A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases.

Συγγραφείς: Feng ZW; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Zeng T; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Shu Q; Department of Pharmacy, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China., Li XZ; Department of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, China., Yu HG; Department of Rheumatology and Immunology, Children's Hospital of Nanjing Medical University, Nanjing, China., Dai W; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Liu XC; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Tian XJ; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Xu F; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Li H; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Zhou YL; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Zhang SD; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Li LL; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Chen NN; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Liu XY; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Liu ZW; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Yin J; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Shen HT; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Che CC; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Chen MR; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China., Wang DD; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China., Sun LY; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China. lingyunsun@nju.edu.cn., Xiao YB; State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, China. yibei.xiao@cpu.edu.cn.; Chongqing Innovation Institute, China Pharmaceutical University, Chongqing, China. yibei.xiao@cpu.edu.cn., You QD; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. youqd@163.com.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China. youqd@163.com., Xu XL; Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. xuxiao_li@126.com.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China. xuxiao_li@126.com.

Πηγή: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Aug 04; Vol. 11 (1). Date of Electronic Publication: 2026 Aug 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Membrane Proteins*/genetics , Membrane Proteins*/chemistry , Membrane Proteins*/antagonists & inhibitors , Autoimmune Diseases*/genetics , Autoimmune Diseases*/drug therapy , Autoimmune Diseases*/pathology , Protein Multimerization*/drug effects , Protein Multimerization*/genetics , Inflammation*/genetics , Inflammation*/drug therapy , Inflammation*/pathology, Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/pathogenicity ; Interferon Type I/genetics ; STING Protein ; Humans ; Animals ; Mice ; cGAS-STING Signaling Pathway

Heterogeneous structural and pathogenic properties of transthyretin dimeric variants.

Συγγραφείς: Si JB; Department of New Biology, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Bak HS; Department of New Biology, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Kim HY; Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute (KBSI), Cheongju, Republic of Korea., Park J; Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute (KBSI), Cheongju, Republic of Korea., Cha S; Center for Protein Structure and Drug Mechanism Research, Korea Basic Science Institute (KBSI), Cheongju, Republic of Korea., Ko YH; Center for van der Waals Quantum Solids, Institute for Basic Science (IBS), Pohang, Republic of Korea., Dağ Ç; Nanofabrication and Nanocharacterization Center for Scientific and Technological Advanced Research (n2STAR), Koc University, Istanbul, Turkiye., Ji S; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Yu W; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Kim JH; Department of New Biology, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea; New Biology Research Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea. Electronic address: jinhaekim@dgist.ac.kr.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Oct 22; Vol. 836, pp. 154561. Date of Electronic Publication: 2026 Sep 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Prealbumin*/chemistry , Prealbumin*/genetics , Prealbumin*/metabolism , Amyloid Neuropathies, Familial*/genetics , Amyloid Neuropathies, Familial*/metabolism , Amyloid Neuropathies, Familial*/pathology , Protein Multimerization*, Humans ; Scattering, Small Angle ; X-Ray Diffraction ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related

A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization inhibitor.

Συγγραφείς: Ravishankar V; Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS, UMR 7255 - Aix-Marseille Université, Marseille, France., Borges-Araújo L; Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.; Centre Blaise Pascal de Simulation et de Modélisation Numérique, Ecole Normale Supérieure de Lyon, Lyon, France., Rajendran M; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Lafargue E; U1325 Aix-Marseille Université, INSERM, DyNaMo, Turing Centre for Living System, Marseille, France., Byrne D; Biomass and Protein Engineering Aix-Marseille Université, CNRS, IMM UAR2044, Marseille, France., Buzhinsky N; U1325 Aix-Marseille Université, INSERM, DyNaMo, Turing Centre for Living System, Marseille, France., Wolfe MS; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Fitzgerald W; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Bautista NA; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Beyene BG; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Larimi MG; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Duneau JP; Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS, UMR 7255 - Aix-Marseille Université, Marseille, France., Sturgis J; Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS, UMR 7255 - Aix-Marseille Université, Marseille, France., Bezrukov SM; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Casuso I; U1325 Aix-Marseille Université, INSERM, DyNaMo, Turing Centre for Living System, Marseille, France., Rostovtseva TK; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States., Bergdoll L; Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS, UMR 7255 - Aix-Marseille Université, Marseille, France.

Πηγή: ELife [Elife] 2026 Oct 09; Vol. 15. Date of Electronic Publication: 2026 Oct 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Voltage-Dependent Anion Channel 1*/metabolism , Voltage-Dependent Anion Channel 1*/antagonists & inhibitors , Voltage-Dependent Anion Channel 1*/chemistry , Protein Multimerization*/drug effects , Mitochondrial Membranes*/drug effects , Mitochondrial Membranes*/metabolism, Humans ; HeLa Cells ; Microscopy, Atomic Force

Polymorphic structures of rapidly twisting 40-residue amyloid-β fibrils.

Συγγραφείς: Larimi MG; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA., Thurber KR; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA., Tycko R; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Electronic address: robertty@mail.nih.gov.

Πηγή: Biophysical journal [Biophys J] 2026 Oct 06; Vol. 125 (19), pp. 5526-5541. Date of Electronic Publication: 2026 Aug 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Amyloid beta-Peptides*/chemistry , Peptide Fragments*/chemistry , Amyloid*/chemistry , Protein Multimerization*, Models, Molecular ; Cryoelectron Microscopy ; Protein Conformation

Coarse-grained simulation studies of gasdermin self-assembly and pore formation.

Συγγραφείς: Jiang X; 2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, P.R. China; Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P.R. China., Farrell JD; Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P.R. China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P.R. China; Songshan Lake Materials Laboratory, Dongguan, Guangdong 523808, P.R. China. Electronic address: farrelljd@iphy.ac.cn., Jiao F; Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P.R. China., Dobnikar J; Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P.R. China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P.R. China; Wenzhou Institute of the University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, P.R. China; Faculty for Mathematics and Physics, University of Ljubljana, Ljubljana, Slovenia.

Πηγή: Biophysical journal [Biophys J] 2026 Oct 06; Vol. 125 (19), pp. 5482-5493. Date of Electronic Publication: 2026 Aug 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Molecular Dynamics Simulation* , Protein Multimerization*, Kinetics ; Porosity ; Protein Conformation

A biased allosteric modulator is a molecular glue for β2AR dimerization.

Συγγραφείς: Shen J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Peddada TN; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Komolov KE; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., De Pascali F; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Garces AM; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Ehsan M; Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea., Chae PS; Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea., Lerch MT; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA., Benovic JL; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Xu J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. xuj8@sustech.edu.cn.; Department of Medical Neuroscience, SUSTech Homeostatic Medicine Institute, School of Medicine, Institute for Biology Electron Microscopy, Southern University of Science and Technology, Shenzhen, China. xuj8@sustech.edu.cn., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.

Πηγή: Nature [Nature] 2026 Oct; Vol. 658 (8135), pp. 556-564. Date of Electronic Publication: 2026 Aug 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Adrenergic, beta-2*/chemistry , Receptors, Adrenergic, beta-2*/metabolism , Receptors, Adrenergic, beta-2*/ultrastructure , Protein Multimerization*/drug effects , Cryoelectron Microscopy*, Allosteric Regulation/drug effects ; beta-Arrestins/metabolism ; beta-Arrestins/chemistry ; Signal Transduction/drug effects ; Models, Molecular ; Humans ; Animals ; Ligands ; HEK293 Cells

Oligomer-dependent heme-binding to human peroxiredoxin 1.

Συγγραφείς: Uchida T; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-8628, Japan. Electronic address: uchida@sci.hokudai.ac.jp., Osawa H; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-8628, Japan., Ishimori K; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan; Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-8628, Japan.

Πηγή: International journal of biological macromolecules [Int J Biol Macromol] 2026 Oct; Vol. 377, pp. 153693. Date of Electronic Publication: 2026 Jul 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Peroxiredoxins*/metabolism , Peroxiredoxins*/chemistry , Heme*/metabolism , Heme*/chemistry , Protein Multimerization*, Hydrogen Peroxide/metabolism ; Hydrogen Peroxide/chemistry ; Humans ; Protein Binding ; Oxidation-Reduction

Regulation of HIV-2 Vpx/Vpr expression by the poly-proline motif: Enhancement of protein dimerization and translation.

Συγγραφείς: Nakamura Y; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Ahagon-Edamura A; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Koga R; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Shimagaki K; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Uesugi M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Fujino H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Beyri B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Arakaki Y; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Ciftci H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan; Department of Molecular Biology and Genetics, Burdur Mehmet Akif Ersoy University, Burdur, 15200, Turkey; Research and Development, Science Farm Ltd., Kumamoto, 862-0976, Japan., Masunaga T; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan., Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan; Research and Development, Science Farm Ltd., Kumamoto, 862-0976, Japan., Yamaguchi Y; Environmental Safety Center, Kumamoto University, Kumamoto, 860-8555, Japan., Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan; Department of Molecular Biology and Genetics, Burdur Mehmet Akif Ersoy University, Burdur, 15200, Turkey. Electronic address: mfujita@kumamoto-u.ac.jp.

Πηγή: Virology [Virology] 2026 Oct; Vol. 623, pp. 111016. Date of Electronic Publication: 2026 Jun 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Viral Regulatory and Accessory Proteins*/genetics , Viral Regulatory and Accessory Proteins*/metabolism , Viral Regulatory and Accessory Proteins*/chemistry , HIV-2*/genetics , HIV-2*/physiology , HIV-2*/metabolism , vpr Gene Products, Human Immunodeficiency Virus*/genetics , vpr Gene Products, Human Immunodeficiency Virus*/metabolism , vpr Gene Products, Human Immunodeficiency Virus*/chemistry , Peptides*/metabolism , Peptides*/genetics , Peptides*/chemistry , Protein Multimerization* , Gene Expression Regulation, Viral* , Protein Biosynthesis*, Macrophages/virology ; Humans ; Amino Acid Motifs ; Cell Line ; Virus Replication

Synthetic FLS2 receptor oligomer boosts plant innate immunity.

Συγγραφείς: Ma Z; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Yazhouwan National Laboratory, Sanya 572024, Hainan, China., Xie Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Zhu X; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Chng CP; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Liang Q; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Huang C; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Miao Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, Singapore.

Πηγή: Science advances [Sci Adv] 2026 Sep 25; Vol. 12 (39), pp. eaeg6872. Date of Electronic Publication: 2026 Sep 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Arabidopsis*/immunology , Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Protein Kinases*/metabolism , Protein Kinases*/chemistry , Protein Kinases*/genetics , Plant Immunity* , Immunity, Innate* , Protein Multimerization*, Signal Transduction ; Innate Immunity Recognition

The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA.

Συγγραφείς: Niwa S; Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai, Japan.; Graduate School of Life Sciences, Tohoku University, Sendai, Japan., Furusaki N; Graduate School of Life Sciences, Tohoku University, Sendai, Japan., Kita T; Graduate School of Life Sciences, Tohoku University, Sendai, Japan., Suzuki Y; Mie University, Graduate School of Engineering, Tsu, Japan., Chiba K; Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai, Japan.

Πηγή: ELife [Elife] 2026 Sep 16; Vol. 13. Date of Electronic Publication: 2026 Sep 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Kinesins*/metabolism , Kinesins*/chemistry , Kinesins*/genetics , Microtubules*/metabolism , DNA*/metabolism , Protein Multimerization*, Humans ; Animals ; Protein Domains ; DNA-Binding Proteins

Isolation and characterization of plant plasma membrane P-type H⁺-ATPase dimers.

Συγγραφείς: Malysenko E; Department of Molecular Biochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, 44780, Bochum, Germany., Günther Pomorski T; Department of Molecular Biochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, 44780, Bochum, Germany.; Department of Plant and Environmental Sciences, University of Copenhagen, 1871, Frederiksberg, Denmark., Justesen BH; Department of Molecular Biochemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, 44780, Bochum, Germany. bo.justesen@ruhr-uni-bochum.de.

Πηγή: Scientific reports [Sci Rep] 2026 Sep 15; Vol. 16 (1). Date of Electronic Publication: 2026 Sep 15.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proton-Translocating ATPases*/chemistry , Proton-Translocating ATPases*/isolation & purification , Proton-Translocating ATPases*/metabolism , Cell Membrane*/enzymology , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/isolation & purification , Arabidopsis*/enzymology , Protein Multimerization*, Liposomes/metabolism ; Chromatography, Gel

The oligomeric state of chitooligosaccharide deacetylase from the marine bacterium Vibrio campbellii.

Συγγραφείς: Pongnan S; School of Biomolecular Science and Engineering (BSE), Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand., Robinson RC; School of Biomolecular Science and Engineering (BSE), Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand., Kamonsutthipaijit N; Synchrotron Light Research Institute (Public Organization), Nakhon Ratchasima, Thailand., Fukamizo T; School of Biomolecular Science and Engineering (BSE), Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand. Electronic address: tamo.f@vistec.ac.th., Suginta W; School of Biomolecular Science and Engineering (BSE), Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand. Electronic address: wipa.s@vistec.ac.th.

Πηγή: Biophysical reports [Biophys Rep (N Y)] 2026 Sep 09; Vol. 6 (3), pp. 100275. Date of Electronic Publication: 2026 Jun 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Elsevier Country of Publication: United States NLM ID: 9918266001106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-0747 (Electronic) Linking ISSN: 26670747 NLM ISO Abbreviation: Biophys Rep (N Y) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Vibrio*/enzymology , Amidohydrolases*/chemistry , Amidohydrolases*/metabolism , Bacterial Proteins*/chemistry , Protein Multimerization*, Models, Molecular

SCR Organism: Vibrio campbellii

Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis.

Συγγραφείς: Bohorquez LC; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands., Strahl H; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Marenduzzo D; SUPA, School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom., Thiele MJ; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Burmann F; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Hamoen L; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.

Πηγή: ELife [Elife] 2026 Sep 02; Vol. 13. Date of Electronic Publication: 2026 Sep 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Bacillus subtilis*/metabolism , Bacillus subtilis*/genetics , Bacterial Proteins*/metabolism , Cell Membrane*/metabolism , Adenosine Triphosphatases*/metabolism , Membrane Proteins*/metabolism , Protein Multimerization*, Escherichia coli

Oligomerization of the Recombinant CD40L Increases Its Agonist Activity upon Stimulation of Human B Cells.

Συγγραφείς: Mikhailov AA; Institute of Immunology National Research Center, Federal Medical-Biological Agency, Moscow, 115522, Russia.; Immunology Department, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia., Byazrova MG; Institute of Immunology National Research Center, Federal Medical-Biological Agency, Moscow, 115522, Russia.; P. Lumumba Peoples' Friendship University of Russia, Ministry of Science and Higher Education of the Russian Federation, Moscow, 117198, Russia., Sukhova MM; Institute of Immunology National Research Center, Federal Medical-Biological Agency, Moscow, 115522, Russia.; Immunology Department, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia., Petukhov MV; Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, 119071, Russia., Shtykova EV; Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, 119071, Russia., Filatov AV; Institute of Immunology National Research Center, Federal Medical-Biological Agency, Moscow, 115522, Russia. avfilat@yandex.ru.; Immunology Department, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.

Πηγή: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2026 Sep; Vol. 91 (9), pp. 1690-1703.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CD40 Ligand*/chemistry , CD40 Ligand*/metabolism , CD40 Ligand*/pharmacology , CD40 Ligand*/genetics , B-Lymphocytes*/metabolism , B-Lymphocytes*/immunology , B-Lymphocytes*/cytology , B-Lymphocytes*/drug effects , Protein Multimerization*, Recombinant Proteins/chemistry ; Recombinant Proteins/pharmacology ; Recombinant Proteins/metabolism ; NF-kappa B/metabolism ; Adiponectin/chemistry ; Adiponectin/metabolism ; Adiponectin/genetics ; Humans ; Signal Transduction ; Lymphocyte Activation ; Cell Proliferation

Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers.

Συγγραφείς: Nowinska M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Suh E; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Mogilevsky C; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.

Πηγή: Protein science : a publication of the Protein Society [Protein Sci] 2026 Sep; Vol. 35 (9), pp. e70754.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Amyloid beta-Peptides*/chemistry , Amyloid beta-Peptides*/immunology , Amyloid beta-Peptides*/metabolism , Peptide Fragments*/chemistry , Peptide Fragments*/immunology , Peptide Fragments*/metabolism , Single-Domain Antibodies*/chemistry , Single-Domain Antibodies*/genetics , Single-Domain Antibodies*/immunology , Protein Multimerization*, Humans ; Alzheimer Disease

Dimerization in the SLC12 family: Structural and biochemical perspectives.

Συγγραφείς: Náplavová A; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine. Department of Molecular Biology and Genetics, Aarhus University, Denmark., Nissen P; Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine. Department of Molecular Biology and Genetics, Aarhus University, Denmark., Flygaard RK; Department of Molecular Biology and Genetics, Aarhus University, Denmark. Electronic address: rkf@mbg.au.dk.

Πηγή: Journal of structural biology [J Struct Biol] 2026 Sep; Vol. 218 (3), pp. 108356. Date of Electronic Publication: 2026 Aug 11.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 9011206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8657 (Electronic) Linking ISSN: 10478477 NLM ISO Abbreviation: J Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Multimerization* , Solute Carrier Family 12*, Humans ; Cryoelectron Microscopy ; Protein Conformation ; Models, Molecular ; Animals ; Ion Transport

C-terminus-independent multimerization of Hv1 proton channels.

Συγγραφείς: Rosa V; Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico City, Mexico., Rangel-Yescas GE; Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico City, Mexico., Flores-Herrera O; Departamento de Bioquímica, Facultad de Medicina, UNAM, Mexico City, Mexico., Esparza-Perusquia M; Departamento de Bioquímica, Facultad de Medicina, UNAM, Mexico City, Mexico., Cristóbal-Mondragón GR; Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico City, Mexico., Ramsey IS; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, USA., Rosenbaum T; Departamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, UNAM, Mexico City, Mexico., Islas LD; Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico City, Mexico. Electronic address: leon.islas@gmail.com.

Πηγή: The Journal of biological chemistry [J Biol Chem] 2026 Sep; Vol. 302 (9), pp. 113387. Date of Electronic Publication: 2026 Aug 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ion Channels*/chemistry , Ion Channels*/metabolism , Ion Channels*/genetics , Protein Multimerization*, Animals ; Humans ; Protein Domains ; Protons

Actin filament assembly driven by distributive polymerases clustered on membrane surfaces.

Συγγραφείς: Mullins RD; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: dyche.mullins@ucsf.edu., Kondev J; Department of Physics, Brandeis University, Waltham, MA, USA., Skruber K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.

Πηγή: Biophysical journal [Biophys J] 2026 Sep 01; Vol. 125 (17), pp. 4809-4827. Date of Electronic Publication: 2026 Aug 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Actin Cytoskeleton*/metabolism , Actin Cytoskeleton*/chemistry , Cell Membrane*/metabolism , Protein Multimerization*, Profilins/metabolism ; Actins/metabolism ; Surface Properties ; Models, Biological ; Polymerization

Conformational bifurcation of tau R3-R4 oligomers underlies fibril polymorphism.

Συγγραφείς: Zhang T; School of Physics, Shandong University, Jinan 250100, China., Dai L; School of Physics, Shandong University, Jinan 250100, China., Ma Y; Dongying Science and Technology Innovation Service Center, Dongying 257091, China., Xu S; Institute of Biophysics, Dezhou University, Dezhou 253023, China., Liu X; School of Physics, Shandong University, Jinan 250100, China., Zhao M; School of Physics, Shandong University, Jinan 250100, China., Li W; School of Physics, Shandong University, Jinan 250100, China; Institute of Biophysics, Dezhou University, Dezhou 253023, China., Wang J; Department of Colorectal and Anal Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan 250100, China. Electronic address: wangjiayong120@icloud.com., Liu Y; School of Physics, Shandong University, Jinan 250100, China; Institute of Biophysics, Dezhou University, Dezhou 253023, China. Electronic address: lylyn2011@sdu.edu.cn.

Πηγή: Biophysical journal [Biophys J] 2026 Sep 01; Vol. 125 (17), pp. 4756-4767. Date of Electronic Publication: 2026 Jul 18.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): tau Proteins*/chemistry , tau Proteins*/metabolism , Amyloid*/chemistry , Amyloid*/metabolism , Protein Multimerization* , Protein Aggregates*, Molecular Dynamics Simulation ; Protein Folding ; Protein Conformation ; Thermodynamics ; Amino Acid Sequence ; Hydrophobic and Hydrophilic Interactions

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching.

Συγγραφείς: Wang Y; Department of Cellular and Genetic Medicine, Shandong Key Laboratory of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, P.R. China., Li X; Department of Cellular and Genetic Medicine, Shandong Key Laboratory of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, P.R. China., Wang M; Department of Medical Laboratory, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, Shandong 264000, P.R. China., Zhai N; Department of Respiratory and Critical Care Medicine, Shandong Medical and Pharmaceutical University Hospital, Shandong Medical and Pharmaceutical University, Binzhou, Shandong 256603, P.R. China., Jiang M; Department of Cellular and Genetic Medicine, Shandong Key Laboratory of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, P.R. China., Liu B; Department of Respiratory and Critical Care Medicine, Shandong Medical and Pharmaceutical University Hospital, Shandong Medical and Pharmaceutical University, Binzhou, Shandong 256603, P.R. China., Lv C; Department of Respiratory and Critical Care Medicine, Shandong Medical and Pharmaceutical University Hospital, Shandong Medical and Pharmaceutical University, Binzhou, Shandong 256603, P.R. China., Zhang S; Department of Cellular and Genetic Medicine, Shandong Key Laboratory of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, P.R. China., Song X; Department of Cellular and Genetic Medicine, Shandong Key Laboratory of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, P.R. China., Zhang J; Department of Cellular and Genetic Medicine, Shandong Key Laboratory of Complex Medical Intelligence and Aging, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, P.R. China.

Πηγή: International journal of molecular medicine [Int J Mol Med] 2026 Sep; Vol. 58 (3). Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Pulmonary Fibrosis*/genetics , Pulmonary Fibrosis*/pathology , Pulmonary Fibrosis*/metabolism , Pyruvate Kinase*/metabolism , Pyruvate Kinase*/genetics , Pyruvate Kinase*/chemistry , Protein Multimerization*, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Metabolic Reprogramming ; Male