Detection of extracellular amyloid beta aggregates by an Aducanumab-based synNotch receptor: an in vitro proof-of-concept study.

Συγγραφείς: Bergo NJ; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA., Lee S; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA., Siebrand CJ; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.; USC Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90191, USA., Mayeri Z; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA., Andersen JK; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA. jandersen@buckinstitute.org., Walton CC; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA. chaskacwalton@gmail.com.

Πηγή: Journal of translational medicine [J Transl Med] 2025 Nov 10; Vol. 23 (1), pp. 1255. Date of Electronic Publication: 2025 Nov 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Amyloid beta-Peptides*/metabolism , Protein Aggregates* , Receptors, Notch*/metabolism , Antibodies, Monoclonal, Humanized*/pharmacology , Proof of Concept Study* , Extracellular Space*/metabolism, Animals ; Humans ; Mice ; NIH 3T3 Cells

Regulatory Interactions and Learnings-RADIAL the Trials@Home Proof-of-Concept Trial on Decentralization.

Συγγραφείς: Gardarsdottir H; Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Department of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands., Traore H; UCB Biopharma, Brussels, Belgium., Huntley K; Global Regulatory Sciences, Pfizer R&D UK Limited, Kent, UK., Mistry D; Fortrea Development Ltd UK, Leeds, UK., de Jong AJ; Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Legathe A; Sanofi, Paris, France., de Smedt T; UCB Biopharma, Brussels, Belgium., Askin S; Novartis Pharma AG, Basel, Switzerland., Heath M; Sanofi, Reading, UK., Corriol-Rohou S; AstraZeneca R&D, Paris, France., Lagerwaard B; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Zuidgeest MGP; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

Συλλογικό Έργο: IMI Trials@Home Consortium

Πηγή: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Nov; Vol. 118 (5), pp. 1046-1056. Date of Electronic Publication: 2025 Oct 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Clinical Trials as Topic*/legislation & jurisprudence , Clinical Trials as Topic*/methods , Proof of Concept Study*, Humans ; Research Design ; Europe ; European Union ; Politics

Clinical trials of prevention of acquired epilepsy: New proof-of-concept approach to restart trials.

Συγγραφείς: Klein P; Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland, USA., Koepp M; Department of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology, London, UK., Rotenberg A; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hameed MQ; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Löscher W; Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the Ear, Nose and Throat Clinics, Hannover Medical School, Hannover, Germany.

Πηγή: Epilepsia [Epilepsia] 2025 Aug; Vol. 66 (8), pp. 2679-2689. Date of Electronic Publication: 2025 Apr 04.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proof of Concept Study* , Clinical Trials as Topic*/methods , Epilepsy, Post-Traumatic*/prevention & control , Epilepsy, Post-Traumatic*/etiology , Epilepsy, Post-Traumatic*/diagnosis , Brain Injuries, Traumatic*/complications , Epilepsy*/prevention & control , Epilepsy*/etiology, Humans ; Anticonvulsants/therapeutic use

The human photosensitive epilepsy model for clinical proof-of-principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model.

Συγγραφείς: Löscher W; Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany., Trenité DK; Department of Neurosurgery and Epilepsy, University Medical Center Utrecht, Utrecht, the Netherlands.; NESMOS Department, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.

Πηγή: Epilepsia [Epilepsia] 2025 Aug; Vol. 66 (8), pp. 2619-2638. Date of Electronic Publication: 2025 May 10.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Anticonvulsants*/therapeutic use , Epilepsy, Reflex*/drug therapy , Epilepsy, Reflex*/physiopathology , Clinical Trials as Topic* , Proof of Concept Study*, Humans ; Electroencephalography ; Predictive Value of Tests

A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury.

Συγγραφείς: Whitehouse DP; Department of Medicine: Perioperative, Acute, Critical Care and Emergency Medicine (PACE) Section, University of Cambridge, Cambridge, UK. dw555@cam.ac.uk., Needham EJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Bernstock JD; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery Boston Children's Hospital Harvard Medical School, Boston, MA, USA.; David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology, Cambridge, MA, USA., Gaude E; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.; Upfront Diagnostics, Pockit Diagnostics Ltd, Cambridge, UK., Barrett L; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ebrahimi S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Menon DK; Department of Medicine: Perioperative, Acute, Critical Care and Emergency Medicine (PACE) Section, University of Cambridge, Cambridge, UK., Newcombe VFJ; Department of Medicine: Perioperative, Acute, Critical Care and Emergency Medicine (PACE) Section, University of Cambridge, Cambridge, UK.

Πηγή: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2025 Jul 12; Vol. 45 (1), pp. 69. Date of Electronic Publication: 2025 Jul 12.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Netherlands NLM ID: 8200709 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Glial Fibrillary Acidic Protein*/blood , Brain Injuries, Traumatic*/blood , Brain Injuries, Traumatic*/diagnosis , Proof of Concept Study*, Humans ; Male ; Female ; Biomarkers/blood ; Middle Aged ; Adult ; Aged ; Young Adult

Galantamine combined with cognitive rehabilitation on post-stroke cognitive impairment: a proof-of-concept study.

Συγγραφείς: Planton M; Department of Neurology, Toulouse University Hospital, Toulouse, France.; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France., Nemmi F; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France., Pages B; Department of Neurology, Toulouse University Hospital, Toulouse, France., Albucher JF; Department of Neurology, Toulouse University Hospital, Toulouse, France.; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France., Raposo N; Department of Neurology, Toulouse University Hospital, Toulouse, France.; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France., Danet L; Department of Neurology, Toulouse University Hospital, Toulouse, France.; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France., Péran P; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France., Pariente J; Department of Neurology, Toulouse University Hospital, Toulouse, France.; Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.

Πηγή: Brain injury [Brain Inj] 2025 Jan 28; Vol. 39 (2), pp. 108-117. Date of Electronic Publication: 2024 Oct 03.

Τύπος έκδοσης: Journal Article; Randomized Controlled Trial

Στοιχεία περιοδικού: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8710358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-301X (Electronic) Linking ISSN: 02699052 NLM ISO Abbreviation: Brain Inj Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Galantamine*/therapeutic use , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/rehabilitation , Cognitive Dysfunction*/drug therapy , Stroke*/complications , Proof of Concept Study* , Stroke Rehabilitation*/methods, Humans ; Male ; Female ; Double-Blind Method ; Middle Aged ; Aged ; Treatment Outcome ; Quality of Life ; Neuropsychological Tests ; Combined Modality Therapy ; Cholinesterase Inhibitors/therapeutic use ; Cognitive Behavioral Therapy/methods ; Magnetic Resonance Imaging ; Cognitive Training

The Effects of Whole-Body Exercise on Swallowing Function in Older Adults With Parkinson's Disease: A Proof-of-Principle Study.

Συγγραφείς: Chan H; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Tang A; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Li O; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Orprecio AJ; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Abrams SW; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Wiley E; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., MacDonald K; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Ma J; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Namasivayam-MacDonald A; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.

Πηγή: American journal of speech-language pathology [Am J Speech Lang Pathol] 2025 Jan 07; Vol. 34 (1), pp. 314-332. Date of Electronic Publication: 2024 Dec 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Speech-Language-Hearing Association Country of Publication: United States NLM ID: 9114726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-9110 (Electronic) Linking ISSN: 10580360 NLM ISO Abbreviation: Am J Speech Lang Pathol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Parkinson Disease*/physiopathology , Parkinson Disease*/therapy , Deglutition*/physiology , Deglutition Disorders*/physiopathology , Deglutition Disorders*/therapy , Deglutition Disorders*/etiology , Exercise Therapy*/methods , Proof of Concept Study* , Tongue*/physiopathology, Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Muscle Strength ; Treatment Outcome ; Respiratory Rate ; Cough/physiopathology ; Time Factors

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study.

Συγγραφείς: Das S; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Ge Y; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Guo Y; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Rajwal S; Department of Computer Science and Informatics, Emory University, Atlanta, GA, United States., Hairston J; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Powell J; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Walker D; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Peddireddy S; Department of Behavioral, Social & Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, GA, United States., Lakamana S; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Bozkurt S; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Reyna M; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States., Sameni R; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States.; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States., Xiao Y; Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States., Kim S; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States., Chandler R; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, United States., Hernandez N; Center for Maternal Health Equity, Morehouse School of Medicine, Atlanta, GA, United States., Mowery D; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Wightman R; Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, United States., Love J; Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Spadaro A; Department of Emergency Medicine, Rutgers New Jersey Medical School, Newark, NJ, United States., Perrone J; Department of Emergency Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States., Sarker A; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States.; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States.

Πηγή: Journal of medical Internet research [J Med Internet Res] 2025 Jan 06; Vol. 27, pp. e66220. Date of Electronic Publication: 2025 Jan 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 100959882 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-8871 (Electronic) Linking ISSN: 14388871 NLM ISO Abbreviation: J Med Internet Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Social Media*/statistics & numerical data , Natural Language Processing* , Proof of Concept Study*, Humans ; Information Storage and Retrieval/methods

Virtual reality exposure therapy for sexual aversion: a proof-of-concept study on acceptability, adequacy, and clinical effects.

Συγγραφείς: Lafortune D; Department of Sexology, Université du Québec à Montréal, Montreal, Quebec, H2L 2C4, Canada., Lapointe VA; Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, H2L 2C4, Canada., Dubé S; Kinsey Institute, Indiana University, Bloomington, Indiana, 47405, United States., Bonneau J; School of Media, Université du Québec à Montréal, Montreal, Quebec, H2L 2C4, Canada.

Πηγή: The journal of sexual medicine [J Sex Med] 2025 Jan 03; Vol. 22 (1), pp. 124-131.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: Netherlands NLM ID: 101230693 Publication Model: Print Cited Medium: Internet ISSN: 1743-6109 (Electronic) Linking ISSN: 17436095 NLM ISO Abbreviation: J Sex Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Virtual Reality Exposure Therapy*/methods , Proof of Concept Study* , Sexual Dysfunctions, Psychological*/therapy , Sexual Dysfunctions, Psychological*/psychology, Humans ; Female ; Adult ; Male ; Middle Aged ; Anxiety/therapy ; Surveys and Questionnaires ; Treatment Outcome ; Sexual Behavior/psychology ; Disgust ; Virtual Reality

A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors.

Συγγραφείς: Cillo U; Hepato-Biliary-Pancreatic Surgery and Liver Transplant Unit, General Surgery 2, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., Lonati C; Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20100, Milan, Italy. caterina.lonati@gmail.com., Bertacco A; Hepato-Biliary-Pancreatic Surgery and Liver Transplant Unit, General Surgery 2, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., Magnini L; Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20100, Milan, Italy., Battistin M; Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20100, Milan, Italy., Borsetto L; Hepato-Biliary-Pancreatic Surgery and Liver Transplant Unit, General Surgery 2, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., Dazzi F; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK., Al-Adra D; Division of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Gringeri E; Hepato-Biliary-Pancreatic Surgery and Liver Transplant Unit, General Surgery 2, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., Bacci ML; Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy., Schlegel A; Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20100, Milan, Italy.; Transplantation Center, Digestive Disease and Surgery Institute, Department of Immunity and Inflammation, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44106, USA., Dondossola D; General and Liver Transplant Surgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20100, Milan, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20100, Milan, Italy.

Συλλογικό Έργο: Liver NMP Consortium

Πηγή: Nature communications [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 283. Date of Electronic Publication: 2025 Jan 02.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism , Bioreactors* , Perfusion*/methods , Perfusion*/instrumentation , Liver*/metabolism , Liver*/cytology , Proof of Concept Study*, Animals ; Rats ; Swine ; Male ; Organ Preservation/methods ; Organ Preservation/instrumentation ; Models, Animal ; Mesenchymal Stem Cell Transplantation/methods

Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study.

Συγγραφείς: Jindal N; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Sharma P; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Punia S; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Dass M; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Anthwal D; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Gupta RK; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Bhalla M; Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India., Singhal R; Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India., Behera A; Department of Internal Medicine, PGIMER, Chandigarh, India., Yadav R; Department of Medical Microbiology, PGIMER, Chandigarh, India., Sethi S; Department of Medical Microbiology, PGIMER, Chandigarh, India., Dhooria S; Department of Pulmonary Medicine, PGIMER, Chandigarh, India., Aggarwal AN; Department of Pulmonary Medicine, PGIMER, Chandigarh, India., Haldar S; Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address: sagarikahaldar.pgimer@gmail.com.

Πηγή: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2025 Jan; Vol. 150, pp. 102578. Date of Electronic Publication: 2024 Nov 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Antigens, Bacterial*/immunology , Antigens, Bacterial*/analysis , Extracellular Vesicles*/immunology , Extracellular Vesicles*/metabolism , Mycobacterium tuberculosis*/immunology , Tuberculosis, Pleural*/diagnosis , Tuberculosis, Pleural*/immunology , Tuberculosis, Pleural*/microbiology , Bacterial Proteins*/immunology , Bacterial Proteins*/analysis , Enzyme-Linked Immunosorbent Assay* , Pleural Effusion*/microbiology , Pleural Effusion*/immunology , Proof of Concept Study*, Humans ; Male ; Female ; Middle Aged ; Adult ; Predictive Value of Tests ; Reproducibility of Results ; Aged

Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study.

Συγγραφείς: de Sire A; Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Marotta N; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Physical and Rehabilitative Medicine Unit, Department of Experimental and Clinical Medicine, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Sconza C; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; IRCCS Humanitas Research Hospital, Milan, Italy., Lippi L; Department of Scientific Research, Campus LUdeS Lugano (CH), Off-Campus Semmelweis University of Budapest, Budapest, Hungary., Drago Ferrante V; Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Respizzi S; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; IRCCS Humanitas Research Hospital, Milan, Italy., Invernizzi M; Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.; Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Translational Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., Ammendolia A; Physical and Rehabilitative Medicine Unit, Department of Medical and Surgical Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.

Πηγή: Disability and rehabilitation [Disabil Rehabil] 2025 Jan; Vol. 47 (2), pp. 452-458. Date of Electronic Publication: 2024 Apr 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9207179 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5165 (Electronic) Linking ISSN: 09638288 NLM ISO Abbreviation: Disabil Rehabil Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Osteoarthritis*/therapy , Osteoarthritis*/rehabilitation , Osteoarthritis*/drug therapy , Ozone*/therapeutic use , Oxygen* , Proof of Concept Study* , Pain Measurement* , Pain Management*/methods , Physical Therapy Modalities*, Humans ; Female ; Male ; Aged ; Prospective Studies ; Middle Aged ; Injections, Intra-Articular ; Combined Modality Therapy ; Treatment Outcome ; Carpometacarpal Joints/physiopathology ; Trapezium Bone ; Muscle Strength

'Home inspections' for life sciences companies going public before clinical proof-of-concept.

Συγγραφείς: Bespalov A; PAASP, Am Aukopf 14/1, Heidelberg 69118, Germany. Electronic address: anton.bespalov@paasp.net., Miller R; PAASP US, 29745 N Environ Cir, Lake Bluff, IL 60044, USA., Emmerich CH; PAASP, Am Aukopf 14/1, Heidelberg 69118, Germany.

Πηγή: Drug discovery today [Drug Discov Today] 2025 Jan; Vol. 30 (1), pp. 104278. Date of Electronic Publication: 2024 Dec 22.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Biological Science Disciplines*/economics , Proof of Concept Study* , Drug Industry*/economics , Biotechnology*/economics, Humans ; Investments

A proof-of-concept study of pitolisant for excessive daytime sleepiness in patients with Prader-Willi syndrome.

Συγγραφείς: Revana A; Baylor College of Medicine, Texas Children's Hospital, Houston, Texas., Bhattacharjee R; Rady Children's Hospital, University of California San Diego, San Diego, California., Miller JL; University of Florida Health Shands Hospital, Gainesville, Florida., Chidekel A; Nemours Children's Health, Wilmington, Delaware., Khanna P; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Ratnam S; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Runyan G; Harmony Biosciences, Plymouth Meeting, Pennsylvania., Bauer E; Harmony Biosciences, Plymouth Meeting, Pennsylvania., Davis Rapchak K; Harmony Biosciences, Plymouth Meeting, Pennsylvania., Seiden D; Harmony Biosciences, Plymouth Meeting, Pennsylvania., Budur K; Harmony Biosciences, Plymouth Meeting, Pennsylvania., Dayno JM; Harmony Biosciences, Plymouth Meeting, Pennsylvania.

Πηγή: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2025 Nov 01; Vol. 21 (11), pp. 1893-1902.

Τύπος έκδοσης: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II

Στοιχεία περιοδικού: Publisher: American Academy of Sleep Medicine Country of Publication: United States NLM ID: 101231977 Publication Model: Print Cited Medium: Internet ISSN: 1550-9397 (Electronic) Linking ISSN: 15509389 NLM ISO Abbreviation: J Clin Sleep Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Disorders of Excessive Somnolence*/drug therapy , Disorders of Excessive Somnolence*/etiology , Piperidines*/therapeutic use , Piperidines*/administration & dosage , Prader-Willi Syndrome*/complications, Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Proof of Concept Study ; Treatment Outcome

High-dose inhaled NO for the prevention of nosocomial pneumonia after cardiac surgery under cardiopulmonary bypass: A proof-of-concept prospective randomised study.

Συγγραφείς: Kalashnikova TP; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Kamenshchikov NO; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Arsenyeva YA; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Podoksenov YK; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Kravchenko IV; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Kozulin MS; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Tyo MA; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Churilina EA; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Kim EB; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Svirko YS; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Kozlov BN; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation., Boshchenko AA; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation.

Πηγή: Pulmonology [Pulmonology] 2025 Dec 31; Vol. 31 (1), pp. 2471706. Date of Electronic Publication: 2025 Feb 28.

Τύπος έκδοσης: Journal Article; Randomized Controlled Trial

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101723786 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2531-0437 (Electronic) Linking ISSN: 25310429 NLM ISO Abbreviation: Pulmonology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cardiac Surgical Procedures*/adverse effects , Cardiopulmonary Bypass*/adverse effects , Cardiopulmonary Bypass*/methods , Cross Infection*/prevention & control , Healthcare-Associated Pneumonia*/prevention & control , Healthcare-Associated Pneumonia*/epidemiology , Nitric Oxide*/administration & dosage , Nitric Oxide*/adverse effects , Postoperative Complications*/epidemiology , Postoperative Complications*/prevention & control, Aged ; Female ; Humans ; Male ; Middle Aged ; Administration, Inhalation ; Incidence ; Pilot Projects ; Prospective Studies ; Treatment Outcome ; Proof of Concept Study

Feasibility of a Specialized Large Language Model for Postgraduate Medical Examination Preparation: Single-Center Proof-Of-Concept Study.

Συγγραφείς: Leong YH; Division of Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, Singapore.; Department of Anesthesiology, Sengkang General Hospital, Singapore, Singapore., Nambiar L; Division of Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, Singapore., Tay VYJ; Division of Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, Singapore.; Department of Anesthesiology, Sengkang General Hospital, Singapore, Singapore., Lie SA; Division of Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, Singapore.; Department of Anesthesiology, Sengkang General Hospital, Singapore, Singapore., Yuhe K; Division of Anesthesiology and Perioperative Medicine, Singapore General Hospital, Singapore, Singapore.; Department of Anesthesiology, Sengkang General Hospital, Singapore, Singapore.

Πηγή: JMIR formative research [JMIR Form Res] 2025 Dec 03; Vol. 9, pp. e77580. Date of Electronic Publication: 2025 Dec 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101726394 Publication Model: Electronic Cited Medium: Internet ISSN: 2561-326X (Electronic) Linking ISSN: 2561326X NLM ISO Abbreviation: JMIR Form Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Educational Measurement*/methods , Education, Medical, Graduate*/methods , Anesthesiology*/education , Language*, Humans ; Feasibility Studies ; Singapore ; Reproducibility of Results ; Proof of Concept Study ; Female ; Internship and Residency ; Male ; Adult ; Surveys and Questionnaires ; Clinical Competence ; Large Language Models

Radiomics-based MRI models for predicting breast cancer axillary lymph node involvement in comparison with Node-RADS: a proof-of-concept study.

Συγγραφείς: Maroncelli R; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy. roberto.maroncelli@uniroma1.it.; Department of Experimental Medicine, Sapienza-University of Rome, Rome, Italy. roberto.maroncelli@uniroma1.it., Rizzo V; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy., Pasculli M; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy., Coppola S; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy., De Nardo C; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy., Moschetta M; Interdisciplinary Department of Medicine (DIM), Section of Radiology and Radiation Oncology, University of Bari, Bari, Italy., Catalano C; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy., Pediconi F; Department of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, Rome, Italy.

Πηγή: European radiology experimental [Eur Radiol Exp] 2025 Dec 02; Vol. 9 (1), pp. 117. Date of Electronic Publication: 2025 Dec 02.

Τύπος έκδοσης: Journal Article; Comparative Study; Multicenter Study

Στοιχεία περιοδικού: Publisher: SpringerOpen Country of Publication: England NLM ID: 101721752 Publication Model: Electronic Cited Medium: Internet ISSN: 2509-9280 (Electronic) Linking ISSN: 25099280 NLM ISO Abbreviation: Eur Radiol Exp Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Breast Neoplasms*/pathology , Breast Neoplasms*/diagnostic imaging , Lymphatic Metastasis*/diagnostic imaging , Magnetic Resonance Imaging*/methods , Lymph Nodes*/diagnostic imaging , Lymph Nodes*/pathology, Humans ; Female ; Middle Aged ; Retrospective Studies ; Axilla ; Proof of Concept Study ; Adult ; Aged ; Machine Learning ; Predictive Value of Tests ; Sensitivity and Specificity ; Radiomics

Proton pencil beam scanning ultra-high dose rate 3D lattice radiotherapy: A proof-of-concept FLASH SFRT study.

Συγγραφείς: Wei S; New York Proton Center, New York, USA., Qi H; New York Proton Center, New York, USA., Xu L; New York Proton Center, New York, USA., Selvaraj B; New York Proton Center, New York, USA., Zhao X; New York Proton Center, New York, USA., Zheng A; New York Proton Center, New York, USA., Vermeulen M; New York Proton Center, New York, USA., Lee NY; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA., Bakst R; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, USA., Guha C; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, USA., Tsai P; New York Proton Center, New York, USA.; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA., Kang M; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin, USA., Wu X; Executive Medical Physics Associates, North Miami Beach, Florida, USA.; Innovative Cancer Institute, South Miami, Florida, USA., Yacoub I; New York Proton Center, New York, USA., Choi JI; New York Proton Center, New York, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA., Chhabra A; New York Proton Center, New York, USA., Simone CB 2nd; New York Proton Center, New York, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA., Lin H; New York Proton Center, New York, USA.; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, USA.; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.

Πηγή: Medical physics [Med Phys] 2025 Dec; Vol. 52 (12), pp. e70187.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proton Therapy*/methods , Proton Therapy*/instrumentation , Radiation Dosage*, Radiotherapy Dosage ; Humans ; Radiotherapy Planning, Computer-Assisted ; Proof of Concept Study ; Feasibility Studies ; Phantoms, Imaging ; Radiotherapy, Intensity-Modulated/methods ; Radiometry

An Open-Label, Single-Center Proof of Concept Study Evaluating the Efficacy and Safety of Tirzepatide for Moderate to Severe Hidradenitis Suppurativa.

Συγγραφείς: Acosta-Madiedo AS, Gutierrez M, Gutierrez M, Villacampa A, Kerdel F

Πηγή: Journal of drugs in dermatology : JDD [J Drugs Dermatol] 2025 Dec 01; Vol. 24 (12), pp. 1246-1251.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Physicians Continuing Education Corporation Country of Publication: United States NLM ID: 101160020 Publication Model: Print Cited Medium: Internet ISSN: 1545-9616 (Print) Linking ISSN: 15459616 NLM ISO Abbreviation: J Drugs Dermatol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hidradenitis Suppurativa*/drug therapy , Hidradenitis Suppurativa*/diagnosis, Humans ; Adult ; Male ; Female ; Treatment Outcome ; Proof of Concept Study ; Severity of Illness Index ; Middle Aged ; Quality of Life ; Tirzepatide

An absorbed dose-based source strength determination for diffusing alpha-emitters radiation therapy (DaRT) brachytherapy seeds - Proof of concept.

Συγγραφείς: Jollota SP; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Radtke JL; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., DeWerd LA; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Khan AU; Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Πηγή: Medical physics [Med Phys] 2025 Dec; Vol. 52 (12), pp. e70167.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Brachytherapy*/methods , Brachytherapy*/instrumentation , Alpha Particles*/therapeutic use , Radiation Dosage*, Radiotherapy Dosage ; Monte Carlo Method ; Diffusion ; Proof of Concept Study ; Humans