Temporal Regulation of Signal Recognition Particle During Translation.

Authors: Qian R; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gora RJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Chandrasekar S; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Shan SO; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: sshan@caltech.edu.

Source: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169482. Date of Electronic Publication: 2025 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH Terms: Signal Recognition Particle*/metabolism , Signal Recognition Particle*/genetics , Signal Recognition Particle*/chemistry , Protein Biosynthesis*, Ribosomes/metabolism ; Endoplasmic Reticulum/metabolism ; Fluorescence Resonance Energy Transfer ; Protein Binding ; Receptors, Peptide/metabolism ; Protein Transport ; Receptors, Cytoplasmic and Nuclear/metabolism

Anti-Signal Recognition Particle Antibody-Positive Immune-Mediated Necrotizing Myopathy Diagnosed by Re-Evaluation 40 Years After Symptom Onset.

Authors: Yoshida K; Division of Neurology, Department of Brain and Neuroscience, Tottori University, Yonago, Japan., Adachi T; Division of Neuropathology, Department of Brain and Neuroscience, Tottori University, Yonago, Japan., Suzuki S; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Nishino I; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan., Hanajima R; Division of Neurology, Department of Brain and Neuroscience, Tottori University, Yonago, Japan.

Source: Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2025 Dec; Vol. 45 (6), pp. e70034.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Blackwell Science Asia Country of Publication: Australia NLM ID: 9606526 Publication Model: Print Cited Medium: Internet ISSN: 1440-1789 (Electronic) Linking ISSN: 09196544 NLM ISO Abbreviation: Neuropathology Subsets: MEDLINE

MeSH Terms: Signal Recognition Particle*/immunology , Myositis*/immunology , Myositis*/diagnosis , Myositis*/pathology , Autoantibodies*/blood, Humans ; Female ; Middle Aged ; Muscle, Skeletal/pathology ; Necrosis

Identification of a novel bacteriophage attachment site into ffs, the 4.5S non-coding RNA component of the signal recognition particle.

Authors: Stevens RH; Laboratory of Oral Infectious Diseases, Department of Endodontics, Temple University Kornberg School of Dentistry, Philadelphia, PA, USA., Zhang H; Laboratory of Oral Infectious Diseases, Department of Endodontics, Temple University Kornberg School of Dentistry, Philadelphia, PA, USA., Fouts DE; Genomic Medicine, The J. Craig Venter Institute, Rockville, MD, USA. dfouts@jcvi.org.

Source: Scientific reports [Sci Rep] 2025 Oct 21; Vol. 15 (1), pp. 36634. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Enterococcus faecalis*/virology , Enterococcus faecalis*/genetics , Bacteriophages*/genetics , Bacteriophages*/physiology , Signal Recognition Particle*/genetics , Signal Recognition Particle*/metabolism , Attachment Sites, Microbiological*/genetics, Lysogeny/genetics ; Endopeptidases

srp54 promotes motor neuron development and is required for motility in zebrafish.

Authors: Losievski N; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Neuroscience Graduate Program, The Ohio State University, Columbus, OH, USA., Kamath P; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Fox A; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Aloi NM; English Department, PhD Program in Writing, Rhetoric, and Literacy, The Ohio State University, Columbus, OH, USA., Baird MC; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Everest A; Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA., Gallagher TL; Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA; Center for RNA Biology, The Ohio State University, Columbus, OH, USA., Amacher SL; Department of Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Molecular Genetics, The Ohio State University, Columbus, OH, USA; Center for RNA Biology, The Ohio State University, Columbus, OH, USA; Center for Muscle Health and Neuromuscular Disorders, The Ohio State University and Nationwide Children's Hospital, Columbus, OH, USA., Kolb SJ; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Center for RNA Biology, The Ohio State University, Columbus, OH, USA; Center for Muscle Health and Neuromuscular Disorders, The Ohio State University and Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: Stephen.Kolb@osumc.edu.

Source: Neuroscience [Neuroscience] 2025 Jul 23; Vol. 579, pp. 24-34. Date of Electronic Publication: 2025 May 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

MeSH Terms: Motor Neurons*/metabolism , Motor Neurons*/physiology , Zebrafish Proteins*/genetics , Zebrafish Proteins*/metabolism , Signal Recognition Particle*/genetics , Signal Recognition Particle*/metabolism, Animals ; Zebrafish ; Axons/metabolism ; Axons/physiology ; Animals, Genetically Modified

Successful methotrexate and rituximab combination therapy for a Taiwanese patient with anti-signal recognition particle antibody-positive immune-mediated necrotizing myopathy: a case report.

Authors: Toshina H; Department of Dermatology, Wakayama Medical University, Wakayama, Japan., Iwata S; Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan., Matsumiya R; Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan., Nakayama Y; Department of Neurology, Wakayama Medical University, Wakayama, Japan., Iwamoto R; Department of Human Pathology, Wakayama Medical University, Wakayama, Japan., Miyamoto K; Department of Neurology, Wakayama Medical University, Wakayama, Japan., Fujii T; Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan.

Source: Modern rheumatology case reports [Mod Rheumatol Case Rep] 2025 Jul 25; Vol. 9 (2).

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101761026 Publication Model: Print Cited Medium: Internet ISSN: 2472-5625 (Electronic) Linking ISSN: 24725625 NLM ISO Abbreviation: Mod Rheumatol Case Rep Subsets: MEDLINE

MeSH Terms: Rituximab*/therapeutic use , Signal Recognition Particle*/immunology , Methotrexate*/therapeutic use , Methotrexate*/administration & dosage , Muscular Diseases*/drug therapy , Muscular Diseases*/immunology , Muscular Diseases*/pathology, Humans ; Female ; Aged ; Drug Therapy, Combination ; Taiwan ; Treatment Outcome ; Autoantibodies/blood

Alu RNA pseudoknot alterations influence SRP9/SRP14 association.

Authors: Gussakovsky D; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Brown MJF; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Pereira HS; Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada., Meier M; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Padilla-Meier GP; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Black NA; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Booy EP; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Stetefeld J; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada., Patel TR; Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada., McKenna SA; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada sean.mckenna@umanitoba.ca.

Source: RNA (New York, N.Y.) [RNA] 2025 Jul 16; Vol. 31 (8), pp. 1154-1175. Date of Electronic Publication: 2025 Jul 16.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

MeSH Terms: Alu Elements*/genetics , Signal Recognition Particle*/metabolism , Signal Recognition Particle*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Humans ; Nucleic Acid Conformation ; Mutation

Clinicopathological features of anti-HMGCR and anti-SRP myopathies that do not satisfy the EULAR/ACR criteria of inflammatory myopathies.

Authors: Komaki S; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kubota A; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kitamura A; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Maeda M; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kadoya M; Department of Neurology, National Hospital Organization Shimoshizu National Hospital, Chiba, Japan., Hokkoku K; Department of Neurology, Teikyo University Hospital, Tokyo, Japan., Kobayashi S; Department of Neurology, Teikyo University Hospital, Tokyo, Japan., Bannai T; Department of Neurology, Tokyo Teishin Hospital, Tokyo, Japan., Shiio Y; Department of Neurology, Tokyo Teishin Hospital, Tokyo, Japan., Uchio N; Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan., Uesaka Y; Department of Neurology, Toranomon Hospital, Tokyo, Japan., Kikuchi J; Department of Neurology, Toranomon Hospital Kajigaya, Kanagawa, Japan., Sugimoto I; Department of Neurology, Toranomon Hospital Kajigaya, Kanagawa, Japan., Mikata T; Department of Neurology, National Hospital Organization Shimoshizu National Hospital, Chiba, Japan., Okudera R; Division of Neurology, Internal Medicine, National Defense Medical College, Saitama, Japan., Suzuki K; Division of Neurology, Internal Medicine, National Defense Medical College, Saitama, Japan., Arai N; Department of Neurology, National Center for Global Health and Medicine, Tokyo, Japan., Sakiyama Y; Department of Neurology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Tokushige SI; Department of Neurology, Kyorin University School of Medicine, Tokyo, Japan., Ichikawa Y; Department of Neurology, Kyorin University School of Medicine, Tokyo, Japan., Yajima N; Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan., Nakashima R; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Mimori T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Rheumatology, Takeda Clinic for Rheumatic Diseases, Kyoto, Japan., Shimizu J; Department of Physical Therapy, Tokyo University of Technology, Tokyo, Japan., Komai T; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tsuchiya H; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Fujio K; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Toda T; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Source: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2025 Aug 01; Vol. 64 (8), pp. 4580-4588.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE

MeSH Terms: Myositis*/immunology , Myositis*/diagnosis , Myositis*/pathology , Myositis*/classification , Hydroxymethylglutaryl CoA Reductases*/immunology , Autoantibodies*/blood , Autoantibodies*/immunology , Signal Recognition Particle*/immunology, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Diagnosis, Differential ; Prognosis ; Muscle, Skeletal/pathology ; Necrosis

Paraneoplastic anti-SRP antibody positive immune-mediated necrotizing myopathy in a young female associated with lymphoma.

Authors: Heugenhauser J; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Pauli FD; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Stockhammer G; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Chott A; Institute of Pathology, Klinik Ottakring, Vienna, Austria., Feistritzer C; Department of Internal Medicine V, Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria., Egle D; Department of Gynecology, Breast Cancer Center Tirol, Medical University of Innsbruck, Innsbruck, Austria., Henninger B; Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria., Wanschitz J; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Source: Journal of neuromuscular diseases [J Neuromuscul Dis] 2025 Jul; Vol. 12 (4), pp. 567-574. Date of Electronic Publication: 2025 Apr 23.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101649948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-3602 (Electronic) Linking ISSN: 22143599 NLM ISO Abbreviation: J Neuromuscul Dis Subsets: MEDLINE

MeSH Terms: Lymphoma, Large-Cell, Anaplastic*/complications , Lymphoma, Large-Cell, Anaplastic*/immunology , Signal Recognition Particle*/immunology , Muscular Diseases*/immunology , Muscular Diseases*/complications , Paraneoplastic Syndromes*/immunology , Autoantibodies*/blood, Humans ; Female ; Adult

Unravelling the role of the A domain and N-terminal alpha-helices of FtsY in archaeal signal recognition particle.

Authors: Gupta S; Department of Bioengineering, University of Oregon, 1505 Franklin Blvd., Eugene, OR 97403, USA., Sinha S; Department of Bioengineering, University of California, 900 University Avenue, Riverside, CA 92521, USA., Bhakta K; Department of Biological Sciences, Bose Institute, EN 80, Sector V, Bidhan Nagar, Kolkata 700091, WB, India., Bhowmick A; Department of Biological Sciences, Bose Institute, EN 80, Sector V, Bidhan Nagar, Kolkata 700091, WB, India., Ghosh A; Department of Biological Sciences, Bose Institute, EN 80, Sector V, Bidhan Nagar, Kolkata 700091, WB, India. Electronic address: abhrajyoti.ghosh@jcbose.ac.in.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 May; Vol. 306 (Pt 4), pp. 141645. Date of Electronic Publication: 2025 Mar 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Signal Recognition Particle*/metabolism , Signal Recognition Particle*/chemistry , Signal Recognition Particle*/genetics , Archaeal Proteins*/chemistry , Archaeal Proteins*/metabolism , Archaeal Proteins*/genetics , Archaea*/metabolism, Protein Binding ; Molecular Dynamics Simulation ; Protein Conformation, alpha-Helical ; Protein Domains

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp.

Authors: Zegarra V; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany.; Department of Chemistry, Philipps-University Marburg, Germany., Weiland P; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany.; Center for Tumor Biology and Immunology, Department of Medicine, Philipps-University Marburg, Germany., Plitzko PA; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany.; Department of Chemistry, Philipps-University Marburg, Germany., Thiery J; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany., Czech L; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany., Willmund F; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany.; Department of Biology, Philipps-University Marburg, Germany., Bedrunka P; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany.; Department of Chemistry, Philipps-University Marburg, Germany., Bange G; Center for Synthetic Microbiology (SYNMIKRO), Philipps University Marburg, Germany.; Department of Chemistry, Philipps-University Marburg, Germany.; Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.

Source: FEBS letters [FEBS Lett] 2025 May; Vol. 599 (10), pp. 1373-1385. Date of Electronic Publication: 2025 Feb 11.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

MeSH Terms: Signal Recognition Particle*/metabolism , Signal Recognition Particle*/chemistry , Signal Recognition Particle*/genetics , Chloroplasts*/metabolism , Guanosine Pentaphosphate*/metabolism , Guanosine Pentaphosphate*/chemistry , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/genetics , Guanosine Tetraphosphate*/metabolism , Guanosine Tetraphosphate*/chemistry, Protein Binding ; Arabidopsis/metabolism ; Arabidopsis/genetics ; Models, Molecular ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, Cytoplasmic and Nuclear/chemistry ; GTP Phosphohydrolases/metabolism ; GTP Phosphohydrolases/chemistry

Switchable client specificity in a dual functional chaperone coordinates light-harvesting complex biogenesis.

Authors: Siegel AR; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kroon G; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Zhao C; School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR 999077, P.R. China.; State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, SAR 999077, P.R. China., Wang P; School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR 999077, P.R. China.; State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, SAR 999077, P.R. China., Wright PE; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Shan SO; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Source: Science advances [Sci Adv] 2025 Jun 13; Vol. 11 (24), pp. eadu5791. Date of Electronic Publication: 2025 Jun 13.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH Terms: Light-Harvesting Protein Complexes*/metabolism , Light-Harvesting Protein Complexes*/chemistry , Light-Harvesting Protein Complexes*/biosynthesis , Light-Harvesting Protein Complexes*/genetics , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/genetics , Arabidopsis*/metabolism , Arabidopsis*/genetics , Molecular Chaperones*/metabolism , Molecular Chaperones*/chemistry , Signal Recognition Particle*/metabolism , Signal Recognition Particle*/chemistry , Signal Recognition Particle*/genetics, Protein Conformation ; Photosynthesis ; Chlorophyll/biosynthesis

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss.

Authors: Xi X; Department of Biochemistry and Molecular Biology and Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Liu L; Department of Biochemistry and Molecular Biology and Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Tuano N; Murdoch Children Research Institute, Parkville, VIC 3052, Australia., Tailhades J; Department of Biochemistry and Molecular Biology and Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Mouradov D; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia., Steen J; Clinical Genomics, School of Translational Medicine, Monash University, Melbourne, VIC 3168, Australia., Sieber O; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia.; Department of Surgery, The University of Melbourne, Parkville, VIC 3050, Australia., Cryle M; Department of Biochemistry and Molecular Biology and Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Nguyen-Dumont T; Clinical Genomics, School of Translational Medicine, Monash University, Melbourne, VIC 3168, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC 3010, Australia., Segelov E; Department of Clinical Research, Faculty of Medicine, University of Bern, Inselspital, Bern 3000, Switzerland.; Department of Radiation Oncology, Bern University Hospital, Inselspital, Bern 3000, Switzerland., Rosenbluh J; Department of Biochemistry and Molecular Biology and Cancer Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Functional Genomics Platform, Monash University, Melbourne, VIC 3800, Australia.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Apr 15; Vol. 122 (15), pp. e2409677122. Date of Electronic Publication: 2025 Apr 10.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Adenomatous Polyposis Coli Protein*/genetics , Adenomatous Polyposis Coli Protein*/metabolism , Signal Recognition Particle*/metabolism , Signal Recognition Particle*/genetics , Adenomatous Polyposis Coli*/genetics , Adenomatous Polyposis Coli*/metabolism, Humans ; Animals ; Mice ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Protein Transport ; Genes, APC

7SL RNA and signal recognition particle orchestrate a global cellular response to acute thermal stress.

Authors: Bujisic B; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, 02114, USA., Lee HG; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, 02114, USA., Xu L; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, 02114, USA., Weissbein U; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, 02114, USA., Rivera C; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, 02114, USA., Topisirovic I; Lady Davis Institute, Gerald Bronfman Department of Oncology and Departments of Biochemistry and Experimental Medicine, McGill University, Montreal, QC, Canada., Lee JT; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA. lee@molbio.mgh.harvard.edu.; Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA, 02114, USA. lee@molbio.mgh.harvard.edu.

Source: Nature communications [Nat Commun] 2025 Feb 14; Vol. 16 (1), pp. 1630. Date of Electronic Publication: 2025 Feb 14.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Signal Recognition Particle*/metabolism , Signal Recognition Particle*/genetics , Heat-Shock Response*/genetics , RNA, Small Cytoplasmic*/metabolism , RNA, Small Cytoplasmic*/genetics, Humans ; Protein Biosynthesis ; Mitochondria/metabolism ; Cell Nucleus/metabolism ; Ribosomes/metabolism ; Cytosol/metabolism ; HeLa Cells ; Animals ; Transcription, Genetic ; Protein Transport

Successful treatment of anti-signal recognition particle antibody-positive myositis with intravenous cyclophosphamide: A case report.

Authors: Temmoku J; Department of Rheumatology, Fukushima Medical University School of Medicine., Yoshida S; Department of Rheumatology, Fukushima Medical University School of Medicine., Tsuchihashi K; Department of Neurology, Fukushima Medical University School of Medicine., Sumichika Y; Department of Rheumatology, Fukushima Medical University School of Medicine., Saito K; Department of Rheumatology, Fukushima Medical University School of Medicine., Matsumoto H; Department of Rheumatology, Fukushima Medical University School of Medicine., Fujita Y; Department of Rheumatology, Fukushima Medical University School of Medicine., Matsuoka N; Department of Rheumatology, Fukushima Medical University School of Medicine., Asano T; Department of Rheumatology, Fukushima Medical University School of Medicine., Matsuda N; Department of Neurology, Fukushima Medical University School of Medicine., Sato S; Department of Rheumatology, Fukushima Medical University School of Medicine., Migita K; Department of Rheumatology, Fukushima Medical University School of Medicine.

Source: Fukushima journal of medical science [Fukushima J Med Sci] 2025 Jan 18; Vol. 71 (1), pp. 63-68. Date of Electronic Publication: 2024 Dec 07.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: Fukushima Society of Medical Science Country of Publication: Japan NLM ID: 0374626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2185-4610 (Electronic) Linking ISSN: 00162590 NLM ISO Abbreviation: Fukushima J Med Sci Subsets: MEDLINE

MeSH Terms: Cyclophosphamide*/administration & dosage , Cyclophosphamide*/therapeutic use , Signal Recognition Particle*/immunology , Myositis*/drug therapy , Myositis*/immunology , Autoantibodies*/blood , Immunosuppressive Agents*/administration & dosage, Humans ; Male ; Middle Aged

Disruption of the signal recognition particle pathway leading to impaired growth, sugar metabolism and acid resistance of Lactococcus lactis.

Authors: Wang M; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China., Yue Y; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China., Zhu X; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China., Wang M; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China., Zhang Y; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China., Kong J; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China., Guo T; State Key Laboratory of Microbial Technology, Shandong University, No. 72 Binhai Road, Qingdao 266237, PR China. Electronic address: guotingting@sdu.edu.cn.

Source: International journal of food microbiology [Int J Food Microbiol] 2025 Jan 02; Vol. 426, pp. 110929. Date of Electronic Publication: 2024 Oct 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8412849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3460 (Electronic) Linking ISSN: 01681605 NLM ISO Abbreviation: Int J Food Microbiol Subsets: MEDLINE

MeSH Terms: Lactococcus lactis*/metabolism , Lactococcus lactis*/genetics , Lactococcus lactis*/growth & development , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Signal Recognition Particle*/metabolism , Signal Recognition Particle*/genetics, Carbohydrate Metabolism ; Gene Expression Regulation, Bacterial ; Mutation ; Acids/metabolism ; Hydrogen-Ion Concentration ; Signal Transduction ; Glucose/metabolism

Clinical characteristics of idiopathic inflammatory myopathies related to anti-SRP: a single center experience.

Authors: Tang Q; Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, Hunan, People's Republic of China., Xie X; Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, Hunan, People's Republic of China., He J; Department of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, People's Republic of China., Li F; Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, Hunan, People's Republic of China., Chen J; Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, Hunan, People's Republic of China., Mao N; Department of Rheumatology and Immunology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. Monica2021@csu.edu.cn.; Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, Hunan, People's Republic of China. Monica2021@csu.edu.cn.

Source: Scientific reports [Sci Rep] 2024 Oct 28; Vol. 14 (1), pp. 25788. Date of Electronic Publication: 2024 Oct 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Myositis*/immunology , Myositis*/diagnosis , Myositis*/epidemiology , Myositis*/pathology , Autoantibodies*/blood , Autoantibodies*/immunology , Signal Recognition Particle*/immunology , Lung Diseases, Interstitial*/immunology , Lung Diseases, Interstitial*/diagnosis, Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; Prognosis ; Muscle Weakness

A Case Report of Immune Mediated Necrotising Myopathy With Myocardial Involvement: A Lesson in Multi-Disciplinary Care.

Authors: Rashed A; Department of Cardiology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK., Jupudi S; Department of Cardiology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK., Wong E; Department of Rheumatology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK., Guha K; Department of Cardiology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.

Source: British journal of hospital medicine (London, England : 2005) [Br J Hosp Med (Lond)] 2025 Nov 25; Vol. 86 (11), pp. 1-6. Date of Electronic Publication: 2025 Nov 05.

Publication Type: Journal Article; Case Reports

Journal Info: Publisher: MA Healthcare Country of Publication: England NLM ID: 101257109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-8460 (Print) Linking ISSN: 17508460 NLM ISO Abbreviation: Br J Hosp Med (Lond) Subsets: MEDLINE

MeSH Terms: Heart Failure*/etiology , Cardiomyopathies* , Myositis*/complications , Myositis*/diagnosis , Myositis*/drug therapy , Myositis*/immunology , Muscular Diseases*/complications , Muscular Diseases*/immunology, Humans ; Female ; Middle Aged ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Signal Recognition Particle/immunology ; Necrosis

And now for something completely different in co-translational targeting.

Authors: Bykov YS; Quantitative Cell Biology, Rhineland-Palatinate Technical University (RPTU), 67663 Kaiserslautern, Germany. Electronic address: yury.bykov@rptu.de.

Source: Molecular cell [Mol Cell] 2025 Oct 02; Vol. 85 (19), pp. 3551-3553.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH Terms: Protein Biosynthesis* , Ribosomes*/metabolism , Mitochondria*/metabolism, Protein Transport ; Humans ; Endoplasmic Reticulum/metabolism ; Signal Recognition Particle/metabolism ; Animals

The pathogenesis of immune-mediated necrotizing myopathy: Progress and therapeutic implications.

Authors: Yang M; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Bi Z; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Li Z; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Zhan J; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Gao H; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Zhang Q; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Tang Z; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: ddjtzp@163.com., Bu B; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: bubitao@tjh.tjmu.edu.cn.

Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Oct; Vol. 191, pp. 118525. Date of Electronic Publication: 2025 Sep 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

MeSH Terms: Myositis*/immunology , Myositis*/pathology , Myositis*/therapy , Muscle, Skeletal*/pathology , Muscle, Skeletal*/immunology , Muscle, Skeletal*/drug effects , Autoimmune Diseases*/immunology , Autoimmune Diseases*/pathology , Autoimmune Diseases*/therapy, Humans ; Animals ; Necrosis ; Autoantibodies/immunology ; Hydroxymethylglutaryl CoA Reductases/immunology ; Immunotherapy/methods ; Signal Recognition Particle/immunology

Anti-SRP myositis: a diagnostic and therapeutic challenge.

Authors: Polat MC; Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye., Ardıçlı D; Division of Pediatric Neurology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye., Çelikel Acar B; Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye., Talim B; Pediatric Pathology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Türkiye., Şenbil N; Division of Pediatric Neurology, Department of Pediatrics, Kırıkkale University Faculty of Medicine, Kırıkkale, Türkiye., Çelikel E; Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.

Source: The Turkish journal of pediatrics [Turk J Pediatr] 2024 Dec 19; Vol. 66 (6), pp. 792-800. Date of Electronic Publication: 2024 Dec 19.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Hacettepe University, Institute of Child Health Country of Publication: Turkey NLM ID: 0417505 Publication Model: Electronic Cited Medium: Internet ISSN: 2791-6421 (Electronic) Linking ISSN: 00414301 NLM ISO Abbreviation: Turk J Pediatr Subsets: MEDLINE

MeSH Terms: Myositis*/diagnosis , Myositis*/immunology , Myositis*/drug therapy , Signal Recognition Particle*/immunology , Autoantibodies*/blood, Humans ; Female ; Child, Preschool ; Rituximab/therapeutic use ; Immunologic Factors/therapeutic use