High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

Συγγραφείς: Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S

Πηγή: International Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3991-4006 (2013)

Θεματικοί όροι: Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: http://www.dovepress.com/high-efficiency-liposomal-encapsulation-of-a-tyrosine-kinase-inhibitor-a14746; https://doaj.org/toc/1176-9114; https://doaj.org/toc/1178-2013

Σύνδεσμος πρόσβασης: https://doaj.org/article/11dae53320914469884c34ee146ef524

Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor

Συγγραφείς: Jacques S, Gaikwad H, Pillatzke J, Moghimi SM, Simberg D

Πηγή: Chemical Communications, 2026

Περιγραφή αρχείου: application/pdf

Relation: https://eprints.ncl.ac.uk/312485; https://eprints.ncl.ac.uk/fulltext.aspx?url=312485/E2E6BE16-7D15-44AD-A9BA-56F192D37100.pdf&pub_id=312485

Διαθεσιμότητα: https://eprints.ncl.ac.uk/312485

Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles

Συγγραφείς: Moghimi SM, Haroon HB, Yaghmur A, Simberg D, Trohopoulos PN

Πηγή: J Control Release
Moghimi, S M, Haroon, H B, Yaghmur, A, Simberg, D & Trohopoulos, P N 2022, ' Nanometer-and angstrom-scale characteristics that modulate complement responses to nanoparticles ', Journal of Controlled Release, vol. 351, pp. 432-443 . https://doi.org/10.1016/j.jconrel.2022.09.039
Journal of Controlled Release

Θεματικοί όροι: Inflammation, 0301 basic medicine, Dendrimers, Mannose-binding lectin, Complement system, Complement C1q, Factor H, Complement System Proteins, Antibodies, Article, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Humans, Nanoparticles, Complement Activation, C1q

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36152807
https://curis.ku.dk/ws/files/321274791/Moghimi_et_al_2022_JCR.pdf
https://doi.org/10.1016/j.jconrel.2022.09.039
https://researchprofiles.ku.dk/da/publications/64c75b92-2c6a-4c28-bc6d-a9cd93fed6ef

Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors

Συγγραφείς: Li Y, Jacques S, Gaikwad H, Nebbia M, Banda NK, Holers VM, Tomlinson SA, Scheinman RI, Monte A, Saba L, Lasda E, Hasselberth J, Busquet N, Zelek WM, Moghimi SM, Simberg D

Πηγή: Science Advances, 11 July 2025

Περιγραφή αρχείου: application/pdf

Relation: https://eprints.ncl.ac.uk/306991; https://eprints.ncl.ac.uk/fulltext.aspx?url=306991/1B57E720-F8A9-49C6-87B9-25433FBA28CD.pdf&pub_id=306991

Διαθεσιμότητα: https://eprints.ncl.ac.uk/306991

Complement opsonization of nanoparticles: Differences between humans and preclinical species

Συγγραφείς: Li Y, Wang G, Griffin L, Banda NK, Saba LM, Groman EV, Scheinman R, Moghimi SM, Simberg D

Πηγή: Journal of Controlled Release. 338:548-556

Θεματικοί όροι: 0301 basic medicine, Mice, Inbred BALB C, 0303 health sciences, Complement C3, Rats, 3. Good health, Mice, Inbred C57BL, Mice, 03 medical and health sciences, Dogs, Animals, Humans, Rats, Long-Evans, Complement Activation

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/34481928

Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins

Συγγραφείς: Li Y, Jacques S, Gaikwad H, Wang G, Banda NK, Holers VM, Scheinman RI, Tomlinson S, Moghimi SM, Simberg D

Πηγή: Nature Nanotechnology, 2023

Περιγραφή αρχείου: application/pdf

Relation: https://eprints.ncl.ac.uk/294300; https://eprints.ncl.ac.uk/fulltext.aspx?url=294300/511E31A8-004F-48A6-8896-05A639345A04.pdf&pub_id=294300

Διαθεσιμότητα: https://doi.org/10.57711/nnr1-2k52
https://eprints.ncl.ac.uk/294300

Perspectives on complement and phagocytic cell responses to nanoparticles: From fundamentals to adverse reactions

Συγγραφείς: Moghimi SM, Haroon HB, Yaghmur A, Hunter AC, Papini E, Farhangrazi ZS, Simberg D, Trohopoulos PN

Πηγή: Journal of Controlled Release, April 2023

Περιγραφή αρχείου: application/pdf

Relation: https://eprints.ncl.ac.uk/290364; https://eprints.ncl.ac.uk/fulltext.aspx?url=290364/7CB8E4E4-8EF0-445B-9A54-3A2E26F94FA7.pdf&pub_id=290364

Διαθεσιμότητα: https://eprints.ncl.ac.uk/290364

Pharmacokinetic analysis reveals limitations and opportunities for nanomedicine targeting of endothelial and extravascular compartments of tumours

Συγγραφείς: Benchimol MJ, Bourne D, Moghimi SM, Simberg D

Πηγή: Journal of Drug Targeting. 27:690-698

Θεματικοί όροι: Diffusion, 0301 basic medicine, 03 medical and health sciences, Nanomedicine, Cell Line, Tumor, Neoplasms, Humans, Nanoparticles, Antineoplastic Agents, Endothelium, 02 engineering and technology, 0210 nano-technology

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc6679937?pdf=render
https://pubmed.ncbi.nlm.nih.gov/30614276

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Συγγραφείς: Wu L-P, Ficker M, Christensen JB, Simberg D, Trohopoulos PN, Moghimi SM

Πηγή: Nature Communications, December 2021

Περιγραφή αρχείου: application/pdf

Relation: https://eprints.ncl.ac.uk/276634; https://eprints.ncl.ac.uk/fulltext.aspx?url=276634/EFB3FA0A-205D-4FBF-8319-A9B2DA594558.pdf&pub_id=276634

Διαθεσιμότητα: https://eprints.ncl.ac.uk/276634

Complement activation turnover on surfaces of nanoparticles

Συγγραφείς: Moghimi, S.M. ^{a, ⁎}, Simberg, D. ^b

Πηγή: In Nano Today August 2017 15:8-10

Validation of dot blot immunoassay for measurement of complement opsonization of nanoparticles

Συγγραφείς: Li Y, Monte A, Dylla L, Moghimi SM, Simberg D

Πηγή: Journal of Immunological Methods. 528:113668

Θεματικοί όροι: Immunoassay, Opsonization, Complement C3a, Nanoparticles, Complement C5, Complement C5a, Complement Membrane Attack Complex, Complement Activation

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38574804

PEGylation technology: addressing concerns, moving forward

Συγγραφείς: Simberg D, Barenholz Y, Roffler SR, Landfester K, Kabanov AV, Moghimi SM

Πηγή: Drug Delivery, 2025

Περιγραφή αρχείου: application/pdf

Relation: https://eprints.ncl.ac.uk/305680; https://eprints.ncl.ac.uk/fulltext.aspx?url=305680/36B891D9-1469-4C1D-BF35-86A429428CDB.pdf&pub_id=305680

Διαθεσιμότητα: https://eprints.ncl.ac.uk/305680

Macromolecular Pairing On Nanoparticle Surface Modulates Immune Response

Συγγραφείς: Haroon, H. B., Moghimi, S. M., Maghalaes, P. V., Papini, E., Christensen, J. B., Simberg, D., Trohopoulos, P. N.

Πηγή: Haroon , H B , Moghimi , S M , Maghalaes , P V , Papini , E , Christensen , J B , Simberg , D & Trohopoulos , P N 2024 , ' Macromolecular Pairing On Nanoparticle Surface Modulates Immune Response ' , 9th World Congress on Recent Advances in Nanotechnology, RAN 2024 , London , United Kingdom , 08/04/2024 - 10/04/2024 . https://doi.org/10.11159/nddte24.141

Διαθεσιμότητα: https://researchprofiles.ku.dk/da/publications/4cc75e01-b844-4139-a5fa-15aaf051245f
https://doi.org/10.11159/nddte24.141

Different Effect of Hydrogelation on Antifouling and Circulation Properties of Dextran–Iron Oxide Nanoparticles

Συγγραφείς: Karmali, PP Karmali, Priya Prakash, Chao, Y Chao, Ying, Park, JH Park, Ji-Ho, Sailor, MJ Sailor, Michael J., Ruoslahti, E Ruoslahti, Erkki, Esener, SC Esener, Sadik C., Simberg, D Simberg, Dmitri

Πηγή: Molecular Pharmaceutics. 9:539-545

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Kininogens, Dextrans, Ferric Compounds, Hydrogel, Polyethylene Glycol Dimethacrylate, Mice, Inbred C57BL, Mice, 03 medical and health sciences, Animals, Nanoparticles, Female, Iron-Dextran Complex, Protein Binding

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc3295900?pdf=render
https://pubmed.ncbi.nlm.nih.gov/22243419

Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts

Συγγραφείς: Li Y, Saba L, Scheinman RI, Banda NK, Holers M, Monte A, Dylla L, Moghimi SM, Simberg D

Πηγή: ACS Nano, 22 October 2024

Relation: https://eprints.ncl.ac.uk/302250

Διαθεσιμότητα: https://eprints.ncl.ac.uk/302250

Optimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin

Συγγραφείς: Li Y, Ettah U, Jacques S, Gaikwad H, Monte A, Dylla L, Guntupalli S, Moghimi SM, Simberg D

Πηγή: Molecular Pharmaceutics, 2024

Relation: https://eprints.ncl.ac.uk/298763

Διαθεσιμότητα: https://eprints.ncl.ac.uk/298763

Nanoparticle transport pathways into tumors

Συγγραφείς: Moghimi, S. M., Simberg, D.

Συνεισφορές: Newcastle University

Πηγή: Journal of Nanoparticle Research ; volume 20, issue 6 ; ISSN 1388-0764 1572-896X

Διαθεσιμότητα: https://doi.org/10.1007/s11051-018-4273-8
http://link.springer.com/article/10.1007/s11051-018-4273-8/fulltext.html
http://link.springer.com/content/pdf/10.1007/s11051-018-4273-8.pdf

Contact activation of kallikrein–kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo

Συγγραφείς: Simberg, D Simberg, Dmitri, Zhang, WM Zhang, Wan-Ming, Merkulov, S Merkulov, Sergei, McCrae, K McCrae, Keith, Park, JH Park, Ji-Ho, Sailor, MJ Sailor, Michael J., Ruoslahti, E Ruoslahti, Erkki

Πηγή: Journal of Controlled Release. 140:301-305

Θεματικοί όροι: 0301 basic medicine, Mice, Inbred BALB C, 0303 health sciences, Kallikrein-Kinin System, Dextrans, Thrombosis, Blood Proteins, Ferric Compounds, Enzyme Activation, Mice, Inbred C57BL, Molecular Weight, Magnetics, Mice, 03 medical and health sciences, Drug Delivery Systems, Animals, Nanoparticles, Fluorescein-5-isothiocyanate, Fluorescent Dyes

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc2787880?pdf=render
https://pubmed.ncbi.nlm.nih.gov/19508879

Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance

Συγγραφείς: Simberg, D Simberg, Dmitri, Park, JH Park, Ji-Ho, Karmali, PP Karmali, Priya P., Zhang, WM Zhang, Wan-Ming, Merkulov, S Merkulov, Sergei, McCrae, K McCrae, Keith, Bhatia, SN Bhatia, Sangeeta N., Sailor, M Sailor, Michael, Ruoslahti, E Ruoslahti, Erkki

Συνεισφορές: Harvard University--MIT Division of Health Sciences and Technology, Bhatia, Sangeeta N.

Πηγή: PMC

Θεματικοί όροι: Proteomics, 0301 basic medicine, 0303 health sciences, Kupffer Cells, Iron, Proteins, Dextrans, Oxides, Ferrosoferric Oxide, 3. Good health, Mice, Plasma, 03 medical and health sciences, Animals, Nanoparticles, Magnetite Nanoparticles, Cells, Cultured, Protein Binding

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://dspace.mit.edu/bitstream/1721.1/75311/1/Bhatia_Differential%20proteomics.pdf
https://pubmed.ncbi.nlm.nih.gov/19394687
http://hdl.handle.net/1721.1/75311
https://orcid.org/0000-0002-1293-2097

Systematic Surface Engineering of Magnetic Nanoworms for In vivo Tumor Targeting

Συγγραφείς: Park, JH Park, Ji-Ho, von Maltzahn, G von Maltzahn, Geoffrey, Zhang, LL Zhang, Lianglin, Derfus, AM Derfus, Austin M., Simberg, D Simberg, Dmitri, Harris, TJ Harris, Todd J., Ruoslahti, E Ruoslahti, Erkki, Bhatia, SN Bhatia, Sangeeta N., Sailor, MJ Sailor, Michael J.

Πηγή: Small. 5:694-700

Θεματικοί όροι: Surface Properties, Carcinoma, 02 engineering and technology, Ferric Compounds, 01 natural sciences, Nanostructures, 0104 chemical sciences, Magnetics, Drug Delivery Systems, Nanomedicine, Cell Line, Tumor, Materials Testing, Humans, Particle Size, 0210 nano-technology

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc3058937?pdf=render
https://pubmed.ncbi.nlm.nih.gov/19263431