org/content/293/23/8994.full.pdf
https://pubmed.ncbi.nlm.nih.gov/29700109
https://pub.dzne.de/record/140001
https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=53458

Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1

Συγγραφείς: Mahtal, Nassim, Brewee, Clémence, Pichard, Sylvain, Visvikis, Orane, Cintrat, Jean-Christophe, Barbier, Julien, Lemichez, Emmanuel, Gillet, Daniel

Συνεισφορές: DELARUE, NADINE, Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de Chimie Bio-Organique et de Marquage (SCBM), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA), This work was funded by the joint ministerial program of Research and Development against Chemical, Biological, Radiological, and Nuclear (CBRNE) risks, recurrent funding from Institut National de la Santé et de la Recherche Médicale (INSERM), the French Alternative Energies and Atomic Energy Commission (CEA), and Labellisation de la Ligue Nationale contre le Cancer to E.L. N.M. was supported by a DGA‐MRIS scholarship and CEA. SIMOPRO and SCBM are members of the Laboratory of Excellence LERMIT, supported by a grant from the Agence Nationale de la Recherche (ANR‐10‐LABX‐33)., ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011)

Πηγή: ChemMedChem. 13:754-761

Θεματικοί όροι: rac1 GTP-Binding Protein, 0301 basic medicine, MESH: Small Molecule Libraries/pharmacology, [SDV]Life Sciences [q-bio], [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], MESH: Bepridil/pharmacology, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], inhibitors, Diphtheria Toxin, MESH: Human Umbilical Vein Endothelial Cells, Immunoassay, 0303 health sciences, Escherichia coli Proteins, MESH: Escherichia coli Proteins/antagonists & inhibitors, MESH: Lasalocid/pharmacology, CNF1, 3. Good health, [SDV] Life Sciences [q-bio], [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Escherichia coli Proteins/adverse effects, MESH: Amodiaquine/pharmacology, MESH: Diphtheria Toxin/adverse effects, MESH: Immunoassay, MESH: Drug Repositioning, Rac1, MESH: rac1 GTP-Binding Protein/metabolism, Lasalocid, MESH: rac1 GTP-Binding Protein/immunology, Bacterial Toxins, Bepridil, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: Escherichia coli Proteins/metabolism, drug discovery, Small Molecule Libraries, 03 medical and health sciences, MESH: Monensin/pharmacology, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Escherichia coli, Human Umbilical Vein Endothelial Cells, Humans, MESH: Bacterial Toxins/metabolism, Monensin, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, MESH: rac1 GTP-Binding Protein/chemistry, MESH: Humans, MESH: Bacterial Toxins/antagonists & inhibitors, screening, Drug Repositioning, Amodiaquine, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 13. Climate action, MESH: HeLa Cells, MESH: Bacterial Toxins/adverse effects, MESH: Escherichia coli/chemistry, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, HeLa Cells

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/29359495

The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes

Συγγραφείς: Singh, Sumeet Pal, Ninov, Nikolay

Πηγή: The International journal of developmental biology, 62 (6-7-8
Int. J. Dev. Biol. 62, 453-464 (2018)

Θεματικοί όροι: Insulin Secretion -- physiology, Small Molecule Libraries -- pharmacology, 0301 basic medicine, 0303 health sciences, Reprogramming, Regeneration, Protection, Diabetes, Islets of Langerhans Transplantation, Sciences bio-médicales et agricoles, Diabetes Mellitus -- metabolism -- physiopathology -- therapy, 3. Good health, Cell Proliferation -- physiology, Small Molecule Libraries, 03 medical and health sciences, Insulin-Secreting Cells -- cytology -- metabolism -- physiology, Regeneration -- physiology, Cytoprotection -- drug effects, Cytoprotection, Insulin-Secreting Cells, Insulin Secretion, Diabetes Mellitus, Animals, Humans, Islets of Langerhans Transplantation -- methods, Cell Proliferation

Περιγραφή αρχείου: 2 full-text file(s): application/pdf; application/pdf

Σύνδεσμος πρόσβασης: http://www.ijdb.ehu.es/web/descarga/paper/180067nn
https://pubmed.ncbi.nlm.nih.gov/29938757
https://dipot.ulb.ac.be/dspace/bitstream/2013/301361/1/doi_285005.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/301361/4/doi_285005.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/301361
https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=54958