Exosomes promise better bone regeneration

Authors: Shuaiwen Hu, Shaogeng Wang, Xiaomao Yang, Ping Li, Zhiguo Li, Bin Luo, Yujie Liang, Xiaohua Pan

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 389-402 (2025)

Subject Terms: Medicine (General), Fracture repair, R5-920, QH573-671, Regeneration, Review, Extracellular vesicles, Exosomes, Cytology

Access URL: https://doaj.org/article/c5a941169a4a402683160ebe939b8624

A bibliometric analysis of the global status of platelet-rich plasma in regenerative medicine from 2004 to 2023

Authors: Siwen Zhang, Xudong Zhang, Haochen Zhang, Shengqing Zhang, Zichen Liu, Shanshan Wu, Yimeng Lu, Chao Han, Jichun Tan

Source: Regenerative Therapy, Vol 30, Iss, Pp 456-464 (2025)

Subject Terms: PRP, Medicine (General), R5-920, Platelet-rich plasma, Bibliometric analysis, QH573-671, Regenerative medicine, Cytology

Access URL: https://doaj.org/article/48d510368bae49b3b0d79f43c70d8939

The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling

Authors: Menghua Zhao, Yizhong Wu, Li Huang, Juanmei Wang, Aimin Zhang

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 321-332 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, GSK3β/β-catenin pathway, Hypoxic-ischemic encephalopathy, HUCB-Exo, Autophagy, Ferroptosis, Original Article, MFG-E8, Cytology

Access URL: https://doaj.org/article/6da000cb205145b2bba5677757cc34d2

Fabrication of Piezo1 protein encapsulated pressure-sensitive multifunctional hydrogel in modulating cellular response and wound healing in pressure ulcer conditions

Authors: Jing Ning, Feng Li, Zhi Xin Pei, Zhi Li

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 371-383 (2025)

Subject Terms: Piezo1 protein, Medicine (General), R5-920, QH573-671, Multifunctional hydrogel, Wound healing, Original Article, Cytology, Pressure ulcer

Access URL: https://doaj.org/article/5fc4424fb3774329962e8daf0944b353

Global research dynamics in the induced pluripotent stem cell and diabetes: A bibliometric analysis of the past twenty years

Authors: Jiatong Wang, Sirui Huang, Kaiyuan Li, Jing Li, Xin Huang

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 341-350 (2025)

Subject Terms: Medicine (General), iPSC, Disease modeling, Gene therapy, R5-920, QH573-671, Diabetes, Original Article, Cytology

Access URL: https://doaj.org/article/89360508bb74413f8dfb853d13cca72a

Generation of canine induced pluripotent stem cell-derived mesenchymal stem cells: Comparison of differentiation strategies and cell origins

Authors: Masaya Tsukamoto, Chiaki Kawabata, Kohei Shishida, Takumi Yoshida, Kazuto Kimura, Kazuya Edamura, Kikuya Sugiura, Shingo Hatoya

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 112-122 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, Induced pluripotent stem cell, Original Article, Veterinary regenerative medicine, Cytology, Neural crest cell, Canine, Mesenchymal stem cell

Access URL: https://doaj.org/article/3ec0b2806c62443eaf47b9cbae4b6649

Transplantation of adipose-derived stem cell aggregates via hydrogel microspheres that incorporate growth factors increases muscle strength

Authors: Tomohiro Abe, Emiko Tanaka Isomura, Toshie Kuwahara, Ryo Mitsui, Makoto Matsukawa, Kiyoko Nakagawa, Susumu Tanaka, Yasuhiko Tabata

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 299-308 (2025)

Subject Terms: Adipose-derived stem cells, Medicine (General), Cell aggregates, R5-920, QH573-671, Muscle strength, Stem cell transplantation, Original Article, Cytology

Access URL: https://doaj.org/article/b31327d5d25a4a5fa3671bfc9c448c6b

Comparative analysis of the use of autologous exosomes and platelet-derived growth factors in women with premature ovarian insufficiency and infertility: A prospective, randomized, observational, analytical study

Authors: Carmen Navarro, Pedro Torrecillas Cabrera, Alejandro Teppa Garrán

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 309-320 (2025)

Subject Terms: Medicine (General), R5-920, Ovarian regeneration, QH573-671, Autologous exosomes, Infertility, Platelet-derived growth factor, Ovarian insufficiency, Original Article, Cytology

Access URL: https://doaj.org/article/b4259b2af25643ca85ab1da98b3054af

Evaluation of the usage of more than 50 sheets of autologous cultured epidermis (JACE®) sheets in treating patients with severe burns beyond insurance coverage limits

Authors: Yoshimi Yashiro, Masukazu Inoie

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 415-420 (2025)

Subject Terms: Regenerative medical products, Medicine (General), R5-920, QH573-671, Autologous cultured epidermis, Insurance coverage, Severe burn, Usage survey, Cytology, Article

Access URL: https://doaj.org/article/3b9fdcf4606241e9a6759536a8d447f6

Rat adipose-derived mesenchymal stem cell-derived exosomes loaded with miR-375 promote neurite outgrowth and peripheral nerve regeneration via activation of Akt by targeting EPHA4

Authors: Zhiwei Liu, Yuanyuan Han, Chunjie Song

Source: Regenerative Therapy, Vol 30, Iss, Pp 491-502 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, Peripheral nerve injury, Akt, Adipose-derived mesenchymal stem cells, EPHA4, Exosomes, Cytology, miR-375

Access URL: https://doaj.org/article/9b35987cc7ea459fb0e7d55a6c9618a6

Assessment of the official national insurance coverage of regenerative medical products for ophthalmic diseases in Japan following regulatory approval

Authors: Kenichi Kimura, Kojiro Imai, Morio Ueno, Chie Sotozono

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 384-388 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, Central Social Insurance Medical Council in Japan, Regulatory approval, Insurance coverage, Ophthalmic regenerative medical products, Cytology, Article

Access URL: https://doaj.org/article/7938f9847ad54e119ad9eea8799c1b90

Human growth hormone-overexpressing adipose-derived stem cells enhance fibroblast activity and accelerate burn wound healing via ERK pathway therapeutic potential of ADSCs in burn wound repair

Authors: Yang Shao, Mei Han, Guodong Song, Cong Gao

Source: Regenerative Therapy, Vol 30, Iss, Pp 465-475 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, Adipose-derived mesenchymal stem cells, ERK pathway, Burns, Cytology, Growth hormone, Wound repair

Access URL: https://doaj.org/article/c1c92f1bca1e45efbbb4be63c1c12de4

Tracking adipose-derived mesenchymal stromal cells in the eye: Integrating IVIS imaging and Alu PCR for enhanced detection of human cells

Authors: Robert M. Rusch, Emi Inagaki, Kentaro Ago, Tetsu Yoshida, Yui Ueno, Hidenori Nonaka, Hideyuki Okano, Masaya Nakamura, Shigeto Shimmura

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 333-338 (2025)

Subject Terms: Medicine (General), Cell tracking, R5-920, QH573-671, Adipose mesenchymal stem cells (adMSCs), In vivo imaging system (IVIS), Original Article, Cell transplantation, Cytology, Bioluminescence imaging (BLI)

Access URL: https://doaj.org/article/93b20553bf3f47d0912a353bacd254ab

Subretinal suspensions of hiPSC-derived retinal pigment epithelium cells form functional monolayers in NOD-SCID mice facilitating treatment of advanced retinal diseases

Authors: Xiaojing Song, Guanjie Gao, Ke Ye, Ping Xu, Yuan Wang, Suai Zhang, Dandan Zheng, Jian Ge, Xiufeng Zhong

Source: Regenerative Therapy, Vol 30, Iss, Pp 503-514 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, Age-related macular degeneration, Monolayer, Human induced pluripotent stem cells, Cytology, Retinal pigment epithelium, Cell therapy

Access URL: https://doaj.org/article/513aaa3f0ed64f04bcd8d2d36cd8072e

The role of telomeres in leukemic stem cells function

Authors: Raheleh Farahzadi, Behnaz Valipour, Ezzatollah Fathi, Sakhavat Abolhasani

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 351-357 (2025)

Subject Terms: Medicine (General), Telomere length, R5-920, QH573-671, Therapeutic approaches, Telomerase enzyme, Review, Cytology, Leukemic stem cells

Access URL: https://doaj.org/article/a20300accaa942c9aebc9a113f16a9d2

Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands

Authors: Takashi I, Riho Kanai, Makoto Seki, Hideki Agata, Hideaki Kagami, Hiroshi Murata, Izumi Asahina, Simon D. Tran, Yoshinori Sumita

Source: Regenerative Therapy, Vol 30, Iss, Pp 476-490 (2025)

Subject Terms: Medicine (General), R5-920, QH573-671, Cytology

Access URL: https://doaj.org/article/f94ada4562dd4ac7ad53567b35814ac1

Current challenges and future directions of ATMPs in regenerative medicine

Authors: Fatemeh Abbasi Kakroodi, Elaheh Khodadoust, Marzieh Alizadeh, Reyhaneh Sadat Hayaei Tehrani, Pedram Asadi Sarabi, Mohammad Rahmanian, Massoud Vosough

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 358-370 (2025)

Subject Terms: Medicine (General), Advanced therapy medicinal product, ATMPs challenges, R5-920, QH573-671, Manufacturing challenges, Translational medicine, Review, Cytology

Access URL: https://doaj.org/article/dc66e477351b4741a3eb2745e554a3e6

Mesenchymal stem cell application in Alzheimer's disease

Authors: Qianying Feng, Fengxia Chen, Rui Liu, Dan Li, Huigen Feng, Junzheng Yang

Source: Regenerative Therapy, Vol 30, Iss, Pp 439-445 (2025)

Subject Terms: Underlying mechanisms, Preclinical application, Medicine (General), R5-920, QH573-671, Mesenchymal stem cells, Alzheimer's disease, Clinical applications, Cytology

Access URL: https://doaj.org/article/b5b3f8a150284a1b9f93c82c93a844d4

Tangeretin suppresses RANKL-induced osteoclastogenesis and alleviates postmenopausal osteoporosis by inhibiting Notch signaling

Authors: Tengfei Wu, Fang Wang, Changqing Ai, Li Li, Fan Wu

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 136-143 (2025)

Subject Terms: Medicine (General), Postmenopausal osteoporosis, R5-920, QH573-671, Osteoclast differentiation, TGN, Original Article, Cytology, Notch signaling

Access URL: https://doaj.org/article/7e6d3f2ea100400db190cfe3f084f2bc

Platelet rich plasma promotes cell migration of adipose-derived stem cells by up-regulation of focal adhesion kinase and paxillin

Authors: Karis Chen, Yen-Chia Chen, Tung-Yang Yu, Li-Ping Lin, Hung-Chih Hsu, Yu-Cih Liao, Jong-Hwei Su Pang, Wen-Chung Tsai

Source: Regen Ther
Regenerative Therapy, Vol 30, Iss, Pp 9-19 (2025)

Subject Terms: Adipose-derived stem cells, Medicine (General), R5-920, QH573-671, Focal adhesion kinase, Original Article, Platelet rich plasma, Paxillin, Cytology, Migration, Actin

Access URL: https://doaj.org/article/c21c5e21344c496699b47f1b9b128209