ARNTL2 regulated the oncogene c-myc and promoted the progression of esophageal cancer through activatingANXA2transcription .

Συγγραφείς: Qin Y; Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.; Department of Pathology, Bengbu Medical University, Bengbu, China.; Department of Pathology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China., Ci H; Department of Pathology, Bengbu Medical University, Bengbu, China., Wang Z; Department of Pathology, Bengbu Medical University, Bengbu, China., Zhang Y; Department of Pathology, Bengbu Medical University, Bengbu, China., Xu X; Department of Pathology, Bengbu Medical University, Bengbu, China., Wu Q; Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.; Department of Pathology, Anhui Medical University, Hefei, China.

Πηγή: Cancer biology & therapy [Cancer Biol Ther] 2025 Dec 31; Vol. 26 (1), pp. 2574544. Date of Electronic Publication: 2025 Nov 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137842 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-8576 (Electronic) Linking ISSN: 15384047 NLM ISO Abbreviation: Cancer Biol Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Esophageal Neoplasms*/pathology , Esophageal Neoplasms*/genetics , Esophageal Neoplasms*/metabolism , Annexin A2*/genetics , Annexin A2*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism, Humans ; Animals ; Mice ; Gene Expression Regulation, Neoplastic ; Disease Progression ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Mice, Inbred BALB C ; Cell Line, Tumor ; Male ; Female ; Mice, Nude ; Cell Movement ; Promoter Regions, Genetic ; Middle Aged

ICAT drives lactylation of tumor-associated macrophages via the c-Myc-ENO1 axis to promote cervical cancer progression.

Συγγραφείς: Dang T; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., You Y; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Wei L; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Li Q; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Sun H; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Sun M; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Li X; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Yang S; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Zeng T; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Zhang L; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., He X; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Wang K; Department of Clinical Laboratory, Yongchuan District People's Hospital, Chongqing, 402160, China., Tang J; Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing, 404120, China. Electronic address: 20160010@cqtgmc.edu.cn., Zhang Y; Key Laboratory of Medical Diagnostics of Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China. Electronic address: yanzhang@cqmu.edu.cn.

Πηγή: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 16; Vol. 241, pp. 316-329. Date of Electronic Publication: 2025 Sep 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/metabolism , Uterine Cervical Neoplasms*/immunology , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/pathology , Tumor-Associated Macrophages*/immunology , Tumor Suppressor Proteins*/genetics , Tumor Suppressor Proteins*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Phosphopyruvate Hydratase*/genetics , Phosphopyruvate Hydratase*/metabolism, Humans ; Female ; Tumor Microenvironment ; Animals ; Mice ; Glycolysis ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Movement ; Biomarkers, Tumor

Gold-palladium composite nanomaterial dual-amplification-assisted sensitive electrochemical immunosensor for c-Myc protein detection.

Συγγραφείς: Si M; Key Laboratory of the Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China., Han G; School of Medicine, Southeast University, Nanjing, 210009, China., Liu T; Key Laboratory of the Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China., Wang X; Key Laboratory of the Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China. wxy@seu.edu.cn.

Πηγή: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2025 Dec; Vol. 417 (29), pp. 6679-6691. Date of Electronic Publication: 2025 Nov 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Gold*/chemistry , Proto-Oncogene Proteins c-myc*/analysis , Proto-Oncogene Proteins c-myc*/blood , Electrochemical Techniques*/methods , Palladium*/chemistry , Biosensing Techniques*/methods, Humans ; Limit of Detection ; Immunoassay/methods ; Graphite/chemistry ; Reproducibility of Results ; Lymphoma/diagnosis ; Metal Nanoparticles/chemistry ; Nanocomposites/chemistry

Mechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.

Συγγραφείς: Zhou R; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China., Wang X; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China., Jin Y; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China., Chen B; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China., Liu H; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China., Zhao X; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China., Jing D; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China. Electronic address: dg142625@163.com., Zhao B; Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China. Electronic address: zzbb3737@126.com.

Πηγή: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 457-471. Date of Electronic Publication: 2025 Aug 22.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lidocaine*/pharmacology , Lidocaine*/adverse effects , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/genetics , Intervertebral Disc Degeneration*/chemically induced , Intervertebral Disc Degeneration*/drug therapy , DNA Breaks, Double-Stranded*/drug effects , Reactive Oxygen Species*/metabolism , Tumor Suppressor Protein p53*/metabolism , Tumor Suppressor Protein p53*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics, Animals ; Cellular Senescence/drug effects ; Mice ; Nucleus Pulposus/drug effects ; Nucleus Pulposus/metabolism ; Nucleus Pulposus/pathology ; Male ; Humans ; Oxidative Stress/drug effects ; Cells, Cultured ; Disease Models, Animal ; Signal Transduction/drug effects ; Anesthetics, Local ; Intervertebral Disc/drug effects ; Intervertebral Disc/pathology ; Intervertebral Disc/metabolism

PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein.

Συγγραφείς: Zhou H; General Surgery Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China., Wang Y; Gastrointestinal Surgery Department, Tangshan Central Hospital, Tangshan, Hebei, China., Wang D; Anesthesiology Department, Nanjing Chest Hospital, Nanjing, Jiangsu, China., Zhang M; General Surgery Department. II, Tangshan Nanhu Hospital, Tangshan, Hebei, China., Wang K; Geriatrics Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China., Liu C; General Surgery Department, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.

Πηγή: Epigenetics [Epigenetics] 2025 Dec; Vol. 20 (1), pp. 2509044. Date of Electronic Publication: 2025 May 22.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2308 (Electronic) Linking ISSN: 15592294 NLM ISO Abbreviation: Epigenetics Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein-Arginine N-Methyltransferases*/genetics , Protein-Arginine N-Methyltransferases*/metabolism , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/immunology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Arginine*/metabolism , Repressor Proteins*/genetics , Repressor Proteins*/metabolism, Humans ; Methylation ; Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Immune Evasion ; Tumor Escape ; Cell Movement

An Integrative Drug-Induced Transcriptomic Analysis Identifies Novel MYC Antagonists and Potential Synergistic Drug Combinations.

Συγγραφείς: Aceto A; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA., Wang Y; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA., Yang D; Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA.; Department of Computational and System Biology, University of Pittsburgh, Pittsburgh, USA.

Πηγή: Molecular carcinogenesis [Mol Carcinog] 2025 Dec; Vol. 64 (12), pp. 2052-2062. Date of Electronic Publication: 2025 Sep 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proto-Oncogene Proteins c-myc*/antagonists & inhibitors , Proto-Oncogene Proteins c-myc*/genetics , Gene Expression Regulation, Neoplastic*/drug effects , Transcriptome*/drug effects , Neoplasms*/genetics , Neoplasms*/drug therapy , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Antineoplastic Agents*/pharmacology, Humans ; Drug Synergism ; Gene Expression Profiling/methods ; Doxycycline/pharmacology ; Cell Line, Tumor

Targeting the BCKDK/BCLAF1/MYC/HK2 axis to alter aerobic glycolysis and overcome Trametinib resistance in lung cancer.

Συγγραφείς: Wu H; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China., Yang J; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China., Yang Z; Department of Medical Laboratory, Tianjin Hospital, Tianjin University, Jiefang Nan Road 406, Hexi District, Tianjin, 300211, China., Xiao Y; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China., Liu R; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China., Jia J; Kangzhe Pharmaceutical Technology Development Company, Ltd., Tianjin, 300110, China., Zhang X; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China., Zhang Y; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China., Fu Z; Kangzhe Pharmaceutical Technology Development Company, Ltd., Tianjin, 300110, China. fuzhengcn@vip.sina.com., Yao Z; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China. yaozhi@tmu.edu.cn., Lv J; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, 300070, China. lvjunqiang@tmu.edu.cn.

Πηγή: Cell death and differentiation [Cell Death Differ] 2025 Dec; Vol. 32 (12), pp. 2210-2224. Date of Electronic Publication: 2025 May 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Drug Resistance, Neoplasm*/drug effects , Pyridones*/pharmacology , Pyridones*/therapeutic use , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Hexokinase*/metabolism , Pyrimidinones*/pharmacology , Pyrimidinones*/therapeutic use , Repressor Proteins*/metabolism, Humans ; Glycolysis/drug effects ; Cell Line, Tumor ; Mice ; Animals ; Gene Expression Regulation, Neoplastic/drug effects

MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes.

Συγγραφείς: Li S; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China., Yang C; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China., Li J; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China., Liu Z; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China., Gong F; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China., Ke X; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China., Ruan GX; Department of Basic Medicine and Medical Laboratory Science, School of Medicine, Taizhou University, Taizhou, 318000, Zhejiang, China. ruangx@tzc.edu.cn., Huang H; Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, 330115, China. huanghengjun@itcmhi.ac.cn.; Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, 330115, China. huanghengjun@itcmhi.ac.cn.

Πηγή: Scientific reports [Sci Rep] 2025 Nov 28; Vol. 15 (1), pp. 42598. Date of Electronic Publication: 2025 Nov 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): B-Lymphocytes*/metabolism , B-Lymphocytes*/immunology , RNA Splicing Factors*/genetics , RNA Splicing Factors*/metabolism , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Lymphocyte Activation*/genetics , RNA Splicing*, Animals ; Mice ; Germinal Center/metabolism ; Germinal Center/cytology ; Germinal Center/immunology ; E2F1 Transcription Factor/metabolism ; E2F1 Transcription Factor/genetics ; Alternative Splicing ; Spliceosomes/genetics ; Spliceosomes/metabolism ; Promoter Regions, Genetic ; Gene Expression Regulation

AlphaFold-Guided Discovery of an Overlapping MYC/Miz-1 Interface Enables Peptidomimetic Disruption of MYC/MAX.

Συγγραφείς: Ellenbroek BD; Leiden University, Leiden, 2333 CC, The Netherlands.; Oncode Institute, Utrecht, 3521 AL, The Netherlands., Tirtosentono ASS; Leiden University, Leiden, 2333 CC, The Netherlands., Pomplun SJ; Leiden University, Leiden, 2333 CC, The Netherlands.; Oncode Institute, Utrecht, 3521 AL, The Netherlands.

Πηγή: ChemMedChem [ChemMedChem] 2025 Nov 28; Vol. 20 (23), pp. e202500740. Date of Electronic Publication: 2025 Oct 26.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Peptidomimetics*/chemistry , Peptidomimetics*/pharmacology , Peptidomimetics*/chemical synthesis , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/chemistry , Proto-Oncogene Proteins c-myc*/antagonists & inhibitors , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/chemistry , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/antagonists & inhibitors, Humans ; Protein Binding/drug effects ; Binding Sites ; Kruppel-Like Transcription Factors

Highly Specific Inhibition of c-Myc Oncogene Expression through Shifting the G-Quadruplex toward a Triplex Structure.

Συγγραφείς: Lisowiec-Wąchnicka J, Zielińska K, Pasternak A

Πηγή: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24424-24435. Date of Electronic Publication: 2025 Nov 12.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): G-Quadruplexes*/drug effects , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/antagonists & inhibitors , Proto-Oncogene Proteins c-myc*/metabolism , DNA*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Oligonucleotides*/pharmacology , Oligonucleotides*/chemistry, Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Structure-Activity Relationship

Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC.

Συγγραφείς: Rosen HT; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA., Li K; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA., Stieger CE; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA., Li EL; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA., Currier B; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA., Brittain SM; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Garcia FJ; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Beard DC; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Jones MD; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Haenni-Holzinger S; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Dovala D; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., McKenna JM; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Schirle M; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.; Novartis Biomedical Research, Emeryville, CA, USA.; Novartis Biomedical Research, Cambridge, MA, USA.; Novartis Biomedical Research, Basel, Switzerland., Maimone TJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA., Nomura DK; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, Berkeley, CA, 94720, USA.; Novartis-Berkeley Translational Chemical Biology Institute, Berkeley, CA, 94720, USA.

Πηγή: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 24; Vol. 64 (48), pp. e202508518. Date of Electronic Publication: 2025 Sep 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/antagonists & inhibitors , Proto-Oncogene Proteins c-myc*/genetics , Aziridines*/chemistry , Aziridines*/pharmacology, Humans ; Stereoisomerism ; Cell Line, Tumor ; Molecular Structure

Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation.

Συγγραφείς: Eskandari N; Department of Cell and Molecular Pharmacology & Experimental Therapeutics; Medical University South Carolina, Charleston, SC, USA., Delisi D; Department of Cell and Molecular Pharmacology & Experimental Therapeutics; Medical University South Carolina, Charleston, SC, USA., O'Neil R; Department of Microbiology and Immunology, Medical University South Carolina, Charleston, SC, USA.; Ralph H Johnson VA Medical Center, Charleston, SC, USA., Bocchetta M; Cancer Biology Department, Loyola University Chicago, Maywood, IL, USA., Gentile S; Department of Cell and Molecular Pharmacology & Experimental Therapeutics; Medical University South Carolina, Charleston, SC, USA. gentilsa@musc.edu.

Πηγή: Communications biology [Commun Biol] 2025 Nov 20; Vol. 8 (1), pp. 1615. Date of Electronic Publication: 2025 Nov 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , ERG1 Potassium Channel*/metabolism , ERG1 Potassium Channel*/genetics , ERG1 Potassium Channel*/agonists , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics, Humans ; Proteolysis ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Mice ; Adenocarcinoma of Lung/metabolism ; A549 Cells ; Gene Expression Regulation, Neoplastic ; Ether-A-Go-Go Potassium Channels

MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1.

Συγγραφείς: Wu X; Jinan University, Guangzhou, Guangdong, China.; Department of Nephrology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China., Liu L; Department of Nephrology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China., Zhao R; Department of Nephrology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China., Chen W; Jinan University, Guangzhou, Guangdong, China. 3902666150@qq.com.; Department of Nephrology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China. 3902666150@qq.com.

Πηγή: Immunologic research [Immunol Res] 2025 Nov 15; Vol. 73 (1), pp. 166. Date of Electronic Publication: 2025 Nov 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): GTP Phosphohydrolases*/metabolism , GTP Phosphohydrolases*/genetics , Mitochondria*/metabolism , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Glomerulonephritis, IGA*/metabolism , Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/immunology , Glomerulonephritis, IGA*/genetics, Humans ; Animals ; Ubiquitination ; Mice ; Proteolysis ; Male ; Mitochondrial Membrane Transport Proteins

MYC amplification and MYC protein expression are poor prognostic markers in pediatric and young adult osteosarcoma.

Συγγραφείς: Nagy MR; Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA., Puopolo O; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA., Alston E; Harvard Medical School, Boston, Massachusetts, USA.; Department of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA., Challa S; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Ceca E; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA., Li Y; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Cherniack AD; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Lazo de la Vega L; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA., Meyerson M; Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Church AJ; Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA., Janeway K; Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

Πηγή: Cancer [Cancer] 2025 Nov 15; Vol. 131 (22), pp. e70161.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Osteosarcoma*/genetics , Osteosarcoma*/pathology , Osteosarcoma*/mortality , Osteosarcoma*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Gene Amplification* , Bone Neoplasms*/genetics , Bone Neoplasms*/pathology , Bone Neoplasms*/mortality , Bone Neoplasms*/metabolism , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism, Humans ; Female ; Adolescent ; Child ; Male ; Prognosis ; Young Adult ; Adult ; Kaplan-Meier Estimate

MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-cell and Immunotherapy Responses in Prostate Cancer.

Συγγραφείς: Murphy KC; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., DeMarco KD; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Zhou L; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Peura J; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts.; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Giwa HK; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Lopez-Diaz Y; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Ho YJ; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Li J; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Bai S; Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts., Simin K; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Zhu LJ; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts.; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Pitarresi JR; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts.; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Mercurio AM; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Ruscetti M; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts.; Immunology and Microbiology Program, University of Massachusetts Chan Medical School, Worcester, Massachusetts.; Cancer Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts.

Πηγή: Cancer research [Cancer Res] 2025 Nov 14; Vol. 85 (22), pp. 4359-4379.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , Vascular Endothelial Growth Factor A*/metabolism , Vascular Endothelial Growth Factor A*/genetics , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , T-Lymphocytes, Cytotoxic*/immunology , T-Lymphocytes, Cytotoxic*/metabolism , Prostatic Neoplasms, Castration-Resistant*/immunology , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/pathology , Prostatic Neoplasms, Castration-Resistant*/therapy, Male ; Animals ; Mice ; Humans ; Immunotherapy/methods ; Signal Transduction ; Tumor Microenvironment/immunology ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Cell Line, Tumor

The MYC-dependent lncRNA MB3 inhibits apoptosis in Group 3 Medulloblastoma by regulating the TGF-β pathway via HMGN5.

Συγγραφείς: Grandioso A; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy., Tollis P; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Rome, Italy., Pellegrini FR; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy., Falvo E; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy., Palma A; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy., Migliaccio F; Department of Electrical Engineering and Information Technology, University Federico II, Naples, Italy.; Institute for Applied Mathematics 'Mauro Picone', National Research Council of Italy, Naples, Italy., Belvedere A; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy., Rea J; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Rome, Italy., Tisci G; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy.; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy., Carissimo A; Institute for Applied Mathematics 'Mauro Picone', National Research Council of Italy, Naples, Italy., Bozzoni I; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Rome, Italy., Trisciuoglio D; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy., Ballarino M; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy., Ceci P; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy., Laneve P; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy. pietro.laneve@cnr.it.; Institute of Molecular Biology and Pathology, National Research Council of Italy, Rome, Italy. pietro.laneve@cnr.it.

Πηγή: Cell death & disease [Cell Death Dis] 2025 Nov 06; Vol. 16 (1), pp. 800. Date of Electronic Publication: 2025 Nov 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Medulloblastoma*/genetics , Medulloblastoma*/pathology , Medulloblastoma*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Apoptosis*/genetics , Apoptosis*/drug effects , Transforming Growth Factor beta*/metabolism , Transforming Growth Factor beta*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Cerebellar Neoplasms*/genetics , Cerebellar Neoplasms*/pathology , Cerebellar Neoplasms*/metabolism, Humans ; Animals ; Cell Line, Tumor ; Signal Transduction ; Mice ; Gene Expression Regulation, Neoplastic

Phosphorylation of c-Myc at Ser62 via the protein kinase activity of acetaldehyde dehydrogenase 18A1 promotes tumor growth.

Συγγραφείς: Wang D; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China., Wang XY; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Li WJ; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Liang CH; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Zou YX; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Xiao JW; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Kang QM; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China., Wang JH; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Mao L; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Chen JJ; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Zhai XJ; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Zhuang JT; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Yang XY; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China., Jiang HY; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Shen TH; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Liu J; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China., Wen Q; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China., Duan JJ; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China., Wang J; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China., Yu SC; Department of Stem Cell and Regenerative Medicine, International Joint Research Center for Precision Biotherapy, Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital (Southwest Hospital) of Army Medical University. Chongqing 400038, China; Jin-feng Laboratory, Chongqing 401329, China. Electronic address: yushicang@163.com.

Πηγή: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Nov 05; Vol. 33 (11), pp. 5860-5882. Date of Electronic Publication: 2025 Aug 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/chemistry , Neoplasms*/metabolism , Neoplasms*/pathology , Neoplasms*/genetics , Aldehyde Oxidoreductases*/metabolism , Aldehyde Oxidoreductases*/genetics , Aldehyde Dehydrogenase*/metabolism , Aldehyde Dehydrogenase*/genetics, Humans ; Phosphorylation ; Animals ; Mice ; Cell Line, Tumor ; Serine/metabolism ; Cell Proliferation

Ionizing radiation leads to exosome secretion in macrophages through MYC-mediated pathways.

Συγγραφείς: Lee H; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, Republic of Korea., Jeong GH; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, Republic of Korea., Kim GJ; Department of Biological Sciences and Research Center of Ecomimetics, College of Natural Science, Chonnam National University, Gwangju, Republic of Korea., Lee SS; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, Republic of Korea.; Department of Radiation Science, University of Science and Technology (UST), Daejeon, Republic of Korea., Chung BY; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, Republic of Korea., Bai HW; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, Republic of Korea.; Department of Radiation Science, University of Science and Technology (UST), Daejeon, Republic of Korea.

Πηγή: PloS one [PLoS One] 2025 Nov 05; Vol. 20 (11), pp. e0336322. Date of Electronic Publication: 2025 Nov 05 (Print Publication: 2025).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Exosomes*/metabolism , Exosomes*/radiation effects , Macrophages*/metabolism , Macrophages*/radiation effects , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Radiation, Ionizing*, Mice ; Animals ; Signal Transduction/radiation effects ; Myosin Heavy Chains/metabolism ; Myosin Heavy Chains/genetics ; Gamma Rays ; Cardiac Myosins/metabolism ; Cardiac Myosins/genetics ; Humans ; ErbB Receptors/metabolism

C-Myc Indirectly Controls ATP13A2 Levels via HIF-1α Activation.

Συγγραφείς: Tiryakiler AB; Molecular Biology-Genetics and Biotechnology, Graduate School, Istanbul Technical University, Istanbul, Turkey., Temizci B; Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey., Karabay A; Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.

Πηγή: Journal of neurochemistry [J Neurochem] 2025 Nov; Vol. 169 (11), pp. e70296.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/genetics , Proton-Translocating ATPases*/metabolism , Proton-Translocating ATPases*/genetics , Proton-Translocating ATPases*/biosynthesis , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics, Humans

NF1 Mutated Gastrointestinal Stromal Tumors With Coamplification of MDM2 and MYC.

Συγγραφείς: Chen X; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China., Lu Y; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China., He X; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China., He D; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China., Chen M; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China., Zhang H; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.

Πηγή: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2025 Nov; Vol. 64 (11), pp. e70096.

Τύπος έκδοσης: Journal Article; Case Reports

Στοιχεία περιοδικού: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9007329 Publication Model: Print Cited Medium: Internet ISSN: 1098-2264 (Electronic) Linking ISSN: 10452257 NLM ISO Abbreviation: Genes Chromosomes Cancer Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Gastrointestinal Stromal Tumors*/genetics , Gastrointestinal Stromal Tumors*/pathology , Proto-Oncogene Proteins c-mdm2*/genetics , Proto-Oncogene Proteins c-mdm2*/metabolism , Neurofibromin 1*/genetics , Proto-Oncogene Proteins c-myc*/genetics , Proto-Oncogene Proteins c-myc*/metabolism , Gastrointestinal Neoplasms*/genetics , Gastrointestinal Neoplasms*/pathology, Humans ; Male ; Middle Aged ; Mutation ; Anoctamin-1 ; Neoplasm Proteins